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Continuous Apomorphine Infusion in Patients with Advanced Parkinson’s Disease with Varying Degrees of Functional Impairment

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Journal of Behavioral and Brain Science 2016年第10期6卷 393-403页

作者： Gabriel Salazar marta Fragoso Jonatan martí Noelia martín Rosó Bernal Neurology Department Hospital Consorci Sanitari de Terrassa Barcelona Spain Day-Hospital Nursing Department Hospital Consorci Sanitari de Terrassa Barcelona Spain

Introduction: Continuous apomorphine infusion (CAI) is effective in improving complications in advanced Parkinson’s disease (APD). The effectiveness and tolerance of CAI in patients with APD with varying degrees of functional impairment was studied. Methods: In this comparative observational study, consecutive APD who started treatment with CAI were included. They were classified into two groups of functional impairment: A) moderate (Schwab and England (S & E) = 60% - 80% and Hoehn and Yahr (H & Y) = 2 - 3;Group (A), and (B) severe (S & E 3;Group B). Clinical follow-up was performed with concomitant medication and CAI adjustment at 3, 6 and 12 months. Clinical evaluation included a dyskinesia diary and AIMS, S & E, NPI, NMSS and HADS questionnaires. Results: Eighteen patients participated (A = 9 and B = 9) with EP diagnosed 7 (A) and 13 (B) years before. Their baseline dose of levodopa was 728 mg (A) and 925 mg (B), which did not change during follow-up. Dopamine agonists were progressively reduced in both groups. Progressive titration of CAI resulted in abandonment of apomorphine bolus administration. Both groups experienced improvements in all variables, higher in group A;motor fluctuations = 69% (A), 53% (B);AIMS = 82% (A), 71 (B);S & E = 32% (A), 18% (B);NMS = 62% (A), 19% (B);NPI = 75% (A), 50% (B);HADS (anxiety) = 26% (A), 21% (B);HADS (depression) = 52% (A), 31% (B). Adverse effects were generally mild and resolved without reducing CAI dose. There were no withdrawals. Conclusions: Patients with APD and moderate functional impairment treated with CAI may obtain greater functional, cognitive and emotional improvement than patients more severely affected.

关键词： Parkinson’s Disease Apo Morphine Continuous Dopaminergic Stimulation

Real-world data on the infliximab biosimilar CT-P13 (Remsima®) in inflammatory bowel disease

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World Journal of Clinical Cases 2021年第36期9卷 11285-11299页

作者： Jose María Huguet Xavier Cortés marta Maia Bosca-Watts Marian Aguas Nuria Maroto Lidia martí Cirilo Amorós Jose María Paredes Department of Gastroenterology General University Hospital of ValenciaValencia 46014Spain Department of Gastroenterology Hospital de SaguntoSagunto 46520Spain Department of Gastroenterology Hospital Clinico Universitario de ValenciaValencia 46010Spain Department of Gastroenterology Hospital Universitario y Politecnico la Fe de ValenciaValencia 46026Spain Department of Gastroenterology Hospital de ManisesManises 46940Spain Department of Gastroenterology Hospital Comarcal Francesc de BorjaGandia 46702Spain Department of Gastroenterology Hospital Arnau de Vilanova de ValenciaValencia 46015Spain Department of Gastroenterology Hospital Universitario Doctor Peset de ValenciaValencia 46017Spain

BACKGROUND In recent years,biological therapies have revolutionized the management of inflammatory bowel disease(IBD);however,they are *** development of biosimilar products has allowed us to reduce healthcare costs and improve patients’access to these *** various studies support the similarity between infliximab and its biosimilar CT-P13 in terms of efficacy and safety,there are unmet needs regarding research on these agents in the context of *** To analyze clinical response rates to CT-P13 and adverse events in IBD patients treated in real-life *** An observational,prospective,multicenter study of IBD patients treated with CTP13 in clinical practice who were naïve to biological treatments or failed to respond to other anti-tumor necrosis factor drugs or had switched from infliximab originator was carried *** diagnostic or follow-up interventions were conducted on patients outside usual clinical *** primary endpoints were clinical response rates and number of adverse *** primary efficacy variable was the proportion of patients who were in clinical remission and/or had a clinical response at 3,6,9,and 12 *** A total of 220 IBD patients treated with CT-P13(Remsima®)were included in the study:87(40%)with ulcerative colitis and 133(60%)with Crohn’s *** age of the patients was 41.47(SD 15.74)years,and 58%were ***(9%)patients started treatment with CT-P13 after switching from *** the remaining 201 patients,142(65%)were naïve to biologic *** baseline,68.6%(n=138/201)of patients presented with active *** 12 mo of treatment,14.8%(n=12/81)presented with active disease,and 64.2%(n=52/81)were in clinical remission without *** 3 mo,75.5%(n=115/152)had a clinical response or achieved clinical remission,which was sustained for 12 mo(85.2%;n=69/81).There was a decrease in specific IBD indices at 3,6,9,and 12 mo(P<0.001).A total of 34 adverse events

关键词： Crohn’s disease Ulcerative colitis Inflammatory bowel disease Infliximab Biosimilar CT-P13

Are TrkB receptor agonists the right tool to fulfill the promises for a therapeutic value of the brain-derived neurotrophic factor?

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Neural Regeneration Research 2024年第1期19卷 29-34页

作者： marta Zagrebelsky martin Korte Division of Cellular Neurobiology Zoological InstituteTU BraunschweigBraunschweigGermany Helmholtz Centre for Infection Research AG NINDBraunschweigGermany

Brain-derived neurotrophic factor signaling via its receptor tro pomyosin receptor kinase B regulates several crucial physiological *** has been shown to act in the brain,promoting neuronal survival,growth,and plasticity as well as in the rest of the body where it is involved in regulating for instance aspects of the *** to its crucial and very pleiotro pic activity,reduction of brain-derived neurotrophic factor levels and alterations in the brain-derived neurotrophic factor/tropomyosin receptor kinase B signaling have been found to be associated with a wide spectrum of neurological *** r,because of its poor bioavailability and pharmacological properties,brain-derived neurotrophic factor itself has a very low therapeutic ***,the concomitant binding of exogenous brain-derived neurotrophic factor to the p75 neurotrophin receptor has the potential to elicit several unwanted and deleterious side *** re,developing tools and approaches to specifically promote tropomyosin receptor kinase B signaling has become an important goal of translational *** the newly developed tools are different categories of tropomyosin receptor kinase B receptor agonist *** this review,we give a comprehensive description of the diffe rent tro pomyosin receptor kinase B receptor agonist drugs developed so far and of the res ults of their application in animal models of several neurological ***,we discuss the main benefits of tropomyosin receptor kinase B receptor agonists,concentrating especially on the new tropomyosin receptor kinase B agonist *** benefits observed both in vitro and in vivo upon application of tropomyosin receptor kinase B receptor agonist drugs seem to predominantly depend on their general neuroprotective activity and their ability to promote neuronal ***,tro pomyosin receptor kinase B agonist antibodies have been shown to specifically bind the tropomyosin recepto

关键词： Alzheimer's disease brain-derived neurotrophic factor depression Parkinson's disease tropomyosin receptor kinase B receptor

Neurotrophic factors and corneal nerve regeneration

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Neural Regeneration Research 2017年第8期12卷 1220-1224页

作者： marta Sacchetti Alessandro Lambiase Department of Sense Organs Sapienza University of Rome Rome Italy

The cornea has unique features that make it a useful model for regenerative medicine studies. It is an avascular, transparent, densely innervated tissue and any pathological changes can be easily detected by slit lamp examination. Corneal sensitivity is provided by the ophthalmic branch of the trigeminal nerve that elicits protective reflexes such as blinking and tearing and exerts trophic support by releasing neuromediators and growth factors. Corneal nerves are easily evaluated for both function and morphology using standard instruments such as corneal esthesiometer and in vivo confocal microscope. All local and systemic conditions that are associated with damage of the trigeminal nerve cause the development of neurotrophic keratitis, a rare degenerative disease. Neurotrophic keratitis is characterized by impairment of corneal sensitivity associated with development of persistent epithelial defects that may progress to corneal ulcer, melting and perforation. Current neurotrophic keratitis treatments aim at supporting corneal healing and preventing progression of corneal damage. Novel compounds able to stimulate corneal nerve recovery are in advanced development stage. Among them, nerve growth factor eye drops showed to be safe and effective in stimulating corneal healing and improving corneal sensitivity in patients with neurotrophic keratitis. Neurotrophic keratitis represents an useful model to evaluate in clinical practice novel neuro-regenerative drugs.

关键词： neurotrophic keratitis corneal sensitivity nerve regeneration nerve growth factor

Insights into adsorbent tortuosity across aqueous adsorption systems

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Particuology 2024年第5期88卷 71-88页

作者： Ackmez Mudhoo marta Otero Khim Hoong Chu Department of Chemical and Environmental Engineering Faculty of EngineeringUniversity of MauritiusRéduit 80837Mauritius Department of Applied Chemistry and Physics Universidad de LeónCampus de Vegazana 24071 LeónSpain Department of Chemical Engineering Faculty of EngineeringUniversity of MalayaKuala Lumpur 50603Malaysia

Pore network,pore connectivity,and the resulting effective adsorbate pore diffusivity within an adsorbent are critical physical considerations in mass transport modeling of aqueous *** to these three adsorbent features are the adsorbent tortuosity and tortuosity factor *** concepts encompass the collective hindrance to intra-adsorbent adsorbate transport arising because of a disorderly adsorbent porous *** is crucial for materials scientists,chemists,chemical engineers,and water treatment specialists to understand the complex and variable connections among adsorbate chemistry,adsorbent chemistry,adsorbent porosity,pore shape,size,and tortuosity,pore wall effect,adsorbate-adsorbent interactions,and adsorbate-adsorbate interactions in competitively contaminated aqueous *** tortuosity has been sporadically studied in aqueous adsorption *** the small population of these studies,insightful observations and inferences have been ***,as it appears,no review has been published to compile,compare,and contrast these ***,this review concisely brings up those observations and interpretations around adsorbent tortuosity for aqueous adsorption *** notion of an adsorbent's tortuosity being single-valued is argued to be ***,perspectives are aired on possible research and development directions for elucidating the dynamic attributes of adsorbent tortuosity and applying them in real-scale adsorption-oriented water *** data acquired by filling in these research gaps can enable the design of adsorbents more adapted for real-scale water purification.

关键词： Adsorbent Tortuosity Porosity Pore diffusion models Aqueous systems

Genetic and experimental evidence for the involvement of the CD6 lymphocyte receptor in psoriasis

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Cellular & Molecular Immunology 2018年第10期15卷 898-906页

作者： marta Consuegra-Fernández Marc Julià Mario martínez-Florensa Fernando Aranda Cristina Català Noelia Armiger-Borràs María-Teresa Arias Francisca Santiago Antonio Guilabert Anna Esteve Carlos Muñoz Carlos Ferrándiz José-Manuel Carrascosa Edurne Pedrosa Jorge Romaní MercèAlsina José-Manuel Mascaró-Galy Francisco Lozano Immunoreceptores del Sistema Innat i Adaptatiu Institut d'Investigacions Biomèdiques August Pi i Sunyer(IDIBAPS)Barcelona 08036Spain Servicio de Dermatologia Hospital Universitario de BasurtoBilbao 48013Spain Servei d’Immunologia Centre de Diagnòstic BiomèdicHospital Clínic de BarcelonaBarcelona 08036Spain Servei de Dermatologia Hospital General de GranollersBarcelona 08402Spain Centre d’Estudis Epidemiològics sobre les ITS i Sida de Catalunya(CEEISCAT) ASPCCIBER Epidemiologia y Salud PúblicaBadalona 08916Spain Servei de Dermatologia Hospital Universitari Germans Trias i PujolBadalona 08916Spain Laboratori d’Immunobiologia per Investigaciói Aplicacions al Diagnòstic Banc de Sang i Teixits(BST)Institut d’Investigacióen Ciències de la Salut Germans Trias i PujolDepartament de Biologia Cel·lularFisiologia i ImmunologiaUniversitat Autònoma de BarcelonaBellaterra 08193Spain Servei de Dermatologia Consorci Sanitari Parc Taulí08208 Sabadell.Universitat Autónoma de BarcelonaBellaterra 08193Spain Servei de Dermatologia Hospital Clínic de BarcelonaBarcelona 08036Spain Departament de Biomedicina Universitat de BarcelonaBarcelona 08036Spain

Psoriasis is a chronic inflammatory skin disease with a strong genetic background and is triggered by environmental *** evidence supports CD6,a lymphocyte surface receptor mostly expressed by T cells,as a putative target in ***,a humanized anti-CD6 antibody has been assayed for the treatment of certain autoimmune disorders,including ***,we present novel evidence in mice and humans for a direct involvement of CD6 in psoriasis ***,an attenuated form of imiquimod-induced psoriasis-like skin inflammation was demonstrated in CD6-deficient mice,as deduced from lower epidermal thickness and local reduced production of pro-inflammatory cytokines,namely,***,isolated CD4+CD62L+T cells from CD6-deficient mice displayed decreased in vitro T-helper type 17 ***,a statistically significant association between CD6 single-nucleotide polymorphisms(rs17824933,rs11230563 and rs12360861)and more severe forms of psoriasis was demonstrated in a cohort of 304 patients at three public hospitals from the metropolitan area of *** together,these results provide new supportive evidence of the contribution of the CD6 lymphocyte receptor in psoriasis at both experimental and clinical levels.

关键词： ALCAM CD5 CD6 lymphocyte psoriasis

Analysis of Anisotropic Nonlocal Diffusion Models:Well-Posedness of Fractional Problems for Anomalous Transport

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Numerical Mathematics(Theory,Methods and Applications) 2022年第4期15卷 851-875页

作者： marta D’Elia Mamikon Gulian Data Science and Computing Sandia National LaboratoriesCAUSA

We analyze the well-posedness of an anisotropic,nonlocal diffusion *** an equivalence between weighted and unweighted anisotropic nonlocal diffusion operators in the vein of unified nonlocal vector calculus,we apply our analysis to a class of fractional-order operators and present rigorous estimates for the solution of the corresponding anisotropic anomalous diffusion ***,we extend our analysis to the anisotropic diffusion-advection equation and prove well-posedness for fractional orders s∈[0.5,1).We also present an application of the advection-diffusion equation to anomalous transport of solutes.

关键词： Nonlocal models fractional models anomalous diffusion anisotropic diffusion solute transport

Impact of Distance Measures on the Performance of AIS Data Clustering

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Computer Systems Science & Engineering 2021年第1期36卷 69-82页

作者： marta Mieczyńska Ireneusz Czarnowski Department of Maritime Telecommunications Gdynia Maritime UniversityMorska 81-8781-225GdyniaPoland Department of Information Systems Gdynia Maritime UniversityMorska 81-8781-225GdyniaPoland

Automatic Identification System(AIS)data stream analysis is based on the AIS data of different vessel’s behaviours,including the vessels’*** the AIS data consists of outliers,noises,or are incomplete,then the analysis of the vessel’s behaviours is not possible or is *** the data consists of outliers,it is not possible to automatically assign the AIS data to a particular *** this paper,a clustering method is proposed to support the AIS data analysis,to qualify noises and outliers with respect to their suitability,and finally to aid the reconstruction of the vessel’s *** this paper,clustering results have been obtained using selected algorithms,including k-means,k-medoids,and fuzzy *** on the clustering results,it is possible to decide on the qualification of data with outliers and on their usefulness in the reconstruction of the vessel *** main aim of this paper is to answer how different distance measures during a clustering process can influence AIS data clustering *** main core question is whether or not they have an impact on the process of reconstruction of the vessel trajectories when the data are *** research question during the computational experiments asked whether or not distance measure influence AIS data clustering *** computational experiments have been carried out using original AIS *** general,the experiment and the results confirm the usefulness of the cluster-based analysis when the data include outliers that are derived from the natural *** is also possible to monitor and to analyse AIS data using clustering when the data include *** computational experiment results confirm that the k-means with Euclidean distance has the best performance.

关键词： AIS SAT-AIS AIS data stream clustering maritime data analysis

Zn-Mg and Zn-Cu alloys for stenting applications:From nanoscale mechanical characterization to in vitro degradation and biocompatibility

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Bioactive Materials 2021年第12期6卷 4430-4446页

作者： Claudia García-Mintegui Laura Catalina Córdoba Judit Buxadera-Palomero Andrea Marquina Emilio Jiménez-Piqué Maria-Pau Ginebra JoséLuis Cortina marta Pegueroles Biomaterials Biomechanics and Tissue Engineering GroupDepartment of Materials Science and EngineeringTechnical University of Catalonia(UPC)Barcelona East School of Engineering(EEBE)08019BarcelonaSpain Resource Recovery and Environmental Management Group UPCEEBE08019BarcelonaSpain Barcelona Research Center in Multiscale Science and Engineering UPCEEBE08019BarcelonaSpain Institute for Bioengineering of Catalonia(IBEC) 08028BarcelonaSpain Structural Integrity Micromechanics and Reliability of Materials GroupDepartment of Materials Science and EngineeringUPCEEBE08019BarcelonaSpain

In the recent decades,zinc(Zn)and its alloys have been drawing attention as promising candidates for bioresorbable cardiovascular stents due to its degradation rate more suitable than magnesium(Mg)and iron(Fe)***,its mechanical properties need to be improved in order to meet the criteria for vascular *** work investigates the mechanical properties,biodegradability and biocompatibility of Zn-Mg and Zn-Cu alloys in order to determine a proper alloy composition for optimal stent *** measurements are performed to characterize the mechanical properties at the nanoscale as a function of the Zn microstructure variations induced by *** biodegradation mechanisms are discussed and correlated to microstructure,mechanical performance and bacterial/cell *** of Mg or Cu alloying elements refined the microstructure of Zn and enhanced yield strength(YS)and ultimate tensile strength(UTS)proportional to the volume fraction of secondary ***-1Mg showed the higher YS and UTS and better performance in terms of degradation stability in Hanks’***-Cu alloys presented an antibacterial effect for *** controlled by diffusion mechanisms and by *** was dependent on the degradation rate and the nature of the corrosion products.

关键词： Zinc alloys Bioresorbable metals Galvanic corrosion Nanoindentation Biocompatibility