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Development and Implementation of a Rotating Nanoimprint Lithography Tool for Orthogonal Imprinting on Edges of Curved Surfaces

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Nanomanufacturing and Metrology 2021年第3期4卷 175-180页

作者： Shraddha Supreeti Ralf Schienbein Patrick FeBer Florian Fern martin hoffmann Stefan Sinzinger Electronics Technology Group Technical University of IlmenauIlmenauGermany Institute for Design and Precision Engineering Technical University of IlmenauIlmenauGermany Technical Optics Group Technical University of IlmenauIlmenauGermany JUMO GmbH&Co.KG FuldaGermany Microsystems Technology Group Ruhr-University BochumBochum.Germany

Uniform molding and demolding of structures on highly curved surfaces through conformal contact is a crucial yet often-overlooked aspect of nanoimprint lithography(NIL).This study describes the development of a NIL tool and its integration into a nanopositioning and nanomeasuring machine to achieve high-precision orthogonal molding and demolding for soft ultraviolet-assisted NIL(soft UV-NIL).The process was implemented primarily on the edges of highly curved plano-convex substrates to demonstrate structure uniformity on the edges.High-resolution nanostructures of sub-200-nm lateral dimension and microstructures in the range of tens of microns were imprinted.However,the nanostructures on the edges of the large,curved substrates were difficult to characterize precisely.Therefore,microstructures were used to measure the structure fidelity and were characterized using profilometry,white light interferometry,and confocal laser scanning microscopy.Regardless of the restricted imaging capabilities at high inclinations for high-resolution nanostructures,the scanning electron microscope(SEM)imaging of the structures on top of the lens substrate and at an inclination of 45°was performed.The micro and nanostructures were successfully imprinted on the edges of the plano-convex lens at angles of 45°,60°,and 90°from the center of rotation of the rotating NIL tool.The method enables precise imprinting at high inclinations,thereby presenting a different approach to soft UV-NIL on curved surfaces.

关键词： Nanoimprint lithography Rotating NIL tool Curved surface Imprinting Nanopositioning

Derotational osteotomy and internal fixation of a 180°malrotated humerus:A case report

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World Journal of Orthopedics 2022年第10期13卷 940-948页

作者： Katharina Elisabeth Wenning Thomas Armin Schildhauer Clifford Barry Jones martin Franz hoffmann Department of General and Trauma Surgery BG University Hospital Bergmannsheil BochumBochum 44789Germany Department of Orthopaedic Surgery Creighton Medical School PhoenixPhoenix85012United States

BACKGROUND Humeral shaft fractures are relatively common in adults.Rotational malalignment is reported as one complication but severe rotational deformity of the humerus is extremely rare.To our knowledge,only three cases of symptomatic humeral malrotation have been reported.There are sparse literature reports of humeral reconstruction correction.CASE SUMMARY We present a case of extreme rotational deformity of the humerus(180°)after humeral shaft fracture.The patient complained of pain and difficulties with activities of daily living.In addition,she found the deformity cosmetically unacceptable.Therefore,she was searching for surgical correction.Neurolysis of the radial nerve followed by derotational osteotomy of the humerus and internal fixation were performed.Postoperatively,the patient demonstrated transient iatrogenic radial nerve palsy which recovered completely during postoperative follow-up.The Disabilities of the Arm,Shoulder,and Hand score improved from 55 preoperatively to 16 at the final 2-year follow-up.CONCLUSION Single-stage radial neurolysis,derotational osteotomy and stable fixation is a feasible option to improve anatomic and functional problems of severely malrotated humeral shaft fractures.

关键词： Humerus Malrotation Corrective osteotomy Plate osteosynthesis Radial nerve palsy Case report

Wetting Behaviour of Glasses on Nanostructured Silicon Surfaces

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Journal of Electrical Engineering 2015年第1期3卷 15-20页

作者： Sebastian Gropp Michael Fischer Lars Dittrich Beate Capraro Jens Mtiller martin hoffmann Technische Universitat Ilmenau IMN MacroNano PF 100565 Ilmenau 98694 Germany Fraunhofer Institute for Ceramic Technologies and Systems Hermsdorf 1 07629 Germany

The behavior of molten glass on nanostructured silicon surface is of essential importance for the fabrication of a strong bond interface between glass (or glass-based ceramic tapes) and silicon. It was found that typical glasses do not wet the silicon surface that is always coated with a thin silica layer. It is shown that the high surface tension of molten glasses at high temperatures in combination with the dewetting surface of the structured silicon prohibits the formation of an interlocking bond between the two substrates. The theory of wetting can be applied to molten glasses, too. As a consequence, a similar solution as for liquids is investigated: the surface has to be chemically modified to become wettable. Investigations with sputtered metals on the nanostructured silicon improve wetting of the surface and result in a better bond homogeneity of the SiCer compound during sintering with low pressure.

关键词：电气工程电气测试集中参数频率

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智能化的流程泵监控系统

现代制造 2012年第8期 36-37页

作者： martin hoffmann

据了解，Allweiler公司现已研发成功了一种能够监控和调节流程泵工作的智能化系统，同时能对流程泵的工作进行故障诊断。该系统不仅降低了流程泵设备的维护保养工作和能源费用，提高流程泵的工作可靠性，还能优化流程泵的工作状态，使... 详细信息

据了解，Allweiler公司现已研发成功了一种能够监控和调节流程泵工作的智能化系统，同时能对流程泵的工作进行故障诊断。该系统不仅降低了流程泵设备的维护保养工作和能源费用，提高流程泵的工作可靠性，还能优化流程泵的工作状态，使其保持在最佳工作点工作。

关键词：智能化系统监控系统流程泵维护保养工作最佳工作点故障诊断能源费用工作状态

无创性多层螺旋CT冠状动脉造影的临床应用与发展趋势

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放射学实践 2005年第8期20卷 739-741页

作者：史河水 martin hoffmann 韩萍孔祥泉冯敢生华中科技大学同济医学院附属协和医院放射科武汉430022 德国Ulm大学临床医院放射科

促进冠心病(coronary artery disease,CAD)有效治疗方法进展的最初诊断工具是创伤性冠状动脉造影.然而,这种创伤性检查在少数情况下会产生潜在的、可危及患者生命安全的并发症[1].40%以上的创伤性冠状动脉造影只是用来排除冠心病,而不... 详细信息

促进冠心病(coronary artery disease,CAD)有效治疗方法进展的最初诊断工具是创伤性冠状动脉造影.然而,这种创伤性检查在少数情况下会产生潜在的、可危及患者生命安全的并发症[1].40%以上的创伤性冠状动脉造影只是用来排除冠心病,而不需要进一步的介入或外科治疗[2].有关无创性冠状动脉造影的研究最初是建立在MRI[3]、电子束CT(electron beam CT,EBCT)[4]和多层螺旋CT(multislice spiral CT,MSCT)[5]的基础上.

关键词：无创性多层螺旋CT 冠状动脉造影临床应用发展趋势

Noninvasive Detection of Coronary Artery Stenosis Using 16-slice Spiral CT: a Comparison with Selective X-ray Coronary Angiography

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2006年第3期26卷 338-340页

作者：史河水韩萍孔祥泉冯敢生 martin HK hoffmann Department of Radiology Union hospital Tongji medical college Huazhong University of Science and Technology Wuhan 430022 China Department of Radiology Ulm University Ulm 89075 Germany

The role of 16-slice spiral CT was selective X-ray coronary angiography （SCA） who were suspected of having coronary heart evaluated in the diagnosis of coronary stenosis, with serving as the reference standard. Sixty-five patients disease, without percutaneous transluminal coronary angioplasty or coronary bypass-grafting, were investigated using 16-slice CT. Eight patients with pre-scan heart rate of more than 80 beats/min were given β-blockers. After the retrospectively ECG-gated axial imaging reconstruction, volume redering （VR）, multi-planar reconstruction （MPR）, curved MPR and maximum intensity projection （MIP） were used to reconstruct. Every segment of coronary artery with a diameter ≥1.5 mm was assessed, and the presence on CT with a stenosis exceeding 50 % diameter reduction was compared with that on SCA. The reasons which lead to some segments unevaluable were analysed. Compared with SCA, 93 % coronary segments and 94 % main branches were evaluable. Residual cardiac motion artifacts, severe calcification and poor opacification made 58 %, 28 % and 14 % of the remaining 60 segments unevaluable respectively. Without routine administration of β-blockers, good coronary imaging quality can be acquired using 16-slice spiral CT. It is a reliable noninvasive method for detection of obstructive coronary artery disease.

关键词： tomography, X-ray computed angiography coronary artery stenosis

Are TrkB receptor agonists the right tool to fulfill the promises for a therapeutic value of the brain-derived neurotrophic factor?

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Neural Regeneration Research 2024年第1期19卷 29-34页

作者： Marta Zagrebelsky martin Korte Division of Cellular Neurobiology Zoological InstituteTU BraunschweigBraunschweigGermany Helmholtz Centre for Infection Research AG NINDBraunschweigGermany

Brain-derived neurotrophic factor signaling via its receptor tro pomyosin receptor kinase B regulates several crucial physiological processes.It has been shown to act in the brain,promoting neuronal survival,growth,and plasticity as well as in the rest of the body where it is involved in regulating for instance aspects of the metabolism.Due to its crucial and very pleiotro pic activity,reduction of brain-derived neurotrophic factor levels and alterations in the brain-derived neurotrophic factor/tropomyosin receptor kinase B signaling have been found to be associated with a wide spectrum of neurological diseases.Howeve r,because of its poor bioavailability and pharmacological properties,brain-derived neurotrophic factor itself has a very low therapeutic value.Moreover,the concomitant binding of exogenous brain-derived neurotrophic factor to the p75 neurotrophin receptor has the potential to elicit several unwanted and deleterious side effects.Therefo re,developing tools and approaches to specifically promote tropomyosin receptor kinase B signaling has become an important goal of translational research.Among the newly developed tools are different categories of tropomyosin receptor kinase B receptor agonist molecules.In this review,we give a comprehensive description of the diffe rent tro pomyosin receptor kinase B receptor agonist drugs developed so far and of the res ults of their application in animal models of several neurological diseases.Moreover,we discuss the main benefits of tropomyosin receptor kinase B receptor agonists,concentrating especially on the new tropomyosin receptor kinase B agonist antibodies.The benefits observed both in vitro and in vivo upon application of tropomyosin receptor kinase B receptor agonist drugs seem to predominantly depend on their general neuroprotective activity and their ability to promote neuronal plasticity.Moreover,tro pomyosin receptor kinase B agonist antibodies have been shown to specifically bind the tropomyosin receptor kinase B receptor and not p75 neurotrophin rec

关键词： Alzheimer's disease brain-derived neurotrophic factor depression Parkinson's disease tropomyosin receptor kinase B receptor

Comprehensive Euler/Lagrange modelling including particle erosion for confined gas-solid flows

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Particuology 2024年第1期84卷 209-235页

作者： Guiherme A.Novelletto Ricardo martin Sommerfeld Multiphase Flow Systems Institute of Process EngineeringOtto-von-Guericke-University MagdeburgHoher Weg 7b06120Halle(Saale)Germany

The present research aims to assess the capability of a comprehensive Euler/Lagrange approach for predicting gas-solid flows and the associated solid particle erosion.The open-source code OpenFOAM®4.1 was used to carry out the numerical simulations,where the standard Lagrangian libraries were substantially extended to account for all necessary models.Particles are tracked considering both translational and rotational motion as well as all relevant forces,such as gravity/buoyancy,drag and transverse lift due to shear and particle rotation.The tracking time step was dynamically adapted ac-cording to the locally relevant time scales,which drastically reduces computational times.Stochastic approaches are adopted to model particle turbulent dispersion,particle collisions with rough walls and particle-particle interactions.Five solid particle erosion models,available in the literature,were considered to estimate pipe bend erosion.Three study cases are provided to validate the adopted nu-merical approach and erosion models extensively.The first case intends to evaluate the ability of the extended CFD code to predict the behaviour of gas-solid flows in pneumatic conveying systems.This goal is achieved by comparing the numerical results with the experimental data obtained by Huber(1997)and Huber and Sommerfeld(1994,1998)in a pneumatic conveying system.Here,the importance of considering inter-particle collisions and surface roughness for predicting particle velocity,mass flux and mean diameter distributions in gas-solid flows is highlighted.The second and third case intend to evaluate the ability of the erosion models in estimating bend erosion in diluted gas-solid flows.The erosion data obtained experimentally by Mazumder et al.(2008)and Solnordal et al.(2015)in very dilut pneumatic conveying systems is used for validating the numerical results,neglecting now inter-particle collisions and two-way coupling.Besides a comprehensive analysis of the different influential properties on erosion,the innovation of the present stud

关键词： Pneumatic conveying Pipe bend Numerical calculation(CFD) Euler/Lagrange approach Erosion models Wall roughness

Differential roles of seed and sprout regeneration in forest diversity and productivity after disturbance

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Forest Ecosystems 2024年第3期11卷 371-380页

作者： Marek Mejstrík martin Svatek martina Pollastrini martin Sramek Radim Matula Department of Forest Ecology Faculty of Forestry and Wood SciencesCzech University of Life Sciences PragueKamýcka 12916500PragueCzech Republic Department of Forest Botany Dendrology and GeobiocoenologyFaculty of Forestry and Wood TechnologyMendel University in BrnoZemedelska 361300BrnoCzech Republic Department of Agriculture FoodEnvironment and ForestryUniversity of FirenzePiazzale Delle Cascine 2850144FirenzeItaly

Natural regeneration after disturbances is a key phase of forest development,which determines the trajectory of successional changes in tree species composition and diversity.Regenerating trees can originate from either seeds or sprouts produced by disturbed trees with sprouting ability.Although both regeneration strategies often develop and co-occur after a disturbance,they tend to affect forest development differently due to significant functional differences.However,the origin of tree regeneration is rarely distinguished in post-disturbance forest surveys and ecological studies,and the differential roles of seed and sprout regeneration in forest productivity and diversity remain poorly understood.To address these research gaps,we explored the role of sprout and seed regeneration in the formation of woody species diversity and above-ground biomass(AGB)productivity in early-stage forest development.Data were collected in two experimental forest stands in the Czech Republic,where trees were cut with varying intensities with the density of residual(uncut)trees ranging from 0 to 275 trees per hectare.All trees were mapped and their sizes were measured before cutting and then,either as a stump with sprouts or a residual tree,remeasured 11 years later.In addition,all tree saplings were mapped and measured 11 years after logging,and their origin(sprout or seed)was identified.To assess abundances and productivity,we estimated AGB of all2,685 sprouting stumps of 19 woody species and 504 generative(i.e.,seed origin)individuals of 16 woody species,using allometric equations.Mixed-effects models were used to analyze the effects of each regeneration strategy on woody species diversity and the total AGB under varying densities of residual trees.Nonmetric multidimensional scaling was used to evaluate the effect of regeneration strategies on species composition.AGB and diversity of sprouts were significantly higher than those of seed regeneration.Sprouts formed on average97.1%of the total regeneration AGB in H ady and 98.6%in

关键词： Resprouting Seeding Residual trees Tree diversity Above-ground biomass