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Neuromodulatory effects of ethyl acetate fraction of Zingiber officinale Roscoe extract in rats with lead-induced oxidative stress

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Journal of Integrative Medicine 2019年第2期17卷 125-131页

作者： mary abiola okesola Basiru Olaitan Ajiboye Babatunji Emmanuel Oyinloye Oluwafemi Adeleke Ojo Department of Biochemistry Covenant University Department of Biochemistry Afe Babalola University Department of Biochemistry University of Ilorin

Objective: This study investigated the ameliorative potential of Zingiber officinale Roscoe extract against lead-induced brain damage in ***: Thirty male rats were divided into 5 groups of 6 rats each. Lead-acetate toxicity was induced by intraperitoneal injection(10 mg/kg body weight(b.w.)) in Groups B–E. Group A(control) and Group B(lead-acetate) were left untreated; vitamin C(200 mg/kg b.w.) was administered to Group C; ethyl acetate fraction from Z. officinale extract(200 and 100 mg/kg b.w.) was administered to Group D and E by oral gavage once daily for 7 days. Changes in the content of some key marker enzymes such as acetylcholinesterase(AChE), butyrylcholinesterase(BChE), monoamine oxidase(MAO), epinephrine, dopamine,Na^+/K^+-ATPase, catalase(CAT), superoxide dismutase(SOD) and glutathione peroxidase(GPx) as well as malonaldehyde(MDA) levels were determined in ***: Exposure to lead acetate resulted in a significant decrease(P < 0.05) in the activities of BChE,AChE, Na^+/K^+-ATPase, SOD, CAT and GPx with a corresponding increase in the levels of MDA, xanthine oxidase, epinephrine, dopamine and MAO relative to the control group. Levels of all disrupted parameters were alleviated by co-administration of Z. officinale fraction and by the standard drug, vitamin ***: These results suggest that ethyl acetate fraction of Z. officinale extract attenuates leadinduced brain damage and might have therapeutic potential as a supplement that can be applied in lead poisoning.

关键词： Zingiber officinale Acetylcholinesterase Monoamine oxidase Na^(+)/K^(+)-ATPase Lead acetate Neurodegenerative disorders

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