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2007年全国砌体结构基本理论与工程应用学术会议

作者： Allen J.Clark Rod Larson Tony Y.Yang Bozidar Stojadinovic Jack P.Moehle Robert Tremblay Nilolay Velev Sina Merzouq martin leclerc Pierre Leger Bruno Massicotte Caroline Blais Colin Rogers M.Pangiotou Jose I.Restrepo Robert E.Englekirk Nathan Johnson M.Saiid Saiidi David Sanders Richard T.Ranf Marc Eberhard Andrei M.Reinhorn Mettupalayam V.Sivaselvan Zach Liang Mark Pittman Scot Weinreber MTS Systems Corporation Department of Civil and Environmental Engineering University of California at Berkeley Group for Research and Studies in Structural Engineering.Department of Civil Geological and Mining Engineering.Ecole Polytechnique Department of Civil Engineering and Applied Mechanics McGill University Department of Structural Engineering University of California at San Diego Englekirk Partners Consulting Structural Engineers Inc. University of Nevada University of Washington Department of Civil Structural and Environmental Engineering University of Buffalo

＜正＞Earthquake damage of property and loss and injury of human life *** many laboratories worldwide have increased their abilities to mitigate the hazards of these reoccurring natural *** paper presents new experimental techniques and applications from five laboratories,one in Canada,and four in the United *** new techniques and technologies range from combining computational analyses with structural testing with strong wall and strong floor at the University of California at Berkelely, a new technique for increasing the capability of a medium size uniaxial shaking table at Ecole Polytechnique,a description of the world’s highest capacity outdoor shaking table at the University of California at San Diego,testing with multiple biaxial shaking tables at the University of Reno,Nevada,and finally,the combination of strong wall dynamic structural actuators with a shaking table and real time computational sub-structuring computations at the University at Buffalo（SUNY）.These new capabilities allow the researcher to increase the size of the specimens of interest,allowing much better results to study nonlinear behaviors and failure mechanisms.

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Decrease of memory retention in a parasitic wasp： an effect of host manipulation by Wolbachia？

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Insect Science 2017年第4期24卷 569-583页

作者： Hossein Kishani Farahani Ahmad Ashouri Seyed Hossein Goldansaz martin S. Shapiro Jean-Sebastien Pierre Joan van Baaren Faculty of Agriculture and Natural Resources Department of Plant Protection University of Tehran Karaj Iran Department of Psy- chology California State University Fresno USA UMR-CNRS 6553 EcoBio University of Rennes 1 Avenue du General Leclerc Campus de Beaulieu 35042 Rennes Cedex France

Several factors, such as cold exposure, aging, the number of experiences and viral infection, have been shown to affect learning ability in different organisms. Wol- bachia has been found worldwide as an arthropod parasite/mutualist symbiont in a wide range of species, including insects. Differing effects have been identified on physiology and behavior by Wolbachia. However, the effect of Wolbachia infection on the learning ability of their host had never previously been studied. The current study carried out to compare learning ability and memory duration in 2 strains of the parasitoid Trichogramma brassicae： 1 uninfected and I infected by Wolbachia. Both strains were able to associate the novel odors with the reward of an oviposition into a host egg. However, the percentage of females that responded to the experimental design and displayed an ability to learn in these conditions was higher in the uninfected strain. Memory duration was longer in uninfected wasps （23.8 and 21.4 h after conditioning with peppermint and lemon, respectively） than in infected wasps （18.9 and 16.2 h after conditioning with peppermint and lemon, respec- tively）. Memory retention increased in response to the number of conditioning sessions in both strains, but memory retention was always shorter in the infected wasps than in the uninfected ones. Wolbachia infection may select for reduced memory retention because shorter memory induces infected wasps to disperse in new environments and avoid compe- tition with uninfected wasps by forgetting cues related to previously visited environments, thus increasing transmission of Wolbachia in new environments.

关键词： associative learning memory duration spacing learning Trichgramma bras-sicae Wolbachia infection

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Neoadjuvant sorafenib combined with gemcitabine plus oxaliplatin in advanced hepatocellular carcinoma

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World Journal of Gastroenterology 2011年第17期17卷 2255-2258页

作者： Nicolas Williet Olivier Dubreuil Tarek Boussaha Isabelle Trouilloud Bruno Landi martin Housset Muriel Botti Philippe Rougier Jacques Belghiti Julien Taieb Department of Gastroenterology Europeen Georges Pompidou HospitalMedical University75908 ParisFrance Department of Radiotherapy Europeen Georges Pompidou HospitalMedical University75908 ParisFrance Beaujon Hspital Medical University100boulevard du Général Leclerc92110 ClichyFrance

This paper reports the first case of a patient with hepatocellular carcinoma with lymph node metastasis treated by sorafenib combined with gemcitabine plus oxaliplatin,with a partial response and normalization of α fetoprotein,which allowed curative *** potential synergy between these three drugs needs to be confirmed,and is currently being investigated in a randomized phase Ⅱ trial.

关键词： Hepatocellular carcinoma Gemcitabine Oxaliplatin Sorafenib Neoadjuvant therapy

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Role of interleukin-1-family cytokines on effector CD4 T cell differentiation

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World Journal of Immunology 2017年第2期7卷 24-31页

作者： Thaiz Rivera Vargas Fran?ois martin Lionel Apetoh INSERM Faculté de Médecine Université de Bourgogne Centre Georges Fran?ois leclerc

The ability of CD4 T cells to differentiate into various effector or regulatory T cell subsets explains the successful adaptation of immune responses to different types of infectious pathogens. Immune responses in the context of cancer are also shaped by CD4 T cells, which can directly affect cancer prognosis in patients. While the proinflammatory mediator interleukin(IL)-1β was initially shown to enhance Th2 cell responses, recent findings support a predominant role of two other members of the IL-1 family, IL-18 and IL-33, on the production of Th1 and Th2-derived cytokines. In addition, IL-1β was found to profoundly affect the biology of two recently identified CD4 T cell subsets, Th17 and Th9 cells. IL-1β is critical for Th17 cell differentiation and it enhances the production of IL-9 and IL-21 by Th9 cells, thus increasing their anticancer properties. We will here review the mechanisms accounting for the ability of IL-1 cytokines to affect the differentiation of CD4 effector T cells with a focus on Th17 and Th9 cells. The physiopathological relevance of IL-1-driven effects on CD4 T cells will also be discussed.

关键词： Inflammation Innate immunity Adaptive immunity CD4 Th17 Th9 Interleukin-1 Inflammatory diseases Cancer

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