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Interaction between inflammatory bowel disease,physical activity,and myokines:Assessment of serum irisin levels

World Journal of Gastroenterology 2024年第22期30卷 2923-2926页

作者： marwan sm al-nimer Department of Therapeutics and Clinical Pharmacology College of MedicineUniversity of DiyalaBaqubah 32001Iraq

Inflammatory bowel disease(IBD),including Crohn’s disease and ulcerative colitis,showed a wide spectrum of intestinal and extra-intestinal manifestations,which rendered the patients physically inactive and impaired their quality of *** has been found that physical activity is a non-pharmacological intervention that improves the quality of life for those *** is one member of the myokines secreted by muscle contraction during exercise and could be used as an antiinflammatory biomarker in assessing the physical activity of IBD *** addition,experimental studies showed that exogenous irisin significantly decreased the inflammatory markers and the histological changes of the intestinal mucosa observed in experimental ***,irisin produces changes in the diversity of the ***,endogenous or exogenous irisin,via its anti-inflammatory effects,will improve the health of IBD patients and will limit the barriers to physical activity in patients with IBD.

关键词： Irisin Inflammatory bowel disease Physical activity Myokines Prognostic marker

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Concomitant dysregulation of androgen secretion and dysfunction of adipose tissue induced insulin resistance

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World Journal of Diabetes 2022年第5期13卷 417-419页

作者： marwan sm al-nimer Department of Clinical Pharmacology and Therapeutics College of MedicineUniversity of DiyalaBaqubah 32001DiyalaIraq

Hyperandrogenism and hyperinsulinemia have resulted from dysfunction of the theca cell of the ovary and adipose tissue and each one potentiates the other in patients with androgen excess disorders e.g.,polycystic ovary disease and idiopathic *** external and/or internal triggers can produce such cellular *** is evidence that sodium valproate acts as a trigger of cellular dysfunction and produces both hyperinsulinemia and ***,the elimination of these triggers can help the patients to recover from hyperinsulinemia,insulin resistance and hyperandrogenism.

关键词： Hyperandrogenism Hyperinsulinism Central triggers Polycystic ovary disease

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Is COVID-19-induced liver injury different from other RNA viruses?

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World Journal of Meta-Analysis 2021年第2期9卷 108-127页

作者： marwan sm al-nimer Department of Clinical Pharmacy Hawler Medical UniversityErbil 44001Iraq College of Medicine University of DiyalaBaqubah 32001Iraq

Coronavirus disease 2019 is a pandemic disease caused by a novel RNA coronavirus,SARS coronavirus 2(SARS-CoV-2),which is implicated in the respiratory ***-CoV-2 also targets extrapulmonary systems,including the gastrointestinal tract,liver,central nervous system and ***-CoV-2,like other RNA viruses,targets the liver and produces liver *** literature review showed that SARS-CoV-2-induced liver injury is different from other RNA viruses by a transient elevation of hepatic enzymes and does not progress to liver fibrosis or other unfavorable ***,SARS-CoV-2-induced liver injury usually occurs in the presence of risk factors,such as nonalcoholic liver fatty *** review highlights the important differences between RNA viruses inducing liver injury taking into consideration the clinical,biochemical,histopathological,postmortem findings and the chronicity of liver injury that ultimately leads to liver fibrosis and hepatocellular carcinoma.

关键词： Liver injury COVID-19 RNA-viruses Risk factors Liver enzymes Liver fibrosis

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