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代谢型谷氨酸受体可作为一种新型恶性胶质瘤治疗靶点（英文）

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中华神经外科疾病研究杂志 2017年第1期16卷 94-94页

作者： pereira MS Klamt F Thomé CC Worm PV de Oliveira DL Department of Biochemistry Laboratory of Cellular NeurochemistryInstituto de Ciências Básicas da SaúdeUniversidade Federal do Rio Grande do Sul Department of Biochemistry Laboratory of Cellular BiochemistryInstituto de Ciências Básicas da SaúdeUniversidade Federal do Rio Grande do Sul Department of Neurosurgery Cristo Redentor Hospital-GHCPorto Alegre RS Department of Neurosurgery So José HospitalComplexo Hospitalar Santa Casa

Objective Metabotropic glutamate receptors(mG luR)are predominantly involved in maintenance of cellular homeostasis of central nervous ***,evidences have suggested other roles of mG luR in human *** mG luR signaling has been shown to participate in transformation and maintenance of various cancer types,including malignant brain *** review intends to summarize recent findings regarding the involvement of mG luR-mediated intracellular signaling pathways in progression,aggressiveness,and recurrence of malignant gliomas,mainly glioblastomas(GBM),highlighting the potential therapeutic applications of mG luR *** addition to the growing number of studies reporting mG luR gene or protein expression in glioma samples(resections,lineages,and primary cultures),pharmacological blockade in vitro of mG luR1 and mG luR3 by selective ligands has been shown to be anti-proliferative and anti-migratory,decreasing activation of MAPK and PI3K *** addition,mG luR3 antagonists promoted astroglial differentiation of GBM cells and also enabled cytotoxic action of temozolomide(TMZ).mG luR3-dependent TMZ toxicity was supported by increasing levels of MGMT transcripts through an intracellular signaling pathway that sequentially involves PI3K and NF-κ***,continuous pharmacological blockade of mG luR1 and mG luR3 have been shown to reduced growth of GBM tumor in two independent in vivo xenograft *** parallel,low levels of mG luR3 mRNA in GBM resections may be a predictor for long survival rate of *** several Phase I,II and III clinical trials are being performed using group I and II mG luR modulators,there is a strong scientifically-based rationale for testing mG luR antagonists as an adjuvant therapy for malignant brain tumors.

关键词：期刊编辑工作英文摘要

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全膝关节置换术后低位髌骨

临床骨科杂志 2021年第2期24卷 242-242页

作者： LUM Z C SAIZ A M pereira G C 胡孔足(译) 不详

全膝关节置换术后低位髌骨可导致撞击、疼痛、活动度减少等并发症。形成原因包括以前膝关节手术史,例如前交叉韧带重建术、逆行髓内钉固定术、髌下脂肪垫切除术和膝关节置换术史。诊断包括Insall-Salvati和Blackburne-Peel等方法。需要... 详细信息

全膝关节置换术后低位髌骨可导致撞击、疼痛、活动度减少等并发症。形成原因包括以前膝关节手术史,例如前交叉韧带重建术、逆行髓内钉固定术、髌下脂肪垫切除术和膝关节置换术史。诊断包括Insall-Salvati和Blackburne-Peel等方法。需要区分真正的低位髌骨和假性低位髌骨。治疗方法包括胫骨结节截骨、股骨远端垫块、翻修、髌骨上移、胫骨假体改良、髌韧带“Z”字成形等。

关键词：膝关节置换术低位髌骨膝关节手术髌下脂肪垫髌韧带前交叉韧带重建术股骨远端髓内钉固定术

枯草芽孢杆菌孢子对奶牛泌乳性能、消化率的影响

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饲料博览 2017年第8期27卷 50-50页

作者： Souza V L Lopes N M Zacaroni O F Silveira V A pereira R A N Freitas J A Almeida R Salvati G G S pereira M N

枯草芽孢杆菌是消化道内一种短期微生物,对动物不致病,能形成孢子耐冷热环境。作为动物饲料益生菌,可提高饲料消化率和动物免疫力。试验探讨了枯草芽孢杆菌孢子对奶牛产奶量、乳成分和饲料消化率的影响。两项试验中,哺乳期奶牛均在饲料... 详细信息

枯草芽孢杆菌是消化道内一种短期微生物,对动物不致病,能形成孢子耐冷热环境。作为动物饲料益生菌,可提高饲料消化率和动物免疫力。试验探讨了枯草芽孢杆菌孢子对奶牛产奶量、乳成分和饲料消化率的影响。两项试验中,哺乳期奶牛均在饲料槽中饲喂,每天喂1次料。试验1中,18头荷斯坦奶牛在泌乳后期(产奶246±75 d)饲喂枯草芽孢杆菌C-3102(菌落形成3.0×109·d^(-1)孢子)或安慰剂,共39 d,在此过程中,有10 d的空白期,28 d进行饲喂后进行评估。添加枯草芽孢杆菌对饲料摄入量无显著变化(18.3 kg·d^(-1),P=0.91),产奶量无显著变化(25.3 kg·d^(-1),P=0.66),乳中固体物浓度和含量、总消化道养分消化率和反刍活动均无显著变化。试验2选取20头奶牛(产奶161±72 d),牛奶体细胞数(725 000个·mL^(-1)),试验为期16周,随着时间推移,随机分组设计的相关变量重复进行调整适应。枯草芽孢杆菌显著增加了产奶量(25.3和23.6 kg·d^(-1),P=0.02),显著增加乳蛋白质含量(0.816和0.763 kg·d^(-1),P=0.01),乳中总固体物含量增加(2.718和2.566 kg·d^(-1),P=0.05),牛奶总能量显著增加(60.7和56.5 MJ·d^(-1),P=0.02),牛奶尿素氮含量有降低趋势(19.3和20.8 mg·dL^(-1),P=0.06)。牛奶中体细胞含量各组间无显著差异。哺乳期奶牛饲料中添加枯草芽孢杆菌孢子作为益生菌,饲喂16周对饲料消化率无显著影响。

关键词：枯草芽孢杆菌奶牛乳成分产奶量益生菌

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肠道中与高血压相关的病理生理改变

中华高血压杂志 2016年第10期24卷 909-909页

作者：刘莉叶鹏 Santisteban MM Qi Y Zubcevic J Kim S Yang T Shenoy V ColeJeffrey CT Lobaton GO Stewart DC Rubiano A Simmons CS Garcia-pereira F Johnson RD Pepine CJ Raizada MK

交感神经系统对炎症的控制在高血压中发挥中心作用。肠道接受交感神经支配,密集附着有多样的微生物生态系统,并且存在明显影响整体炎症动态平衡的免疫细胞。该研究旨在验证肠道交感神经活性增强是否与肠壁通透性增加、炎症状态增强、微... 详细信息

交感神经系统对炎症的控制在高血压中发挥中心作用。肠道接受交感神经支配,密集附着有多样的微生物生态系统,并且存在明显影响整体炎症动态平衡的免疫细胞。该研究旨在验证肠道交感神经活性增强是否与肠壁通透性增加、炎症状态增强、微生物生态失调加重相关,以及这些肠道病理变化是否导致高血压。

关键词：病理生理改变高血压肠道微生物生态系统交感神经系统交感神经支配交感神经活性炎症状态

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高校图书馆信息共享空间利用率提升策略研究

教育教学研究前沿

教育教学研究前沿 2024年第1期2卷 87-90页

作者：塔伊斯·达·席尔瓦·佩雷拉乔昂·维托尔·桑托斯·苏萨巴西伯南布哥大学孔子学院巴西累西腓50030

高校图书馆作为学术信息资源的重要承载机构,其信息共享空间的利用率对于提高学术资源的传播效率和服务质量具有重要意义。然而,在当前信息技术快速发展的背景下,图书馆信息共享空间的利用率仍存在影响其发展的一些因素亟待解决。如何... 详细信息

高校图书馆作为学术信息资源的重要承载机构,其信息共享空间的利用率对于提高学术资源的传播效率和服务质量具有重要意义。然而,在当前信息技术快速发展的背景下,图书馆信息共享空间的利用率仍存在影响其发展的一些因素亟待解决。如何提升高校图书馆信息共享空间利用率,帮助学生和教师更好地获取和利用学术资源,是值得高校管理人员深入探讨的重要课题。对此,本文首先阐述了影响高校图书馆信息共享空间利用率的因素,进而探究提升高校图书馆信息共享空间利用率的策略,以期为高校图书馆的发展提供有益的参考和借鉴。

关键词：高校图书馆共享空间

神经元特异性烯醇酶及S100蛋白在孔源性视网膜脱离患者视网膜下液中的浓度

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世界核心医学期刊文摘（眼科学分册） 2006年第5期2卷 39-39页

作者： Quintyn J.C pereira F Hellot M.F 陈立军(译) Service d' Ophtalmologie H~pital de Rangueil 1 av. Jean Poulhes 31403 Toulouse France 不详

Background: Neuron-specific enolase and S100 protein are markers of neuronal lysis. To assess the neuronal suffering in rhegmatogenous retinal detachment we quantified neuron-specific enolase and S100 protein in the subretinal fluid. Methods: The puncture was performed in the sclera with a Merseture 5/0 round needle, and the fluid was collected with a glass capillary tube. Twelve subretinal fluid samples were obtained from 12 eyes with rhegmatogenous retinal detachment undergoing retinal detachment surgery. Vitreous from ten eyes with macular hole or epimacular membrane served as negative control group, and vitreous collected during cornea procurement from ten deceased patients served as positive control group. Results: The mean concentration of neuron-specific enolase (in nanogram mes per millilitre) was 602 in the subretinal fluid of rhegmatogenous retinal detachment, 10.2 in the serum of these patients, 2.9 in the vitreous of the negative control group, and 364 in the positive control group. The mean concentration of S100 protein (in nanogrammes per millilitre) was 104 in the subretinal fluid of rhegmatogenous retinal detachment, < 0.1 in the serum of these patients and in the vitreous of the control negative group, and 11.18 in the positive control group. Conclusion: Neuronspecific enolase (NSE) and S100 are known to be good markers of brain stress and, thus, are good markers of retinal stress.

关键词：神经元特异性烯醇酶孔源性视网膜脱离 S100蛋白视网膜下液浓度患者神经细胞影响程度阴性对照黄斑前膜

Improving ITS sequence data for identification of plant pathogenic fungi

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Fungal Diversity 2014年第4期67卷 11-19页

作者： R.Henrik Nilsson Kevin D.Hyde Julia Pawlowska Martin Ryberg Leho Tedersoo Anders Bjornsgard Aas Siti A.Alias Artur Alves Cajsa Lisa Anderson Alexandre Antonelli A.Elizabeth Arnold Barbara Bahnmann Mohammad Bahram Johan Bengtsson-Palme Anna Berlin Sara Branco Putarak Chomnunti Asha Dissanayake Rein Drenkhan Hanna Friberg Tobias Guldberg Froslev Bettina Halwachs Martin Hartmann Beatrice Henricot Ruvishika Jayawardena Ari Jumpponen Havard Kauserud Sonja Koskela Tomasz Kulik Kare Liimatainen Bjorn D.Lindahl Daniel Lindner Jian-Kui Liu Sajeewa Maharachchikumbura Dimuthu Manamgoda Svante Martinsson Maria Alice Neves Tuula Niskanen Stephan Nylinder Olinto Liparini pereira Danilo Batista Pinho Teresita M.Porter Valentin Queloz Taavi Riit Marisol Sánchez-García Filipe de Sousa Emil Stefańczyk Mariusz Tadych Susumu Takamatsu Qing Tian Dhanushka Udayanga Martin Unterseher Zheng Wang Saowanee Wikee Jiye Yan Ellen Larsson Karl-Henrik Larsson Urmas Koljalg Kessy Abarenkov Department of Biological and Environmental Sciences University of GothenburgBox 46140530 GothenburgSweden Institute of Excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand School of Science Mae Fah Luang UniversityChiang Rai 57100Thailand Department of Plant Systematics and Geography Faculty of BiologyUniversity of WarsawAl.Ujazdowskie 400-478 WarsawPoland Department of Organismal Biology Uppsala UniversityNorbyvagen 18D75236 UppsalaSweden Institute of Ecology and Earth Sciences University of TartuLai 40Tartu 51005Estonia Microbial Evolution Research Group University of OsloBlindernveien 310371 OsloNorway Institute of Biological Sciences University of Malaya50603 Kuala LumpurMalaysia Department of Biology CESAMUniversity of Aveiro3810-193 AveiroPortugal School of Plant Sciences The University of Arizona1140 E South Campus DriveForbes 303TucsonAZ 85721USA Laboratory of Environmental Microbiology Institute of Microbiology ASCRVídeňská108314220 Prague 4Czech Republic Department of Infectious Diseases Institute of BiomedicineSahlgrenska AcademyUniversity of GothenburgGuldhedsgatan 1041346 GoteborgSweden Department of Forest Mycology and Plant Pathology Swedish University of Agricultural SciencesBox 702675007 UppsalaSweden University of California at Berkeley 321 Koshland Hall University of CaliforniaBerkeleyCA 94720-3102USA Agriculture and Forestry Sciences Beijing 100097China Institute of Forestry and Rural Engineering Estonian University of Life SciencesKreutzwaldi551014 TartuEstonia Natural History Museum of Denmark Øster Voldgade 5-71350 København KDenmark Institute for Genomics and Bioinformatics Graz University of Technology8010 GrazAustria Core Facility Bioinformatics Austrian Centre of Industrial Biotechnology8010 GrazAustria Forest Soils and Biogeochemistry Swiss Federal Research Institute WSLZuercherstrasse 1118903 BirmensdorfSwitzerland Molecular Ecology Institute for Sustainability SciencesAgroscopeReckenholzstrasse 191

Plant pathogenic fungi are a large and diverse assemblage of eukaryotes with substantial impacts on natural ecosystems and human *** taxa often have complex and poorly understood life cycles,lack observable,discriminatory morphological characters,and may not be amenable to in vitro *** a result,species identification is frequently ***(DNA sequence)data have emerged as crucial information for the taxonomic identification of plant pathogenic fungi,with the nuclear ribosomal internal transcribed spacer(ITS)region being the most popular ***,international nucleotide sequence databases are accumulating numerous sequences of compromised or low-resolution taxonomic annotations and substandard technical quality,making their use in the molecular identification of plant pathogenic fungi *** we report on a concerted effort to identify high-quality reference sequences for various plant pathogenic fungi and to re-annotate incorrectly or insufficiently annotated public ITS sequences from these fungal lineages.A third objective was to enrich the sequences with geographical and ecological *** results-a total of 31,954 changes-are incorporated in and made available through the UNITE database for molecular identification of fungi(http://***),including standalone FASTA files of sequence data for local BLAST searches,use in the next-generation sequencing analysis platforms QIIME and mothur,and related *** present initiative is just a beginning to cover the wide spectrum of plant pathogenic fungi,and we invite all researchers with pertinent expertise to join the annotation effort.

关键词： Phytopathogenic fungi Molecular identification ITS Taxonomy Annotation

广东农村信息服务项目实施效果分析——以“山村信息化”和“信息直通车”为例

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南方农村 2013年第1期 4-9页

作者：易法敏 CAROL Ting 华南农业大学经济管理学院澳门大学资讯管理系

我国的农村信息化目前处于整合资源、统一平台、强化服务阶段。广东的农村信息化起步早,分析广东的农村信息服务项目实施效果,有助于提炼出很多普遍性的问题。本文认为,政府有必要对前期的农村信息服务项目建设效果进行评估,并在今后的... 详细信息

我国的农村信息化目前处于整合资源、统一平台、强化服务阶段。广东的农村信息化起步早,分析广东的农村信息服务项目实施效果,有助于提炼出很多普遍性的问题。本文认为,政府有必要对前期的农村信息服务项目建设效果进行评估,并在今后的工作中加强部门间协调和引导社会各方力量间的合作。首先,在大规模的网络建设之前应该对政策措施实施更好的评估;另外,必须协调不同各部门间的无序竞争,并以法定形式保证部门行动的一致性和政策的连续性。

关键词：农村信息服务山区信息化信息直通车

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囊性纤维化肝病肝纤维化的血清标志物

世界核心医学期刊文摘（胃肠病学分册） 2005年第3期1卷 57-57页

作者： pereira T.N. Lewindon P.J. Smith J.L. 姜志茹

Hepatic fibrosis contributes to adverse outcome in cystic fibrosis (CF). Early detection of CF liver disease (CFLD) may identify patients at risk of significant complications. To evaluate the utility of serum markers to detect hepatic fibrosis in children with CFLD vs. CF patients without liver disease (CFnoLD) and controls. Sera from 36 CFLD, 30 CFnoLD and 39 controls were assessed for tissue inhibitor of matrix metalloproteinase (MMP) (TIMP)-1, collagen (CL) IV, MMP-2, hyaluronic acid (HA) and prolyl hydroxylase (PH) by enzyme immunoassay and were correlated with hepatic fibrosis score in CFLD. TIMP-1, PH and CL IV were increased in CFLD vs. CFnoLD and controls. Fibrosis score was negatively correlated with TIMP 1 (r=-0.34, P=0.06) and PH(r=-0.48, P=0.008). Receiver operating characteristics analysis showed CL IV (AUC 0.785, P<0.0001) and TIMP-1 (AUC 0.765, P<0.0001) differentiated CFLD from CFnoLD and controls, while PH (AUC 0.814, P < 0.0001) predicted early fibrogenesis. Diagnostic accuracy improved using logistic regression combining (i) CL IV, TIMP-1, PH to identify CFLD (AUC 0.831, P< 0.0001) and (ii) TIMP-1, PH to identify CFLD patients with no fibrosis (AUC 0.852, P < 0.02). Elevated TIMP-1, CL IV, PH may be indicators of hepatic fibrogenesis in CF. Increased TIMP-1, PH may be early markers of CFLD.

关键词：肝纤维化血清标志物囊性纤维化 TIMP 酶联免疫法脯氨酰羟化酶早期标志早期检测负相关能将