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Optical coherence tomography angiography in wet age-related macular degeneration(AMD)

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Eye Science 2016年第1期31卷 1-3页

作者： Joao pedro marques Rufino Silva Department of Ophthalmology Centro Hospitalar e Universitairio de Coimbra(CHUC)3000-075 CoimbraPortugal Association for Innovation and Biomedical Research on Light and Image(MBILI) 3000-548 CoimbraPortugal Faculty of Medicine University of Coimbra(FMUC)CoimbraPortugal

Over the last decades,substantial developments in retinal imaging offered a paradigmatic change in the understanding of the pathophysiology of wet age-related macular degeneration(AMD).We have reached a point of sophi... 详细信息

关键词：年龄相关 AMD 血管造影断层扫描光学相干变性黄斑病理生理学

Applying a Context-based Method to Build a Knowledge Graph for the Blue Amazon

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Data Intelligence 2024年第1期6卷 64-103页

作者： pedro de Moraes Ligabue Anarosa Alves Franco Brandão Sarajane marques Peres Fabio Gagliardi Cozman Paulo Pirozelli Escola Politécnica Universidade de São PauloRua Visconde da Luz60São PauloSão Paulo 05508-010Brazi Escola Politécnica Universidade de São PauloAv.Prof.Luciano Gualbertotv 3158São Paulo 05508-010Brazil Escola de Artes Ciências e Humanidades Universidade de São PauloRua Arlindo Béttio1000São Paulo 03828-000Brazil Instituto de Estudos Avançados Universidade de São PauloRua da Praça do Relógio109São Paulo 05508-050Brazil

Knowledge graphs are employed in several tasks,such as question answering and recommendation systems,due to their ability to represent relationships between *** constructing such a graphs,however,remains an unresolved challenge within knowledge *** tackle this challenge,we propose CtxKG,a method specifically aimed at extracting knowledge graphs in a context of limited resources in which the only input is a set of unstructured text *** is based on OpenIE(a relationship triple extraction method)and BERT(a language model)and contains four stages:the extraction of relationship triples directly from text;the identification of synonyms across triples;the merging of similar entities;and the building of bridges between knowledge graphs of different *** method distinguishes itself from those in the current literature(i)through its use of the parse tree to avoid the overlapping entities produced by base implementations of OpenIE;and(ii)through its bridges,which create a connected network of graphs,overcoming a limitation similar methods have of one isolated graph per *** compare our method to two others by generating graphs for movie articles from Wikipedia and contrasting them with benchmark graphs built from the OMDb movie *** results suggest that our method is able to improve multiple aspects of knowledge graph *** also highlight the critical role that triple identification and named-entity recognition have in improving the quality of automatically generated graphs,suggesting future paths for ***,we apply CtxKG to build BlabKG,a knowledge graph for the Blue Amazon,and discuss possible improvements.

关键词： knowledge graph word embeddings relationship triple extraction Blue Amazon Atlantic Ocean Brazilian coast

Employing electrochemically derived pH gradients for Lab-on-PCB protein preconcentration devices

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Microsystems & Nanoengineering 2024年第1期10卷 79-87页

作者： Grace Maxted pedro Estrela Despina Moschou Department of Electronic and Electrical Engineering University of BathBath BA27AYUK Centre for Bioengineering and Biomedical Technologies(CBio) University of BathBath BA27AYUK

Protein preconcentration is an essential sample preparation step for analysis in which the targeted proteins exist in low concentrations,such as bodily fluids,water,or ***,very few practical implementations of miniaturized protein preconcentration devices have been demonstrated in practice,and even fewer have been integrated with other microanalytical *** approaches rely heavily on additional chemicals and reagents and introduce complexity to the overall *** this paper,we propose a novel miniaturized isoelectric focusing-based protein preconcentration screening device based on electrochemically derived pH gradients rather than existing chemical reagent *** this way,we reduce the need for additional chemical reagents to zero while enabling device incorporation in a seamlessly integrated full protein analysis microsystem via Lab-on-PCB *** apply our previously presented Lab-on-PCB approach to quantitatively control the pH of a solution in the vicinity of planar electrodes using electrochemical acid generation through redox-active self-assembled *** presented device comprises a printed circuit board with an array of gold electrodes that were functionalized with 4-aminothiophenol;this formed a self-assembled monolayer that was electropolymerized to improve its electrochemical *** preconcentration was performed in two *** first was open and needed the use of a holder to suspend a well of fluid above the electrodes;the second used microfluidic channels to enclose small volumes of *** here are the resulting data for protein preconcentration in both these forms,with a quantitative concentration factor shown for the open form and qualitative proof shown for the microfluidic.

关键词： electrochemical proof qualitative

Conformational dynamics as an intrinsic determinant of prion protein misfolding and neurotoxicity

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Neural Regeneration Research 2024年第10期19卷 2095-2096页

作者： Alessandro Cembran pedro Fernandez-Funez Department of Chemistry and Biochemistry University of Minnesota DuluthDuluthMNUSA Department of Biomedical Sciences University of Minnesota Medical SchoolDuluth CampusDuluthMNUSA

The prion protein(PrP) is the key molecular and pathological mediator of prion diseases,a heterogeneous group of brain disorders with fatal *** diseases are rare but deserve special attention because of their unique f... 详细信息

关键词： folding intrinsic dynamics

Effect of the Coulomb and dielectric forces on the onset of Rayleigh-Bénard convection

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Acta Mechanica Sinica 2024年第6期40卷 64-77页

作者： Zhonglin Du pedro A.Vázquez Jian Wu School of Energy Science and Engineering Harbin Institute of TechnologyHarbin150001China Heilongjiang Key Laboratory of Micro-and Nano-scale Fluid Flow and Heat Transfer Harbin150001China Departamento de Física Aplicada III ETSIIUniversidad de SevillaSevilla41092Spain

In this paper,the effect of Coulomb and dielectric forces on the onset of Rayleigh-Bénard convection(RBC)in a dielectric liquid layer contained between two parallel electrode plates has been numerically *** different operating conditions have been considered in electrohydrodynamic(EHD)conduction:ohmic and saturation,and variations in the physical properties of the dielectric fluid with *** electric equations and the state equations based on the Boussinesq approximation are integrated in the framework of OpenFOAM buoyantBoussinesqPimpleFoam *** results show that in the ohmic regime,the combined effect of Coulomb and dielectric forces promotes the onset of RBC flow,while in the saturation state,the inhibition of RBC flow by Coulomb force is more *** value of the critical Rayleigh number Ra decreases with increasing electric Reynolds number ReE in the ohmic regime,whereas in the saturation state,the critical Ra increases with increasing *** the saturation regime,the flow field always has a steady flow in the range of parameters ***,the onset of the RBC flow promoted by the dielectric force is more pronounced in the ohmic *** to the presence of the dielectric force,the flow field exhibits periodic oscillatory flow at low electric Reynolds numbers for the range of parameters considered.

关键词： EHD conduction Dielectric force Rayleigh-Bénard convection OpenFOAM

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明媚一隅葡萄牙某私人住宅

室内设计与装修 2020年第6期 74-79页

作者： [葡萄牙]Romeu Ribeiro Josépedro marques 立夏(编译) 不详

现代住宅的设计由于受到时代特色、地域限制等因素的影响,呈现更加多元化的趋势。这栋位于葡萄牙吉马朗伊什市郊的别墅,作为一例精品范例,向人们展示了如何结合建筑用地的地形以及周边居住环境的特色,打造出属于业主的独一无二的居住空... 详细信息

现代住宅的设计由于受到时代特色、地域限制等因素的影响,呈现更加多元化的趋势。这栋位于葡萄牙吉马朗伊什市郊的别墅,作为一例精品范例,向人们展示了如何结合建筑用地的地形以及周边居住环境的特色,打造出属于业主的独一无二的居住空间。本案设计师经过勘察得出结论,这块地皮的周边建筑密集,处理好建筑和周围环境的关系非常重要。设计伊始,建筑师从住宅的私密性和高度两方面进行考量,将其设计成上下两层。

关键词：私人住宅周围环境现代住宅居住环境居住空间私密性建筑用地地域限制

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A住宅

现代装饰 2020年第2期 154-161页

作者： Romeu Ribeiro Jose pedro marques 郭映琴(编译) 无不详 Ivo Tavares Studio

该住宅坐落于葡萄牙北部古城吉马良斯郊外,场地周边建筑密集。该项目直接围绕场地的私密性和高度问题展开。整栋建筑分为两层,且基于不同的使用功能、场景和需求,划分出私人和社交娱乐等不同区域。住宅外部的间隙和庭院不仅能为社交提... 详细信息

该住宅坐落于葡萄牙北部古城吉马良斯郊外,场地周边建筑密集。该项目直接围绕场地的私密性和高度问题展开。整栋建筑分为两层,且基于不同的使用功能、场景和需求,划分出私人和社交娱乐等不同区域。住宅外部的间隙和庭院不仅能为社交提供场地,还能在窗框完全打开时扩展房屋的居住面积,建立起一种更为多元化的内外部空间关系。私人区域的特别之处在于其所处的独特下沉位置。由于被挡土墙所环绕,住宅的环境也显得格外清幽。其中一堵有着几何状穿孔的隔墙被打造成一个开口,以通向地势较高的外部区域,使得周围环境的光影关系变得可控。围墙从地下车库开始,经过泳池,勾勒出整个建筑的外部轮廓。覆盖着呈斜线状排列的木材的屋顶体块,就像一个为住户遮风挡雨的巨型巢穴。混凝土和木材在灰色阴影下融合,呈现出一种细微的动态视觉效果。

关键词：地下车库周围环境私密性挡土墙住宅遮风挡雨外部区域泳池

Distributed phase-matching measurement for dynamic strain and temperature sensing based on stimulated Brillouin scattering enhanced four-wave mixing

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Photonics Research 2024年第1期12卷 141-153页

作者： YUAN WANG pedro TOVAR JUNTONG YANG LIANG CHEN XIAOYI BAO Nexus for Quantum Technologies University of OttawaOttawaOntario K1N 6N5Canada

A Brillouin dynamic grating(BDG) can be used for distributed birefringence measurement in optical fibers,offering high sensitivity and spatial resolution for sensing ***,it is quite a challenge to simultaneously achieve dynamic measurements with both high accuracy and high spatial *** this work,we propose a sensing mechanism to achieve distributed phase-matching measurement using a chirped pulse as a probe *** BDG reflection,the peak reflection corresponds to the highest four-wave mixing(FWM) conversion efficiency,and it requires the Brillouin frequency in the fast and slow axes to be equal,which is called the phase-matching *** condition changes at different fiber positions,which requires a range of frequency injection for the probe *** proposed method uses a chirped pulse as a probe wave to cover this frequency range associated with distributed birefringence *** allows us to detect distributed phase matching for birefringence changes that are introduced by temperature and strain *** to the single shot and direct time delay measurement capability,the acquisition rate in our system is only limited by the fiber ***,unlike conventional BDG spectrum recovery-based systems,the spatial resolution here is determined by both the frequency chirping rate of the probe pulse and the birefringence profile of the *** the experiments,an acquisition rate of 1 k Hz(up to fiber length limits) and a spatial resolution of 10 cm using a 20 ns probe pulse width are *** minimum detectable temperature and strain variation are 5.6 mK and 0.37 με along a 2 km long polarization-maintaining fiber(PMF).

关键词： fiber scattering polarization

Inversion of walkaway VSP data in the presence of lateral velocity heterogeneity

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Energy Geoscience

Energy Geoscience 2024年第2期5卷 304-313页

作者： Vladimir Grechka Ilya Tsvankin pedro Contreras CWP Department of GeophysicsColorado School of MinesGoldenCO80401USA PDVSA-INTEVEP Apartado 76343Caracas1070AVenezuela Borehole Seismic LLC USA Department of Physics ULAVenezuela

Multi-azimuth walkaway vertical seismic profiling is an established technique for the estimation of in situ slowness surfaces and inferring anisotropy ***,this technique requires the assumption of lateral homogeneity,which makes the horizontal slowness components at depths of downhole receivers equal to those measured at the *** violations of this assumption,such as lateral heterogeneity or nonzero dip of intermediate interfaces,lead to distortions in reconstructed slowness surfaces and,consequently,to errors in estimated anisotropic *** this work,we relax the assumption of lateral homogeneity and discuss how to correct vertical seismic profile data for weak lateral *** describe a procedure of downward continuation of recorded traveltimes that accounts for the presence of both vertical inhomogeneity and weak lateral heterogeneity,which produces correct slowness surfaces at depths of downhole receivers,noticing that sufficiently dense receiver coverage along a borehole is required to separate influences of vertical and lateral heterogeneity on measured traveltimes and obtain accurate estimates of the slowness *** the slowness surfaces are found and a desired type of anisotropic model to be inverted is selected,the corresponding anisotropic parameters,providing the best fit to the estimated slownesses,can be *** invert the slowness surfaces of P-waves for parameters of the simplest anisotropic model describing dipping fractures(transversely isotropic medium with a tilted symmetry axis).Five parameters of this model,namely,the P-wave velocity V0 in the direction of the symmetry axis,Thomsen's anisotropic coefficients e and d,the tilt n,and the azimuth b of the symmetry axis,can be estimated in a stable manner when maximum source offset is greater than half of receiver depth.

关键词： Walkaway vertical seismic profile Lateral velocity heterogeneity Anisotropic parameter estimation Vertical inhomogeneity