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Hepatobiliary Surgery and Nutrition 2024年第2期13卷 382-386页

作者： Björn Nashan Utz Settmacher martina koch The Transplantation Center First Affiliated HospitalSchool of Life Sciences and Medical CenterUniversity of Sciences&Technology of ChinaHefeiChina Department of General Visceral and Vascular SurgeryJena University HospitalJenaGermany General Visceraland Transplantation SurgeryUniversity Medical CenterMainzGermany

Since the inception of solid organ transplantation through the 50s and 60s of the 20th century,transplantation has evolved into a major driver not only in the field of surgery,but immunology,pharmacology,pathology,internal medicine,providing new techniques and concepts to provide services for patients,that had been doomed to succumb to their acute or chronic *** surgeons not only developed surgical techniques but were drivers in the development of immunosuppression as well as the inclusion of other specialties into multidisciplinary teams.

关键词： Education in transplantation board certification interdisciplinary curriculum German Transplant Certification

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Yangtze Three Gorges Reservoir, China: A holistic assessment of organic pollution, mutagenic effects of sediments and genotoxic impacts on fish

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Journal of Environmental Sciences 2015年第12期27卷 63-82页

作者： Tilman Floehr Bj?rn Scholz-Starke Hongxia Xiao Josef koch Lingling Wu Junli Hou Anja Wolf Axel Bergmann Kerstin Bluhm Xingzhong Yuan martina Ro?-Nickoll Andreas Sch?ffer Henner Hollert Department of Ecosystem Analysis Institute for Environmental ResearchRWTH Aachen University Key Laboratory of Yangtze River Water Environment Ministry of EducationTongji University East China Sea Fisheries Research Institute IWW Rhenish-Westfalian Institute for Water Research Institute for Applied Geosciences Technische Universit?t Darmstadt College of Resources and Environmental Science Chongqing University State Key Laboratory of Pollution Control and Research Reuse School of the EnvironmentNanjing University

Besides obvious benefits,the Three Gorges Dam＇s construction resulted in new pollution scenarios with the potentials to threaten the Three Gorges Reservoir（TGR） *** order to record organic contamination,to find links to ecotoxicological impacts and to serve as reference for ensuing monitoring,several sites in the TGR area were screened applying the triad approach with additional lines-of-evidence as a holistic assessment *** and the benthic fish species Pelteobagrus vachellii were sampled in 2011 and 2012 to determine organic pollution levels,mutagenic potentials and genotoxic *** regional hot-spots near the cities of Chongqing and Kaixian were identified and further investigated in *** polycyclic aromatic hydrocarbons（PAHs） could be detected in sediments in 2011（165-1653 ng/g）,emphasizing their roles as key pollutants of the *** ubiquity was confirmed at Chongqing（150-433 ng/g） and Kaixian（127-590 ng/g） *** were comparable to other major Chinese and German ***,the immense sediment influx suggested a deposition of 216-636 kg PAH/day（0.2-0.6 mg PAH/（m2·day））,indicating an ecotoxicological *** source analysis highlighted primary impacts of combustion sources on the more industrialized upper TGR section,whereas petrogenic sources dominated the mid-low ***,sediment extracts from several sites exhibited significant activities of frameshift promutagens in the Ames fluctuation ***,significant genotoxic impairments in erythrocytes of *** were detected（Chongqing/Kaixian）,demonstrating the relevance of genotoxicity as animportant mode of action in the TGR＇s ***,their derivatives and non-target compounds are considered as main causative agents.

关键词： Yangtze Three Gorges Reservoir Triad approach Sediment Fish Mutagenicity Genotoxicity PAH

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Differential gene expression of chemokines in KRAS and BRAF mutated colorectal cell lines:Role of cytokines

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World Journal of Gastroenterology 2014年第11期20卷 2979-2994页

作者： Sajjad Khan Silke Cameron martina Blaschke Federico Moriconi Naila Naz Ahmad Amanzada Giuliano Ramadori Ihtzaz Ahmed Malik Clinic of Gastroenterology and Endocrinology University Medical CenterRobert-Koch-Str. 4037075 GoettingenGermany

AIM: To study KRAS/BRAF mutations in colorectal-cancer (CRC) that influences the efficacy of treatment. To develop strategies for overcoming combination of treatment.

关键词： Colorectal-cancer, KRAS, BRAF, CXCL1 (GROα ), CXCL10 (IP-10), CXCL8 (IL-8), Tumor necrosis factor-α , Interleukin-1β , Interferon-γ , siRNA

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