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Emerging insights into the function of very long chain fatty acids at cerebellar synapses

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Neural regeneration research 2025年第6期20卷 1709-1710页

作者： martin-Paul Agbaga Mohiuddin Ahmad Department of Cell Biology and Ophthalmology University of Oklahoma Health Sciences Centerand Dean McGee Eye InstituteOklahoma CityOKUSA

Very long chain-saturated and-polyunsaturated fatty acids(VLC-SFA and VLC-PUFA, respectively) are a functionally important class of fatty acids containing 28 carbons or more in their acyl chain. They are synthesized by the elongation of very long fatty acids-4(ELOVL4) enzyme, expressed mainly in the brain, retina, skin, testes, and meibomian gland, where these fatty acids are found(Agbaga et al., 2008). Further, these organs exhibit tissuespecific VLC-PUFA and VLC-SFA biosynthesis and incorporation into complex lipids for specific functions. In the brain, skin, and Meibomian glands, the ELOVL4 mainly makes VLC-SFA, which are incorporated into complex sphingolipids. In the retina, the ELOVL4 makes VLC-PUFA that are incorporated into phosphatidylcholine, that are critical for visual function, while in testes and sperm, the VLC-PUFA are incorporated into sphingolipids that are critical for fertility(Yeboah et al., 2021).

关键词： functions function insight

Getting physical with medical education:Exercise based virtual anatomy review classes for medical students

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World Journal of Methodology 2025年第1期15卷 20-25页

作者： Nadeesha r Samarasinghe Taniya S Nagpal Michele L Barbeau Charys M martin Division of General Surgery Faculty of MedicineUniversity of British ColumbiaVancouver V6T 1Z3BCCanada Faculty of Kinesiology Sport and RecreationUniversity of AlbertaEdmonton T6G 2R3ABCanada Anatomy and Cell Biology University of Western OntarioLondon N6A 3K7ONCanada Department of Anatomy and Cell Biology Schulich School of Medicine and DentistryThe University of Western OntarioLondon N6A 3K7ONCanada

The benefits of regular physical activity are well ***,few studies have examined the effectiveness of integrating physical activity(PA)into curricula within a post-secondary *** investigate the incorporation of PA into medical curriculum,we developed a series of optional exercise-based review sessions designed to reinforce musculoskeletal(MSK)anatomy course *** synchronous sessions were co-taught by a group fitness instructor and an anatomy *** fitness instructor would lead students through both strength and yoga style exercises,while the anatomy instructor asked questions about relevant anatomical structures related to course material previously *** the sessions,participants were asked to evaluate the classes on their self-reported exam preparedness in improving MSK anatomy knowledge,PA levels,and mental *** participants completed surveys;a majority agreed that the classes increased understanding of MSK concepts(90.0%)and activity levels(97.7%).Many(70.0%)felt that the classes helped reduce *** majority of respondents(90.0%)agreed that the classes contributed to increased feelings of social ***,medical students saw benefit in PA based interventions to supplement MSK course *** with increasing activity levels and promoting health behaviours,integrating PA into medical curriculum may improve comprehension of learning material,alleviate stress and foster social connectivity among medical students.

关键词： Medical education Musculoskeletal Anatomy Exercise Online learning

Movement analysis in the diagnosis and management of Parkinson’s disease

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Neural regeneration research 2025年第2期20卷 485-486页

作者： Johannes Burtscher Nicolas Bourdillon Jules MJanssen Daalen Aurélien Patoz Julien FBally martin Kopp Davide Malatesta Bastiaan rBloem Institute of Sport Sciences University of LausanneLausanneSwitzerland radboud University Medical Center Department of NeurologyDonders Institute for BrainCognition and BehaviorCenter of Expertise for Parkinson and Movement DisordersNijmegenThe Netherlands radboud University Medical Center Department of Medical BioSciencesNijmegenThe Netherlands research and Development Department Volodalen Swiss Sport LabAigleSwitzerland Service of Neurology Department of Clinical NeurosciencesLausanne University Hospital(CHUV)and University of Lausanne(UNIL)LausanneSwitzerland Department of Sport Science University of InnsbruckInnsbruckAustria

Challenges in the diagnosis and treatment of Parkinson’s disease:Parkinson’s disease(PD)is an increasingly prevalent neurodegenerative disease,at first sight primarily characterized by motor symptoms,although non-motor symptoms also constitute a major part of the overall ***,this disease cannot be diagnosed reliably until a large part of the vulnerable dopaminergic neurons has been irretrievably lost,and the disease progresses *** biological criteria for PD have been proposed recently and might eventually improve early diagnosis,but they require further validation,and their use will initially be restricted to a research environment(Darweesh et al.,2024).

关键词： diagnosis Clinical eventually

Alternative Strategy for Development of Dielectric Calcium Copper Titanate‑Based Electrolytes for Low‑Temperature Solid Oxide Fuel Cells

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Nano-Micro Letters 2025年第1期17卷 310-332页

作者： Sajid rauf Muhammad Bilal Hanif Zuhra Tayyab Matej Veis MAKYousaf Shah Naveed Mushtaq Dmitry Medvedev Yibin Tian Chen Xia martin Motola Bin Zhu College of Mechatronics and Control Engineering Shenzhen UniversityShenzhen 518060People’s Republic of China Department of Inorganic Chemistry Faculty of Natural SciencesComenius University BratislavaIlkovicova684215 BratislavaSlovakia Energy Storage Joint research Center School of Energy and EnvironmentSoutheast UniversityNanjing 210096People’s Republic of China Hydrogen Energy Laboratory Ural Federal University620002 EkaterinburgRussia Laboratory of Electrochemical Devices Based on Solid Oxide Proton Electrolytes Institute of High Temperature Electrochemistry620066 EkaterinburgRussia School of Microelectronics Hubei UniversityWuhan 430062People’s Republic of China

The development of low-temperature solid oxide fuel cells(LT-SOFCs)is of significant importance for realizing the widespread application of *** has stimulated a substantial materials research effort in developing high oxide-ion conductivity in the electrolyte layer of *** this context,for the first time,a dielectric material,CaCu_(3)Ti_(4)O_(12)(CCTO)is designed for LT-SOFCs electrolyte application in this *** individual CCTO and its heterostructure materials with a p-type Ni_(0.8)Co_(0.15)Al_(0.05)LiO_(2−δ)(NCAL)semiconductor are evaluated as alternative electrolytes in LT-SOFC at 450–550℃.The single cell with the individual CCTO electrolyte exhibits a power output of approximately 263 mW cm^(-2) and an open-circuit voltage(OCV)of 0.95 V at 550℃,while the cell with the CCTO–NCAL heterostructure electrolyte capably delivers an improved power output of approximately 605 mW cm^(-2) along with a higher OCV over 1.0 V,which indicates the introduction of high hole-conducting NCAL into the CCTO could enhance the cell performance rather than inducing any potential short-circuiting *** is found that these promising outcomes are due to the interplay of the dielectric material,its structure,and overall properties that led to improve electrochemical mechanism in CCTO–***,density functional theory calculations provide the detailed information about the electronic and structural properties of the CCTO and NCAL and their heterostructure CCTO–*** study thus provides a new approach for developing new advanced electrolytes for LT-SOFCs.

关键词： LT-SOFCs Dielectric CaCu_(3)Ti_(4)O_(12) Semiconductor Ni_(0.8)Co_(0.15)Al_(0.05)LiO_(2−δ) Ionic conductivity Heterostructure electrolyte

Aggregation-induced delayed fluorescence (AIDF) materials： a new break-through for nondoped OLEDs

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Science China Chemistry 2017年第12期60卷 1561-1562页

作者： martin r. Bryce Department of Chemistry Durham UniversityDurham DH1 3LEUK

Nowadays, purely organic materials with delayed fluorescence （DF） are being enthusiastically developed and extensively utilized as light-emitting materials to fabricate OLEDs because of their high exciton utilization and metal-flee nature. These DF materials usually have a small single-triplet splitting （AEsT）, and the nonradiative triplet excitons （75%） can be converted into radiative singlet excitons via thermally promoted reverse intersystem crossing （rISC） processes,

关键词： Aggregation-induced delayed fluorescence (AIDF) materials a new break-through nondoped OLEDs

Finding a home for hyoliths

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National Science review 2020年第2期7卷 470-471页

作者： martin r.Smith Department of Earth Sciences Durham University NSr

Many of the animal lineages that arose during the Cambrian evolutionary radiation, 540 million years ago, are difficult to relate to living taxa. Constraining the phylogenetic position of these highly disparate taxa allows their idiosyncratic morphologies to illuminate the stepwise establishment of modern body plans[1–3].Hyoliths are one such lineage; their operculate conical shells

关键词： Finding a home for hyoliths

Evaluation for Small Visual Difference Between Conforming Meshes on Strain Field

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Journal of Computer Science & Technology 2009年第1期24卷 65-75页

作者：边哲胡事民 ralph r.martin Department of Computer Science and Technology Tsinghua University School of Computer Science Cardiff UniversityCardiffU.K.

This paper gives a method of quantifying small visual differences between 3D mesh models with conforming topology, based on the theory of strain fields. Strain field is a geometric quantity in elasticity which is used to describe the deformation of elastomer. In this paper we consider the 3D models as objects with elasticity. The further demonstrations are provided： the first is intended to give the reader a visual impression of how our measure works in practice; and the second is to give readers a visual impression of how our measure works in evaluating filter algorithms. Our experiments show that our difference estimates are well correlated with human perception of differences. This work has applications in the evaluation of 3D mesh watermarking, 3D mesh compression reconstruction, and 3D mesh filtering.

关键词： 3D conforming meshes mesh comparison perception strain fields

Heavy atom effects benefit organic light emitting diode(OLED)performance

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Science China Chemistry 2023年第1期66卷 1-3页

作者： martin r.Bryce Departmentof Chemistry Durham UniversityDurham DHI3LEUnited Kingdom

This Highlight is inspired by a recent article in Nature Photonics in which Yang and co-workers [1] from Shenzhen University report new selenium-integrated thermally activated delayed fluorescence(TADF) molecules and their applications in organic light-emitting diodes(OLEDs).This work represents an important development in this field due to the remarkably high efficiency with which light is emitted from the devices.

关键词： OLED emitting diode

3D Morphing Using Strain Field Interpolation

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Journal of Computer Science & Technology 2007年第1期22卷 147-155页

作者：严寒冰胡事民 ralph r martin National Computer Network Emergency response Technical Team/Coordination Center of China Beijing 100029 China Department of Computer Science and Technology Tsinghua University Beijing 100084 China School of Computer Science Cardiff University Cardiff U.K.

In this paper, we present a new technique based on strain fields to carry out 3D shape morphing for applications in computer graphics and related areas. Strain is an important geometric quantity used in mechanics to describe the deformation of objects. We apply it in a novel way to analyze and control deformation in morphing. Using position vector fields, the strain field relating source and target shapes can be obtained. By interpolating this strain field between zero and a final desired value we can obtain the position field for intermediate shapes. This method ensures that the 3D morphing process is smooth. Locally, volumes suffer minimal distortion, and no shape jittering or wobbling happens： other methods do not necessarily have these desirable properties. We also show how to control the method so that changes of shape （in particular, size changes） vary linearly with time.

关键词： morphing strain field interpolation