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Dyslipidaemias and Physical Activity in Children with Cerebral Palsy

Health 2014年第10期6卷 1030-1037页

作者： Maciste Habacuc Macías-Cervantes martha susana arriola-nunez Francisco J.Díaz-Cisneros Antonio E.Rivera-Cisneros Jose María de la Roca-Chiapas Victoriano Pérez-Vázquez Departamento de Ciencias Medicas Division de Ciencias de la SaludUniversidad de GuanajuatoLeonMexico Universidad del Valle de Atemajac GuadalajaraMexico Departamento de Ciencias Aplicadas al Trabajo Division de Ciencias de la SaludUniversidad de GuanajuatoLeonMexico Division de Ciencias de la Salud Universidad de GuanajuatoLeonMexico Departamento Psicología Division de Ciencias de la SaludUniversidad de GuanajuatoLeonMexico

Cerebral palsy people present movement difficulty and are liable to develop disorders associated with sedentary lifestyles such as dyslipidaemias and cardiovascular diseases. This study aimed to assess physical activity and the prevalence of lipid abnormalities in 29 children with cerebral palsy who were being treated in two care centers in the state of Guanajuato, Mexico. Physical activity was calculated using a survey. Blood glucose, total cholesterol, HDL-C, LDL-C, and triglycerides were determined. Forty-eight percent had at least one dyslipidaemia. The most frequent lipid abnormalities were hypertriglyceridaemia and low HDL-C. High prevalence of the atherogenic index was found. The physical activity of children was lower than recommended for their age. Sixty-two percent attended rehabilitation sessions, 10% attended sports classes, 14% rehabilitation plus sports and 14% did not engage in intentional physical activity. There is high frequency of lipid disorders in children with cerebral palsy. Greater participation in physical activity should be promoted in children to improve their metabolic status and quality of life, especially those suffering from cerebral palsy.

关键词： Hypertriglyceridaemia HDL-C Atherogenic Index

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Ursane derivatives isolated from leaves of Hylocereus undatus inhibit glycation at multiple stages

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Chinese Journal of Natural Medicines 2018年第11期16卷 856-865页

作者： ROSA martha Pérez-Gutiérrez susana GABRIELA Enriquez-Alvirde Research Laboratory of Natural Products School of Chemical Engineering and Extractive Industries National Polytechnic Institute

The present study was designed to evaluate the therapeutic potential of bioactive compounds from chloroform extract of the leaves of Hylocereus undatus in the formation of advanced glycation end products(AGEs) in vitro. Bioactivity-guided fractionation of chloroform extract from Hylocereus undatus afforded two novel 12-ursen-type triterpenes, 3β, 16α, 23-trihydroxy-urs-12-en-28-oic acid(1) and 3β, 6β, 19α, 22α-tetrahydroxy-urs-12-en-28-oic acid(2), as well as four known triterpenes 2α, 3β, 23-tetrahydroxy-urs-11-en-28-oic acid(3), 3β-acetoxy-28-hydroxyolean-12-ene(4), 3β, 16α-dihidroxyolean-12-ene(5) and 3β-acetoxy-olean-12-ene(6). Our results revealed that triterpenes 1–3 were able to inhibit the formation of AGEs in all tested assays. The data indicated that the triterpenes had inhibitory activity at the múltiple stages of glycation and that there might be a high potential for decreasing protein oxidation and protein glycation that can enhance glycative stress in diabetic complications.

关键词： Hylocereus undatus Advanced glycation end product Triterpenes

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