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中国建筑装饰装修 2012年第4期 238-239页

作者： Meinhard von Gerkan Nikolaus Goetze Klaus Lenz Nicole Flores martin friedrich Jessica Last Udo Meyer Duc Tran Cong Marcus Bredt

穿过园林景观来访者可从四个方向进入博物馆。在正方形的建筑体中庭内,一座圆形的挑空大厅将入口层面于其上的三层展览空间连接起来。如同倒置的金字塔般,中庭向上呈阶梯状展开。来访者向外望去,仿佛"漂浮"于主题公园景观之上。盘旋上... 详细信息

穿过园林景观来访者可从四个方向进入博物馆。在正方形的建筑体中庭内,一座圆形的挑空大厅将入口层面于其上的三层展览空间连接起来。如同倒置的金字塔般,中庭向上呈阶梯状展开。来访者向外望去,仿佛"漂浮"于主题公园景观之上。盘旋上升的坡道作为极富表现力的空间元素,将人们吸引至建筑顶部,并且实现了展览空间与中庭的视线交流。由于展览空间全部安排在建筑的首层至三层,会议、科研中心,办公空间以

关键词：博物馆博物院文化机构建筑体中庭

Investigations on the Flow Field in an Unshrouded Pump Impeller Geometry

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Journal of Thermal Science 2012年第2期21卷 136-144页

作者： Sten Sieber friedrich Frhlig Saban Caglar martin Gabi Fchgebiet Strmungsmaschinen Karlsruhe Institute of Technology Germany

Transient CFD simulations are performed to investigate the flow behaviour inside an unshrouded pump using the SAS method. Two blade designs are compared at two different tip clearances and the results are validated by measurements. The detected vortex structure is visualized by the normalized helicity, further discussed regarding its development and behaviour and finally implicated to the efficiency of the two different blade designs.

关键词： unshrouded pump tip clearance helicity

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Establishment and characterization of cell lines from chromosomal instable colorectal cancer

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World Journal of Gastroenterology 2015年第1期21卷 164-176页

作者： Claudia Maletzki Michael Gock martin Randow Ernst Klar Maja Huehns friedrich Prall Michael Linnebacher Section of Molecular Oncology and Immunotherapy University of RostockD-18057 RostockGermany Department of General Surgery University of RostockD-18057 RostockGermany Institute of Pathology University of RostockD-18057 RostockGermany

AIM: To generate novel tumor models for preclinicalvalidation of biomarkers that allow drug response prediction and individual therapeutic ***: Cell line establishment was conducted by both direct in vitro culturing and in vivo xenografting followed by in vitro culturing procedure.A comprehensive characterization was subsequently *** included quality control,consisting of the confirmation of human and colorectal cancer(CRC) origin by DNA fingerprint and epithelial cell adhesion molecule(EpC AM) staining,as well as mycoplasma and human virus *** analysis was done by light microscopy and multicolor flow *** examination(β-catenin and cytokeratin staining) was conducted in direct comparison to parental tumor *** molecular-pathological profiling included mutation analysis for CRC-associated driver mutations,assessment of chromosomal and microsatellite instability,and the grade of CpG island ***,an arraybased comparative genomic hybridization analysis was *** responsiveness was assessed for a panel of classical and novel substances in clinical use for the treatment of solid ***,tumorigenicity of the cell lines was tested by xenografting into immunocompromised nude ***: Herein we describe the establishment of three ultra-low passage cell lines from two individual patients suffering from sporadic *** cell line was derived directly from an early stage case(HROC18),whereas two cell lines could be established both direct from patient material and after xenografting from a late stage tumor(HROC32).All cell lines were free of contaminating mycoplasma and *** analysis allowed all cell lines to be classified as chromosomal instable(CIN+).They were aneuploid,with CpG island promoter methylation and microsatellite instability being *** following mutational profile was observed both in the cell lines and the parental t

关键词： Patient-derived tumor model Colorectal cancer Indi

Eosinophilic cholangitis is a potentially underdiagnosed etiology in indeterminate biliary stricture

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World Journal of Gastroenterology 2017年第6期23卷 1044-1050页

作者： Dirk Walter Sylvia Hartmann Eva Herrmann Jan Peveling-Oberhag Wolf O Bechstein Stefan Zeuzem martin-Leo Hansmann Mireen friedrich-Rust Jorg G Albert Department of Internal Medicine I Johann Wolfgang Goethe-University Hospital Dr.Senckenberg Institute for Pathology Johann Wolfgang Goethe-University Hospital Institute of Biostatistics and Mathematical Modeling Johann Wolfgang Goethe-University Hospital Department for Gastroenterology Hepatology and EndocrinologyRobert-Bosch Hospital Department of General and Visceral Surgery Johann Wolfgang Goethe-University Hospital

To investigate presence and extent of eosinophilic cholangitis (EC) as well as IgG4-related disease in patients with indeterminate biliary stricture (IBS).METHODSAll patients with diagnosis of sclerosing cholangitis (SC) and histopathological samples such as biopsies or surgical specimens at University Hospital Frankfurt from 2005-2015 were included. Histopathological diagnoses as well as further clinical course were reviewed. Tissue samples of patients without definite diagnosis after complete diagnostic work-up were reviewed regarding presence of eosinophilic infiltration and IgG4 positive plasma cells. Eosinophilic infiltration was as well assessed in a control group of liver transplant donors and patients with primary sclerosing *** hundred and thirty-five patients with SC were included. In 10/135 (13.5%) patients, no potential cause of IBS could be identified after complete diagnostic work-up and further clinical course. After histopathological review, a post-hoc diagnosis of EC was established in three patients resulting in a prevalence of 2.2% (3/135) of all patients with SC as well as 30% (3/10) of patients, where no cause of IBS was identified. 2/3 patients with post-hoc diagnosis of EC underwent surgical resection with suspicion for malignancy. Diagnosis of IgG4-related cholangitis was observed in 7/135 patients (5.1%), whereas 3 cases were discovered in post-hoc analysis. 6/7 cases with IgG4-related cholangitis (85.7%) presented with eosinophilic infiltration in addition to IgG4 positive plasma cells. There was no patient with eosinophilic infiltration in the control group of liver transplant donors (n = 27) and patients with primary sclerosing cholangitis (n = 14).CONCLUSIONEC is an underdiagnosed benign etiology of SC and IBS, which has to be considered in differential diagnosis of IBS.

关键词： Indeterminate biliary stricture endoscopy endoscopic retrograde cholangiopancreatography eosinophilic cholangitis bile duct stenosis IgG4-related disease primary sclerosing cholangitis

Nodal, zonal, or uniform electricity pricing： how to deal withnetwork congestion

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Frontiers in Energy 2017年第2期11卷 210-232页

作者： martin WEIBELZAHI friedrich-Alexander-University Erlangen-Nuremberg Discrete Optimi-zation Cauerstr. 11 91058 Erlangen Germany Energy CampusNuremberg Ffirther Str. 250 90429 Nuremberg Germany

In this paper, the main contributions to congestion management and electricity pricing, i.e., nodal, zonal, and uniform electricity pricing, are surveyed. The key electricity market concepts are structured and a formal model framework is proposed for electricity transportation, production, and consumption in the context of limited transmission networks and competitive, welfare maximizing electricity markets. In addition, the main results of existing short-run and long-run congestion management studies are explicitly summarized. In particular, the important interconnection between short-run network management approaches and optimal long-run investments in both generation facilities and network lines are highlighted.

关键词： nodal pricing zonal pricing uniform pricing competitive electricity markets welfare maximization redispatch optimization models

Adaptive optical microscopy: the ongoing quest for a perfect image

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Light(Science & Applications) 2014年第1期3卷 243-249页

作者： martin J Booth Department of Engineering Science University of OxfordOxford OX13PJUK Centre for Neural Circuits and Behaviour University of OxfordOxford OX13SRUnited Kingdom School in Advanced Optical Technologies Friedrich-Alexander Universita¨t Erlangen-Nu¨rnberg91052 ErlangenGermany

Adaptive optics is becoming a valuable tool for high resolution microscopy,providing correction for aberrations introduced by the refractive index structure of *** is proving particularly promising for applications that require images from deep within biological tissue *** review recent developments in adaptive microscopy,including methods and applications.A range of advances in different microscope modalities is covered and prospects for the future are discussed.

关键词： aberrations adaptive optics microscopy

The relaxin peptide family–potential future hope for neuroprotective therapy? A short review

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Neural Regeneration Research 2018年第3期13卷 402-405页

作者： Marius Nistor martin Schmidt René Schiffner Department of Neurology Jena University Hospital Friedrich Schiller University Jena Germany Orthopaedic Department Jena University Hospital Friedrich Schiller University Jena Germany Institute for Biochemistry II Jena University Hospital Friedrich Schiller University Jena Germany

Since its discovery in the 1920’s the relaxin peptide hormone family has not only grown in number to now seven members （relaxin-1, relaxin-2, relaxin-3, insulin-like peptide （INSL） 3, INSL4, INSL5 and INSL6）, but ever more effects, suchs as vasodilatory, angiogenic, anti-apoptopic, anti-fibriotic and anti-inflammatory, have been linked to them. While relaxin-2 has mainly been investigated in the context of cardiac protection, most comprehensively in the RELAX-AHF and RELAX AHF2 studies, a small number of studies have furthermore assessed the potential neuroprotective effects of especially relaxin-2 and other members of the relaxin family. In this short review we summarise and discuss recent efforts to utilize relaxin hormones for neuroprotection and point out potential future fields of research and translational applications. While many questions still need to be answered, the promising results of the available studies definitely warrant future well-designed studies on neuroprotection by relaxin peptides.

关键词： relaxin relaxin-2 neuroprotection stroke hemorrhagic shock cerebral

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H^2-Stabilization of the Isothermal Euler Equations: a Lyapunov Function Approach

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Chinese Annals of Mathematics,Series B 2012年第4期33卷 479-500页

作者： martin GUGAT Günter LEUGERING Simona TAMASOIU Department of Mathematics Friedrich-Alexander University Erlangen-Nuremberg Cauerstrasse 11 91058 Erlangen Germany

The authors consider the problem of boundary feedback stabilization of the 1D Euler gas dynamics locally around stationary states and prove the exponential stability with respect to the H2-norm. To this end, an explicit Lyapunov function as a weighted and squared H2-norm of a small perturbation of the stationary solution is constructed. The authors show that by a suitable choice of the boundary feedback conditions, the H2- exponential stability of the stationary solution follows. Due to this fact, the system is stabilized over an infinite time interval. Furthermore, exponential estimates for the C norm are derived.

关键词： Boundary control Feedback stabilization Quasilinear hyperbolic system,Balance law Gas dynamics Isothermal Euler equations Exponential stabil-ity Lyapunov function H2-norm Stationary state Characteristic variable

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Low-energy ion channeling in nanocubes

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Nano Research 2023年第1期16卷 1522-1526页

作者： Shiva Choupanian Wolfhard Möller martin Seyring Carsten Ronning Institute of Solid State Physics Friedrich Schiller University JenaMax-Wien-Platz 107743 JenaGermany Helmholtz-Zentrum Dresden-Rossendorf Bautzner Landstraße 40001328 DresdenGermany Otto Schott Institute of Materials Research Friedrich Schiller University JenaLoebdergraben 3207743 JenaGermany

Focused ion beam(FIB)processing with low-energy ions has become a standard technique for the manipulation of *** underlying ion beam effects that deviate from conventional high-energy ion irradiation of bulk systems are considered today;however,ion channeling with its consequence of significant deeper penetration depth has been only theoretically investigated in this *** present here an experimental approach to determine the channeling of low-energy ions in crystalline nanoparticles by measuring the sputter yield derived from scanning electron microscopy(SEM)images taken after irradiation under various incident ion *** maps of 30 and 20 keV Ga+ions in Ag nanocubes have been identified and fit well with the ***,channeling has a significant impact on the transport of energetic ions in crystals due to the large critical angle at low ion energies,thus being relevant for any ***,the obtained sputter yield clearly differs from amorphous materials;therefore,it is recommended not to rely only on,e.g.,ion distribution depths predicted by standard Monte-Carlo(MC)algorithms for amorphous materials.

关键词： ion nanostructure interaction ion channeling metallic nanoparticles focused ion beam