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中华核医学与分子影像杂志 2019年第11期39卷 698-704页

作者：陈聪霞(译) 李文婵(译) 郭悦(译) 姚稚明(审校者) Delphine L.Chen Joseph Cheriyan Edwin R.Chilvers Gourab Choudhury Christopher Coello martin connell Marie Fisk Ashley M.Groves Roger N.Gunn Beverley F.Holman Brian F.Hutton Sarah Lee William MacNee Divya Mohan David Parr Deepak Subramanian Ruth Tai-Singer Kris Thielemans Edwin J.R.van Beek Laurence Vass Jeremy W.Wellen Ian Wilkinson Frederick J.Wilson 北京医院核医学科、国家老年医学中心 100730 Mallinckrodt Institute of Radiology Washington University School of MedicineSt.LouisMissouri Department of Medicine University of CambridgeCambridgeUnited Kingdom Cambridge University Hospitals NHS Foundation Trust CambridgeUnited Kingdom Queen's Medical Research Institute University of EdinburghEdinburghUnited Kingdom Imanova Ltd. London y United Kingdom Institute of Nuclear Medicine University College LondonLondonUnited Kingdom Department of Medicine Imperial College LondonLondonUnited Kingdom Medical Image Analysis Consultant LondonUnited Kingdom Clinical Discovery Respiratory Therapy Area UnitGlaxoSmithKline R&DKing of PrussiaPennsylvania University Hospitals Coventry and Warwickshire CoventryUnited Kingdom Derby Teaching Hospitals NHS Foundation Trust DerbyUnited Kingdom Worldwide Research and Development PfizerInc.CambridgeMassachusetts Experimental Medicine Imaging GlaxoSmithKlineStevenageUnited Kingdom

数百万人受呼吸系统疾病的影响,导致巨大的全球性健康困扰。由于目前对导致呼吸系统疾病发展和进展的潜在机制认识不足,治疗选择仍然有限。为克服此局限和理解相关分子变化,将无创影像技术如PET和SPECT用于探索生物标志物,其中18F-脱氧... 详细信息

数百万人受呼吸系统疾病的影响,导致巨大的全球性健康困扰。由于目前对导致呼吸系统疾病发展和进展的潜在机制认识不足,治疗选择仍然有限。为克服此局限和理解相关分子变化,将无创影像技术如PET和SPECT用于探索生物标志物,其中18F-脱氧葡萄糖(FDG)PET显像的研究最多。由于肺内组织、气体、血液和水的构成比变异,定量分析肺的分子影像数据仍具挑战性。这些成分的比例随着肺部疾病的不同而不同,因此有不同的定量分析方法来显示这种变化,但迄今为止还没有开发出对数据标准化的方法。该文回顾了肺部疾病中18F-FDG PET定量分析方法的数据,聚焦于解释肺内成分变化的方法,解读衍生参数。分析的疾病包括急性呼吸窘迫综合征、慢性阻塞性肺疾病、肺间质性疾病如特发性肺纤维化。基于对既往文献、进行中的研究以及作者间讨论的回顾,作者提出了建议性的注意事项,以协助解读从这些方法及未来研究设计中衍生的参数。

关键词：肺肺部炎症分子成像正电子发射计算机断层显像

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Association of Genetic Variation in the Promoter Region of OXTR with Differences in Social Affective Neural Processing

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Journal of Behavioral and Brain Science 2012年第1期2卷 60-66页

作者： Garret O’connell Heather C. Whalley Prerona Mukherjee Andrew C. Stanfield Christian Montag Jeremy Hall martin Reuter Center for Economics and Neuroscience University of Bonn Bonn Germany Department of Psychology University of Bonn Bonn Germany Division of Psychiatry University of Edinburgh Scotland UK

Evidence supports the involvement of oxytocin in social behavior. The oxytocin receptor gene (OXTR) has been associated with differences in social brain function and risk for autism. Motivated by recent work, we investigated the effect of variation in the common functional rs2268498 T/C polymorphism in the promoter region of OXTR on neural responses to fear expressions. 46 healthy subjects were divided into genotype groups of C carriers (n = 32) and TT ho-mozygous (n = 14) and neural activity was measured during the recognition of fear and neutral expressions. Results showed that during the recognition of fear expressions, the TT genotype group exhibited increased responding in the inferior occipital gyrus, considered important for face processing, compared to carriers of the C allele (P < 0.005;cluster corrected for whole brain), an effect not found for neutral faces. These results indicate the impact of this OXTR genetic variant on individual differences in social affective neural processing.

关键词： OXTR Promoter Region Inferior Occipital Gyrus fMRI Emotional Facial Processing

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Parametric Study of Calibration Blackbody Uncertainty Using Design of Experiments

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Journal of Analytical Sciences, Methods and Instrumentation 2012年第3期2卷 109-119页

作者： Nipa Phojanamongkolkij Joe A. Walker Richard P. Cageao martin G. Mlynczak Joseph J. O’connell Rosemary R. Baize Aeronautics System Engineering Engineering Directorate NASA Langley Research Center Hampton USA Clarreo Project Office Flight Projects Directorate NASA Langley Research Center Hampton USA. Climate Science Branch Science Directorate NASA Langley Research Center Hampton USA Remote Sensing Flight Systems Engineering Directorate NASA Langley Research Center Hampton USA Science Systems and Applications Inc. Hampton USA

NASA is developing the Climate Absolute Radiance and Refractivity Observatory (CLARREO) mission to provide accurate measurements to substantially improve understanding of climate change. CLARREO will include a Reflected Solar (RS) Suite, an Infrared (IR) Suite, and a Global Navigation Satellite System-Radio Occultation (GNSS-RO). The IR Suite consists of a Fourier Transform Spectrometer (FTS) covering 5 to 50 micrometers (2000-200 cm-1 wavenumbers) and on-orbit calibration and verification systems. The IR instrument will use a cavity blackbody view and a deep space view for on-orbit calibration. The calibration blackbody and the verification system blackbody will both have Phase Change Cells (PCCs) to accurately provide a SI reference to absolute temperature. One of the most critical parts of obtaining accurate CLARREO IR scene measurements relies on knowing the spectral radiance output from the blackbody calibration source. The blackbody spectral radiance must be known with a low uncertainty, and the magnitude of the uncertainty itself must be reliably quantified. This study focuses on determining which parameters in the spectral radiance equation of the calibration blackbody are critical to the blackbody accuracy. Fourteen parameters are identified and explored. Design of Experiments (DOE) is applied to systematically set up an experiment (i.e., parameter settings and number of runs) to explore the effects of these 14 parameters. The experiment is done by computer simulation to estimate uncertainty of the calibration blackbody spectral radiance. Within the explored ranges, only 4 out of 14 parameters were discovered to be critical to the total uncertainty in blackbody radiance, and should be designed, manufactured, and/or controlled carefully. The uncertainties obtained by computer simulation are also compared to those obtained using the “Law of Propagation of Uncertainty”. The two methods produce statistically different uncertainties. Nevertheless, the difference

关键词： Calibration Uncertainty Design of Experiments

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次国家政府如何制定和实施独特的政策议程?

国际行政科学评论（中文版）

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国际行政科学评论（中文版） 2022年第4期 265-283页

作者：安德鲁·康奈尔艾米丽·圣丹尼史蒂夫·马丁王进旭(译) 熊缨(审校) 英国卡迪夫大学威尔士公共政策中心丹麦哥本哈根大学政治学系威尔士公共政策中心英国卡迪夫大学北京石墨烯研究院不详

次国家政府制定和实施独特政策的方式对我们理解有效的多层次治理体系至关重要。现有著述侧重于机构自治和赋予次国家政府的正式权力,但这都只是一个侧面而已。成功还取决于政策参与者如何部署其权力、资源和合法性。本文对两种不同的... 详细信息

次国家政府制定和实施独特政策的方式对我们理解有效的多层次治理体系至关重要。现有著述侧重于机构自治和赋予次国家政府的正式权力,但这都只是一个侧面而已。成功还取决于政策参与者如何部署其权力、资源和合法性。本文对两种不同的尝试进行了实证分析,这些尝试在次国家层面上制定了不同的政策框架。它表明,必须超越正式的机构权力,关注决策者的政治技能和知名度,以及他们在部署正式权力时采用的战略和战术。报告特别强调,次国家政府有必要把重点放在它们能够发挥作用的问题上,并利用它们在政策网络中的节点性,促进与能够带来互补资源的国家和非国家组织的合作。

关键词：议程设置酒精政策治理无家可归次国家政府政策工具

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Performance and calibration of quark/gluon-jet taggers using 140 fb^(-1) of pp collisions at √s=13 TeV with the ATLAS detector

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Chinese Physics C 2024年第2期48卷 1-25页

作者： G. Aad B. Abbott K. Abeling N.J. Abicht S.H. Abidi A. Aboulhorma H. Abramowicz H. Abreu Y. Abulaiti B.S. Acharya C. Adam Bourdarios L. Adamczyk S.V. Addepalli M.J. Addison J. Adelman A. Adiguzel T. Adye A.A. Affolder Y. Afik M.N. Agaras J. Agarwala A. Aggarwal C. Agheorghiesei A. Ahmad F. Ahmadov W.S. Ahmed S. Ahuja X. Ai G. Aielli A. Aikot M. Ait Tamlihat B. Aitbenchikh I. Aizenberg M. Akbiyik T.P.A. Åkesson A.V. Akimov D. Akiyama N.N. Akolkar K. Al Khoury G.L. Alberghi J. Albert P. Albicocco G.L. Albouy S. Alderweireldt M. Aleksa I.N. Aleksandrov C. Alexa T. Alexopoulos F. Alfonsi M. Algren M. Alhroob B. Ali H.M.J. Ali S. Ali S.W. Alibocus M. Aliev G. Alimonti W. Alkakhi C. Allaire B.M.M. Allbrooke J.F. Allen C.A. Allendes Flores P.P. Allport A. Aloisio F. Alonso C. Alpigiani M. Alvarez Estevez A. Alvarez Fernandez M. Alves Cardoso M.G. Alviggi M. Aly Y. Amaral Coutinho A. Ambler C. Amelung M. Amerl C.G. Ames D. Amidei S.P. Amor Dos Santos K.R. Amos V. Ananiev C. Anastopoulos T. Andeen J.K. Anders S.Y. Andrean A. Andreazza S. Angelidakis A. Angerami A.V. Anisenkov A. Annovi C. Antel M.T. Anthony E. Antipov M. Antonelli F. Anulli M. Aoki T. Aoki J.A. Aparisi Pozo M.A. Aparo L. Aperio Bella C. Appelt A. Apyan N. Aranzabal S.J. Arbiol Val C. Arcangeletti A.T.H. Arce E. Arena J-F. Arguin S. Argyropoulos J.-H. Arling O. Arnaez H. Arnold G. Artoni H. Asada K. Asai S. Asai N.A. Asbah J. Assahsah K. Assamagan R. Astalos S. Atashi R.J. Atkin M. Atkinson H. Atmani P.A. Atmasiddha K. Augsten S. Auricchio A.D. Auriol V.A. Austrup G. Avolio K. Axiotis G. Azuelos D. Babal H. Bachacou K. Bachas A. Bachiu F. Backman A. Badea P. Bagnaia M. Bahmani A.J. Bailey V.R. Bailey J.T. Baines L. Baines O.K. Baker E. Bakos D. Bakshi Gupta V. Balakrishnan R. Balasubramanian E.M. Baldin P. Balek E. Ballabene F. Balli L.M. Baltes W.K. Balunas J. Balz E. Banas M. Bandieramonte A. Bandyopadhyay S. Bansal L. Barak M. Barakat E.L. Barberio D. Barberis M. Barbero M.Z. Barel K.N. Barends T. Barillari M-S. Barisits T. Barklow P. Baron D.A. Baron Mo The ATLAS Collaboration

The identification of jets originating from quarks and gluons,often referred to as quark/gluon tagging,plays an important role in various analyses performed at the Large Hadron Collider,as Standard Model measurements and searches for new particles decaying to quarks often rely on suppressing a large gluon-induced *** paper describes the measurement of the efficiencies of quark/gluon taggers developed within the ATLAS Collaboration,using √s=13 TeV proton–proton collision data with an integrated luminosity of 140 fb^(-1) collected by the ATLAS *** taggers with high performances in rejecting jets from gluon over jets from quarks are studied:one tagger is based on requirements on the number of inner-detector tracks associated with the jet,and the other combines several jet substructure observables using a boosted decision tree.A method is established to determine the quark/gluon fraction in data,by using quark/gluon-enriched subsamples defined by the jet *** in tagging efficiency between data and simulation are provided for jets with transverse momentum between 500 GeV and 2 TeV and for multiple tagger working points.

关键词： ATLAS JET QUARK GLUON TAGGING

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