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Full-term pregnancy in breast cancer survivor with fertility preservation: A case report and review of literature

World Journal of Clinical Cases 2019年第1期7卷 58-68页

作者： marta garrido-marín Pedro maria Argacha Luís Fernández Florencia Molfino Fina martínez-Soler Avelina Tortosa Pepita Gimenez-Bonafé Department of Physiological Sciences Physiology Unit Faculty of Medicine and Health Sciences Bellvitge Campus Universitat de BarcelonaIDIBELL L’Hospitalet del Llobregat Hospital Universitari General de Catalunya Servicio de Oncología Médica Consorcio Corporación Sanitaria Parc Taulí Instituto de Reproducción Cefer Department of Basic nursing Faculty of Medicine and Health Sciences Universitat de Barcelona IDIBELL L’Hospitalet del Llobregat

A 43-year-old woman with an associated history of gynecological pathology and breast cancer with only one cryopreserved embryo wished to be a *** factors that influenced the success of the pregnancy in this case were analyzed. Favorable factors included: triple positive breast cancer [positive hormone receptors and positive human epidermal growth factor receptor 2],which is more hormosensitive and chemosensitive; absence of metastasis; correct endometrium preparation; and the patient's optimistic attitude and strict health habits. In contrast, the factors against success were: breast cancer; adjuvant breast cancer therapy gonadotoxicity; the age of the patient(> 40-year-old);endometriosis; ovarian cyst; hydrosalpinx; submucosal fibroids and the respective associated surgery done for the above-mentioned pathology(all resolved prior to the embryo transfer); and a low quantity of ovules(low ovarian reserve) after ovarian stimulation. This is a very special clinical case of a patient with theoretically low pregnancy success probability due to the consecutive accumulation of gynecological and oncological pathologies, who nonetheless became pregnant and delivered a full-term infant and was able to provide adequate breastfeeding.

关键词： Breast cancer Fertility preservation Gonadotoxicity Pregnancy In vitro fertilization Hydrosalpinx Endometriosis Case report

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Survival effects of antibiotic exposure during the larval and adult stages in the West nile virus vector Culex pipiens

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Insect Science 2024年第2期31卷 542-550页

作者： marta Garrigos mario garrido Manuel Morales-Yuste Josuémartinez-de la Puente Jesus Veiga Faculty of Pharmacy Department of ParasitologyUniversity of GranadaGranadaSpain CIBER de Epidemiologia y Salud Publica(CIBERESP) MadridSpain

The ability of mosquitoes to transmit a pathogen is affected,among other factors,by their survival rate,which is partly modulated by their *** microbiota is acquired during the larval phase and modified during their development and adult feeding behavior,being highly dependent on environmental *** residues including antibiotics are widespread pollutants potentially being present in mosquito breeding waters likely affecting their ***,we used Culex pipiens mosquitoes to assess the impact of antibiotic exposure during the larval and adult stages on the survival rate of adult ***-collected larvae were randomly assigned to two treatments:larvae maintained in water supplemented with antibiotics and control *** adults were subsequently assigned to each of two treatments,fed with sugar solution with antibiotics and fed only with sugar solution(controls).Larval exposure to antibiotics significantly increased the survival rate of adult females that received a control *** addition,the effect of adult exposure to antibiotics on the survival rate of both male and female mosquitoes depended on the number of days that larvae fed ad libitum in the laboratory before *** particular,shorter larval ad libitum feeding periods reduced the survival rate of antibiotic-treated adult mosquitoes compared with those that emerged after a longer larval feeding *** differences were not found in control adult *** results extend the current understanding of the impact of antibiotic exposure of mosquitoes on a key component of vectorial capacity,that is the vector survival rate.

关键词： antibiotics avian malaria microbiota mosquitoes vector competence vector survival

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Ocular trauma in an urban Spanish population:epidemiology and visual outcome

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International Journal of Ophthalmology(English edition) 2021年第9期14卷 1327-1333页

作者： marta Belmonte-Grau Guadalupe garrido-Ceca Paula marticorena-álvarez Department of Ophthalmology Hospital Universitario de La PrincesaMadrid 28006Spain Universidad Autónoma de Madrid Medicine UniversityMadrid 28006Spain

AIM:To describe epidemiological aspects,clinical findings,and visual results in eye trauma patients requiring urgent surgery at a tertiary ***:Retrospective review of adult patients requiring urgent surgery for trauma to the eyeball from January 2010 and April *** was collected relative to age,gender,mechanism of the injury,type of wound,initial and final visual acuity,number and type of surgeries carried *** were classed according to the Birmingham Eye Trauma Terminology(BETT)and the Ocular Trauma Score(OTS)***:The survey included 92 *** age was 54.76±22.18 *** most frequent cause was domestic accidents(44.6%),followed by aggression(22.80%)and occupational accidents(17.4%).Trauma from aggression was more frequent in men(P=0.006)and accidents in the home more common in women(P=0.011).Patients over 65 y presented an odds ratio(OR)of 10.71 for suffering a domestic *** between 15-45 and 46-65 y were at higher risk of trauma from aggression(OR=17.52 and OR=10.94,respectively).As for the type of injury,63.04%were open-globe lesions,Zone II being the most frequently affected(27.2%).In Logistic regression analysis,old age(P=0.05)and retinal involvement(P=0.001)were found to be associated with higher rate of unfavourable visual ***:The epidemiological aspects of eye trauma are highly dependent on the area of population *** accidents are more relevant than workplace accidents in older urban areas with high socioeconomic status.A better knowledge of the epidemiological characteristics is useful for implementing specific prevention measures and appropriate treatment strategies.

关键词： ocular trauma epidemiology domestic accident

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Human sperm testicular angiotensin-converting enzyme helps determine human embryo quality

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Asian Journal of Andrology 2018年第5期20卷 498-504页

作者： marta Gianzo Itziar Urizar-Arenaza Iraia Munoa-Hoyos Zaloa Larreategui nicolas garrido Luis Casis Jon Irazusta nerea Subiran Department of Physiology Faculty of Medicine and Nursery University of the Basque Country (UPV/EHU) Leioa Biscay 48940 Spain In Vitro Fertilization Laboratory IVI Bilbao Landabarri Promenade 1 Leioa Biscay 48940 Spain IVI Foundation IVI Valencia Local Police Square 3 Valencia 46015 Spain

Angiotensin-converting enzyme functions in the male reproductive system, but the extent of its function in reproduction is not fully understood. The primary objective of this work was to investigate the relationship between the testicular isoform of angiotensin-converting enzyme present in human spermatozoa and semen parameters, human embryo quality, and assisted reproduction success. A total of 81 semen samples and 635 embryos from couples undergoing oocyte donation cycles at the IVI Bilbao Clinic were analyzed. Semen parameters, embryos quality, and blastocyst development were examined according to the World Health Organization standards and the Spanish Association of Reproduction Biology Studies criteria. The percentage of testicular angiotensin-converting enzyme-positive spermatozoa and the number of molecules per spermatozoon were analyzed by flow cytometry. Both parameters were inversely correlated with human sperm motility. Higher percentages of testicular angiotensin-converting enzyme-positive spermatozoa together with fewer enzyme molecules per spermatozoon were positively correlated with better embryo quality and development. Our results suggest that embryos with a higher implantation potential come from semen samples with higher percentages of testicular angiotensin-converting enzyme-positive cells and fewer enzyme molecules per spermatozoon. Based on these findings, we propose that testicular angiotensin-converting enzyme could be used to aid embryologists in selecting better semen samples for obtaining high-quality blastocysts during in vitro fertilization procedures.

关键词： angiotensin-converting enzyme ART embryonic development human sperm male fertility

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Physiological strategies of moult-migrating Black-necked Grebes(Podiceps nigricollis)in a polluted staging site according to blood chemistry

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Avian Research 2023年第3期14卷 453-459页

作者： Juan A.Amat nico Varo marta I.Sanchez Andy J.Green Damaso Hornero-Mendez Juan garrido-Fernandez Cristina Ramo Departamento de Ecología y Evolucion Estacion Biologica de Donana(EBD-CSIC)41092SevillaSpain Independent researcher 41010SevillaSpain Departamento de Biología de la Conservacion y Cambio Global Estacion Biologica de Donana(EBD-CSIC)41092SevillaSpain Departamento de Fitoquímica de Alimentos Instituto de la Grasa(IG-CSIC)41013SevillaSpain

After breeding,Black-necked Grebes(Podiceps nigricollis)perform a moult-migration to autumn hypersaline staging sites,where they moult the flight feathers and forage on superabundant brine shrimp(Artemia spp.)before leaving for wintering *** the stay in moulting sites,the grebes experience changes in organs and muscle size(atrophy,hypertrophy),and almost double their body mass,which has been suggested to act as an insurance against a collapse in prey availability in late *** two years we collected blood samples from hundreds of individuals at one of the most important European moulting sites(the Odiel marshes,SW Spain),which is a highly polluted area due to mining drainage and chemical *** assessed the potential effect of moulting stage,day of the year and body condition on 16 blood biochemical *** of the changes in prey availability and body composition of grebes,we expected some physiological adjustments during *** levels of cholesterol suggested that birds in active moult increased foraging effort to face the costs of *** was increased amount of lactate dehydrogenase,corresponding to periods of breast muscle *** in active moult augmented protein ingestion,likely to account for the requirements of feather *** also show that the probability of fasting due to low prey availability increased late in the moulting season,as demonstrated by an increase in plasmaβ-hydroxy-butyrate.

关键词： Blood biochemistry Eared grebe Fasting Feather replacement Odiel marshes Waterbird

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Towards curative therapy in gastric cancer:Faraway, so close!

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World Journal of Gastroenterology 2015年第41期21卷 11609-11620页

作者： marília Cravo Catarina Fidalgo Rita garrido Tania Rodrigues Gon?alo Luz Carolina Palmela marta Santos Fábio Lopes Rui Maio Gastroenterology Department Surgery and Oncology ClinicsHospital Beatriz Angelo

Although recent diagnostic and therapeutic advances have substantially improved the survival of patients with gastric cancer(GC), the overall prognosis is still poor. Surgery is the only curative treatment and should be performed in experienced centers. Due to high relapse following surgery, complementary and systemic treatment aimed at eradicating micrometastasis should be performed in most cases. Cytotoxic treatments are effective in downstaging locally advanced cancer, but different sensitivities and toxicities probably exist in different GC subtypes. Current treatment protocols are based primarily on clinical data and histological features, but molecular biomarkers that would allow for the prediction of treatment responses are urgently needed. Understanding how host factors are responsible for inter-individual variability of drug response or toxicity will also contribute to the development of more effective and less toxic treatments.

关键词： Gastric cancer Multidisciplinary treatment Therapeutic strategies Curative surgery

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Impact of the Transboundary Transport of Air Pollutants on Air Quality in Spain

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Journal of Environmental Protection 2012年第9期3卷 1167-1175页

作者： marta G. Vivanco Inmaculada Palomino Juan Luis garrido Ma ángeles González Gonzalo Alonso Fernando martín Centro de Investigaciones Energéticas Medioambientales y Teconológicas (CIEMAT) Air Pollution Unit Madrid Spain

Although compliance with the European limit values for air pollutants has been achieved over large parts in Spain, some challenges remain for O3 on the maximum daily 8-hour mean and information limit values, for particulate matter on the PM10 annual and daily limit values and for nO2 on annual and hourly limit values. Transboundary transport of air pollutants has started to be recognized as a mechanism affecting air quality. nevertheless, as a consequence of the complexity of atmospheric chemistry it is not easy to determine the importance of this effect. Photochemical models constitute an adequate tool to address this challenge, allowing the identification of pollutant pathways and the quantifi- cation of the influence of long-range transport of air pollutants. In this paper we evaluate the influence of out-of-Spain emissions on this non-compliance picture by using the CHIMERE photochemical model. For this purpose the model was run at a 0.2?-horizontal resolution for a European domain. Although at this resolution not all the local effects can be captured, transboundary transport of air pollutants can be examined. Several simulations were performed considering different emission scenarios. To see all out-of-Spain emissions influence, all the emissions were set to zero, excepting those in Spain. This includes examining European and ships effects on air quality in Spain. A second simulation was performed setting to zero just European-countries emissions, to see the effect of Europe. The third and fourth simulations were carried out by setting to zero France and Portugal emissions respectively. Ozone has been found to be the pollutant more affected by this transboundary transport, in particular in the summer period. The model indicates that the incoming air masses contributed in 2009 to the non-compliance with the European normative regulating the maximum daily 8-hour mean.

关键词： Transboundary Transport Air Pollution

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