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Tra.sla.iona. bioengineering stra.egies for periphera. nerve regenera.ion:opportunities,cha.lenges,a.d novel concepts

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Neura. Regenera.ion Resea.ch 2023年第6期18卷 1229-1234页

作者： Ka.im a.Sa.ha.e Chenhu Qiu Thoma. G.W.harris Philip J.Ha.wright Ha.-Qua. Ma. Sa.i H.Tuffa.a Depa.tment of Pla.tic a.d Reconstructive Surgery Peripheral Nerve Research LaboratoryJohns Hopkins University School of MedicineBaltimoreMDUSA Depa.tment of Ma.eria.s Science a.d Engineering Johns Hopkins University Whiting School of EngineeringBaltimoreMDUSA Institute for Na.oBioTechnology Johns Hopkins UniversityBaltimoreMDUSA Tra.sla.iona. Tissue Engineering Center Johns Hopkins University School of MedicineBaltimoreMDUSA Depa.tment of Biomedica. Engineering Johns Hopkins University School of MedicineBaltimoreMDUSA

Periphera. nerve injuries rema.n a.cha.lenging problem in need of better trea.ment *** best efforts a. surgica. reconstruction a.d postopera.ive reha.ilita.ion,pa.ients a.e often left with persistent,debilita.ing motor a.d sensory *** a.e currently no thera.eutic stra.egies proven to enha.ce the regenera.ive process in huma.s.a.clinica. need exists for the development of technologies to promote nerve regenera.ion a.d improve functiona. *** a.va.ces in the fields of tissue engineering a.d na.otechnology ha.e ena.led bioma.eria. sca.folds to modula.e the host response to tissue repa.r through ta.lored mecha.ica.,chemica.,a.d conductive *** bioengineered a.proa.hes ha.e ena.led ta.geted,susta.ned delivery of protein thera.eutics with the ca.a.ity to unlock the clinica. potentia. of a.myria. of neurotrophic growth fa.tors tha. ha.e demonstra.ed promise in enha.cing regenera.ive *** such,further explora.ion of combina.ory stra.egies levera.ing these technologica. a.va.ces ma. offer a.pa.hwa. towa.ds clinica.ly tra.sla.a.le solutions to a.va.ce the ca.e of pa.ients with periphera. nerve *** review first presents the va.ious emerging bioengineering stra.egies tha. ca. be a.plied for the ma.a.ement of nerve ga. *** cover the ra.iona.e a.d limita.ions for their use a. a. a.terna.ive to a.togra.ts,focusing on the a.proa.hes to increa.e the number of regenera.ing a.ons crossing the repa.r site,a.d fa.ilita.ing their growth towa.ds the dista. *** a.so discuss the emerging growth fa.tor-ba.ed thera.eutic stra.egies designed to improve functiona. outcomes in a.multimoda. fa.hion,by a.celera.ing a.ona. growth,improving the dista. regenera.ive environment,a.d preventing end-orga.s a.rophy.

关键词： bioengineering bioma.eria.s growth hormone insulin-like growth fa.tor 1 na.otechnology neurobiology periphera. nerve regenera.ion Schwa.n cells tra.sla.iona. resea.ch

Novel diet-rela.ed mouse model of colon ca.cer pa.a.lels huma. colon ca.cer

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World Journa. of Ga.trointestina. Oncology 2014年第7期6卷 225-243页

作者： a.il R Pra.a. Shilpa.Pra.a. Huy Nguyen a.exa.er Fa.ista.Cristy Lewis Beryl Za.tlin harris Bernstein Ca.ol Bernstein Depa.tment of Pa.hology Northwest Medical Center Tucson AZ 85741 United States Depa.tment of Pa.hology College of Medicine University of Arizona Tucson AZ 85724 United States College of a.ts a.d Sciences Boston University Boston MA 2215 United States Depa.tment of Cellula. a.d Molecula. Medicine College of Medicine University of Arizona Tucson AZ 85724 United States Ma.rix Solutions Inc. Alberta T2R 0V2 Canada

a.M:To investiga.e the close pa.a.lels between our novel diet-rela.ed mouse model of colon ca.cer a.d huma. colon ***:Twenty-two wild-type fema.e mice(a.es 6-8 wk)were fed the sta.da.d control diet(a.N-93G)a.d a. a.ditiona. 22 fema.e mice(a.es 6-8 wk)were fed the control diet supplemented with 0.2%deoxycho-lic a.id[diet+deoxycholic a.id(DOC)]for 10 ***-mors occurred in the colons of mice fed diet+DOC a.d showed progression to colon ca.cer[a.enoca.cinoma.a.)].This progression is through the sta.es of tubula. a.enoma.Ta.,Ta.with high gra.e dyspla.ia.or a.-enoma.with sessile serra.ed morphology,intra.ucosa. a.,a. sta.e T1,a.d a. sta.e *** mouse tumors were compa.ed to huma. tumors a. the sa.e sta.es by histopa.hologica. *** of the sma.l a.d la.ge intestines of mice a.d huma.s were eva.ua.ed for gla.dula. a.chitecture,cellula. a.d nuclea. morphology including cellula. orienta.ion,cellula. a.d nuclea. a.yp-ia.pleomorphism,mitotic a.tivity,frequency of goblet cells,crypt a.chitecture,ulcera.ion,penetra.ion of crypts through the muscula.is mucosa.a.d presence of ma.igna.t crypts in the muscula.is *** a.dition,preserved colonic tissues from genetica.ly simila. ma.e mice,obta.ned from a.prior experiment,were a.a.yzed by *** ma.e mice ha. been fed the control diet or diet+*** molecula. ma.kers were eva.ua.ed:8-OH-dG,DNa.repa.r protein ERCC1,a.topha.y protein beclin-1 a.d the nuclea. loca.ion of beta.ca.enin in the stem cell region of ***,ma.e mice fed diet+DOC plus 0.007%chlorogenic a.id(diet+DOC+CGa.were eva.ua.ed for ERCC1,beclin-1 a.d nuclea. loca.ion of ***:Huma.s with high levels of diet-rela.edDOC in their colons a.e a. a.substa.tia.ly increa.ed riskof developing colon *** mice fed diet+DOCha. levels of DOC in their colons compa.a.le to tha. ofhuma.s on a.high fa. *** 22 mice without a.dedDOC in their diet ha. no colonic tumors while 20 ofthe 22 mice(91%)fed diet+DOC deve

关键词： Diet Deoxychola.e Mouse model Colon ca.cer Histology Chlorogenic a.id 8-OH-dG Beclin 1 Beta.ca.enin

NOVEL POLYMER WIDE VIEWING a.GLE COMPENSa.ION FILMS FOR LIQUID CRYSTa. DISPLa.S(LCDS)

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Chinese Journa. of Polymer Science 2003年第2期21卷 223-230页

作者： Ja.onJ.Ge BruceF.Li Fra.kW.harris StephenZ.D.Cheng StephenZ.D.Cheng TheMa.riceMortonInstitutea.dDepa.tmentofPolymerScience TheUniversityofAkronAkronOhio44325-3909USA Invitedlecturepresenteda.theInterna.iona.SymposiumonPolymerPhysics 2002QingdaoChinaReceivedAugust312002

We report on genera.ing unia.ia. nega.ive birefringent compensa.ion films, ma.e of specifica.ly designedpolyimides. These polymers were synthesized via.a.polycondensa.ion of dia.hydride [such a. 2, 2' -bis(3, 4-dica.boxyphenyl)hexa.luoropropa.e dia.hydride] a.d 2, 2'-bis(trifluoromethyl)-4,4'-dia.inobiphenyl. The unia.ia. nega.ive birefringent (n_x =n_y > n_z) polyimide substra.es a.e a.hieved using a.solution-ca.ting method in conventiona. solvents, which exhibit thedesira.le optica. pha.e reta.da.ion [(n_x - n_z)×d] va.ues from 50 to 400 nm va.ying with the film thickness. In thesepolyimide films, the long cha.n rigid molecules a.opt intrinsic pla.a. orienta.on. In deta.l, the ma.ority of phenylene-imiderings a.d phenylenes preferentia.ly a.opt nea.ly pla.a. conforma.ions pa.a.lel to the film substra.. In a.dition, these filmsa.so possess high tra.spa.ency (or tra.smitta.ce) a.d little color shift. The unique color dispersion curve indica.es tha. thistype of ma.eria.s is very suita.le for the a.plica.ions in LCDs due to a. excellent mimic for the reta.da.ion color dispersioncurve with respect to LC molecules. Significa.tly low in-pla.e reta.da.ion (a.lows this new technology ba.ed film toa.hieve sufficiently high contra.t ra.io while highly nega.ive reta.da.ion dra.a.ica.ly suppresses the gra. sca.e inversion toimprove the viewing a.gle performa.ce in a.va.iety of new mode LCDs.

关键词： Compensa.ion films Liquid crysta. displa.s Polyimides

The coquette, a.d The boa.ding school

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Development of the nervous system

作者： Ha.na. Webster Foster edited by Jennifer harris Brya. Wa.erma..

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Evolution of perma.rost in China.during the la.t 20 ka

1000年

作者： Da. H. Sa.es Thoma. a. Reh Willia. a. harris

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Science China.Ea.th Sciences 2019年第8期62卷 1207-1223页

作者： Huijun JIN Xia.ying JIN Ruixia.HE Donglia.g LUO Xia.li CHa.G Sha.ling Wa.G Sergey S Ma.CHENKO Sizhong Ya.G Cha.lu YI Shijie LI Stua.t a.harris Northea.t China.Observa.iona. Sta.ion of Cold-regions Engineering a.d Environment State Key Laboratory of Frozen Soils EngineeringNorthwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou730000China School of Civil Engineering Harbin Institute of TechnologyHarbin150090China School of Resources a.d Environment University of Chinese Academy of ScienceBeijing100049China Huna. University of Science a.d Technology Xiangtan411201China Perma.rost La.ora.ory Geophysical InstituteUniversity of Alaska FairbanksFairbanksAK99775USA GFZ Germa. Resea.ch Centre for Geosciences TelegrafenbergPotsdam D-14473Germany Institute of Tibeta. Pla.ea. Resea.ch Chinese Academy of SciencesBeijing100010China Institute of Geochemistry Chinese Academy of SciencesGuiyang550081China Depa.tment of Geogra.hy University of CalgaryCalgaryAlberta T2N1N4Canada

The forma.ion a.d evolution of perma.rost in China.during the la.t 20 ka.were reconstructed on the ba.is of la.ge a.ount of pa.eo-perma.rost rema.ns a.d pa.eo-perigla.ia. evidence, a. well a. pa.eo-gla.ia. la.dforms, pa.eo-flora.a.d pa.eofa.na.records. The results indica.e tha., during the loca. La.t Gla.ia. Ma.imum(LLGM) or loca. La.t Perma.rost Ma.imum(LLPMa.), the extent of perma.rost of China.rea.hed 5.3×106-5.4×106 km2, or thrice tha. of toda., but perma.rost shra.k to only0.80×106-0.85×106 km2, or 50% tha. of present, during the loca. Holocene Mega.herma. Period(LHMP), or the loca. La.t Perma.rost Minimum(LLPMin). On the ba.is of the da.ing of perigla.ia. rema.ns a.d their distributive fea.ures, the extent of perma.rost in China.wa. delinea.ed for the two periods of LLGM(LLPMa.) a.d LHMP(LLPMin), a.d the evolution of perma.rost in China.wa. divided into seven periods a. follows:(1) LLGM in La.e Pleistocene(ca. 20000 to 13000-10800 a.BP)with extensive evidence for the presence of intensive ice-wedge expa.sion for outlining its LLPMa. extent;(2) a.period of dra.a.ica.ly cha.ging clima.e during the ea.ly Holocene(10800 to 8500-7000 a.BP) when perma.rost rema.ned rela.ively sta.le but with a.genera. trend of shrinking a.ea. extent;(3) The LHMP in the Mid-Holocene(8500-7000 to 4000-3000 a.BP)when perma.rost degra.ed intensively a.d extensively, a.d shra.k to the LLPMin;(4) Neogla.ia.ion during the la.e Holocene(4000-3000 to 1000 a.BP, when perma.rost a.a.n expa.ded;(5) Medieva. Wa.ming Period(MWP) in the la.e Holocene(1000-500 a.BP) when perma.rost wa. in a.rela.ive decline;(6) Little Ice a.e(LIa. in the la.e Holocene(500-100 a.BP), when perma.rost rela.ively expa.ded, a.d;(7) Recent wa.ming(during the 20 th century), when perma.rost continuously degra.ed a.d still is degra.ing. The pa.eo-clima.e, geogra.hy a.d pa.eoperma.rost extents a.d other fea.ures were reconstructed for ea.h of these seven periods.

关键词： Perma.rost evolution Cryogenic wedge structures Loca. La.t Gla.ia. Ma.imum(LLGM) Loca. Holocene Mega.herma. Period(LHMP) China

a.sessment of a.Proposed Softwa.e Design for the Solution of Multi-Pha.e Mecha.ics Problems on Networked La.tops

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Intelligent Informa.ion Ma.a.ement 2010年第7期2卷 391-397页

作者： Richa.d harris Thoma. Impelluso 不详

This pa.er presents the design of a.computa.iona. softwa.e system tha. ena.les solutions of multi-pha.e a.d multi-sca.e problems in mecha.ics. It demonstra.ed how mecha.icia.s ca. design “process-driven” softwa.e systems directly, a.d tha. such efforts a.e more suita.le in solving multi-pha.e or multi-sca.e problems, ra.her tha. utilizing the “da.a.driven” a.proa.hes of lega.y network systems. Specifica.ly, this pa.er demonstra.es how this a.proa.h ca. be used to solve problems in flexible dyna.ics. Then it suggests a.view of mecha.ics a.gorithms a. ‘sta.e equilibrium’ enforcers residing a. servers, ra.her tha. a. computer progra.s tha. solve field equa.ions. It puts forth the need for identica. input/output files to ensure widesprea. deployment on la.tops. Then it presents a. a.sessment of the la.top pla.form. a.softwa.e system such a. the one presented here ca. a.so be used to supply virtua. environments, a.ima.ions a.d enterta.nment/educa.ion softwa.e with physics.

关键词： Softwa.e Design Multi-Pha.e Mecha.ics Problems Networked La.tops

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生活英语情境60篇

Geogra.hic a.d tempora. va.ia.ions of sulfa.e a.rosols over the Pa.ific Ocea.

丛书名：英语口语

2009年

作者： Rona.d harris

心里有话千万句，碰到英语，却只能干瞪眼？本书了解你的心，让你口随意到。本书特别收集生活中最常见的60种情境，整理出1500句以上最适用的句型，教你用英语表达自己的想法和情绪，并深入了解各种不同的表达方法，书中附有中西文化差... 详细信息

ISBN: (数字)9787562822783

ISBN: (纸本)9787562822783

心里有话千万句，碰到英语，却只能干瞪眼？本书了解你的心，让你口随意到。本书特别收集生活中最常见的60种情境，整理出1500句以上最适用的句型，教你用英语表达自己的想法和情绪，并深入了解各种不同的表达方法，书中附有中西文化差异的说明、重点词汇注释，内容丰富，实用……

关键词：英语口语

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a.ta.Ocea.ologica.Sinica 1991年第1期10卷 47-71页

作者： F.Pa.ungo C.Na.a.oto B.Kopcewicz J.harris S.Hoyt a.r Resources La.ora.ory NoAA/ERLBoulderColoradoU.S.A.Air Resources LaboratoryNoAA/ERLBoulderColoradoU.S.A.Air Resources LaboratoryNoAA/ERLBoulderColoradoU.S.A.Air Resources LaboratoryNoAA/ERLBoulderColoradoU.S.A.Environmental Analytical Service Inc. San Luis ObispoCaliforniaU. S. A.

To investiga.e the life cycle of ma.ine sulfa.e a.rosols, chemicophysica. cha.a.teristics of ma.ine a.rosolswere mea.ured during five cruises in the Pa.ific Ocea.. Dimethyl sulfide concentra.ions in sea.a.er a.d in the a.r were a.so mea.ured. The geogra.hic va.ia.ion of sulfa.e-a.rosol concentra.ions wa. studied in rela.ion to biogenic a.d a.thropogenic sources,tra.sport with a.r tra.ectories, a.d chemica. tra.sforma.ions in the a.mosphere. The highest concentra.ions were found nea. a.ia. a.d a.erica. ports, indica.ing a.thropogenic pollution is the ma.or sulfa.e a.rosols source. Higher concentra.ions were observed in the upwelling regions tha. in the oligotrophic a.ea.. a.ong the coa.ta. regions, both ma.s a.d number concentra.ions of sulfa.e a.rosols depended on wind direction a.d wind speed, a.d la.d-breeze a.d sea.breeze oscilla.ions; no clea. diurna. va.ia.ion wa. detected. In pela.ic a.ea., a.ong the equa.or, the concentra.ions of sma.l sulfa.e pa.ticles showed a.ma.imum in the a.ternoon a.d the minimum a. night , indica.ing photo-oxida.ion a. a. importa.t process for ga.-to-pa.ticle conversion. Higher sulfa.e-a.rosol concentra.ions were observed in spring tha. in a.tumn a.d higher concentra.ions were found during the La.Nina.a.oma.y tha. during the El Nino a.oma.y. Biogenic source of sulfa.e a.rosols ha. a. importa.t role in the remote ocea.. Ca.e studies of sulfa.e-a.rosol distributions a.e discussed.

关键词： DMS Geogra.hic a.d tempora. va.ia.ions of sulfa.e a.rosols over the Pa.ific Ocea. over