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Perinatal Stroke and Apparent Life-Threatening Event: A Case Report

Open Journal of Emergency Medicine 2014年第3期2卷 62-66页

作者： Antonella Palmieri martina finetti Marta Bertamino Laura Banov Margherita Mancardi Giovanni Morana Salvatore Renna Emergency Department IRCCS Gaslini Genoa Italy Pediatric Reumatology Unit IRCCS Gaslini Genova Italy Hemostasis and Trombosis Unit IRCCS Gaslini Genova Italy Neurology Unit IRCCS Gaslini Genova Italy Neuroradiology Unit IRCCS Gaslini Genova Italy

To analyze how the multidisciplinary clinical, biohumoral, instrumental approach to ALTE (Apparent Life Threatening Event) episode may discover cardiovascular disease in the newborn. Introduction: In the first year of life ALTEs concern 0.8% of access to Pediatric Emergency Department. The cause of apparent life-threatening events (ALTEs) in infants reflects a differential diagnosis that includes an array of congenital or acquired disorders. Approximately 10% - 25% of ap-parent life-threatening events may remain unexplained following a thorough evaluation. Case re-port: B. E., a 2-month-old child, in wellbeing, shortly before meal, during sleep, was not responsive to repeated stimulations;he was hypotonic and unresponsive. About 15 minutes later, he pre-sented a normal tone and state of consciousness. Evaluating the referred symptoms, diagnostic protocol for ALTE was started;the Angio-MRI brain performed as second line analysis showed a focal gliotic lesion at left striatal area. The cardiological evaluation with echocardiography detected a pervium foramen ovale (PFO), with minimum shunt left-right direction. At least, biohumoral tests revealed protrombin gene heterozygosis mutation. Conclusion: Apparent Life-Threatening Events are first manifestation of stroke in infant. Discussion: This report discloses how the multidisciplinary clinical approach is essential in ALTE. The exact management of ALTE patients is very important in situations like this, when the concomitant disease is rare. In fact, arterial stroke incidence in children > 28 days of life is estimated between 1.2 and 7.9 cases/100,000 child-ren/year. However, in the last 20 years, we observed an increased incidence of stroke, probably related to two main causes: a greater attention for this disease and a major survival of children with pathology that arrange for stroke thanks to a better prevention. In conclusion, it’s a fundamental multidisciplinary approach even in following months after the events.

关键词： Perinatal Stroke Apparent Life-Threatening Events Pediatric Emergency Pro-Thrombotic Factor Congenital Heart Defect

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Transcriptome Analysis Provides Novel Insights into Salt Stress Response in Two Egyptian Rice Varieties with Different Tolerance Levels

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Rice science 2022年第6期29卷 499-502页

作者： Shehab MOHAMED Iovene MARINA Ciancio AURELIO Colagiero MARIANTONIETTA finetti-Sialer MARIELLA Rice Research and Training Center Field Crops Research InstituteAgriculture Research CenterSakha Kafr El-Sheikh 33717Egypt Institute of Biosciences and Bioresources National Research CouncilBari 70126Italy Sustainable Plant Protection Institute National Research CouncilBari 70126Italy

The response of rice to salt stress(200 mmol/L NaCl)was investigated at the transcription level in Egyptian varieties Giza 177(salt sensitive variety)and Giza 178(salt tolerant variety).We applied a genome-wide RNA-Se... 详细信息

关键词： varieties Egyptian stress

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Predictive power of tertiary lymphoid structure signature for neoadjuvant chemotherapy response and immunotherapy benefit in HER2-negative breast cancer

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Cancer Communications 2023年第8期43卷 943-946页

作者： François Bertucci Alexandre De Nonneville Pascal finetti Emilie Mamessier11Laboratory of Predictive Oncology Label Team“Ligue contre le cancer”Cancer Research Center of MarseillePaoli-Calmettes InstituteAix-Marseille UniversityInserm UMR1068CNRS UMR725MarseilleFrance Department of Medical Oncology Paoli-Calmettes InstituteMarseilleFrance

Dear Editor,Pembrolizumab,an immune checkpoint inhibitor(ICI),was recently approved for early-stage triple-negative breast cancer(eTNBC),and promising results have been reported in advanced hormone receptor-positive/human epidermal growth factor receptor 2-negative(HR+/HER2-)and HER2+BCs[1].Given the costs and potential toxicity,markers predictive of ICI benefits are ***,neither programmed death-ligand 1(PD-L1)expression nor other tested markers(i.e.,tumor mutational burden,microsatellite instability)effectively predict ICI benefit[2].Tertiary lymphoid structures(TLS)are secondary lymphoid organ-like aggregates that reside in the tumor microenvironment and are associated with clinical response to ICIs in metastatic melanoma,renal cell carcinoma.

关键词： lymphoid breast cancer

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The Monarch Etrial:improving the clinical outcome in HR^(+)/HER2^(−)early breast cancer:recent results and next steps

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Cancer Communications 2023年第8期43卷 938-942页

作者： François Bertucci Pascal finetti Emilie Mamessier Alexandre De Nonneville Laboratory of Predictive Oncology Cancer Research Center of MarseillePaoli-Calmettes InstituteAix-Marseille UniversityINSERM UMR1068CNRS UMR725Team Labelled“Ligue contre le cancer”MarseilleFrance Department of Medical Oncology Paoli-Calmettes InstituteMarseilleFrance

Breast cancer(BC)is the most frequent cancer in women worldwide,and hormone receptor-positive/human epidermal growth factor receptor 2-negative(HR^(+)/HER2^(−))is the most frequent BC *** adjuvant systemic treatment of HR^(+)/HER2^(−)early-stage BC(eBC),based on prognostic factors[1],sometimes includes chemotherapy,and in most cases,it includes endocrine therapy(ET).In the past decade,advancements in ET,such as successive approvals of tamoxifen and aromatase inhibitors and the extension of ET duration to 10 years in high-risk patients.

关键词： HER2 cancer chemotherapy

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Low cholesterol biosynthesis favors epithelial-to-mesenchymal transition maintenance and influences tumor molecular subtyping and disease-free survival in colon cancer patients

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Cancer Communications 2022年第8期42卷 793-797页

作者： Anaïs Aulas Maria Lucia Liberatoscioli Pascal finetti Olivier Cabaud David JBirnbaum Lucas Usclade Daniel Birnbaum François Bertucci Emilie Mamessier Predictive Oncology Laboratory Cancer Research Center of MarseilleInstitut Paoli-Calmettes“Ligue contre le cancer”labelAix-Marseille UniversityMarseille 13009France Department of Digestive Surgery Hospital NordChemin des BourrelyAix-Marseille UniversityMarseille 13015France Department of Medical Oncology Institut Paoli-CalmettesAix-Marseille UniversityMarseille 13009France

Dear Editor,To metastasize,epithelial cancer cells undergo an epithelial-to-mesenchymal transition(EMT)during migration,whereupon they activate a mesenchymal-toepithelial transition(MET)when colonizing the new niche[1].Targeting EMT or MET inducers might thus impair the metastatic process[2,3].However,the identification of genes involved in epithelium-mesenchyme switches(EMS)is difficult in complex samples such as human *** overcome this problem,we used spheroids of a colorectal cancer(CRC)cell line,HT29,to mimic EMS in a controlled environment.

关键词： cancer colon epithelium

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