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Body mass index is not associated with sperm-zona pellucida binding ability in subfertile males

Asian Journal of Andrology 2013年第5期15卷 626-629页

作者： Nathalie Sermondade Charlotte Dupont Celine Faure marouane boubaya Isabelle Cedrin-Durnerin Pascale Chavatte-Palmer Christophe Sifer Rachel Levy Service d'Histologie-Embryologie-Cytogenetique-Biologie de la Reproduction-CECOS Hopital Jean Verdier (AP-HP) HUPSSD Bondy 93143 France INSERM U557 INRA U 1125 CNAM EA3200 Univ Paris 13 CRNH IdF Unite de Recherche en Epidemiologie Nutritionnelle Bobigny 93017 France INRA UMR1198 Biologie du Developpement et Reproduction Jouy-en-Josas 78352 France Unite de Recherche Clinique Hopital Avicenne Bobigny 93009 France Service d'Assistance Medicale a la Procreation Hopital Jean Verdier (AP-HP) Bondy 93143 France

Lifestyle factors, such as weight and nutritional status may affect male fertility, including sperm fertilization ability. The objective of this retrospective study was to evaluate the association between body mass index （BMI） and sperm-zona pellucida binding ability assessed according to the zona binding （ZB） test, which has been described to be a relevant diagnostic tool for the prediction of in vitro fertilization （IVF） ability. Three hundred and six male patients from couples diagnosed with primary idiopathic or mild male factor infertility were included. Correlations between BMI and semen parameters according to ZB test indices were assessed, together with frequencies of positive and negative tests across the BMI categories. In this selected population, BMI was not related to conventional semen parameters or sperm quality assessed according to the ability of spermatozoa to bind to the zona pellucida. The previously described poor outcomes of IVF procedures in cases of male obesity could be due to other sperm defects, such as alterations of sperm capacitation or acrosome reaction. The link between male BMI and biological outcomes during IVF procedures, such as fertilization rates, should be further evaluated.

关键词： body mass index (BMI) fertilization ability obesity semen quality zona binding test

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Obesity leads to higher risk of sperm DNA damage in infertile patients

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Asian Journal of Andrology 2013年第5期15卷 622-625页

作者： Charlotte Dupont Celine Fauret Nathalie Sermondade marouane boubaya Florence Eustache Patrice Clement Pascal Briot Isabelle Berthaut Vincent Levy Isabelle Cedrin-Durnerin Brigitte Benzacken Pascale Chavatte-Palmer Rachel Levy AP-H P Jean Verdier hospital Reproductive Biology unit-CECOS F-93140 Bondy France paris 13 University Sorbonne Paris Cite Nutritional epidemiology unit (UREN U M R U557 Inserm Ul125 Inra Cnam CRNH IdF) F-93017 Bobigny France INRA UMR1198 Biologie du Developpement et Reproduction (Biology of Reproductive and development unit) F-78352 Jouy en Josas France ENVA veterinary school F-94704 Maisons-Alfort France AP-HP Avicenne hospital Clinical research unit F-93000 Bobigny France Clement laboratory Laboratoire Clement F-93150 Le Blanc Mesnil France American hospital of Paris Reproductive Biology unit F-92200 Neuilly sur seine France AP-HP Tenon hospital Reproductive Biology unit-CECOS F-75020 Paris France AP-HP Jean Verdier hospital Reproductive medicine unit Paris 13 University F-93140 Bondv. France

There has been a growing interest over the past few years in the impact of male nutrition on fertility. Infertility has been linked to male overweight or obesity, and conventional semen parameter values seem to be altered in case of high body mass index （BMI）. A few studies assessing the impact of BMI on sperm DNA integrity have been published, but they did not lead to a strong consensus. Our objective was to explore further the relationship between sperm DNA integrity and BMI, through a 3-year multicentre study. Three hundred and thirty male partners in subfertile couples were included. Using the terminal uridine nick-end labelling （TUNEL） assay, we observed an increased rate of sDerm DNA damage in obese men （odds ratio （95% confidence interval）： 2.5 （1.2-5.1））.

关键词： male infertility obesity overweight sperm sperm DNA fragmentation

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Application of Microgravimetry to Assessing Collapse Risk in Carbonate Sinkhole Areas, Cheria Basin, Northeast of Algeria

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Journal of Life Sciences 2017年第5期11卷 232-248页

作者： BOUHLASSA Saddek FEHDI Chemseddine boubaya Djamel Department of Geology Larbi Tebessi University Tebessa 12002 Algeria

This study presents the results and the interpretation of a microgravity survey realized in the MChentel zone near Cheria tone situated in the Northeast Algerian. The microgravity survey, made during April and March, 2016, allowed the obtaining of 614 measures distributed on the whole zone of study. The gravimetric data were measured by means of a gravimeter relative GNU-KC 444 were used with location and the height of stations with centimetric precision by pocket GPS and an electronic theodolite type Qeo FET 420 k. The gravimetric data measured on the ground were connected with a reference gravimetric station situated near the zone of study. On the scale of the zone of study, the gravimetric data show a decrease of the values of the anomaly of Bouguer between both collapses. This trend implies probably an effect of karstification which would explain the decrease of the values of the anomaly of Bouguer by going to the center of the studied zone. The interpretation of gravimetric data shows the presence essentially of two negative zones, they present a deficit of in-depth mass which can be 30 meters.

关键词： Microgravity survey MChentel Bouguer anomaly.

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