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Oxidative stress,the blood-brain barrier and neurodegenerative diseases:The critical beneficial role of dietary antioxidants

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Acta Pharmaceutica Sinica B 2023年第10期13卷 3988-4024页

作者： Jin Feng Youle Zheng Mingyue Guo Irma Ares marta Martínez Bernardo Lopez-Torres María-Rosa Martínez-Larran aga Xu Wang Arturo Anadon María-Aranzazu Martínez National Reference Laboratory of Veterinary Drug Residues(HZAU)and MAO Key Laboratory for Detection of Veterinary Drug Residues Huazhong Agricultural UniversityWuhan 430070China MAO Laboratory for Risk Assessment of Quality and Safety of Livestock and Poultry Products Huazhong Agricultural UniversityWuhan 430070China Department of Pharmacology and Toxicology Faculty of Veterinary MedicineUniversidad Complutense de Madrid(UCM)And Research Institute Hospital 12 de Octubre(i+12)Madrid 28040Spain

In recent years,growing awareness of the role of oxidative stress in brain health has prompted antioxidants,especially dietary antioxidants,to receive growing attention as possible treatments strategies for patients with neurodegenerative diseases(NDs).The most widely studied dietary antioxidants include active substances such as vitamins,carotenoids,flavonoids and *** antioxidants are found in usually consumed foods such as fresh fruits,vegetables,nuts and oils and are gaining popularity due to recently growing awareness of their potential for preventive and protective agents against NDs,as well as their abundant natural sources,generally non-toxic nature,and ease of long-term *** review article examines the role of oxidative stress in the development of NDs,explores the‘two-sidedness’of the blood-brain barrier(BBB)as a protective barrier to the nervous system and an impeding barrier to the use of antioxidants as drug medicinal products and/or dietary antioxidants supplements for prevention and therapy and reviews the BBB permeability of common dietary antioxidant suplements and their potential efficacy in the prevention and treatment of ***,current challenges and future directions for the prevention and treatment of NDs using dietary antioxidants are discussed,and useful information on the prevention and treatment of NDs is provided.

关键词： Dietary antioxidant supplements Oxidative stress Blood-brain barrier Neurodegenerative diseases Vitamins Carotenoids Flavonoids Polyphenols

Mesenchymal stem cells-based therapy as a potential treatment in neurodegenerative disorders: is the escape from senescence an answer?

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Neural Regeneration Research 2015年第6期10卷 850-858页

作者： Alessandro Castorina marta Anna Szychlinska Rubina Marzagalli Giuseppe Musumeci Department of Biomedical and Biotechnological Science Section of Human Anatomy and HistologySchool of MedicineUniversity of Catania

Aging is the most prominent risk factor contributing to the development of neurodegenerative disorders. In the United States, over 35 million of elderly people suffer from age-related diseases. Aging impairs the self-repair ability of neuronal cells, which undergo progressive deterioration. Once initiated, this process hampers the already limited regenerative power of the central nervous system, making the search for new therapeutic strategies particularly difficult in elderly affected patients. So far, mesenchymal stem cells have proven to be a viable option to ameliorate certain aspects of neurodegeneration, as they possess high proliferative rate and differentiate in vitro into multiple lineages. However, accumulating data have demonstrated that during longterm culture, mesenchymal stem cells undergo spontaneous transformation. Transformed mesenchymal stem cells show typical features of senescence, including the progressive shortening of telomers, which results in cell loss and, as a consequence, hampered regenerative potential. These evidences, in line with those observed in mesenchymal stem cells isolated from old donors, suggest that senescence may represent a limit to mesenchymal stem cells exploitation in therapy, prompting scholars to either find alternative sources of pluripotent cells or to arrest the age-re- lated transformation. In the present review, we summarize findings from recent literature, and critically discuss some of the major hurdles encountered in the search of appropriate sources of mesenchymal stem cells, as well as benefits arising from their use in neurodegenerative diseases. Finally, we provide some insights that may aid in the development of strategies to arrest or, at least, delay the aging of mesenchymal stem cells to improve their therapeutic potential.

关键词： aging neurodegenerative disorders telomere shortening MSCs cellular therapy

The role of small vessel disease in development of Alzheimer's disease

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Neural Regeneration Research 2010年第4期5卷 310-320页

作者： marta Grau-Slevin Adria Arboix John Gaffney Mark Slevin School of Biology Chemistry and Health ScienceManchester Metropolitan University Cerebrovascular Division Department of NeurologyHospital Universitari del Sagrat CorUniversitat de Barcelona

Classically Alzheimer＇s disease and vascular dementia have been considered as two different entities, with their own clinical criteria, but relatively recent epidemiological and clinicopathological studies suggest an overlap between them sharing not only most of the risk factors and some clinical aspects but also pathophysiological mechanisms. Cerebrovascular lesions, especially small vessel disease （lacunar infarcts, white matter hyperintensities and microbleeds）, may magnify the effects of mild Alzheimer＇s disease pathology and promote the progression of cognitive decline and may also be a precursor of neuronal damage and dementia. ＂Vascular hypothesis＂ of Alzheimer＇s disease would open a window for new approaches and treatments.

关键词： Alzheimer's disease small vessel disease development risk factors diagnosis neuroimaging studies histopathological studies neurodegenerative disease neural regeneration

Spontaneous regression of pancreatic cancer: Real or a misdiagnosis?

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World Journal of Gastroenterology 2012年第23期18卷 2902-2908页

作者： marta Herreros-Villanueva Elizabeth Hijona Angel Cosme Luis Bujanda Schulze Center for Novel Therapeutics Division of Oncology Research Department of Medicine Mayo Clinic Rochester MN 55905 United States Department of Gastroenterology Centro de Investigación Biomédica en Red en Enfermedades Hepáticas y Digestivas University of the Basque Country Donostia Hospital-Biodonostia Institute 20014 San Sebastian Spain

Spontaneous tumor regression has been subject of numerous studies and speculations for many years. This phenomenon is exceptional, but well reported, in some types of tumors, but not in pancreatic cancer. Pancreatic cancer has the worst five-year survival rate of any cancer. Despite numerous molecular studies and clinical approaches, using several mouse models, this cancer responds poorly to the existing chemotherapeutic agents and progress on treatment remains elusive. Although pancreatic cancer tumors seldom undergo spontaneous regression, and some authors take that with skepticism, there are some cases reported in the literature. However, the variability in the description of the reports and technical details could make this process susceptible to misdiagnosis. Distinguishing between different types of pancreatic carcinoma should be taken with caution as they have wide differences in malignant potential. Diseases such as pancreatic benign tumors, insulinomas, or autoimmune pancreatitis could be responsible for this misdiagnosis as a pancreatic cancer. Here we review different cases reported, their clinical characteristics, and possible mechanisms leading to spontaneous regression of pancreatic cancer. We also discuss the possibilities of misdiagnosis.

关键词：胰腺癌误诊回归良性肿瘤实时临床特点分子生物学自身免疫性

Redox behavior of gold supported on ceria and ceria-zirconia based catalysts

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Journal of Rare Earths 2009年第2期27卷 196-203页

作者： Michela Vicario Jordi Llorca marta Boaro Carla de Leitenburg Alessandro Trovarelli Dipartimento di Scienze e Tecnologie Chimiche Università di UdineVia del Cotonificio 10833100 UdineItaly Institut de Tècniques Energètiques Universitat Politècnica de CatalunyaDiagonal 647ed. ETSEIB08028 BarcelonaSpain

A series of gold-based catalysts were prepared by deposition precipitation or incipient wetness impregnation on CexZ1-xO2 solid solutions （0.28≤x≤1.00）. The morphological and structural characterization of these catalysts were carried out with X-ray diffraction, trans- mission electron microscopy （TEM） analysis and physical adsorption technique, and their redox properties were studied by temperature programmed reduction using both H2 and CO as probe molecules. Two cycles of oxidation/reduction were carried out in order to evaluate the effects of redox aging and gold sintering on the oxygen exchange capability. As observed with other noble metals, gold enhanced and promoted the ceria reduction at lower temperatures. Reduction by CO was shown to be dependent on the fine dispersion of gold and to be nega- tively affected by the ageing process more than reduction with hydrogen. This might have implications in reactions like water gas shift and CO-PROX which involve CO as a main reactant.

关键词： gold ceria zirconia catalysis reduction behaviour nanoparticles temperature programmed reduction X-ray diffraction rare earths

Nutritional quality of Drosophila melanogaster as factitious prey for rearing the predatory bug Orius majusculus

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Insect Science 2021年第1期28卷 191-202页

作者： marta Montoro Henrik H.De Fine Licht Lene Sigsgaard Department of Plant and Environmental Sciences Section of Organismal BiologyUniversity of CopenhagenFrederiksberg CDenmark

The predatory bug,Orius majusculus(Reuter),is an important predator of thrips commercially produced for augmentative releases using the eggs of the Mediterranea n flour moth Ephestia kuehniella(Zeller).In this study,we assessed the potential for using frozen adults of fruit flies,Drosophila melanogaster(Meigen),either as nymphal rearing diet or as diet throughout the entire *** compared life-hi story traits and reproduction of predators when fed *** with high lipid body content(lipid-rich)and with high protein body content(protein-rich),using a diet of 100%*** eggs as *** also analyzed the biochemical composition of both prey and predator in order to assess the nutritional quality of each diet,which partially explained the adequacy of the different diets for *** were significant differences between predators fed the two types of ***,with the protein-rich flies as diet providing the best results in terms of mortality and ***,we show that while feeding *** throughout their development with *** increases mortality and reduces reproduction,protein-rich *** can be used as nymphal diet with minimal reduction in reproductivity and minimal increase in mortality.

关键词： Drosophilidae fitness Hemiptera lipid protein rearing diet

Using NWP to Assess the Influence of the Arctic Atmosphere on Midlatitude Weather and Climate

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Advances in Atmospheric Sciences 2018年第1期35卷 5-13页

作者： Tido SEMMLER Thomas JUNG marta A.KASPER Soumia SERRAR Alfred Wegener Institute Helmholtz Centre for Polar and Marine Research

The influence of the Arctic atmosphere on Northern Hemisphere midlatitude tropospheric weather and climate is explored by comparing the skill of two sets of 14-day weather forecast experiments using the ECMWF model with and without relaxation of the Arctic atmosphere towards ERA-Interim reanalysis data during the integration. Two pathways are identified along which the Arctic influences midlatitude weather: a pronounced one over Asia and Eastern Europe, and a secondary one over North America. In general, linkages are found to be strongest(weakest) during boreal winter(summer) when the amplitude of stationary planetary waves over the Northern Hemisphere is strongest(weakest). No discernible Arctic impact is found over the North Atlantic and North Pacific region, which is consistent with predominantly southwesterly flow. An analysis of the flow-dependence of the linkages shows that anomalous northerly flow conditions increase the Arctic influence on midlatitude weather over the continents. Specifically, an anomalous northerly flow from the Kara Sea towards West Asia leads to cold surface temperature anomalies not only over West Asia but also over Eastern and Central Europe. Finally, the results of this study are discussed in the light of potential midlatitude benefits of improved Arctic prediction capabilities.

关键词： Arctic atmosphere relaxation northern midlatitudes linkage model

Smoothness of the Functional Law Generated by a Nonlinear SPDE

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Chinese Annals of Mathematics,Series B 2008年第2期29卷 113-120页

作者： marta SANZ-SOL Paul MALLIAVIN Facultat de Matemàtiques Universitat de BarcelonaGran Via 585E-08007 BarcelonaSpain. 10 rue Saint Louis-en-I'IleF-74004 ParisFrance

作者在尺寸 d = 考虑一个随机的热方程 1 由添加剂空间时间白人噪音开车；有温和非线性。它的答案的功能的法律绝对是连续的，这被证明；关于相应线性 SPDE 的功能的法律拥有光滑的密度。

关键词：随机热方程概率规则绝对连续性分歧算子

Sensitivity of polyphagous(Plodia interpunctella)and stenophagous(Ephestia kuehniella)storage moths to residual insecticides:effect of formulation and larval age

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Insect Science 2021年第6期28卷 1734-1744页

作者： Vaclav Stejskal Jitka Stara Stano Pekar marta Nesvorna Jan Hubert Crop Research Institute PragueCzechia Faculty of Science Department of Botany and ZoologyMasaryk UniversityBrnoCzechia Faculty of Agrobiology Food and Natural ResourcesCzech University of Life SciencesPragueCzechia

Pyralid moths,Ephestia kuehniella and Plodia interpunctella,are prevalent stored product *** insecticides are the main tool to control these moths in the *** data describing the response of these moths to insecticides are *** lethal effect of the organophosphate,pyrethroid,and halogenated-pyrrole on moths larvae were compared in laboratory *** hypothesis was that the very polyphagous ***-punctella would have generally higher insecticide tolerance than that of the stenophagous *** insecticide concentrations were applied onto the inner surface of glass tube *** larvae of 14 or 21 d old of *** and 7 or 14 d old of *** were used by *** larval mortality was checked after 24 h of *** mortality was significantly influenced by age of larvae and the groups of *** differences among the efficacies of the tested formulations with identical active compounds were found,except significant different mortality of *** on deltamethrin formulations.A comparison of analytical standards showed that *** was less susceptible to the active ingredient pirimiphos-methyl than ***,while *** was less susceptible to deltamethrin than *** differences between the two species were observed for *** therefore rejected the hypothesis that polyphagy/stenophagy can be a general predictor of insecticide tolerance in the two tested storage *** most important finding for effective use was that the young larvae of both species were more susceptible to tested insecticides than older larvae.

关键词： efficacy integrated pest management IRAC pesticides Pyralidae residual