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Physicochemical properties and release characteristics of calcium alginate microspheres loaded with Trichoderma viride spores

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Journal of Integrative Agriculture 2019年第11期18卷 2534-2548页

作者： Slaven Juric Edyta Dermic Snjezana Topolovec-Pintaric marta Bedek Marko Vincekovic Department of Chemistry University of Zagreb Faculty of AgricultureZagreb 10000Croatia Department of Plant Pathology University of Zagreb Faculty of AgricultureZagreb 10000Croatia

Novel agroformulations for simultaneous delivery of chemical and biologically active agents to the plants were prepared by encapsulation of Trichoderma viride spores in calcium alginate *** impact of calcium ions concentration on the viability and sporulation of *** spores as well as on the microsphere important physicochemical properties were *** interactions in microspheres are complex including mainly hydrogen bonds and electrostatic *** germination inside matrix and germ tubes penetration out of microspheres revealed calcium alginate microspheres provide a supportive environment for *** *** in physicochemical properties and bioactive agents release behaviour from microspheres were ascribed to the changes in microsphere *** to Korsmeyer-Peppas empirical model revealed the underlying *** release mechanism as anomalous transport kinetics(a combination of two diffusion mechanisms and the Type II transport(polymer swelling and relaxation of the polymeric matrix)).The increasing amount of *** spores in the surrounding medium is closely related to the release from microspheres and *** rate controlling mechanism of calcium release is Fickian diffusion.A decrease in the release rate with increasing calcium ion concentrations is in accordance with the calcium ions effect on the strength of the alginate network *** germination inside microsphere diminished the amount of released calcium ions and slowed release kinetics in comparison with microspheres prepared without *** results indicated investigated agroformulations have a great potential to be used for plant protection and nutrition.

关键词： agroformulations alginate microspheres calcium ions Trichoderma viride sustainability

A review on the scale-up of high-shear wet granulation processes and the impact of process parameters

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Particuology 2024年第9期92卷 180-195页

作者： Ana Rita Alves marta Filipe Simões Sérgio Simões João Gomes University of Coimbra CERESDepartment of Chemical EngineeringFaculty of Sciences and TechnologyRua Sílvio Lima3030-790CoimbraPortugal Bluepharma-Indústria Farmacêutica São Martinho do BispoCoimbra3045-016Portugal Faculty of Pharmacy University of CoimbraAzinhaga de Santa Comba3000-548CoimbraPortugal

Wet granulation is one of the most important agglomeration processes,and high-shear granulation(HSG)one of the most employed technologies in the pharmaceutical *** most critical process parameters of HSG are discussed in this *** main concern in scaling up the wet granulation process is the differences between scales,which prevent the particles from having the same experience across all *** scale-up of wet granulation processes is commonly divided into two categories:engineering and attribute-based *** engineering-based scale-up approach is a strategy based on dimensional analysis and an attribute-based supported on the principles of“equifinality”,where process variables are adjusted to obtain equivalent granule *** work presents the effect of different HSG process parameters on the scale-up,as well as the use of process analytical tools(PAT)and modelling *** aim is to review applied scale-up approaches in HSG and discuss benefits and *** is proven why the scale-up for oral solid pharmaceutical products is still considered a hot topic and a very challenging task for development and engineering teams.

关键词： High-shear wetgranulation Parametric-based Attribute-based Physics-based modelling Impeller design Scale-up

Organic-walled Microfossils from the Early Middle Cambrian sediments of the Holy Cross Mountains,Poland：Possible Implications for Sedimentary Environment in the SE Margin of the Baltica

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Acta Geologica Sinica(English Edition) 2017年第1期91卷 39-50页

作者： marta BAK Lucyna NATKANIEC-NOWAK Beata NAGLIK Krzysztof BAK Pawel DULEMBA Faculty of Geology Geophysics and Environmental Protection AGH University of Science and Technology Mickiewieza 30 30-059 Krakow Poland Institute of Geography Pedagogical University of Cracow Podchorazych 2 30-084 Krak6w Poland

An association of organic-walled microfossils consisting of filamentous cyanobacteria, algal coenobia and acanthomorphic acritarch have been documented from non-calcareous claystones and mudstones of the Pepper Mountains Shale Formation（PMSF）, located in its stratotype area in the Pepper Mountains, which are part of the Holy Cross Mountains in Poland. These sediments represent the oldest strata of the ？ysogóry Unit, deposited on the edge of the East European Craton（Baltica）. Non-branched, ribbon-like and thread-like cyanobacteria trichomes exhibit morphological similarities to families Nostocaceae and Oscillatoriaceae. Cells assembled in rounded to irregular clusters of monospecific agglomerations represent multicellular algal coenobia, attributed to the family Scenedesmaceae. The co-occurrence of acritarchs belonging to species as Eliasum llaniscum, Cristallinium ovillense and Estiastra minima indicates that the studied material corresponds to the lower Middle Cambrian. Deposition of the PMSF took place in shallow marine environment, influenced by periodical freshwater inputs. The varying degree of coloration of organic-walled microfossils is interpreted in this study as factor indication of possible different source of their derivation. Dark brown walls of cells assembled in algal coenobia might have sustained previous humification in humid, terrestrial environments, which preceded their river transport into the sea together with nutrients, causing occasional blooms of cyanobacteria in the coastal environment and the final deposition of both groups of organisms in marine deposits.

关键词： algal coenobia filamentous cyanobacteria acritarchs Cambrian Baltica Holy Cross Mountains

Emotion recognition and inhibitory control in manifest and pre-manifest Huntington’s disease: evidence from a new Stroop task

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Neural Regeneration Research 2020年第8期15卷 1518-1525页

作者： Thomas Hünefeldt Sabrina Maffi Simone Migliore Ferdinando Squitieri marta Olivetti Belardinelli Sapienza University of Rome RomeItaly Huntington and Rare Diseases Unit Fondazione IRCCS Casa Sollievo della SofferenzaSan Giovanni RotondoItaly

Huntington’s disease(HD)is a genetic neurodegenerative disorder that affects not only the motor but also the cognitive *** particular,cognitive symptoms such as impaired executive skills and deficits in recognizing other individuals’mental state may emerge many years before the motor *** study was aimed at testing two cognitive hypotheses suggested by previous research with a new Stroop task created for the purpose:1)the impairment of emotion recognition in HD is moderated by the emotions’valence,and 2)inhibitory control is impaired in *** manifest and 20 pre-manifest HD patients and their age-and gender-matched controls completed both the traditional“Stroop Color and Word Test”(SCWT)and the newly created“Stroop Emotion Recognition under Word Interference Task”(SERWIT),which consist in 120 photographs of sad,calm,or happy faces with either congruent or incongruent word *** the SERWIT,impaired emotion recognition in manifest HD was moderated by emotion type,with deficits being larger in recognizing sadness and calmness than in recognizing happiness,but it was not moderated by stimulus *** the SCWT,six different interference scores yielded as many different patterns of group *** our results corroborate the hypothesis that impaired emotion recognition in HD is moderated by the emotions’valence,but do not provide evidence for the hypothesis that inhibitory control is impaired in *** research is needed to learn more about the psychological mechanisms underlying the moderating effect of emotional valence on impaired emotion recognition in HD,and to corroborate the hypothesis that the inhibitory processes involved in Stroop tasks are not impaired in *** beyond this study,the SERWIT promises to make important contributions to disentangling the cognitive and the psychomotor aspects of neurological *** research was approved by the Ethics Committee of the“Istituto Leonarda Vaccari”,Rome on January 2

关键词： congruent word interference emotion recognition emotional valence Huntington’s disease incongruent word interference inhibitory control Stroop interference

High-temperature tribological performance of functionally graded Stellite 6/WC metal matrix composite coatings manufactured by laser-directed energy deposition

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Friction 2024年第3期12卷 522-538页

作者： marta OSTOLAZA Alaitz ZABALA Jon Inaki ARRIZUBIETA Iñigo LLAVORI Nagore OTEGI Aitzol LAMIKIZ Department of Mechanical Engineering University of the Basque Country UPV/EHUPlaza Torres Quevedo 1Bilbo 48013Spain Faculty of Engineering Mechanics and Industrial ProductionMondragon UnibertsitateaLoramendi 4Mondragon 20500Spain

Wear-driven tool failure is one of the main hurdles in the *** issue can be addressed through surface coating with ceramic-reinforced metal matrix ***,the maximum ceramic content is limited by *** this work,the tribological behaviour of the functionally graded WC-ceramic-particlereinforced Stellite 6 coatings is *** that end,the wear resistance at room temperature and 400°C is ***,the tribological analysis is supported by crack sensitivity and hardness evaluation,which is of utmost importance in the processing of composite materials with *** indicate that functionally graded materials can be employed to increase the maximum admissible WC content,hence improving the tribological behaviour,most notably at high ***,a shift from abrasive to oxidative wear is observed in high-temperature wear testing.

关键词： friction coating metal matrix composite functionally graded materials high temperature laserdirected energy deposition

Comparison of radiation degradation induced by x-ray and 3-MeV protons in 65-nm CMOS transistors

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Chinese Physics B 2016年第9期25卷 468-473页

作者：丁李利 Simone Gerardin marta Bagatin Dario Bisello Serena Mattiazzo Alessandro Paccagnella State Key Laboratory of Intense Pulsed Radiation Simulation and Effect Northwest Institute of Nuclear Technology RREACT group Department of Information EngineeringPadova University INFN

The total ionizing dose（TID） response of 65-nm CMOS transistors is studied by 10-ke V x-ray and 3-Me V protons up to 1 Grad（SiO_2） total *** degradation levels induced by the two radiation sources are different to some *** main reason is the interface dose enhancement due to the thin gate oxide and the low energy *** holes＇ recombination also contributes to the *** to these two mechanisms,the influence of the dose rate is negligible.

关键词： total ionizing dose(TID) effects grad dose x-ray and protons 65-nm CMOS transistors

Mercury in sediments and vegetation in a moderately contaminated salt marsh (Tagus Estuary, Portugal)

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Journal of Environmental Sciences 2010年第8期22卷 1151-1157页

作者： Joao Canário Carlos Vale Laurier Poissant marta Nogueira Martin Pilote Vasco Branco INRB I.P./IPIMAR Av. Brasília Environment Canada Science and Technology Branch

Depth variations of total mercury （Hg） and methylmercury （MeHg） concentrations were studied in cores from non-colonized sediments, sediments colonized by Halimione portulacoides, Sarcocornia fruticosa and Spartina maritima and belowground biomass, in a moderately contaminated salt marsh （Tagus Estuary, Portugal）. Concentrations in belowground biomass exceeded up to 3 （Hg） and 15 （MeHg） times the levels in sediments, and up to 198 （Hg） and 308 （MeHg） times those found in aboveground parts. Methylmercury in colonized sediments reached 3% of the total Hg, 50 times above the maximum values found in non-colonized sediments. The absence of correlations between total Hg concentrations in sediments and the corresponding MeHg levels suggested that methylation was only dependent on the environmental and microbiological factors. The analysis of belowground biomass at high-depth resolution （2 cm） provided evidence that Hg and MeHg were actively absorbed from sediments, with higher enrichment factors at layers where higher microbial activity was probably occurring. The results obtained in this study indicated that the biotransformation of Hg to the toxic MeHg could increase the toxicity of plant-colonized sediments.

关键词： mercury methylmercury salt marshes Tagus Estuary Portugal

Preliminary notes on brain weight variation across labrid fish species with different levels of cooperative behaviour

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Current Zoology 2015年第2期61卷 274-280页

作者： marta C. SOARES Goncalo I. ANDRE Jose R. PAULA CIBIO Centro de Investiga~ao em Biodiversidade e Recursos Gen6ticos Universidade do Porto Campus AgrS.rio de Vairao4485-661 Vair~o Portugal

Brain size and weight vary tremendously in the animal kingdom. It has been suggested that brain structural develop- ment must evolve balanced between the advantages of dealing with greater social challenges mad the energetic costs of maintain- ing and developing larger brains. Here we ask if interspecific differences in cooperative behaviour （i.e. cleaning behaviour） are related to brain weight variations in four close-related species of Labrid fish： two are obligatory cleanerfish throughout their en- tire life （Labroides dimidiatus and L. bicolor）, one facultative cleaner fish Labropsis australis and one last species that never en- gage in cleaning Labrichthys unilineatus. We first search for the link between the rate of species＇ cooperation and its relative brain weight, and finally, if the degree of social complexity and cooperation are reflected in the weight of its major brain sub- structures. Overall, no differences were found in relative brain weight （in relation to body weight） across species. Fine-scale dif- ferences were solely demonstrated for the facultative cleaner L. australis, at the brainstem level. Furthermore, data visual exami- nation indicates that the average cerebellum and brainstem weights appear to be larger for L. dimidiatus. Because variation was solely found at specific brain areas （such as cerebellum and brainstem） and not for the whole brain weight values, it suggests that species social-ecological and cognitive demands may be directly contributing to a selective investment in relevant brain areas. This study provides first preliminary evidence that links potential differences in cognitive ability in cooperative behaviour to how these may mediate the evolution of brain structural development in non-mammal vertebrate groups .

关键词： Brain weight Body weight Macro-area weight Labridae Cooperation Cleaning behaviour

Neuroinflammation and neurological alterations in chronic liver diseases

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Neuroimmunology and Neuroinflammation 2015年第1期2卷 138-144页

作者： Carmina Montoliu marta Llansola Vicente Felipo Research Foundation of the Clinic Hospital of Valencia Health Research Institute-INCLIVA46010 ValenciaSpain Laboratory of Neurobiology Prince Felipe Research Center46012 ValenciaSpain

Several million people with chronic liver diseases(cirrhosis,hepatitis)show neurological alterations,named hepatic encephalopathy(HE)with cognitive and motor alterations that impair quality of life and reduces life *** acts synergistically with hyperammonemia to induce cognitive and motor alterations in patients with chronic liver disease and minimal hepatic encephalopathy(MHE).Previous studies in animal models have suggested that neuroinflammation is a major player in *** would also be the case in patients with liver cirrhosis or hepatitis C with *** with MHE show microglial activation and neuroinflammation that is associated with cognitive impairment and *** anti-inflammatory drug ibuprofen reduces microglial activation and neuroinflammation and restores cognitive and motor functions in rats with *** hyperammonemia per se induces *** peripheral inflammation and hyperammonemia would contribute to neuroinflammation in chronic liver ***,neuroinflammation may be a key therapeutic target to improve the cognitive and motor alterations in MHE and overt *** new targets to reduce neuroinflammation in MHE without inducing secondary effects would serve to develop new therapeutic tools to reverse the cognitive and motor alterations in patients with HE associated with chronic liver diseases.

关键词： Cognitive impairment hepatic encephalopathy hyperammonemia inflammation motor function neuroinflammation