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Depressive symptoms in neurodegenerative diseases

World Journal of Clinical Cases 2015年第8期3卷 682-693页

作者： Miquel Baquero nuria mart.n Servei de neurologia Hospital Universitari i Politècnic La Fe

Depressive symptoms are very common in chronic conditions. This is true so for neurodegenerative diseases. A number of patients with cognitive decline and dementia due to Alzheimer's disease and related conditions like Parkinson's disease, Lewy body disease, vascular dementia, frontotemporal degeneration amongst other entities, experience depressive symptoms in greater or lesser grade at some point during the course of the illness. Depressive symptoms have aparticular significance in neurological disorders, specially in neurodegenerative diseases, because brain, mind, behavior and mood relationship. A number of patients may develop depressive symptoms in early stages of the neurologic disease, occurring without clear presence of cognitive decline with only mild cognitive deterioration. Classically, depression constitutes a reliable diagnostic challenge in this setting. However, actually we can recognize and evaluate depressive, cognitive or motor symptoms of neurodegenerative disease in order to establish their clinical significance and to plan some therapeutic strategies. Depressive symptoms can appear also lately, when the neurodegenerative disease is fully developed. The presence of depression and other neuropsychiatric symptoms have a negative impact on the quality-of-life of patients and caregivers. Besides, patients with depressive symptoms also tend to further decrease function and reduce cognitive abilities and also uses to present more affected clinical status, compared with patients without depression. Depressive symptoms are treatable. Early detection of depressive symptoms is very important in patients with neurodegenerative disorders, in order to initiate the most adequate treatment. We review in this paper the main neurodegenerative diseases, focusing in depressive symptoms of each other entities and current recommendations of management and treatment.

关键词： neurodegenerative diseases Alzheimer Depressive symptoms Frontotemporal degeneration Vascular dementia Lewy body disease Depression Dementia

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Architecture as device:Estrangement theory from literature to architecture

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Frontiers of Architectural Research 2022年第1期11卷 1-12页

作者： Qirui Wan Sergio mart.n Blas Department of Architectural Design ETSAMUniversidad Politécnica de MadridMadrid28040Spain

What is the estrangement of architecture?The concept has been incessantly mentioned by academics while there seems to be a lack of discussion systematically sorting out the significance,influence,and origins of estrangement asanarchitectural *** aims to discern the meaning of estrangement from the beginning and its process of entering the field of *** first part is expected to answer the following questions:what is estrangement’s original meaning in the field of literature and its variantions?The second part determines what estrangement is in architecture and in what form estrangement is represented according to these *** third part points out the difference during this translation fromliterature to architecture and demonstrates the reasonable inference thatmay actually compose the possibleway of applying the estranging technique in architecture.

关键词： Estrangement Architectural strategy Literature concept Decontextualization Anthropopathic architecture

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MYC inhibitors in multiple myeloma

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Cancer Drug Resistance 2021年第4期4卷 842-865页

作者： Sandra mart.nez-mart.n Laura Soucek Preclinical&Translational Research Program Vall d’Hebron Institute of Oncology(VHIO)Vall d’Hebron Barcelona Hospital CampusBarcelona 08035Spain Peptomyc S.L. Vall d’Hebron Barcelona Hospital CampusBarcelona 08035Spain Department of Biochemistry and Molecular Biology Universitat Autònoma de BarcelonaBellaterra 08193Spain InstitucióCatalana de Recerca i Estudis Avançats(ICREA) Barcelona 08010Spain

The importance of MYC function in cancer was discovered in the late 1970s when the sequence of the avian retrovirus that causes myelocytic leukemia was *** then,over 40 years of unceasing research have highlighted the significance of this protein in malignant transformation,especially in hematologic ***,some of the earliest connections among the higher expression of proto-oncogenes(such as MYC),genetic rearrangements and their relation to cancer development were made in Burkitt lymphoma,chronic myeloid leukemia and mouse *** myeloma(MM),in particular,is a plasma cell malignancy strictly associated with MYC deregulation,suggesting that therapeutic strategies against it would be beneficial in treating this ***,targeting MYC was-and,somehow,still is-challenging due to its unique properties:lack of defined three-dimensional structure,nuclear localization and absence of a targetable enzymatic *** these difficulties,however,many studies have shown the potential therapeutic impact of direct or indirect MYC *** molecules have been tested,in fact,in the context of *** this review,we summarize the current status of the different compounds,including the results of their clinical testing,and propose to continue with the efforts to identify,repurpose,redesign or improve drug candidates to combine them with standard of care therapies to overcome resistance and enable better management of myeloma treatment.

关键词： MYC inhibition multiple myeloma undruggable target targeted therapies transcription factor epigenetics MYC downregulation

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Personalized nutrition to mitigate inflammation in genetically predisposed individuals: a secondary analysis of the Danish PREVEnTOMICS intervention

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Food Science and Human Wellness 2024年

作者： Sebastià Galmés Andreu Palou-March Kristina Pigsborg Mona Adnan Aldubayan Sophia M.O.Gormsen Alberto Calleja Joan Trabal Vanesa mart.nez Biotza Gutiérrez Josep M.Del Bas Faidon Magkos Francisca Serra Eurecat， Centre tecnològic de Catalunya， Biotechnology Area Avd Universitat 1 Laboratory of Molecular Biology， nutrition and Biotechnology (nutrigenomics， Biomarkers and Risk Evaluation-nuBE)， University of the Balearic Islands Health Research Institute of the Balearic Islands (IdISBa) CIBER of Physiopathology of Obesity and nutrition (CIBEROBn)， Carlos III Health Institute (ISCIII) Alimentómica S.L.， Camí de na Pontons.s/n (Pol.11，Parc 3) Department of nutrition， Exercise and Sports， Faculty of Science， University of Copenhagen Department of Clinical nutrition， College of Applied Medical Sciences， King Saud bin Abdulaziz University for Health Sciences R&D， Food & Culinary Department Simple Feast Leitat Technological Center C/Innovació 2 Creaciones Aromáticas Industriales SA， Cuatrecasas i Arumí， Sant Quirze del Valles

Deep phenotyping and genetic characterization of individuals are fundamental to assessing the metabolic status and determining nutrition-specific requirements. This study aimed to ascertain the utmost effectiveness of personalized interventions by aligning dietary adjustments with both the genotype and metabolotype of individuals. Therefore， we assessed here the usefulness of a polygenic score (PGS) characterizing a potential pro-inflammatory profile (PGSi) as a nutrigenetic tool to discern individuals from the Danish PREVEnTOMICS cohort that could better respond to precision nutrition (Pn) plans， specifically targeted at counteracting the low-grade inflammatory profile typically found in obesity. The cohort followed a Pn plan to counteract the pro-inflammatory profile (Pni group) or generic dietary recommendations (Control) for 10 weeks. PGSi was applied for genetic stratification (Low/High). The effects of the intervention on anthropometrics and biomarkers related to inflammatory profile and carbohydrate metabolism were assessed. Around 30% of subjects had a high genetic predisposition to pro-inflammatory status (high-PGSi). These individuals demonstrated the most effective response to the dietary plan， experiencing improved body composition， with significant decreases in body weight (△: -4.84%; p=0.039) and body fat (△: -4.86%; p=0.007)， and beneficial changes in pro- and anti-inflammatory biomarkers， with significant increases in IL-10 (△: 71.3%; p=0.025) and decreases in TnF-α (△: -3.0%; p=0.048)， CRP (△: -31.1%)， ICAM1 (△: -5.8%)， and MCP1 (△: -4.2%) circulating levels， compared to low-PGSi individuals. Both phenotypic and genetic stratification contributed to a better understanding of metabolic heterogeneity in response to diet. This approach allows for refinement of the prediction of individual requirements and potentially for better management of obesity.

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Optical magnetic field enhancement using ultrafast azimuthally polarized laser beams and tailored metallic nanoantennas

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Photonics Research 2024年第5期12卷 1078-1092页

作者： RODRIGO mart.n-HERnAnDEZ LOREnZ GRUnEWALD LUIS SAnCHEZ-TEJERInA LUIS PLAJA EnRIQUECOnEJERO JARQUE CARLOS HERnAnDEZ-GARCIA SEBASTIAn MAI Grupo de Investigacion en Aplicaciones del Laser y Fotonica Departamento de Fisica AplicadaUniversidad de SalamancaE-37008 SalamancaSpain Unidad de Excelencia en Luz y Materia Estructuradas(LUMES) Universidad de SalamancaE-37008 SalamancaSpain Institute of Theoretical Chemistry Faculty of ChemistryUniversity of Vienna1090 ViennaAustria Vienna Doctoral School in Chemistry(DoSChem) Faculty of ChemistryUniversity of Vienna1090 ViennaAustria Departamento de Electricidad y Electrónica Universidad de Valladolid47011 ValladolidSpain

*** *** thank Valentina Shumakova,Elizaveta Gangrskaia,Alessandra Bellissimo,Audrius Pugzlys,and Andrius Baltu?ka for fruitful discussions and computational support by the Vienna Scientific Cluster(VSC 4).The authors thankfully acknowledge the computer resources at Marenostrum and SCAYLE,and the technical support provided by Barcelona Supercomputing Center(RES-FI-2022-3-0041).R.M.-H.,L.S.-T.,L.P.,E.C.J.,and C.H.-*** funding from the European Research Council(ERC)under the European Union’s Horizon 2020 research and innovation program(Grant Agreement no.851201)and support from Ministerio de Ciencia e Innovación(PID2022-142340nB-I00,PID2019-106910GB-I00).This research was funded in whole or in part by the Austrian Science Fund(FWF)(10.55776/ZK91).For open access purposes,the author has applied a CC BY public copyright license to any author accepted manuscript version arising from this submission.

关键词： metallic polarized discussions

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A review of the thermal stability of metastable austenite in steels:mart.nsite formation

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Journal of Materials Science & Technology 2021年第32期91卷 200-214页

作者： Yong Li David San mart.n Jinliang Wang Chenchong Wang Wei Xu State key laboratory of rolling and automation Northeastern UniversityShenyang 110819China Materalia Research Group Centro Nacional de Investigaciones Metalúrgicas(CENIM-CSIC)Avda Gregorio del Amo 8Madrid E-28040Spain School of Mechanical and Power Engineering Guangdong Ocean UniversityZhanjiang 524088China

Metastable austenite plays a critical role in achieving improved combinations of high strength and high ductility/toughness in the design of advanced high-strength steels(AHSS). The thermal stability of metastable austenite determines the transformation characteristics of AHSS and thus primarily determines the microstructure evolution during complex processes, e.g., the quenching and partitioning process, to achieve the desirable microstructure. This study provides a review of the thermal stability of austenite and its influence on mart.nsitic transformation from both experimental and theoretical modeling perspectives. From the experimental perspective, factors affecting the thermal stability are analyzed,the relative sensitivities are compared, and their corresponding mechanisms are discussed. From the theoretical modeling perspective, the most representative kinetic models that describe athermal and isothermal mart.nsitic transformation are reviewed. The advantages, shortcomings, and applicability of each model are discussed. The systematic review of both experimental and theoretical aspects reveals critical factors in tailoring the stability of metastable austenite and, therefore, provides guidance for the design of advanced steels.

关键词： Austenite Thermal stability mart.nsitic transformation Kinetic models

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Cyclooxygenase 2 in liver dysfunction and carcinogenesis: Facts and perspectives

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World Journal of Gastroenterology 2017年第20期23卷 3572-3580页

作者： Paloma mart.n-Sanz marta Casado Lisardo Boscá Department of Metabolism and Cell Signaling Institute of Biomedical Research Alberto Sols Biomedical network Center for the Study of Hepatic and Digestive Disease and Cardiovascular Diseases Metabolic Experimental Pathology Unit Biomedical Institute of ValenciaJaume Roig 11

The biosynthesis of prostaglandins and thromboxanes has been a focus of interest in the management of many liver *** are the enzymes involved in the first step of the biosynthesis of these lipid mediators and selective inhibitors for these isoenzymes as well as pharmacological analogues of prostaglandins have been developed and are currently applied *** we discuss the implications of these enzymes in the onset of metabolic and lipid disorders in the liver and their potential role in the progression of the diseases towards fibrosis and hepatocellular carcinogenesis.

关键词： Cyclooxygenase-2 nAS Prostaglandin non-alcoholic steatohepatitis Hepatocellular carcinoma

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Intestinal bile acid physiology and pathophysiology

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World Journal of Gastroenterology 2008年第37期14卷 5630-5640页

作者： Olga mart.nez-Augustin Fermín Sánchez de Medina Department of Biochemistry and Molecular Biology II School of Pharmacy University of Granada Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y DigestivasGranada 18071 Spain Department of Pharmacology School of Pharmacy University of Granada Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y DigestivasGranada 18071 Spain

Bile acids (BAs) have a long established role in fat digestion in the intestine by acting as tensioactives, due to their amphipatic characteristics. BAs are reabsorbed very efficiently by the intestinal epithelium and recycled back to the liver via transport mechanisms that have been largely elucidated. The transport and synthesis of BAs are tightly regulated in part by specific plasma membrane receptors and nuclear receptors. In addition to their primary effect, BAs have been claimed to play a role in gastrointestinal cancer, intestinal inflammation and intestinal ionic transport. BAs are not equivalent in any of these biological activities, and structural requirements have been generally identified. In particular, some BAs may be useful for cancer chemoprevention and perhaps in inflammatory bowel disease, although further research is necessary in this field. This review covers the most recent developments in these aspects of BA intestinal biology.

关键词： Colitis Bile acid absorption Colon cancer

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Interpolation of Ideal Measures by Abstract K and J Spaces

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Acta Mathematica Sinica,English Series 2007年第8期23卷 1357-1374页

作者： Luz M.FERnnDEZ-CABRERA Antón mart.nEZ Sección Departamental de Matemática Aplicada Escuela de EstadísticaUniversidad Complutense de Madrid28040 MadridSpain Departamento de Matemática Aplicada I E.T.S.Ingenieros IndustrialesUniversidad de Vigo36200

We work with the abstract K and J interpolation method generated by a sequence lattice Г. We investigate the deviation of an interpolated operator from a given operator ideal by establishing formulae for the ideal measure of the interpolated operator in terms of the ideal measures of restrictions of the operator. Formulae are given in terms of the norms of the shift operators on Г.

关键词： real interpolation ideal measures operator ideals shift operators

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CO_2 adsorption using TiO_2 composite polymeric membranes:A kinetic study

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Journal of Environmental Sciences 2015年第9期27卷 163-171页

作者： Sarah Hafeez X.Fan Arshad Hussain C.F.mart.n School of Chemical and Materials Engineering (SCME) National University of Sciences & Technology Institute for Materials and Processes School of Engineering University of Edinburgh University of Aberdeen School of Engineering Fraser Noble Building King's College

CO2is the main greenhouse gas which causes global climatic changes on larger scale. Many techniques have been utilised to capture CO2. Membrane gas separation is a fast growing CO2 capture technique, particularly gas separation by composite membranes. The separation of CO2 by a membrane is not just a process to physically sieve out of CO2 through the controlled membrane pore size. It mainly depends upon diffusion and solubility of gases, particularly for composite dense membranes. The blended components in composite membranes have a high capability to adsorb CO2. The adsorption kinetics of the gases may directly affect diffusion and solubility. In this study, we have investigated the adsorption behaviour of CO2 in pure and composite membranes to explore the complete understanding of diffusion and solubility of CO2 through membranes. Pure cellulose acetate（CA） and cellulose acetatetitania nanoparticle（CA-TiO2） composite membranes were fabricated and characterised using SEM and FTIR analysis. The results indicated that the blended CA-TiO2 membrane adsorbed more quantity of CO2 gas as compared to pure CA membrane. The high CO2 adsorption capacity may enhance the diffusion and solubility of CO2 in the CA-TiO2 composite membrane, which results in a better CO2 separation. The experimental data was modelled by Pseudo first-order, pseudo second order and intra particle diffusion *** to correlation factor R2, the Pseudo second order model was fitted well with experimental data. The intra particle diffusion model revealed that adsorption in dense membranes was not solely consisting of intra particle diffusion.

关键词： Global warming Cellulose acetate Gas adsorption Pseudo order models CO2 Ti O2

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