检索结果-南通市图书馆

Targeting TrkB–PSD-95 coupling to mitigate neurological disorders

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第3期20卷 715-724页

作者： Xin Yang Yu-Wen Alvin Huang John marshall Department of Molecular Biology Cell Biology and BiochemistryBrown UniversityProvidenceRIUSA Department of Neurology Warren Alpert Medical School of Brown UniversityProvidenceRIUSA Center for Translational Neuroscience Robert J.and Nancy D.Carney Institute for Brain Science and Brown Institute for Translational ScienceBrown UniversityProvidenceRIUSA

Tropomyosin receptor kinase B(TrkB)signaling plays a pivotal role in dendritic growth and dendritic spine formation to promote learning and *** activity-dependent release of brain-derived neurotrophic factor at synapses binds to pre-or postsynaptic TrkB resulting in the strengthening of synapses,reflected by long-term ***,the association of postsynaptic density protein-95 with TrkB enhances phospholipase Cγ-Ca^(2+)/calmodulin-dependent protein kinaseⅡand phosphatidylinositol 3-kinase-mechanistic target of rapamycin signaling required for long-term *** this review,we discuss TrkB-postsynaptic density protein-95 coupling as a promising strategy to magnify brain-derived neurotrophic factor signaling towards the development of novel therapeutics for specific neurological disorders.A reduction of TrkB signaling has been observed in neurodegenerative disorders,such as Alzheimer's disease and Huntington's disease,and enhancement of postsynaptic density protein-95 association with TrkB signaling could mitigate the observed deficiency of neuronal connectivity in schizophrenia and *** with brain-derived neurotrophic factor is problematic,due to poor pharmacokinetics,low brain penetration,and side effects resulting from activation of the p75 neurotrophin receptor or the truncated TrkB.T1 *** TrkB agonists and antibodies that activate TrkB are being intensively investigated,they cannot distinguish the multiple human TrkB splicing isoforms or cell type-specific *** TrkB–postsynaptic density protein-95 coupling provides an alternative approach to specifically boost TrkB signaling at localized synaptic sites versus global stimulation that risks many adverse side effects.

关键词： Angelman syndrome autism brain-derived neurotrophic factor depression neurodegenerative disorder neurodevelopmental disorder postsynaptic density protein-95 synaptic plasticity TrkB

Estimating underground mine ventilation friction factors from low density 3D data acquired by a moving LiDAR

在线全文

学校读者我要写书评

暂无评论

International Journal of Mining Science and Technology 2018年第4期28卷 650-655页

作者： Curtis Watson Joshua marshall Mining Systems Laboratory The Robert M.Buchan Department of Mining Queen's University

Ventilation system analysis for underground mines has remained mostly unchanged since the Atkinson method was made popular by Mc Elroy in 1935. Data available to ventilation technicians and engineers is typically limited to the quantity of air moving through any given heading. Because computer-aided modelling, simulation, and ventilation system design tools have improved, it is now important to ensure that developed models have the most accurate information possible. This paper presents a new technique for estimating underground drift friction factors that works by processing 3 D point cloud data obtained by using a mobile Li DAR. Presented are field results that compare the proposed approach with previously published algorithms, as well as with manually acquired measurements.

关键词： Mine ventilation Mine design Mobile mapping Roughness estimation Friction factors LiDAR3D point clouds

Fundamental behaviours of production traffic in underground mine haulage ramps

在线全文

学校读者我要写书评

暂无评论

International Journal of Mining Science and Technology 2015年第1期25卷 7-14页

作者： Haviland David marshall Joshua Golder Associates Ltd. The Robert M. Buchan Department of Mining Queen’s University

Ramps(or declines) are often used in underground mines to transport ore, waste, materials, and personnel. This paper studies mine ramp productivity and presents results from a set of computer simulations designed to model the fundamental behaviours of ramp haulage systems. Simulations show that, under fundamental assumptions without random disturbances, the haulage system always converges to a periodic behaviour in the steady state, but that productivities vary between equilibria. Simulations also demonstrate how productivity per vehicle does not necessarily decrease as more vehicles are added and,for example, in the five-vehicle case, how a 3.1% improvement can be achieved over the use of four vehicles. The result reveals the inefficiency of commonly-used lockout-style vehicle coordination strategies,and suggests a possible avenue for improving the productivity of haulage ramps by controlling the system to achieve more productive behaviours.

关键词： Underground miningFleet managementDiscrete-time simulationVehicle dispatching

Post-infectious irritable bowel syndrome

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2009年第29期15卷 3591-3596页

作者： Marroon Thabane John K marshall Division of Gastro-enterology McMaster University Medical Centre Hamilton Ontario L8N 3Z5 Canada Farncombe Family Digestive Health Research Institute McMaster University Hamilton Ontario L8N 3Z5 Canada Department of Clinical Epidemiology and Biostatistics McMaster University Hamilton Ontario L8N 3Z5 Canada

Post-infectious irritable bowel syndrome (PI-IBS) is a common disorder wherein symptoms of IBS begin after an episode of acute gastroenteritis. Published studies have reported incidence of PI-IBS to range between 5% and 32%. The mechanisms underlying the development of PI-IBS are not fully understood, but are believed to include persistent sub-clinical inflammation, changes in intestinal permeability and alteration of gut flora. Individual studies have suggested that risk factors for PI-IBS include patients' demographics, psychological disorders and the severity of enteric illness. However, PI-IBS remains a diagnosis of exclusion with no specific disease markers and, to date, no definitive therapy exists. The prognosis of PIIBS appears favorable with spontaneous and gradual resolution of symptoms in most patients.

关键词： Irritable bowel syndrome Functionacolonic disease Gastroenteritis Functional bowedisorder

On the design and selection of vehicle coordination policies for underground mine production ramps

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Mining Science and Technology 2016年第4期26卷 623-627页

作者： Michal Pasternak Joshua A.marshall Mining Systems Laboratory The Robert M.Buchan Department of MiningQueen's University

Traffic management in underground mines,especially on production ramps,is a difficult problem to optimize and *** operations use one of a few common policies;e.g.,the so-called ‘‘lock-out" and‘‘loaded-vehicle-priority" *** work presented in this paper uses discrete-event simulation to study the efficiency of multiple *** on simulation results,an improvement to the common lock-out policy is *** new policy utilizes the rules of the lock-out policy but integrates an option that allows a group of vehicles to be given temporary priority in a certain direction of *** results are provided and,based on these,a systematic technique for ramp design that aims to optimize the efficiency of underground mine ramp traffic flow is described.

关键词： Underground mining Fleet managementRamp design Equipment selection Discrete-event simulation

A Novel Framework for Object-Based Coding and Compression of Hyperspectral Imagery

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Electronics 2015年第2期24卷 300-305页

作者： ZHAO Chunhui LI Xiaohui REN Jinchang Stephen marshall College of Information and Communication Engineering Harbin Engineering University Department of Electronic and Electrical Engineering University of Strathclyde

A novel object-based framework is proposed for HSI compression, where targets of interest are extracted and separately coded. With objects removed,the holes are filled with the background average to form a new but more homogenous background for better compression. An improved sparse representation with adaptive spatial support is proposed for target detection. By applying the proposed framework to 2D/3D DCT approaches,reconstructed images from conventional and proposed approaches are compared. Six criteria in three groups are employed for quantitative evaluations to measure the degree of data reduction, the distortion of reconstructed image quality and accuracy in target detection, respectively. Comprehensive experiments on two datasets are used for performance evaluation. It is found that the proposed approaches yield much improved results.

关键词： Hyperspectral imagery(HSI) Objectbased image compression Sparse representation Target detection Remote sensing

Mechanism-directed combinational immunotherapies in liver cancer hold promise

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2023年第11期20卷 1395-1397页

作者： Gregory marshall Jian Cao Rutgers Cancer Institute of New Jersey New BrunswickNJ08901USA Department of Medicine Robert Wood Johnson Medical SchoolRutgersThe State University of New JerseyNew BrunswickNJ08901USA

Hepatocellular carcinoma(HCC)is the most prevalent form of primary liver cancer,and it is the third leading cause of cancer-related mortality *** primary causes of HCC include chronic infections with hepatitis B virus... 详细信息

关键词： cancer mortality hepatitis

Do females use their sexual status to gain resource access？ Investigating food-for-sex in wolves and dogs

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Current Zoology 2017年第3期63卷 323-330页

作者： Rachel DALE Sarah marshall-PESCINI Friederike RANGE Comparative Cognition Messerli Research Institute University of Veterinary Medicine Medical University of Vienna University of Vienna Vienna Austria Wolf Science Center Ernstbrunn Austria

While food sharing among related individuals can be explained by kin selection, food sharing be- tween unrelated individuals has been more of an evolutionary puzzle. The food-for-sex hypothesis provides an explanation for the occurrence of food sharing among nonkin. However, little is known about the socio-ecological factors that can promote such a commodity exchange. A species mating system is a factor potentially influencing food-for-sex patterns of behavior. Here, we compared wolves, which form pair-bonds, with dogs, which are typically promiscuous in freeranging contexts, to investigate the effect of reproductive stages on the behavior around a food source in 2 different contexts. Furthermore, we considered the roles of both the males and the fe- males in the potential food-for-sex exchange. Results indicate that in both species and for both sexes the breeding period promotes decreased aggression. Additionally, females were more per- sistent in their attempts to access the food and were able to monopolize the resource more when in heat as compared to outside the breeding period. Finally, in dogs, but not wolves, females spent more time in proximity to the male＇s bone and had a shorter latency to start eating it when in heat. Overall, this study demonstrates that the food-for-sex hypothesis plays a part in intersexual food sharing in canids, and highlights the role of females in the interaction. These effects were especially the case in dogs, suggesting a potential effect of mating system on food-for-sex responses

关键词： canid food-for-sex food sharing tolerance.

Genetics of inflammatory bowel disease: The role of the HLA complex

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2006年第23期12卷 3628-3635页

作者： Tariq Ahmad Sara E marshall Derek Jewell Gastroenterology Unit University of OxfordGibson LaboratoriesRadcliffe Infirmary Woodstock RoadOxford United Kingdom Department of Immunology Wright-Fleming InstituteImperial CollegeLondonUnited Kingdom Gastroenterology Unit University of OxfordGibson LaboratoriesRadcliffe InfirmaryWoodstock RoadOxfordUnited Kingdom

The human leucocyte antigen （HLA） complex on chromosome 6p21.3 is the most extensively studied genetic region in Inflammatory bowel disease （IBD）. Consistent evidence of linkage to IBD3 （6p21.1-23）, an area which encompasses the HLA complex, has been demonstrated for both Crohn＇s disease and ulcerative colitis, and a number of replicated associations with disease susceptibility and phenotype have recently emerged. However, despite these efforts the HLA susceptibility gene （s） for IBD remain elusive, a consequence of strong linkage disequilibrium, extensive polymorphism and high gene density across this region. This article reviews current knowledge of the role of HLA complex genes in IBD susceptibility and phenotype, and discusses the factors currently limiting the translation of this knowledge to clinical practice.

关键词： Inflammatory bowel disease Human leucocyte antigen complex Crohn's disease Ulcerative colitis Genetics