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Cyclooxygenase-2 and epithelial growth factor receptor up-regulation during progression of Barrett's esophagus to adenocarcinoma

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World Journal of Gastroenterology 2006年第6期12卷 928-934页

作者： Yan Li John M Wo Mukunda B Ray Whitney Jones Ruifeng R Su Susan Ellis Robert C G martin Division of Surgical Oncology University of Louisville School ofMedicine Louisville KY 40202 United States Division of Gastroenterology/Hepatology University of Louisville School of MedicineLouisville KY 40202 United States Department of Anatomical Pathology University of Louisville School of Medicine Louisville KY40202 United States

瞄准：在整个 Barretts 食管的前进调查 cyclooxygenase-2 (COX-2 ) 和上皮的生长因素受体(EGFR ) 的表示() 。方法：COX-2 和 EGFR 蛋白质表情被使用免疫检测组织化学的方法。详细 cytomorphological 改变的 A 是坚定的。COX-2 和 EGFR... 详细信息

瞄准：在整个 Barretts 食管的前进调查 cyclooxygenase-2 (COX-2 ) 和上皮的生长因素受体(EGFR ) 的表示() 。方法：COX-2 和 EGFR 蛋白质表情被使用免疫检测组织化学的方法。详细 cytomorphological 改变的 A 是坚定的。COX-2 和 EGFR 表示的区域被使用计算机成像系统确定。结果：COX-2 和 EGFR 的表情与前进一起增加了从到食管腺癌(EAC ) 。积极关联在 COX-2 表示和 EGFR 表示之间被发现。结论：COX-2 和 EGFR 可能在逐步的前进从是合作的到 EAC，从而导致致癌作用。

关键词：上皮生长因子受体环氧合酶食管疾病食管癌

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美国牛奶过剩不用倒了，来中国吧

商业周刊（中文版） 2014年第12期 32-33页

作者： Andrew martin 竹西(译)

随着全球需求不断增长，美国乳制品出口迭创纪录“中国人的购买已经使得乳制品价格飞涨”

关键词：中国人美国牛奶乳制品

非动脉瘤性与动脉瘤性蛛网膜下腔出血特点的分析

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中国脑血管病杂志 2008年第10期5卷 433-437,460页

作者：黄永凯韩德清刘爱华刘志雄陈风华 martin Schumacher 中南大学湘雅株洲临床学院神经外科湖南412000 北京神经外科研究所神经介入中心中南大学湘雅医院神经外科德国Freiburg大学神经中心

目的探讨非动脉瘤性与动脉瘤性蛛网膜下腔出血(aSAH)的临床特点。方法回顾性分析168例非aSAH和104例aSAH患者入院时的Hunt-Hess分级、CT检查(以德国Freiburg大学神经中心的标准,根据头部CT影像分型)、第1次全脑DSA检查、重复全脑DSA及... 详细信息

目的探讨非动脉瘤性与动脉瘤性蛛网膜下腔出血(aSAH)的临床特点。方法回顾性分析168例非aSAH和104例aSAH患者入院时的Hunt-Hess分级、CT检查(以德国Freiburg大学神经中心的标准,根据头部CT影像分型)、第1次全脑DSA检查、重复全脑DSA及短期和长期预后MRS(Modified Rankin Scale)评分等临床资料。结果①两组患者入院时的Hunt-Hess分级比较,差异有统计学意义,χ2=74.023,P0.05。④中脑周围型蛛网膜下腔出血患者脑积水和脑血管痉挛的发生率,分别为14.5%(8/55)和21.8%(12/55),非中脑周围型蛛网膜下腔出血患者脑积水和脑血管痉挛的发生率,分别为54.4%(31/57)和42.1%(24/57),两组比较,χ2=19.575,P<0.01和χ2=5.283,P<0.05。⑤168例非aSAH患者随访92例,MRS≤2分者占90.2%,中、重度残疾占3.3%;104例aSAH患者随访88例,MRS评分≤2分者占50.0%,中、重度残疾占34.1%,χ2=8.42,P<0.05。结论非aSAH比aSAH患者入院时Hunt-Hess分级低,并发症少、预后好,在中脑周围型蛛网膜下腔出血的患者中表现得更加明显。

关键词：蛛网膜下腔出血颅内动脉瘤队列研究

Desmarestia anceps Montagne (Phaeophyceae) against Colorectal Cancer Cells: Cytotoxic Activity and Proapoptotic Effects

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Advances in Biological Chemistry 2022年第6期12卷 228-245页

作者： Rafaele Frassini Daniela Steffens Sidnei Moura Cesar Aguzzoli Aline Paternostro martins Pio Colepicolo Mutue Toyota Fujii Nair S. Yokoya Cláudio martin Pereira De Pereira Ana Cláudia Phillipus Miriam De Barcellos Falkenberg João Antonio Pêgas Henriques Mariana Roesch-Ely Laboratory of Applied Toxicology and Bioproducts University of Caxias do Sul RS Brazil Laboratory of Biosynthetic and Natural Products of Caxias do Sul RS Brazil Area of Exact Sciences and Engineering University of Caxias do Sul RS Brazil Laboratory of Biochemistry and Molecular Biology of Algae University of S&#227 o Paulo S&#227 o Paulo SP Brazil Nucleus Research Phycology Institute of Botany S&#227 o Paulo SP Brazil Laboratory of Lipidomics and Biorganic-LipidomicaBio Federal University of Pelotas Pelotas RS Brazil Study Group on Natural and Synthetic Products (GEPRONAS) Federal University of Santa Catarina SC Brazil

Impairment of apoptosis promotes abnormal cellular proliferation and accumulation of genetic alterations. Identifying bioactive compounds extracted from seaweeds that induce apoptosis in cancer cells may be explored as new agents for cancer chemoprevention and/or chemotherapy. The present study aimed to determine the chemical composition and biological activity of the chloroform crude extract and fractions from Antarctic seaweed Desmarestia anceps. The chloroform extract was obtained by three consecutive macerations and the fractionation by vacuum liquid chromatography. The chemical characterization of the extract and fractions was performed through Gas Chromatography. The cytotoxicity of the crude extract and fractions was evaluated by the MTT assay. Cell death and cell cycle evaluation after 24 hours of exposure to chloroform extract were performed by flow cytometry. A total of 48 compounds were identified. The results indicate that chloroform extract and its fractions presented cytotoxic activity against HCT 116 cell line in a dose dependent-manner. Proapoptotic events were observed after chloroform extract exposition, which promoted an increase of multinucleated cells and reduced cell viability. This study was the first to explore cytotoxic potential of seaweed D. anceps fractions against HCT colorectal cancer cell line, suggesting that these macroalgae may be a promising candidate against anticancer activity.

关键词： Antarctic Seaweeds Antitumor Activity Apoptosis Proapoptotic Effect Colorectal Cancer

Successful multidisciplinary clinical approach and molecular characterization by whole transcriptome sequencing of a cardiac myxofibrosarcoma: A case report

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World Journal of Clinical Cases 2019年第19期7卷 3018-3026页

作者： Maristella Saponara Valentina Indio Carmine Pizzi Elena-Daniela Serban Milena Urbini Annalisa Astolfi Pasquale Paolisso Sofia martin Suarez Margherita Nannini Davide Pacini Valentina Agostini Ornella Leone Valentina Ambrosini Giuseppe Tarantino Stefano Fanti Fabio Niro Francesco Buia Domenico Attinà Maria Abbondanza Pantaleo Department of Specialized Experimental and Diagnostic MedicineMedical Oncology UnitSant'Orsola-Malpighi HospitalUniversity of BolognaBologna 40138Italy “Giorgio Prodi”Cancer Research Center University of BolognaBologna 40138Italy Department of Specialized Experimental and Diagnostic MedicineCardiology and Transplantation UnitSant’Orsola-Malpighi HospitalUniversity of BolognaBologna 40138Italy Department of Pathology Cardiovascular Pathology UnitSant’Orsola-Malpighi HospitalUniversity of BolognaBologna 40138Italy Departments of Cardiovascular Surgery and Transplantation Sant'Orsola-Malpighi HospitalUniversity of BolognaBologna 40138Italy Department of Specialized Experimental and Diagnostic MedicineNuclear Medicine UnitSant'Orsola-Malpighi HospitalUniversity of BolognaBologna 40138Italy Department of Specialized Experimental and Diagnostic MedicineRadiology UnitSant'Orsola-Malpighi HospitalUniversity of BolognaBologna 40138Italy

BACKGROUND Cardiac tumors are rare and complex *** represents the cornerstone of therapy,while the role of adjuvant treatment remains unclear and,in case of relapse or metastatic disease,the prognosis is very *** of prospective,randomized clinical trials hinders the generation of high level evidence for the optimal diagnostic workup and multimodal treatment of cardiac ***,we describe the multidisciplinary clinical management and molecular characterization of a rare case of cardiac myxofibrosarcoma in an elderly *** SUMMARY A 73-year-old woman presented signs and symptoms of acute left-sided heart *** examination revealed a large,left atrial *** suspicion of a myxoma,she underwent surgery,and symptoms were promptly *** showed a cardiac myxofibrosarcoma,a rare histotype of cardiac *** months later,disease unfortunately relapsed,and after a multidisciplinary discussion,a chemotherapy with doxorubicin and then gemcitabine was started,achieving partial radiologic and complete metabolic response,which was maintained up to 2 years and is still *** report is focused on the entire clinical path of our patient from diagnosis to follow-up,through surgery and strategies adopted at ***,due to their rarity,very little is known about the molecular landscape of ***,we also performed and described preliminary genome analysis of the tumor tissue to get further insight on mechanisms involved in tumor growth,and to possibly unveil new clinically actionable *** We report a case of cardiac myxofibrosarcoma that achieved a very good prognosis due to an integrated surgical,cardiac and oncologic treatment strategy.

关键词： Cardiac sarcoma Myxofibrosarcoma Whole transcriptome sequencing Doxorubicin Gemcitabine Case report

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鹿特丹滨水公园

景观设计 2011年第4期 32-35页

作者： martin knuijt 程美平（翻译）

马斯河上的鹿特丹市鹿特丹市的规划目标是希望可以与马斯河重新建立紧密的联系。码头作为交通中转区域和休闲场所加强了城市和水域之间的联系，尤其是北边的码头的绿色舒适设计风格将该地区的一系列码头连接在一起。

关键词：鹿特丹市公园滨水休闲场所设计风格马斯河码头舒适

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美国劳动节

疯狂英语（新策略） 2019年第9期 13-15,63页

作者： martin Novak 纪乐佳(译) 不详

语篇导读你知道美国的劳动节吗?它在每年九月份的第一个星期一,是美国的全国性节日。这天,美国全国放假一天,并会以独特的方式庆祝它,以示对劳动者的尊重。你想知道为什么美国的劳动节不在五月一日吗?它的庆祝方式又是怎样的呢?

关键词：五月一日劳动节庆祝方式尊重美国劳动者全国性

安乐地逝去——我们需要英国国家医疗卫生服务体系提供多方位的关怀

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英国医学杂志中文版 2007年第3期10卷 189-190页

作者： martin G Duerden 卢杰（译） Meddygfa Gyffin Conwy LL32 8LT 不详

去年我父亲的去世和Newton所讲述的故事有类似之处。78岁的他罹患多发性硬化20余年，病魔逐渐蚕食了他的活动能力和自主运动能力。圣诞节期间他得了肺炎，他自己强烈要求在家治疗，但不久由于又长了褥疮而打消了这个念头。

关键词：医疗卫生服务体系英国多发性硬化运动能力活动能力圣诞节

Analysis of Commercial Assays for the Detection of SARS-CoV-2 Antibodies or Antigens

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Open Journal of Immunology 2020年第2期10卷 21-35页

作者： John M. González William J. Shelton manuel Díaz-Vallejo Victoria E. Rodriguez-Castellanos Juan Diego H. Zuluaga Diego F. Chamorro Daniel Arroyo-Ariza Biomedical Sciences Group School of Medicine Universidad de los Andes Bogotá DC Colombia

Background: COVID-19 produced by SARS-CoV-2 infection has spread worldwide. There is a growing need for immunological assays to detect viral specific antibodies or viral antigen. Current standard of diagnosis is reverse-transcriptase polymerase chain reaction (RT-PCR) in nasopharyngeal swabs. However serological tests can be used to determine previous exposure to the virus and complement the diagnosis. IgM and IgG SARS-CoV-2 specific antibodies can be detected as early as one week after infection and assays can be useful to test large groups of individuals. This work revised the available information concerning assays that detect antibodies and antigens for SARS-CoV-2. Methods: Three sources of information were used: technical data sheets (TDS) web pages of the company’s products and published articles in Pubmed with reference to the use of diagnostic kits. All the information was revised until April 5th 2020. Results: There were 226 tests coming from 20 countries mainly from China. TDS were found only in 50 (22.1%). Most assays detect specific antibodies (n 180) based on immunochromatography methods (n 110) and use blood-derived samples (n 105). Assays for antibodies detection measured mainly IgM/IgG (n 112) and the most common procedure time was in vitro diagnosis (IVD). A total 165 articles were found on PubMed 15 were included and only 4 used the commercial kits reviewed. Conclusions: Due to the urgency of producing diagnostic tests for SARS-CoV-2 there is a broad offer of kits. Many tests need additional information for their application. The data collected may be useful in the selection of assays but more and higher quality information is needed.

关键词： Antibody Antigen Coronavirus Immunoassay SARS