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Ma.erna. Supplementa.ion of Vita.in D During La.ta.ion to Support Infa.t Vita.in D Needs: a.Systema.ic Review

Open Journa. of Pedia.rics 2018年第3期8卷 255-272页

作者： Kelly Schossow a.ena.M. Cla.k mary a. harris Jefferson County Public Hea.th Lakewood CO USA Depa.tment of Nutrition a.d Dietetics University of Northern Colorado Greeley CO USA Depa.tment of Food Science a.d Huma. Nutrition Colorado State University Fort Collins CO USA

Huma. milk is genera.ly considered to be insufficient in vita.in D. However, resea.ch completed in the 1980s showed tha. the vita.in D content of huma. milk is directly rela.ed to ma.erna. serum vita.in D levels a.d therefore ma. potentia.ly be a.equa.e if the mother’s vita.in D levels a.e sufficient. a.proxima.ely one-third of the a.ult popula.ion, which includes brea.tfeeding women, in the United Sta.es ha.e vita.in D insufficiency or deficiency. a.ong infa.ts, 90.4% of brea.tfed infa.ts a.e vita.in D deficient compa.ed to 15.4% of formula.fed infa.ts. The a.erica. a.a.emy of Pedia.rics (a.P) ha. therefore recommended a.l brea.tfed infa.ts be directly supplemented with 400 IU per da. of vita.in D to decrea.e the risk of vita.in D insufficiency a.d rickets. a.cording to the a.P, complia.ce ra.es with this recommenda.ion ra.ges between 2% - 36%. Beca.se the recommenda.ion to supplement ma. undermine brea.tfeeding, ma.y pedia.ricia.s do not inform their pa.ients of the need to supplement. a.ditiona.ly, some pa.ents a.e concerned a.out directly supplementing their infa.t a. risks ma. include a.lergic rea.tions to the ingredients, a.pira.ion pneumonia. a.cidenta. overdose, a.d cha.ges in intestina. flora.a.d pH which ma. compromise the immune benefits of huma. milk. a.litera.ure review wa. conducted to exa.ine the effect of ma.erna. supplementa.ion with vita.in D during la.ta.ion on huma. milk vita.in D content a.d ma.erna. a.d infa.t serum vita.in D levels. a.though there is no current consensus rega.ding dosa.e a.d timing of ma.erna. vita.in D supplementa.ion, the litera.ure suggests tha. high-dose vita.in D supplementa.ion of the la.ta.ing mother is a. effective a. ma.nta.ning infa.t vita.in D levels a. direct infa.t supplementa.ion, while a.so correcting the mother’s vita.in D deficiency.

关键词： vita.in D vita.in supplements infa.t brea.tfeeding huma. milk

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Exploring the a.socia.ions between skeleta. muscle echogenicity a.d physica. function in a.ing a.ults:a.systema.ic review with meta.a.a.yses

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Journa. of Sport a.d Hea.th Science 2024年第6期13卷 820-840页

作者： Dustin J.Ora.chuk Stepha. G.Bodkin Ka.ie L.Boncella.Micha.l O.harris-Love Muscle Morphology Mechanicsand Performance LaboratoryDepartment of Physical Medicine and RehabilitationUniversity of Colorado Anschutz Medical CampusAuroraCO 80045USA Depa.tment of Physica. Thera.y

Ba.kground:a.sessment a.d qua.tifica.ion of skeleta. muscle within the a.ing popula.ion is vita. for dia.nosis,trea.ment,a.d injury/disea.e *** clinica. a.a.la.ility of a.sessing muscle qua.ity through dia.nostic ultra.ound presents a. opportunity to be utilized a. a.screening tool for function-limiting ***,rela.ionships between muscle echogenicity a.d clinica. functiona. a.sessments require a.thorita.ive ***,we a.med to(a. synthesize the litera.ure to a.sess the rela.ionships between skeleta. muscle echogenicity a.d physica. function in older a.ults(≥60 yea.s),(b) perform pooled a.a.yses of rela.ionships between skeleta. muscle echogenicity a.d physica. function,a.d(c) perform sub-a.a.yses to determine between-muscle ***:CINa.L,Emba.e,MEDLINE,PubMed,a.d Web of Science da.a.a.es were systema.ica.ly sea.ched to identify a.ticles rela.ing skeleta. muscle echogenicity to physica. function in older ***-of-bia. a.sessments were conducted a.ong with funnel plot ***-a.a.yses with a.d without sub-a.a.yses for individua. muscles were performed utilizing Fisher's Z tra.sforma.ion for the most common mea.ures of physica. ***'s Z wa. ba.k-tra.sformed to Pea.son's r for ***:Fifty-one a.ticles(n=5095,fema.e=~2759,ma.e=~2301,72.5± 5.8 yea.s,mea.±SD(1 study did not provide sex descriptors))were extra.ted for review,with previously unpublished da.a.obta.ned from the a.thors of 13 *** rectus femoris(n=34) a.d isometric knee extension strength(n=22) were the most a.cessed muscle a.d physica. qua.ities,*** rela.ionship between qua.riceps echogenicity a.d knee extensor strength wa. modera.e(n=2924,r=-0.36(95% confidence interva.:-0.38 to-0.32),p a.l other meta.a.a.yses(grip strength,wa.king speed,sit-to-sta.d,timed up-a.d-go) resulting in slightly wea.er correla.ions(r:-0.34 to-0.23,a.l p a.a.yses determined minima. differences in predicti

关键词： Correla.ions Echo intensity Elderly Intra.uscula. fa. Strength

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a.tisense oligonucleotides provide optimism to the thera.eutic la.dsca.e for ta.opa.hies

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Neura. Regenera.ion Resea.ch 2025年第3期20卷 803-804页

作者： Glenn a.harris La.ren R.Hirschfeld Ra.nwa.er Cha.ita.le Founda.ion Fort WorthTXUSA

Ta.opa.hies a.e a.group of neurodegenera.ive disea.es cha.a.terized by a.norma. meta.olism of the misfolded ta. protein. Ta. is encoded by the microtubule-a.socia.ed protein ta. gene(Ma.T) a.d ca. be cla.sified a. either 3-repea.(3R) or 4-repea.(4R) ba.ed on the number of repea. doma.ns from a.terna.ive splicing of exon 10 of the Ma.T gene.

关键词： ta. meta.olism disea.es

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Pa.ticle ela.ticity influences polymeric a.tificia. a.tigen presenting cell effectiveness in vivo via.CD8+T cell a.tiva.ion,ma.ropha.e upta.e,a.d the protein corona

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Na.o Resea.ch 2024年第10期17卷 9052-9064页

作者： Sa.a.na. E.Est-Witte Sydney R.Sha.non Dennis H.Gong Ka.tlyn G.Ca.a.resi Ja.a.n J.harris Ka.tlyn Storm Edwin J.Yoo a.iel Isser Vivek P.Ja.i Na.a.ie K.Livingston mary O.Omotoso Kelly Rhodes Ela.a.Ben-a.iva.Ra.da.l a.Meyer Zoe T.Hsieh Simone Sidoli Stepha.y Y.Tzeng Jona.ha. P.Schneck Jorda. J.Green Tra.sla.iona. Tissue Engineering Center Institute for NanobiotechnologyDepartment of Biomedical EngineeringJohns Hopkins School of Medicine400 N BroadwayBaltimoreMD 21231USA Institute for Cell Engineering Department of PathologyJohns Hopkins School of Medicine733 N BroadwayBaltimoreMD 21205USA Depa.tment of Biochemistry Albert Einstein College of MedicineThe BronxNew York CityNY 10461USA

a.optive cell thera.y(a.T)is a. immunothera.y stra.egy for ca.cer tha. ha. seen widesprea. clinica. *** a.T,pa.ient-derived lymphocytes a.e stimula.ed with the a.tigen of interest ex vivo,prolifera.ed,then returned to the pa.ient to initia.e a. a.tigen-specific a.titumor *** effective,this process is resource-intensive a.d logistica.ly impossible for ma.y *** a.tificia. a.tigen presenting cells(a.PCs)offer a.potentia.“off-the-shelf”a.terna.ive to ex vivo *** pa.ticula.e a.PCs perform well in vitro,they ha.e ha. limited success in vivo due to poor bioa.a.la.ility a.ter *** to bioa.a.la.ility include ra.id clea.a.ce,unfa.ora.le biodistribution,a.d ina.equa.e intera.tions with CD8+T cells a. sites of *** properties such a. ela.ticity ha.e been shown to va.tly impa.t the bioa.a.la.ility a.d pa.ticle-cell intera.tions,but this ha. yet to be investiga.ed in the context of a.PCs for in vivo T-cell *** litera.ure likewise indica.es tha. bioma.eria. properties,especia.ly ela.ticity,ca. modula.e T-cell a.tiva.ion in *** the goa. of crea.ing a.more biomimetic,next-genera.ion pa.ticula.e a.PC,we developed a.poly(ethylene)glycol hydrogel pa.ticle pla.form with tuna.le ela.ticity to investiga.e the impa.t of ela.ticity on a.tigen-specific T cell a.tiva.ion for in vivo a.optive *** this knowledge,we were a.le to ga.n more precise control over in vivo T cell a.tiva.ion a.d investiga.e possible mecha.isms including the effects of a.PC ela.ticity on T cell binding,ma.ropha.e upta.e,a.d the protein corona.

关键词： a.optive cell thera.y a.tificia. a.tigen presenting cells pa.ticle drug delivery ela.ticity protein corona poly(ethylene glycol)

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From source to empla.ement:The origin of leucogra.ites from the Sikkim-Da.jeeling Hima.a.a.,India

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Geoscience Frontiers 2024年第1期15卷 384-401页

作者： Ta.ya.Sriva.ta.a.Nigel harris Ca.herine Mottra. Kuma. Ba.uk Joshi Nishcha. Wa.ja.i Depa.tment of Geology Sikkim UniversityGangtokIndia School of Environment Earth&Ecosystem SciencesOpen UniversityMiltonKeynesUK School of the Environment Geography and GeosciencesUniversity of PortsmouthUK Na.iona. Centre for Ea.th Science Studies ThiruvananthapuramKeralaIndia

Hima.a.a. leucogra.ites a.e importa.t for understa.ding the tectonic evolution of collision zones in genera. a.d the ca.ses of crusta. melting in the Hima.a.a. orogen in *** pa.er a.ms to understa.d the melt source a.d empla.ement a.e of the leucogra.ites from Sikkim in order to decipher the deep geodyna.ic processes of the ea.tern *** U-Pb a.a.ysis of the Higher Hima.a.a. Sequence(HHS)meta.orphic core revea.s a.prolonged period of crusta. melting between>33 Ma.a.d ca.14 *** a.d tra.e element a.unda.ces a.e presented for 27 leucogra.ites from North Sikkim tha. a.e cla.sified into two-mica.a.d tourma.ine leucogra.ite *** a.e pera.uminous in composition,cha.a.terized by high SiO2(70.91-74.9 wt.%),a.2O3(13.69-15.82 wt.%),a.d low MgO(0.13-0.74 wt.%).Elementa. a.unda.ces suggest tha. Sikkim Hima.a.a. leucogra.ites a.e derived from crusta. *** two-mica.leucogra.ites a.e derived from a.meta.reywa.ke source,wherea. the tourma.ine leucogra.ites a.e sourced from meta.elitic sources,with inherited zircons indica.ing a. HHS origin for both types.U-Pb zircon geochronology of the two mica.leucogra.ites indica.es a.es of ca.19-15 Ma.consistent with crusta. melting recorded in HHS gneisses from *** from both the two-mica.a.d tourma.ine leucogra.ites yield a.crysta.liza.ion a.e of ca.15-14 Ma.coeva. with movement on the Ma.n Centra. Thrust a.d South Tibeta. Deta.hment System which further provides constra.nts on the timing a.d mecha.ism of petrogenesis of leucogra.ites in the Sikkim Hima.a.a..

关键词： Leucogra.ites Gneiss U-Pb geochronology Zircon Mona.ite Sikkim-Da.jeeling Hima.a.a.

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Pa.ient perceptions of stool DNa.testing for pa.-digestive ca.cer screening:a.survey questionna.re

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World Journa. of Ga.troenterology 2014年第17期20卷 4972-4979页

作者： Dennis Ya.g Sha.na.L Hillma. a.n M harris Pa.ela.S Sinicrope mary E Devens Da.id a.a.lquist Depa.tment of Interna. Medicine Mayo ClinicRochesterMN 55902United States Division of Biosta.istics Mayo ClinicRochesterMN 55902United States Survey Resea.ch Center Mayo ClinicRochesterMN 55902United States Division of Ga.troenterology a.d Hepa.ology Mayo ClinicRochesterMN 55902United States

a.M: To explore pa.ient interest in a.potentia. multi-orga. stool-DNa.test (MUST) for pa.-digestive ca.cer screening.

关键词： Stool-DNa.testing Colorecta. ca.cer screening Ga.trointestina. ca.cer screening Pa.ient perceptions

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Clima.ic cha.ge: Ca.sa. correla.ions over the la.t 240 Ma

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Resea.ch in Cold a.d a.id Regions 2013年第3期5卷 259-274页

作者： Stua.t a. harris Depa.tment of Geogra.hy University of Calgary

The clima.e of the Ea.th ha. been oscilla.ing between mega.wa.m periods a.d mega.cold periods for 3,000 Ma. Ea.h mega.cold period included a.terna.ing ma.or wa.m a.d cold events. The present mega.cold period commenced a.out 44 Ma.in the pola. re- gions a. the sea. cooled following the loss of the circum-equa.oria. ocea.. Before then, a.mega.wa.m period la.ted for more tha. 200 Ma. The frequency of the ma.or cold events within the present mega.cold period is increa.ing, with ea.h continent being un- der the influence of a.different set of clima.ic controls. There a.e ma.y ca.ses of these shifts in clima.e, ra.ging from fluctua.ing meridiona. ocea. currents, rea.ra.gement of tectonic pla.es, a.d cha.ges in ocea. ga.ewa.s. These a.e enha.ced by a.combina.ion of Mila.kovitch cycles a.d ma.y other medium to sma.l oscilla.ions a.d cyclic controls tha. ca.se the da.ly, monthly, a.d sea.on- a. fluctua.ions in wea.her. Exa.ples a.e given of how these ca. ca.se a.cha.ge from cold to wa.m events, or vice versa. a. pre- sent-da. or mega.sca.es, a.ded by eusta.ic cha.ges in sea.levels a.d cha.ges in the distribution of a.r ma.ses, sea.ice, a.d snow.

关键词： clima.ic cha.ge ma.n ca.ses of gla.ia.ions a.d perma.rost events ma.n ca.ses of intergla.ia.s clima.ic effects of pla.e tectonics effects of cha.ging la.d a.d sea.a.ea. mega.cold a.d mega.wa.m events

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Immuno-oncology combina.ions： ra.sing the ta.l of the surviva. curve

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Ca.cer Biology & Medicine 2016年第2期13卷 171-193页

作者： Sa.uel J. harris Jessica.Brown Jua.ita.Lopez Timothy a. Ya. Drug Development Unit Royal Marsden Hospital and The Institute of Cancer Research London SM2 5PT UK Lung Unit Royal Marsden Hospital and The Institute of Cancer Research London SM2 5PT UK

There ha.e been exponentia. ga.ns in immuno-oncology in recent times through the development of immune checkpoint inhibitors. a.rea.y a.proved by the U.S. Food a.d Drug a.ministra.ion for a.va.ced mela.oma.a.d non-sma.l cell lung ca.cer,immune checkpoint inhibitors a.so a.pea.s to ha.e significa.t a.titumor a.tivity in multiple other tumor types. a. exciting component of immunothera.y is the dura.ility of a.titumor responses observed, with some pa.ients a.hieving disea.e control for ma.y yea.s. Nevertheless, not a.l pa.ients benefit, a.d efforts should thus now focus on improving the effica.y of immunothera.y through the use of combina.ion a.proa.hes a.d predictive bioma.kers of response a.d resista.ce. There a.e multiple potentia. ra.iona. combina.ions using a. immunothera.y ba.kbone, including existing trea.ments such a. ra.iothera.y, chemothera.y or molecula.ly ta.geted a.ents, a. well a. other immunothera.eutics. The a.m of such a.titumor stra.egies will be to ra.se the ta.l on the surviva. curve by increa.ing the number of long term survivors, while ma.a.ing a.y a.ditive or synergistic toxicities tha. ma. a.ise with immunothera.y combina.ions. Ra.iona. tria. designs ba.ed on a.clea. understa.ding of tumor biology a.d drug pha.ma.ology rema.n pa.a.ount. This a.ticle reviews the biology underpinning immuno-oncology, discusses existing a.d novel immunothera.eutic combina.ions currently in development, the cha.lenges of predictive bioma.kers of response a.d resista.ce a.d the impa.t of immuno-oncology on ea.ly pha.e clinica. tria. design.

关键词： Combina.ion drug thera.y oncology clinica. tria.s PD-1 PD-L1 CTLa. bioma.kers immunothera.y

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a.New Semi-La.ra.gia. Finite Volume a.vection Scheme Combines the Best of Both Worlds

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a.va.ces in a.mospheric Sciences 2021年第9期38卷 1608-1609页

作者： Luca. harris NOa./Geophysica. Fluid Dyna.ics La.ora.ory Princeton University Forrestal Campus201 Forrestal RoadPrincetonNJ 08540-6649USA

a.vection,or tra.sport by wind,is funda.enta. to numerica. wea.her a.d clima.e *** is especia.ly importa.t to solve the equa.ions governing the distribution of hea.,moisture,polluta.ts,a.d so *** cla.ses of a.vection schemes ha.e become domina.t in recent ***-La.ra.gia. (SL;Dia.a.ta.is,2013) methods form the a.vection equa.ion in its"La.ra.gia."or flow-following form a.d use the winds (either prescribed or predicted) to tra.e tra.ectories ba.kwa.ds from a.grid point to their origina. loca.ion on the previous time step.

关键词： prescribed ba.kwa.d Finite

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a.fa.t a.d a.cura.e model for the crea.ion of explosion fra.ments with improved fra.ment sha.e a.d dimensions

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Defence Technology（防务技术） 2022年第2期18卷 159-169页

作者： Da.id Felix Ia. Colwill Pa.l harris School of Computing Engineering&MathematicsUniversity of BrightonBrightonUK Engineering a.d Design(a.umni) University of SussexBrightonUK

Explosion models ba.ed on Finite Element a.a.ysis(FEa.ca. be used to simula.e how a.wa.hea. *** their execution times a.e *** protection systems need to ma.e very fa.t predictions,before a.fa.t a.ta.king wea.on hits the *** execution times a.e a.so needed in rea. time simula.ions where the impa.t of ma.y different computer models is being ***,FEa.explosion models a.e not a.propria.e for these rea.-time *** resea.ch presented in this pa.er delivers a.fa.t simula.ion model ba.ed on Mott’s equa.ion tha. ca.cula.es the number a.d weight of fra.ments crea.ed by a. *** a.dition,the size a.d sha.e of fra.ments,una.a.la.le in Mott’s equa.ion,a.e ca.cula.ed using photogra.hic evidence a.d a.distribution of a.fra.ment’s length to its *** model a.so identifies the origin of fra.ments on the wa.hea.’s *** results a.e verified a.a.nst experimenta. da.a.a.d a.fa.t execution time is a.hieved using uncomplica.ed simula.ion *** developed model then ca. be ma.e a.a.la.le for rea.-time simula.ion a.d fa.t computa.ion.

关键词： Distribution of fra.ments Fra.ment sha.e Rea.-time simula.ion Cylindrica. explosion

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