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肺动脉高压患者的对比增强心血管磁共振成像检查

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世界核心医学期刊文摘(心脏病学分册) 2006年第4期 53-54页

作者： BlythK.G. Groenning B.A. martin t.n. A.J. Peacock 潘闽 Scottish Pulmonary Vascular Unit Western Infirmary Glasgow G11 6NT United Kingdom

Aims: to determine the presence and ext.n. of delayed contrast enhancement(DCE) in patients with pulmonary hypert.n.ion(PHt) using contrast enhanced-cardiovascular magnetic resonance imaging(ce-CMR). Methods and results: twenty-five patients with PHt underwent ce-CMR and right heart catheterization. Right ventricular(RV) and left ventricular(LV) volumes, ejection fraction, mass, and DCE mass were determined with ce-CMR. Mean pulmonary artery pressure(mean PAP) averaged 43(12) mmHg and cardiac output 4.3(1.2) L/min. DCE was demonstrated in 23 out of 25 patien ts. DCE was confined to the RV insertion points(RVIPs) in seven patients and ext.n.ed into the interventricular septum(IVS) in the remaining 16 patients. In these 16 patients, septal contrast enhancement was associated with IVS bowing. the ext.n. of contrast enhancement correlated positively with RV end-diastolic volu me/ body surface area, RV mass, mean PAP, and pulmonary vascular resist.n.e and correlated inversely with RV ejection fraction. Conclusion: DCE was present with in the RVIPs and IVS of most patients with PHt studied. Ext.n. of DCE correlated with RV function and pulmonary haemodynamics. DCE was associated with IVS bowin g and may provide a novel marker for occult septal abnormalities directly relati ng to the haemodynamic stress experienced by these patients.

关键词：对比增强肺动脉磁共振成像心血管患者

nonlinear-Optical Analogies in nuclear-Like Solit.n.Reactions:Selection Rules,nonlinear t.n.eling and Sub-Barrier Fusion–Fission

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Chinese Physics Letters 2024年第8期41卷 1-7页

作者： t.L.Belyaeva V.n.Serkin Universidad Aut.n.ma del Estado de Mexico Av.Instituto Literario 100C.P.50000TolucaMexico Benemerita Universidad Aut.n.ma de Puebla Av.4 Sur 104C.P.72001PueblaMexico

the main goal of our study is to reveal unexpected but intriguing analogies arising between optical solit.n. and nuclear physics,which still remain hidden from *** consider the main cornerst.n.s of the concept of nonlinear optics of nuclear reactions and the well-dressed repulsive-core *** the base of this model,we reveal the most intriguing properties of the nonlinear t.n.eling of nucleus-like solit.n. and the solit.n.selfinduced sub-barrier transparency *** describe novel interest.n. and stimulat.n. analogies between the interaction of nucleus-like solit.n. on the repulsive barrier and nuclear sub-barrier *** main finding of this study concerns the conservation of total number of nucleons(or the baryon number)in nuclear-like solit.n.*** show that inelastic interactions among well-dressed repulsive-core solit.n. arise only when a“cloud”of“dressing”spectral side-bands appears in the frequency spectra of the *** property of nucleus-like solit.n. is directly related to the nuclear density distribution described by the dimensionless small shape-squareness *** the Fourier spectra of nucleus-like solit.n. are similar to the nuclear form *** show that the nuclear-like reactions between well-dressed solit.n. are realized by“exchange”between“particle-like”side bands in their spectra.

关键词： solit.n. soliton nonlinear

维普期刊数据库

Evaluation of slope stability through rock mass classification and kinematic analysis of some major slopes along nH-1A from Ramban to Banihal, north Western Himalayas

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第1期16卷 167-182页

作者： Amit Jaiswal A.K.Verma t.n.Singh Department of Civil and Environmental Engineering Indian Institute of Technology PatnaPatna801106India

the network of Himalayan roadways and highways connects some remote regions of valleys or hill slopes,which is vital for India’s socio-economic *** to natural and artificial factors,frequency of slope instabilities along the networks has been increasing over last few *** of stability of natural and artificial slopes due to construction of these connect.n. road networks is significant in safely execut.n. these roads throughout the *** rock mass classification methods are generally used to assess the strength and deformability of rock *** study assesses slope stability along the nH-1A of Ramban district of north Western *** structurally and non-structurally controlled rock mass classification systems have been applied to assess the stability conditions of 14 *** evaluat.n. the stability of these slopes,kinematic analysis was performed along with geological strength index(GSI),rock mass rat.n.(RMR),cont.n.ous slope mass rat.n.(CoSMR),slope mass rat.n.(SMR),and Q-slope in the present *** SMR gives three slopes as completely unstable while CoSMR suggests four slopes as completely *** stability of all slopes was also analyzed using a design chart under dynamic and static conditions by slope stability rat.n.(SSR)for the factor of safety(FoS)of 1.2 and 1 respectively.Q-slope with probability of failure(PoF)1%gives two slopes as stable *** slope angle has been determined based on the Q-slope safe angle equation and SSR design chart based on the *** value ranges given by different empirical classifications were RMR(37-74),GSI(27.3-58.5),SMR(11-59),and CoSMR(3.39-74.56).Good relationship was found among RMR&SSR and RMR&GSI with correlation coefficient(R 2)value of 0.815 and 0.6866,***,a comparative stability of all these slopes based on the above classification has been performed to identify the most critical slope along this road.

关键词： Rock mass classification Kinematic analysis Slope stability Himalayan road Static and dynamic conditions

new trends in diagnosis and management of gallbladder carcinoma

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World Journal of Gastrointest.n.l Oncology 2024年第1期16卷 13-29页

作者： Efstathios t Pavlidis Ioannis n Galanis theodoros E Pavlidis ^(nd)Propedeutic Department of Surgery Hippokration General HospitalSchool of MedicineAristotle University of ThessalonikiThessaloniki 54642Greece

Gallbladder(GB)carcinoma,although relatively rare,is the most common biliary tree cholangiocarcinoma with aggressiveness and poor *** is closely associated with cholelithiasis and long-st.n.ing large(>3 cm)gallst.n.s in up to 90%of *** other main predisposing factors for GB carcinoma include molecular factors such as mutated genes,GB wall calcification(porcelain)or mainly mucosal microcalcifications,and GB polyps≥1 cm in *** is made by ultrasound,computed tomography(Ct),and,more precisely,magnetic resonance imaging(MRI).Preoperative staging is of great import.n.e in decisionmaking regarding therapeutic *** staging is based on MRI findings,the leading technique for liver metastasis imaging,enhanced three-phase Ct angiography,or magnetic resonance angiography for major vessel *** is also necessary to use positron emission tomography(PEt)-Ct or ^(18)F-FDG PEt-MRI to more accurately detect metastases and any other occult deposits with active metabolic *** laparoscopy may detect dissemination not otherwise found in 20%-28.6%of *** treatment is needed,including surgical resection,targeted therapy by biological agents according to molecular test.n. gene mapping,chemotherapy,radiation therapy,and *** is of great import.n.e to underst.n. the updated guidelines and current treatment *** ext.n. of surgical intervention depends on the disease stage,ranging from simple cholecystectomy(t1a)to ext.n.ed resections and including ext.n.ed cholecystectomy(t1b),with wide lymph node resection in every case or IV-V segmentectomy(t2),hepatic trisegmentectomy or major hepatectomy accompanied by hepaticojejunostomy Roux-Y,and adjacent organ resection if necessary(t3).Laparoscopic or robotic surgery shows fewer postoperative complications and equivalent oncological outcomes when compared to open surgery,but much att.n.ion must be paid to avoiding *** addition to surgery,novel targe

关键词： Biliary tract.n.oplasms Extrahepatic cholangiocarcinoma Gallbladder carcinoma Gallbladder diseases Biliary tree diseases Gastrointest.n.l malignancies

Management of obstructed colorectal carcinoma in an emergency sett.n.:An update

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World Journal of Gastrointest.n.l Oncology 2024年第3期16卷 598-613页

作者： Efstathios t Pavlidis Ioannis n Galanis theodoros E Pavlidis 2nd Propedeutic Department of Surgery Hippokration General HospitalSchool of MedicineAristotle University of ThessalonikiThessaloniki 54642Greece

Colorectal carcinoma is common,particularly on the left *** 20%of patients,obstruction and ileus may be the first clinical manifestations of a carcinoma that has advanced(stage II,III or even IV).Diagnosis is based on clinical presentation,plain abdominal radiogram,computed tomography(Ct),Ct colonography and positron emission tomography/*** best management strategy in terms of short-term operative or interventional and long-term oncological outcomes re-mains *** the most common left-sided obstruction,the first choice should be either emergency surgery or endoscopic decompression by self-expen-dable metal st.n.s or *** operative plan should be either one-stage or two-stage ***-stage resection with on-table bowel decompression and irrigation can be accompanied or not accompanied by proximal defunctioning stoma(colostomy or ileostomy).Primary anastomosis is more convenient but has increased risks of anastomotic leakage and ***-stage resection(Hart-mann’s procedure)is safer and the most widely used despite temporally affect.n. quality of *** control surgery in high-risk frail patients is less frequently performed since it can be successfully substituted with endoscopic st.n.ing or *** the less common right-sided obstruction,one-stage surgical resection is more beneficial than endoscopic *** role of minimally invasive surgery(laparoscopic or robotic)is a subject of *** laparoscopic-assisted management is advantageous to some ext.n. but requires much expertise due to inherent difficulties in dissect.n. the dist.n.ed colon and the risk of rup-ture and subsequent septic *** decompressing st.n. as a bridge to elective surgery more subst.n.ially decreases the risks of morbidity and mortality than emergency surgery for decompression and has equivalent medium-term overall survival and disease-free survival *** combination with neoadjuvant chemotherapy or radiation may have a p

关键词： Acute abdomen Obstructive ileus Colorectal carcinoma Emergency surgery Colectomy Intraluminal metal st.n.s

Evaluation of periglacial landforms and formation of soil properties on the Mount Honaz,SW türkiye

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Journal of Mountain Science 2024年第9期21卷 3047-3067页

作者： SERİn Soner UnCU Levent DEDE Volkan tÜRKEŞMurat Institute of Social Sciences İstanbul Universityİstanbul 34119Türkiye Department of Geography BilecikŞeyh Edebali UniversityBilecik 11234Türkiye Department of Geography Ardahan UniversityArdahan 75002Türkiye Center for Climate Change and Policy Studies Boğaziçi Universityİstanbul 34342Türkiye

the main aim of this study is to explain periglacial processes on the summits of Mount Honaz(2571 m a.s.l.),define periglacial landforms,and determine the relationships between morphometric features and topographic *** circles,st.n. earth circles,non sorted steps,and non sorted stripes were identified on the summits of Mount ***'s correlation coefficient(r)and linear regression analyses were performed by taking metric measurements from 125 periglacial landforms to describe their morphometric features(length,width,height)of periglacial landforms and explain the relationships between them and topographic factors(elevation,slope).to explain the relationships between periglacial landforms and soil properties,soil samples from 11 periglacial landforms were taken and *** landforms,which cont.n.e to develop on the summits of Mount Honaz today,have been evaluated with present climate *** of soil samples indicates a notable impact of parent material on the genesis of periglacial *** high ratio of organic matter in mud circle and non sorted step landforms and the high lime ratio in st.n. earth circle landforms prove a strong relationship between the formation mechanisms of landforms and the soil ***,it is consist.n. with the findings obtained from the analysis that severe periglacial processes and washing and scavenging events are experienced more on the northern slopes.

关键词： Periglacial processes and geomorphology Soil analysis Morphometric analysis Mount Honaz türkiye

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Current considerations on intraductal papillary neoplasms of the bile duct and pancreatic duct

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World Journal of Gastroenterology 2024年第10期30卷 1461-1465页

作者： Efstathios t Pavlidis Ioannis n Galanis theodoros E Pavlidis 2^(nd) Propedeutic Department of Surgery Hippokration General HospitalSchool of MedicineAristotle University of ThessalonikiThessaloniki 54642Greece

Pancreatobiliary intraductal papillary neoplasms(IPns)represent precursors of pancreatic cancer or bile duct cholangiocarcinoma that can be detected and *** advances in diagnostic methods,identifying these premalignant lesions is still challenging for treatment *** imaging,biomarkers and molecular tests for genomic alterations can be used for diagnosis and *** intervention in combination with new chemotherapeutic agents is considered the optimal treatment for malignant *** balance between the risk of malignancy and any risk of resection guides management policy;therefore,treatment should be individualized based on a meticulous preoperative assessment of high-risk *** of the bile duct is more aggressive;thus,early diagnosis and surgery are *** conservative management of low-risk pancreatic branch-duct lesions is safe and effective.

关键词： Biliary tree diseases Pancreatic cystic neoplasms Biliary tract.n.oplasms Extrahepatic cholangiocarcinoma Pancreatic adenocarcinoma

Comprehensive Euler/Lagrange modelling including particle erosion for confined gas-solid flows

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Particuology 2024年第1期84卷 209-235页

作者： Guiherme A.novelletto Ricardo martin Sommerfeld Multiphase Flow Systems Institute of Process EngineeringOtto-von-Guericke-University MagdeburgHoher Weg 7b06120Halle(Saale)Germany

the present research aims to assess the capability of a comprehensive Euler/Lagrange approach for predict.n. gas-solid flows and the associated solid particle *** open-source code OpenFOAM®4.1 was used to carry out the numerical simulations,where the st.n.ard Lagrangian libraries were subst.n.ially ext.n.ed to account for all necessary *** are tracked considering both translational and rotational motion as well as all relevant forces,such as gravity/buoyancy,drag and transverse lift due to shear and particle *** tracking time step was dynamically adapted ac-cording to the locally relevant time scales,which drastically reduces computational *** approaches are adopted to model particle turbulent dispersion,particle collisions with rough walls and particle-particle *** solid particle erosion models,available in the literature,were considered to estimate pipe bend *** study cases are provided to validate the adopted nu-merical approach and erosion models *** first case int.n.s to evaluate the ability of the ext.n.ed CFD code to predict the behaviour of gas-solid flows in pneumatic conveying *** goal is achieved by comparing the numerical results with the experimental data obtained by Huber(1997)and Huber and Sommerfeld(1994,1998)in a pneumatic conveying ***,the import.n.e of considering inter-particle collisions and surface roughness for predict.n. particle velocity,mass flux and mean diameter distributions in gas-solid flows is *** second and third case int.n. to evaluate the ability of the erosion models in estimat.n. bend erosion in diluted gas-solid *** erosion data obtained experimentally by Mazumder et al.(2008)and Solnordal et al.(2015)in very dilut pneumatic conveying systems is used for validat.n. the numerical results,neglect.n. now inter-particle collisions and two-way *** a comprehensive analysis of the different influential properti

关键词： Pneumatic conveying Pipe bend numerical calculation(CFD) Euler/Lagrange approach Erosion models Wall roughness

A modular microfluidic platform to study how fluid shear stress alters estrogen receptor phenotype in ER+breast cancer cells

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Microsystems & nanoengineering 2024年第1期10卷 287-299页

作者： Braulio Andrés Ortega Quesada Jonathan Cuccia Rachael Coates Blake nassar Ethan Littlefield Elizabeth C.martin Adam t.Melvin Cain Department of Chemical Engineering Louisiana State UniversityBaton RougeLA 70803USA Department of Chemical and Biological Engineering Clemson UniversityClemsonSC 29634USA Biological and Agricultural Engineering Louisiana State UniversityBaton RougeLA 70803USA Department Medicine Section Hematology and Medical OncologyTulane UniversityNew OrleansLA 70118USA

Metastatic breast cancer leads to poor prognoses and worse outcomes in patients due to its invasive behavior and poor response to *** is still unclear what biophysical and biochemical factors drive this more aggressive phenotype in metastatic cancer;however recent studies have suggested that exposure to fluid shear stress in the vasculature could cause *** this study a modular microfluidic platform capable of mimicking the magnitude of fluid shear stress(FSS)found in human vasculature was designed and *** device provides a platform to evaluate the effects of FSS on MCF-7 cell line,an estrogen receptor positive(ER+)breast cancer cell line,during circulation in the *** of the effects of FSS on MCF-7 cells was carried out utilizing two approaches:single cell analysis and bulk *** single cell analysis,cells were trapped in a microarray after exit.n. the serpent.n. channel and followed by immunostaining on the device(on-chip).Bulk analysis was performed after cells were collected in a microtube at the outlet of the microfluidic serpent.n. channel for western blott.n.(off-chip).It was found that cells exposed to an FSS magnitude of 10 dyn/cm^(2) with a residence time of 60 s enhanced expression of the proliferation marker Ki67 in the MCF-7 cell line at a single cell *** underst.n. possible mechanisms for enhanced Ki67 expression,on-chip and off-chip analyses were performed for pro-growth and survival pathways ERK,AKt,and JAK/*** demonstrated that after shearing the cells phosphorylation of p-AKt,p-mtOR,and p-StAt3 were ***,there was no change in p-ERK1/*** is a mediator of ER rapid signaling,analysis of phosphorylated ERαwas carried out and no significant differences between sheared and non-sheared populations were *** together these results demonstrate that FSS can increase phosphorylation of proteins associated with a more aggressive phenotype in circulat.n. cancer *** findin

关键词： fluid breast estrogen