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Neurotrophic factors and corneal nerve regeneration

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Neural Regeneration Research 2017年第8期12卷 1220-1224页

作者： marta Sacchetti Alessandro Lambiase Department of Sense Organs Sapienza University of Rome Rome Italy

The cornea has unique features that make it a useful model for regenerative medicine studies. It is an avascular, transparent, densely innervated tissue and any pathological changes can be easily detected by slit lamp examination. Corneal sensitivity is provided by the ophthalmic branch of the trigeminal nerve that elicits protective reflexes such as blinking and tearing and exerts trophic support by releasing neuromediators and growth factors. Corneal nerves are easily evaluated for both function and morphology using standard instruments such as corneal esthesiometer and in vivo confocal microscope. All local and systemic conditions that are associated with damage of the trigeminal nerve cause the development of neurotrophic keratitis, a rare degenerative disease. Neurotrophic keratitis is characterized by impairment of corneal sensitivity associated with development of persistent epithelial defects that may progress to corneal ulcer, melting and perforation. Current neurotrophic keratitis treatments aim at supporting corneal healing and preventing progression of corneal damage. Novel compounds able to stimulate corneal nerve recovery are in advanced development stage. Among them, nerve growth factor eye drops showed to be safe and effective in stimulating corneal healing and improving corneal sensitivity in patients with neurotrophic keratitis. Neurotrophic keratitis represents an useful model to evaluate in clinical practice novel neuro-regenerative drugs.

关键词： neurotrophic keratitis corneal sensitivity nerve regeneration nerve growth factor

Analysis of Anisotropic Nonlocal Diffusion Models:Well-Posedness of Fractional Problems for Anomalous Transport

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Numerical Mathematics(Theory,Methods and Applications) 2022年第4期15卷 851-875页

作者： marta D’Elia Mamikon Gulian Data Science and Computing Sandia National LaboratoriesCAUSA

We analyze the well-posedness of an anisotropic,nonlocal diffusion *** an equivalence between weighted and unweighted anisotropic nonlocal diffusion operators in the vein of unified nonlocal vector calculus,we apply our analysis to a class of fractional-order operators and present rigorous estimates for the solution of the corresponding anisotropic anomalous diffusion ***,we extend our analysis to the anisotropic diffusion-advection equation and prove well-posedness for fractional orders s∈[0.5,1).We also present an application of the advection-diffusion equation to anomalous transport of solutes.

关键词： Nonlocal models fractional models anomalous diffusion anisotropic diffusion solute transport

Impact of Distance Measures on the Performance of AIS Data Clustering

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Computer Systems Science & Engineering 2021年第1期36卷 69-82页

作者： marta Mieczyńska Ireneusz Czarnowski Department of Maritime Telecommunications Gdynia Maritime UniversityMorska 81-8781-225GdyniaPoland Department of Information Systems Gdynia Maritime UniversityMorska 81-8781-225GdyniaPoland

Automatic Identification System(AIS)data stream analysis is based on the AIS data of different vessel’s behaviours,including the vessels’*** the AIS data consists of outliers,noises,or are incomplete,then the analysis of the vessel’s behaviours is not possible or is *** the data consists of outliers,it is not possible to automatically assign the AIS data to a particular *** this paper,a clustering method is proposed to support the AIS data analysis,to qualify noises and outliers with respect to their suitability,and finally to aid the reconstruction of the vessel’s *** this paper,clustering results have been obtained using selected algorithms,including k-means,k-medoids,and fuzzy *** on the clustering results,it is possible to decide on the qualification of data with outliers and on their usefulness in the reconstruction of the vessel *** main aim of this paper is to answer how different distance measures during a clustering process can influence AIS data clustering *** main core question is whether or not they have an impact on the process of reconstruction of the vessel trajectories when the data are *** research question during the computational experiments asked whether or not distance measure influence AIS data clustering *** computational experiments have been carried out using original AIS *** general,the experiment and the results confirm the usefulness of the cluster-based analysis when the data include outliers that are derived from the natural *** is also possible to monitor and to analyse AIS data using clustering when the data include *** computational experiment results confirm that the k-means with Euclidean distance has the best performance.

关键词： AIS SAT-AIS AIS data stream clustering maritime data analysis

Smoothness of the Functional Law Generated by a Nonlinear SPDE

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Chinese Annals of Mathematics,Series B 2008年第2期29卷 113-120页

作者： marta SANZ-SOL Paul MALLIAVIN Facultat de Matemàtiques Universitat de BarcelonaGran Via 585E-08007 BarcelonaSpain. 10 rue Saint Louis-en-I'IleF-74004 ParisFrance

The authors consider a stochastic heat equation in dimension d=1 driven by an additive space time white noise and having a mild *** is proved that the functional law of its solution is absolutely continuous and posses... 详细信息

关键词： Stochastic heat equation Probability law Absolute continuity Divergence operator Gradient operator

Weighted Inequalities for Fractional Type Operators with Some Homogeneous Kernels

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Acta Mathematica Sinica,English Series 2013年第3期29卷 449-460页

作者： María Silvina RIVEROS marta URCIUOLO FaMAF-UNC CIEM-CONICET Ciudad Universitaria

In this paper, we study integral operators of the formappropriate weighted BMO and weak type estimates for certain weights satisfying the above inequality. We also give a Coifman type estimate for these operators.

关键词： Fractional operators Calderon-Zygmund operators BMO Muckenhoupt weights

Changes in hydrological regime in High Arctic non-glaciated catchment in 1979-2020 using a multimodel approach

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Advances in Climate Change Research 2022年第4期13卷 517-530页

作者： Marzena OSUCH Tomasz WAWRZYNIAK marta MAJERSKA Institute of Geophysics Polish Academy of SciencesWarsaw 01-452Poland

Assessing hydrological consequences of climate change at the catchment scale is recently among key problems in *** study focuses on the estimation of changes in the hydrological regime in the Fuglebekken catchment in SW Spitsbergen(Svalbard).For this purpose,50 rainfll-runoff models were calibrated using available hydrometeorological *** models were validated based on archival flow and SWE observations,and proxy data from time-lapse *** models(FLEX-IS,GSM-SOCONT,PRMS,HBV,Nordic HBV,and GR4J)with the best performance were applied to reconstruct the past hydrological conditions and analyse the trends in flow regime in the period *** significant changes at 0.05 level in the flow regime indicators were detected,including the number of days with the active flow during the calendar year(10.8 d per decade),during the mid-May-November period(9.8 d per decade),the date of the first day with the flow(-4.7 d per decade),and the last day with the flow during mid-May-November(8.4 d per decade).A statistically significant increase in runoff was estimated for two periods from mid-May to the end of June and the second part of August till *** changes in the first period result from increases in air temperature and earlier snowmelt-driven *** estimated runoff increase in the second period corresponds to large increases in *** increase in air temperature,earlier disappearance of snow,and decrease in precipitation in July and the first part of August result in runoff *** presented results show that the Fuglebekken‘catchment's hydrological regime has already *** magnitude of the changes is larger compared to catchments located in lower latitudes.

关键词： Hydrological regime Climate change Svalbard High Aretic catchment hydrology Multimodel approach

UGT76B1 controls the growth-immunity trade-off during systemic acquired resistance

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Molecular Plant 2021年第4期14卷 544-546页

作者： marta Pastorczyk-Szlenkier Pawei Bednarek Institute of Bioorganic Chemistry Polish Academy of SciencesNoskowskiego 12/1461-704 PoznanPoland

Higher plants evolved multiple innate immune systems to combat pathogens present in their living ***,activation of the complex immune responses allocates nutrient resources into biosynthesis of various defense molecules,and this in turn often represses growth and development of the entire *** the years,the significance of the effective coregulation of growth and immunity has been demonstrated with dwarf phenotypes of autoimmune mutant lines of model plants displaying constitutive defense responses(van Wersch et al.,2016).This tightly regulated balance,termed the growthimmunity trade-off,is an important objective in plant breeding,which ultimately aims at plant cultivars that are both highly resistant and efficient in terms of growth and yield(Ning et al.,2017).

关键词： breeding cultivar dwarf

Opposite fates of fructose in the development of metabolic syndrome

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World Journal of Gastroenterology 2012年第33期18卷 4478-4480页

作者： marta Alegret Juan C Laguna Department of Pharmacology and Therapeutic Chemistry School of Pharmacy University ofBarcelona Institute of Biomedicine 08028 Barcelona Spain Biomedical Network ResearchCentre Physiopathology of Obesity and Nutrition (CIBERobn)08028 Barcelona Spain

This short review comments on the recently published work of Ishimoto et al regarding the opposing effects of fructokinase C and A isoforms on fructoseinduced metabolic syndrome in mice. The framework for the commentary is the preexisting background of epidemiological and experimental data regarding the association between ingestion of fructose, as present in sweetened beverages, and the development of metabolic syndrome. The work of Ishimoto et al clearly confirms the negative effect of fructose on lipid and glucose metabolism, independently from the amount of energy provided by the ingested sugar. It also confirms the absolute requirement of liver fructose metabolism, driven by fructokinase activity, in order to develop the full spectrum of metabolic syndrome alterations.

关键词： Lipid metabolism Fatty liver Obesity Hyperglycemia Dyslipidemia

Digestive and breast cancer patients managed during the first wave of COVID-19 pandemic:Short and middle term outcomes

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World Journal of Methodology 2024年第2期14卷 107-126页

作者： Jacobo Trébol Ana Carabias-Orgaz María Carmen Esteban-Velasco Asunción García-Plaza Juan Ignacio González-Munoz Ana Belén Sánchez-Casado Felipe Carlos Parreno-Manchado marta Eguía-Larrea José Antonio Alcázar-Montero Cirugía General y del Aparato Digestivo Complejo Asistencial Universitario de SalamancaSalamanca 37007SalamancaSpain Cirugía Universidad de SalamancaSalamanca 37007SalamancaSpain Oftalmología Complejo Asistencial Universitario de SalamancaSalamanca 37007SalamancaSpain

BACKGROUND The first wave of coronavirus disease 2019(COVID-19)pandemic in Spain lasted from middle March to the end of June *** population was subjected to lockdown periods and scheduled surgeries were discontinued or reduced during variable *** our centre,we managed patients previously and newly diagnosed with *** established a strategy based on limiting perioperative social contacts,preoperative screening(symptoms and reverse transcriptionpolymerase chain reaction)and creating separated in-hospital COVID-19-free pathways for non-infected *** also adopted some practice modifications(surgery in different facilities,changes in staff and guidelines,using continuously changing personal protective equipment…),that supposed new *** To analyse cancer patients with a decision for surgery managed during the first wave,focalizing on outcomes and pandemic-related *** We prospectively included adults with a confirmed diagnosis of colorectal,oesophago-gastric,liver-pancreatic or breast cancer with a decision for surgery,regardless of whether they ultimately underwent *** analysed short-term outcomes[30-d postoperative morbimortality and severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection]and outcomes after 3 years(adjuvant therapies,oncological events,death,SARS-CoV-2 infection and vaccination).We also investigated modifications to usual *** From 96 included patients,seven didn’t receive treatment that period and four never(3 due to COVID-19).Operated patients:28 colon and 21 rectal cancers;laparoscopy 53.6%/90.0%,mortality 3.57%/0%,major complications 7.04%/25.00%,anastomotic leaks 0%/5.00%,3-years disease-free survival(DFS)82.14%/52.4%and overall survival(OS)78.57%/76.2%.Six liver metastases and six pancreatic cancers:no mortality,one major complication,three grade A/B liver failures,one bile leak;3-year DFS 0%/33.3%and OS 50.0%/33.3%(liver metastases/pancreatic carcinoma).5 g

关键词： COVID-19 SARS-CoV-2 Colon cancer Rectal cancer Breast cancer Liver cancer Pancreatic cancer Gastric cancer Oesophageal cancer Surgery