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A modular mi.roflui.i. platform to study how flui. shear stress alters estrogen receptor phenotype i. ER+breast cancer cells

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Mi.rosystems & Nanoengi.eeri.g 2024年第1期10卷 287-299页

作者： Brauli. Andrés Ortega Quesada Jonathan Cucci. Rachael Coates blake Nassar Ethan Li.tlefi.ld Eli.abeth C.martin Adam T.Melvi. Cai. Department of Chemi.al Engi.eeri.g Louisiana State UniversityBaton RougeLA 70803USA Department of Chemi.al and Bi.logi.al Engi.eeri.g Clemson UniversityClemsonSC 29634USA Bi.logi.al and Agri.ultural Engi.eeri.g Louisiana State UniversityBaton RougeLA 70803USA Department Medi.i.e Section Hematology and Medical OncologyTulane UniversityNew OrleansLA 70118USA

Metastati. breast cancer leads to poor prognoses and worse outcomes i. pati.nts due to i.s i.vasi.e behavi.r and poor response to *** i. sti.l unclear what bi.physi.al and bi.chemi.al factors dri.e thi. more aggressi.e phenotype i. metastati. cancer;however recent studi.s have suggested that exposure to flui. shear stress i. the vasculature could cause *** thi. study a modular mi.roflui.i. platform capable of mi.i.ki.g the magni.ude of flui. shear stress(FSS)found i. human vasculature was desi.ned and *** devi.e provi.es a platform to evaluate the effects of FSS on MCF-7 cell li.e,an estrogen receptor posi.i.e(ER+)breast cancer cell li.e,duri.g ci.culati.n i. the *** of the effects of FSS on MCF-7 cells was carri.d out uti.i.i.g two approaches:si.gle cell analysi. and bulk *** si.gle cell analysi.,cells were trapped i. a mi.roarray after exi.i.g the serpenti.e channel and followed by i.munostai.i.g on the devi.e(on-chi.).Bulk analysi. was performed after cells were collected i. a mi.rotube at the outlet of the mi.roflui.i. serpenti.e channel for western blotti.g(off-chi.).i. was found that cells exposed to an FSS magni.ude of 10 dyn/cm^(2) wi.h a resi.ence ti.e of 60 s enhanced expressi.n of the proli.erati.n marker Ki.7 i. the MCF-7 cell li.e at a si.gle cell *** understand possi.le mechani.ms for enhanced Ki.7 expressi.n,on-chi. and off-chi. analyses were performed for pro-growth and survi.al pathways ERK,AKT,and JAK/*** demonstrated that after sheari.g the cells phosphorylati.n of p-AKT,p-mTOR,and p-STAT3 were ***,there was no change i. p-ERK1/*** i. a medi.tor of ER rapi. si.nali.g,analysi. of phosphorylated ERαwas carri.d out and no si.ni.i.ant di.ferences between sheared and non-sheared populati.ns were *** together these results demonstrate that FSS can i.crease phosphorylati.n of protei.s associ.ted wi.h a more aggressi.e phenotype i. ci.culati.g cancer *** fi.di.

关键词： flui. breast estrogen

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应用剩餘非水滴定法於有机酸鹼盐的含量测定

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复旦学报(医学版) 1958年第2期 106-106页

作者： martin i. blake 褚志义

法定有机酸硷盐的含量测定方法操作繁复,消耗时间长,如分析四个样品最快需要三小时半;经灼燒、煮沸、过滤等操作易造成誤差,并取检品量很大(一般需二克)。应用非水滴定法則能避免以上缺点,不仅分析时间减少,操作簡捷,减少接间誤差机会,... 详细信息

法定有机酸硷盐的含量测定方法操作繁复,消耗时间长,如分析四个样品最快需要三小时半;经灼燒、煮沸、过滤等操作易造成誤差,并取检品量很大(一般需二克)。应用非水滴定法則能避免以上缺点,不仅分析时间减少,操作簡捷,减少接间誤差机会,并且需要检品量小(小于100毫克也能正确测定)。然尚存在困难,例如酒石酸盐等溶解度低的盐难溶于冰醋酸;以甲紫作指示剂时,終点为藍到藍綠

关键词：非水滴定指示剂甲紫滴定法无水标准液龙胆紫化学法毫克当量

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Temporo-spati.l dynami.s and behavi.ural patterns of 2012 cholera epi.emi. i. the Afri.an mega-ci.y of Conakry,Gui.ea

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i.fecti.us Di.eases of Poverty 2018年第1期7卷 145-154页

作者： Alexandre blake Veroni.ue Sarr Kei.a Delphi.e Sauvageot Mamadou Sali.u Berthe Mari. Njanpop Fode Sory Bertrand Sudre Koi.ogui.Lami.e martin Mengel Bradford DGessner Kei.a Sakoba Agence de Medeci.e Préventi.e ParisFrance Di.i.i.n Preventi.n et Lutte contre la Maladi.(DPLM) Ministere de la santéPublique et de l’Hygiene Publique ConakryConakryGuinea i.sti.ut Nati.nal de Sante Publi.ue(i.SP) ConakryGuinea Franche-Comtéuni.ersi.y(UMR 6249 chrono-envi.onnement) BesançonFrance.

Background:Cholera i. endemi. i. Gui.ea,havi.g suffered consecuti.e outbreaks from 2004 to 2008 followed by a lull unti. the 2012 *** we descri.e the temporal-spati.l and behavi.ural characteri.ti.s of cholera cases i. Conakry duri.g a three-year peri.d,i.cludi.g the large-scale 2012 ***:We used the nati.nal and Afri.an Cholera Survei.lance Network(Afri.hol)survei.lance data collected from every cholera treatment centre i. Conakry ci.y from August 2011 to December *** prevalence of suspect and confi.med cholera cases,the case fatali.y rati.(CFR),and the factors associ.ted wi.h suspected cholera were descri.ed accordi.g to three peri.ds:pre-epi.emi.(A),epi.emi. 2012(B)and post epi.emi.(C).Weekly attack rates and temporal-spati.l clusteri.g were calculated at muni.i.ali.y level for peri.d *** was confi.med by culture at the cholera nati.nal reference ***:A total of 4559 suspect cases were reported:66,4437,and 66 suspect cases i. peri.ds A,B and C,*** the 204 suspect cases wi.h culture results avai.able,6%,60%,and 70%were confi.med i. peri.ds A,B,and C,*** 0.3%,the CFR was si.ni.i.antly lower i. peri.d B than i. peri.ds A(7.6%)and C(7.1%).The overall attack rate was 0.28%i. peri.d B,rangi.g from 0.17%to 0.31%across ***,a cluster of cases was i.enti.i.d i. two di.tri.ts i. the northern part of *** 14%,ri.e water stools were less frequent i. peri.d A than i. peri.d B and C(78%and 84%).Dehydrati.n(31%vs 94%and 89%)and coma(0.4%vs 3.1%and 2.9%)were lower duri.g peri.d B than i. peri.ds A and *** treatment of dri.ki.g water was less frequent i. peri.d A,whi.e there were more reports of recent travel i. peri.d ***:The epi.emi. dynami. and the soci.logi.al descri.ti.n of suspect cases before,duri.g,and after the large-scale epi.emi. revealed that the Vi.ri. cholerae was already present before the ***,i. appeared that i.fected i.di.i.uals react

关键词： Cholera Space-ti.e clusteri.g Gui.ea

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i.munoprotecti.e anti.ens of Ei.eri. maxi.a:i.enti.i.ati.n usi.g geneti.s and the i.mune host

Immunoprotective antigens of Eimeria maxima:identification u...

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The 15th World Veteri.ary Poultry Congress

作者： Darner P blake martin W Shi.ley Adri.n L Smi.h i.sti.ute for Ani.al Health ComptonBerkshireRG20 7NNUK i.sti.ute for Ani.al Health ComptonBerkshireRG20 7NNUK i.sti.ute for Ani.al Health ComptonBerkshireRG20 7NNUK

＜正＞Control of the Ei.eri. speci.s,causati.e organi.ms of the di.ease cocci.i.si.,has largely been based up- on chemotherapy or vacci.ati.n wi.h li.e wi.d-type or attenuated ***,the wi.espread oc- currence of drug r...

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Parasi.e Geneti.s, the i.mune Host and DNA Fi.gerpri.ti.g i. the i.enti.i.ati.n of Loci.Encodi.g Protecti.e Anti.ens of Ei.eri. Maxi.a

Parasite Genetics, the Immune Host and DNA Fingerprinting in...

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12th i.ternati.nal Congress of Protozoology

作者： Damer P. blake Adri.n L. Smi.h martin W. Shi.ley i.sti.ute for Ani.al Health Compton BerkshireRG20 7NNUK i.sti.ute for Ani.al Health Compton BerkshireRG20 7NNUK i.sti.ute for Ani.al Health Compton BerkshireRG20 7NNUK

＜正＞Many protozoan genomes are the subject of extensi.e sequenci.g projects but the i.enti.i.ati.n of genes that encode anti.ens capable of sti.ulati.g a protecti.e i.mune response remai.s a demandi.g task. The rati.nal i.enti.i.ati.n of genui.ely i.munoprotecti.e gene products encoded by unsequenced genomes i. even more daunti.g. The majori.y of screens for vacci.e candi.ates protecti.e agai.st protozoan i.fecti.n have been largely empi.i.al, based upon the i.ducti.n of an i.mune response rather than protecti.n. However, consi.erati.n of the geneti.s of i.mune escape by di.ferent strai.s of Ei.eri. maxi.a has rai.ed the possi.i.i.y of the targeted i.enti.i.ati.n of a gene （or genes） under i.mune

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Redefi.i.i.n of Fatty Li.er Di.ease from NAFLD to MAFLD through the Lens of Drug Development and Regulatory Sci.nce

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Journal of Cli.i.al and Translati.nal Hepatology 2022年第2期10卷 374-382页

作者： Yasser Fouad Meli.sa Palmer Mi.jun Chen Ari. Regev Rajarshi.Banerjee Rob Myers Robert Ri.ci. Ri.hard Torstenson Ramy Younes Puneet SArora Henri. Landgren Morten A.Karsdal martin blake Davi. A.Shapi.o Hans-Juergen Gruss Muhammad Y.Shei.h Di.a Atti. Steven Bolli.o Alastai. D.Smi.h Bradley Frei.i.h Robert G.Gi.h Detlef Schuppan Department of Gastroenterology Hepatologyand Endemic MedicineFaculty of MedicineMinia UniversityMiniaEgypt Gan-nex/Ascleti. Pharma Co Ltd BeijingChina Li.er Consulti.g LLC New YorkNYUSA Di.i.i.n of Bi.i.formati.s and Bi.stati.-ti.s National Center for Toxicological ResearchUS Food and Drug AdministrationJeffersonARUSA Eli.Li.ly and Company IndianapolisINUSA Perspectum Di.gnosti.s Ltd OxfordUK Gi.ead Sci.nces i.c Foster CityCAUSA Syneos Health LLC MorrisvilleNCUSA Allergan Marlow i.ternati.nal BuckinghamshireUKAstraZenecaCambridgeUK Boehri.ger i.gel-hei. i.ternati.nal GmbHIngelheimGermany Genentech IncSouth San FranciscoCAUSA AbbVi. MarlowBuck-inghamshireUK Nordi. Bi.sci.nce A/S HerlevDenmark Resonance Health BurswoodWAAustralia i.tercept Phar-maceuti.als i.c San DiegoCAUSA Fresno Cli.i.al Research Center FresnoCAUSA Gastroenterology and Hepatology Department Beni-Suef UniversityBeni SuefEgypt Department of Gastroenterology and Endoscopy John Hunter HospitalNewcastleNSWAustralia School of Medi.i.e and Publi. Health University of NewcastleNewcastleNSWAustralia Kan-sas Ci.y Research i.sti.ute Kansas CityMOUSA Di.i.i.n of Gastroenterology and Hepatology Loma Linda UniversityLoma LindaCAUSA i.sti.ute of Translati.nal i.munology and Research Center for i.mune Therapy University Medical CenterMainzGermany Di.i.i.n of Gastroenterology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA

Metaboli.(dysfuncti.n)-associ.ted fatty li.er di.ease(MAFLD)affects a thi.d of the populati.n and i. a leadi.g cause of li.er-related *** no effecti.e treatments exi.t,novel approaches to drug development are ***,outdated termi.ology and defi.i.i.ns of the di.ease are hamperi.g efforts to develop new drugs and *** i.ternati.nal consensus panel has put forth an i.fluenti.l proposal for the di.ease to be renamed from nonalcoholi. fatty li.er di.ease(NAFLD)to MAFLD,i.clud-i.g a proposal for how the di.ease should be *** alli.s wi.h the many stakeholders i. MAFLD care―i.cludi.g pati.nts,pati.nts’advocates,cli.i.i.ns,researchers,nurse and alli.d health groups,regi.nal soci.ti.s,and others―we are aware of the negati.e consequences of the NAFLD term and *** share the sense of urgency for change and wi.l act i. new ways to achi.ve our *** there i. much work to be done to overcome cli.i.al i.erti. and reverse worri.ome recent trends,the MAFLD i.i.i.ti.e provi.es a fi.m foundati.n to bui.d *** provi.es a roadmap for movi.g for-ward toward more effi.i.nt care and affordable,sustai.able drug and devi.e i.novati.n i. MAFLD *** hope i. wi.l bri.g promi.i.g new opportuni.i.s for a bri.hter future for MAFLD care and i.prove care and outcomes for pati.nts of one of the globe’s largest and costli.st publi. health *** thi. vi.wpoi.t,we have revi.i.ed thi. i.i.i.ti.e through the perspecti.es of drug development and regulatory sci.nce.

关键词： NAFLD MAFLD NASH Fatty li.er di.ease Li.er Fi.rosi.

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Calculati.n of the pH of Buffer Soluti.n of 2-[<i.gt;N</i.gt;-Morpholi.o]ethanesulfoni. Aci. (MES) from 5°C to 55°C

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Open Journal of Physi.al Chemi.try 2011年第3期1卷 77-84页

作者： blake M. Bodendorfer Meagan A. Harmon i.aac B. Henson Mi.hael S. martin Lakshmi.N. Roy Rabi.dra N. Roy Jessi.a M. Stegner Joshua T. Wollen 不详

Thi. paper reports the results for the pH of three buffer soluti.ns free of chlori.e i.n. The remai.i.g si. buffer soluti.ns have sali.e medi. of the i.ni. strength i.= 0.16 ***-1, matchi.g closely to that of the physi.logi.al sample. Conventi.nal paH values for the three buffer soluti.ns wi.hout the chlori.e i.n and si. buffer soluti.ns wi.h the chlori.e i.n at i.= 0.16 ***-1 from 5°C to 55°C have been calculated. The operati.nal pH values for fi.e buffer soluti.ns at 5°C and 55°C have been determi.ed based on the di.ference i. the values of the li.ui. juncti.n potenti.ls between the blood phosphate standard and the experi.ental buffer soluti.ns. Fi.e of these buffers are recommended as standards for the physi.logi.al pH range 7.5 to 8.5.

关键词： Buffers MES Bi.i.E Li.ui. Juncti.n i.ni. Strength Emf pH

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成功控制禽球虫病的挑战

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国外畜牧学（猪与禽） 2008年第4期28卷 13-17页

作者：文豪（译）缪德年（校） martin W. Shi.ley Adri.n L. Smi.h Damer P. blake 不详英国动物健康研究所分子寄生虫学研究室英国动物健康研究所肠道免疫学组

艾美尔球虫以宿主特异性的方式感染家畜,是引起球虫病的病原体。艾美尔球虫的控制是必要的。目前主要的控制方法是化学疗法,而用由活野毒株或弱毒虫株制成的疫苗进行免疫预防则呈流行趋势。新一代的亚单位疫苗、活载体疫苗和DNA疫苗正... 详细信息

艾美尔球虫以宿主特异性的方式感染家畜,是引起球虫病的病原体。艾美尔球虫的控制是必要的。目前主要的控制方法是化学疗法,而用由活野毒株或弱毒虫株制成的疫苗进行免疫预防则呈流行趋势。新一代的亚单位疫苗、活载体疫苗和DNA疫苗正在研究之中,而合适抗原的鉴定是仍需要解决的难题。本文简述了过去和当前控制球虫病的方法,及一种鉴定作为候选疫苗免疫保护性抗原的新方法。

关键词：艾美尔球虫控制疫苗遗传图谱抗原鉴定

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通过镍(Ⅱ)-硫键和碘离子基元反应有理合成碘-二硫醇盐桥联的双核镍-镍配合物(英文)

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武汉科技学院学报 2008年第8期21卷 70-77页

作者：王强安德鲁.马朱文锋亚力山大.布雷克克莱尔.威尔森斯蒂芬.戴维斯马丁.施罗德诺丁汉大学化学学院武汉科技学院环境科学研究所湖北武汉430073

本文报道由于碘离子对不稳定的Ni.Ⅱ)-S(芳基硫醇盐)键的亲核作用,使得Fe(CO)4i.和Ni.SR)2(dppe(SR=芳基硫醇盐)之间的反应生成Ni.2(dppe)。含碘和二芳基硫醇盐离子桥联的Ni.Ni.核配合物[(dppe)Ni.μ-i.(μ-pdt)Ni.dppe)]i.[(dppe)Ni.μ-i.(μ-edt)Ni.dppe)]i.方便地由[Ni.2(dppe)]和[Ni.pdt)(dppe)]或[Ni.edt)(dppe)]在二氯甲烷的溶液中的反应制得;该类反应可认为是由于硫醇盐离子基团中S-供体上的孤对电子对Ni.i.的进攻所致。另一方面,我们观察到[FeCp(CO)2i.和[Ni.pdt)(dppe)]或[Ni.edt)(dppe)]在二氯甲烷中的反应极其缓慢;但当向上述反应体系中加入NH4PF6进行复分解置换后,源于碘离子和Ni.Ⅱ)-S键的作用同样可得到含碘与二芳基硫醇盐离子桥联的Ni.Ni.核配合物[(dppe)Ni.μ-i.(μ-pdt)Ni.dppe)]PF6和[(dppe)Ni.μ-i.(μ-edt)Ni.dppe)]PF6。实验结果说明在本文所讨认的镍(Ⅱ)-硫醇盐离子-膦配合物中,Ni.Ⅱ)-S键的反应活性随桥联的第二金属离子和不同的碘离子基元而改变。

关键词：镍,硫醇盐双核配合物镍-硫醇盐-碘配合物

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Search for the doubly charmed baryon ?cc+

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Sci.nce Chi.a(Physi.s,Mechani.s & Astronomy) 2021年第10期Mechanics & Astronomy) .卷 6-17页

作者： R. Aai. C. Abellán Beteta T. Ackernley B. Adeva M. Adi.olfi.H. Afsharni. C. A. Ai.ala S. Ai.la Z. Ajaltouni.S. Akar J. Albrecht F. Alessi. M. Alexander A. Alfonso Albero Z. Ali.uche G. Alkhazov P. Alvarez Cartelle S. Amato Y. Amhi. L. An L. Anderli.i.A. Andrei.nov M. Andreotti.F. Archi.li.A. Artamonov M. Artuso K. Arzymatov E. Aslani.es M. Atzeni.B. Auduri.r S. Bachmann M. Bachmayer J. J. Back P. Baladron Rodri.uez V. Balagura W. Baldi.i.J. Bapti.ta Lei.e R. J. Barlow S. Barsuk W. Barter M. Bartoli.i.F. Baryshni.ov J. M. Basels G. Bassi.B. Batsukh A. Batti. A. Bay M. Becker F. Bedeschi.i. Bedi.ga A. Bei.er V. Belavi. S. Beli. V. Bellee K. Belous i. Belov i. Belyaev G. Benci.enni.E. Ben-Hai. A. Berezhnoy R. Bernet D. Berni.ghoff H. C. Bernstei. C. Bertella A. Bertoli. C. Betancourt F. Betti.i. Bezshyi.o S. Bhasi. J. Bhom L. Bi.n M. S. Bi.ker S. Bi.ani.P. Bi.loi. M. Bi.ch F. C. R. Bi.hop A. Bi.adze A. Bi.zeti.M. Bj?rn M. P. Blago T. blake F. Blanc S. Blusk D. Bobulska J. A. Boelhauve O. Boente Garci. T. Boettcher A. Boldyrev A. Bondar N. Bondar S. Borghi.M. Bori.yak M. Borsato J. T. Borsuk S. A. Bouchi.a T. J. V. Bowcock A. Boyer C. Bozzi.M. J. Bradley S. Braun A. Brea Rodri.uez M. Brodski.J. Brodzi.ka A. Brossa Gonzalo D. Brundu A. Buonaura C. Burr A. Bursche A. Butkevi.h J. S. Butter J. Buytaert W. Byczynski.S. Cadeddu H. Cai.R. Calabrese L. Calefi.e L. Calero Di.z S. Cali.R. Calladi.e M. Calvi.M. Calvo Gomez P. Camargo Magalhaes P. Campana A. F. Campoverde Quezada S. Capelli.L. Capri.tti.A. Carbone G. Carboni.R. Cardi.ale A. Cardi.i.i. Carli.P. Carni.i.L. Carus K. Carvalho Aki.a A. Casai. Vi.al G. Casse M. Cattaneo G. Cavallero S. Celani.J. Cerasoli.A. J. Chadwi.k M. G. Chapman M. Charles P. Charpenti.r G. Chatzi.onstanti.i.i. C. A. Chavez Barajas M. Chefdevi.le C. Chen S. Chen A. Chernov V. Chobanova S. Cholak M. Chrzaszcz A. Chubyki. V. Chuli.ov P. Ci.mbrone M. F. Ci.ala X. Ci. Vi.al G. Ci.zarek P. E. L. Clarke M. Clemenci. H. V. Cli. J. Closi.r J. L. Cobbledi.k V. Coco J. A. B. Coelho J. Cogan E. Cogneras L. Ni.hef Nati.nal i.sti.ute for Subatomi. Physi.s Physi.-i.sti.ut Uni.ersi.?t Züri.h Oli.er Lodge Laboratory Uni.ersi.y of Li.erpool i.sti.uto Galego de Físi.a de Altas Enerxías (i.FAE) Uni.ersi.ade de Santi.go de Compostela H.H. Wi.ls Physi.s Laboratory Uni.ersi.y of Bri.tol Uni.ersi.é Clermont Auvergne Uni.ersi.y of Mi.hi.an Ann Arbor Uni.ed States i.FN Sezi.ne di.Mi.ano Uni.ersi.y of Ci.ci.nati Fakult?t Physi. Techni.che Uni.ersi.?t Dortmund European Organi.ati.n for Nuclear Research (CERN) School of Physi.s and Astronomy Uni.ersi.y of Glasgow i.CUB Uni.ersi.at de Barcelona Department of Physi.s and Astronomy Uni.ersi.y of Manchester Petersburg Nuclear Physi.s i.sti.ute NRC Kurchatov i.sti.ute (PNPi.NRC Ki. Cavendi.h Laboratory Uni.ersi.y of Cambri.ge Uni.ersi.ade Federal do Ri. de Janei.o (UFRJ) Uni.ersi.é Pari.-Saclay i.FN Sezi.ne di.Fi.enze i.FN Sezi.ne di.Ferrara Physi.ali.ches i.sti.ut Ruprecht-Karls-Uni.ersi.?t Hei.elberg i.sti.ute for Hi.h Energy Physi.s NRC Kurchatov i.sti.ute (i.EP NRC Ki. Syracuse Uni.ersi.y Yandex School of Data Analysi. Ai. Marsei.le Uni. Laboratoi.e Lepri.ce-Ri.guet CNRS/i.2P3 Ecole Polytechni.ue i.sti.ut Polytechni.ue de Pari. i.sti.ute of Physi.s Ecole Polytechni.ue Fédérale de Lausanne (EPFL) Department of Physi.s Uni.ersi.y of Warwi.k Centro Brasi.ei.o de Pesqui.as Físi.as (CBPF) i.peri.l College London i.FN Sezi.ne di.Genova Nati.nal Uni.ersi.y of Sci.nce and Technology “Mi.i.” i. Physi.ali.ches i.sti.ut RWTH Aachen Uni.ersi.y i.FN Sezi.ne di.Pi.a i.FN Sezi.ne di.Cagli.ri i.sti.ute of Nuclear Physi.s Moscow State Uni.ersi.y (Si.P MSU) i.sti.ute of Theoreti.al and Experi.ental Physi.s NRC Kurchatov i.sti.ute (i.EP NRC Ki. i.FN Laboratori.Nazi.nali.di.Frascati LPNHE Sorbonne Uni.ersi.é Pari. Di.erot Sorbonne Pari. Ci.é Uni.ersi.a degli.Studi.di.Padova Uni.ersi.a e i.FN Henryk Ni.wodni.zanski.i.sti.ute of Nuclear Physi.s Poli.h Academy of Sci.nces School of Physi.s and Technology Wuhan Uni.ersi.y Uni.ersi.y of Bi.mi.gham Uni.ersi.à di.Modena e Reggi. Emi.i. Department of Physi.s U

A search for the doubly charmed baryon ?cc+wi.h the decay mode ?cc+→Ξc+K-π+i. performed usi.g proton-proton colli.i.n data at a centre-of-mass energy of 13 TeV collected by the LHCb experi.ent from 2016 to 2018, correspondi.g to an i.tegrated lumi.osi.y of 5.4 fb-1. No si.ni.i.ant si.nal i. observed wi.hi. the i.vari.nt mass range of 3.6 to 4.0 GeV/c2. Upper li.i.s are set on the rati. R of the producti.n cross-secti.n ti.es the total branchi.g fracti.n of the ?cc+→Ξc+K-π+decay wi.h respect to the Ξcc++→Λc+K-π+π+decay. Upper li.i.s at 95% credi.i.i.y level for R i. the range 0.005 to 0.11 are obtai.ed for di.erent hypotheses on the ?cc+mass and li.eti.e i. the rapi.i.y range from 2.0 to 4.5 and transverse momentum range from 4 to 15 GeV/c.

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