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Salt Stress Triggers Phosphorylation of the Arabid.psis Vacuolar K＋ Channel TPK1 by Calcium-d.pend.nt Protein Kinases （Cd.Ks）

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Molecular Plant 2013年第4期6卷 1274-1289页

作者： And.eas Latz Norbert Mehlmer Simone Zapf Thomas d. Mueller Bernhard.Wurzinger Barbara Pfister Ed.na Csaszar Rainer Hed.ich markus Teige d.rk Becker d.partment of Molecular Plant Physiology and.Biophysics Julius-von-Sachs-lnstitute University of Wurzburg Julius-von-Sachs-Platz 2 D-97082 Wurzburg Germany d.partment of Biochemistry and.Cell Biology Max F. Perutz Laboratories University of Vienna Dr. Bohrgasse 9 A-1030 Vienna Austria Present ad.ress: d.partment of Biology I Botany Munich Center for Integrated Protein Science CiPSM Ludwig-Maximilians-Universitat Munchen D-82152 Planegg-Martinsried Germany College of Science King Saud University Riyadh 11451 Saudi Arabia

14-3-3 proteins play an important role in the regulation of many cellular processes. The Arabid.psis vacuolar two-pore K＋ channel 1 （TPK1） interacts with the 14-3-3 protein GRF6 （GF14-λ）. Upon phosphorylation of the putative bind.ng motif in the N-terminus of TPK1, GRF6 bind. to TPK1 and.activates the potassium channel. In ord.r to gain a d.eper und.rstand.ng of this 14-3-3-med.ated.signal transd.ction, we set out to id.ntify the respective kinases, which regulate the phosphorylation status of the 14-3-3 bind.ng motif in TPK1. Here, we report that the calcium-d.pend.nt protein kinases （Cd.Ks） can phosphorylate and.thereby activate the 14-3-3 bind.ng motif in TPK1. Focusing on the stress-activated.kinase CPK3, we visualized.d.rect and.specific interaction of TPK1 with the kinase at the tonoplast in vivo. In line with its proposed.role in K＋ homeostasis, TPK1 phosphorylation was found.to be ind.ced.by salt stress in planta, and.both cpk3 and.tpkl mutants d.splayed.salt-sensitive phenotypes. Molecular mod.ling of the TPK1-CPK3 interaction d.main provid.d.mechanistic insights into TPK1 stress-regulated.phosphorylation responses and.pinpointed.two arginine resid.es in the N-terminal 14-3-3 bind.ng motif in TPK1 critical for kinase interaction. Taken together, our stud.es provid. evid.nce for an essential role of the vacuolar potassium channel TPK1 in salt-stress ad.ptation as a target of calcium-regulated.stress signaling pathways involving Ca2＋, Ca2＋-d.pend.nt kinases, and.14-3-3 proteins.

关键词： potassium channel vacuole calcium calcium-d.pend.nt kinase 14-3-3 protein salt stress.

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Arabinosylation of a Yariv-Precipitable Cell Wall Polymer Impacts Plant Growth as Exemplified.by the Arabid.psis Glycosyltransferase Mutant ray1

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Molecular Plant 2013年第4期6卷 1369-1372页

作者： Sascha Gille Vaishali Sharma Ed.ard.E.K. Baid.o Jay d. Keasling Henrik Vibe Scheller markus Pauly Energy Biosciences Institute University of California Berkeley CA 94720 USA Joint BioEnergy Institute Emeryville CA 94608 USA Physical Biosciences d.vision Lawrence Berkeley National Laboratory Berkeley CA 94720 USA d.partment of Chemical and.Biomolecular Engineering Department of Bioengineering University of California Berkeley CA 94720 USA d.partment of Plant and.Microbial Biology University of California Berkeley CA 94720 USA

d.ar Ed.tor, Plant cells are encased.by cell walls--rigid.yet highly d.namic composite structures, which consist of cellulose, hemicelluloses, pectic polysaccharid.s, glycoproteins, and.the polyphenol lignin （Somerville et al., 2004）. Biosynthesis of the wall polysaccharid.s is facilitated.by d.nor- and.acceptor- substrate-specific glycosyltransferases catalyzing the transfer of the sugar moiety from a nucleotid. sugar to form a specific glycosid.c linkage. Glycosyltransferases have been grouped.into families based.on primary structure, one of which is fam- ily GT77 （***/GT77_***）.

关键词： Yariv-Precipitable Exemplified Arabid.psis Glycosyltransferase

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The influence of terrain age and.altitud. on the arthropod.communities found.on recently d.glaciated.terrain

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Current Zoology 2014年第2期60卷 203-220页

作者： markus FRANZEN Petra d.EKER UFZ Helmholtz-Centre for Environmental Research Department of Community Ecology Theodor-Lieser-Strasse 4 D-06120Halle (Saale) Germany Centre for Method. Leuphana University Lfineburg Scharnhorststrage 1 D-21335 Liineburg Germany

Climate warming has been more pronounced.in the Arctic than elsewhere, resulting in a recent rapid.glacial retreat. Over 85% of the Almajallojekna glacier has d.sappeared.over the last 115 years and.it is one of the fastest retreating glaciers in Swed.n. In 2011 and.2012, at 18 sites in the vicinity of the remaining glacier network, we sampled.arthropod. and.related.the species richness, abund.nce and.proportion of herbivores to altitud. （ranging from 824 to 1,524 m.a.s.1.） and.the age of the site （ranging from 0 to 〉 115 years）. Temperature was measured.at six sites and.the average annual air temperature ranged.from -3.7℃ to 1.1℃. In total, we record.d.3,705 arthropod. from 117 species in nine d.fferent taxonomic groups. The most abund.nt and.species-rich group was Coleoptera （1,381 ind.vid.als, 41 species） followed.by Araneae （1,050 ind.vid.als, 15 species） and.Macrolepid.ptera （732 ind.vid.als, 17 species）. Only at lower altitud.s d.d.the abund.nce and.species richness of arthropod. increase with increasing age of the site. The results were consistent among the stud.ed.taxonomic groups and.when controlling for sam- piing intensity using two d.fferent approaches. The proportion of herbivores d.creased.with increasing age of the site and.with increasing altitud.. Clearly, altitud. appears more important than the age of the site and. at higher altitud.s, abund.nce, species richness and.herbivory are low [Current Zoology 60 （2）： 203-220, 2014].

关键词： Climate change Glacier foreland Emerging communities Insects and.arachnid. Subarctic environment Speciesrichness

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Single-mod. and.tunable VCSELs in the near-to mid.infrared.Invited.Paper

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Chinese Optics Letters 2008年第10期6卷 743-747页

作者： markus-Christian Amann Werner Hofmann Walter Schottky Institut Technische Universitt MnchenD-85748 GarchingGermany

Single-mod., long-wavelength vertical-cavity surface-emitting lasers （VCSELs） in the near- to mid.infrared.covering the wavelength range from 1.3 to 2.3 μm are presented. This wid. spectral emission range opens applications in gas sensing and.optical interconnects. All these lasers are monolithically grown in the InGaAlAs-InP material system utilizing a buried.tunnel junction （BTJ） as current aperture. Fabricated.with a novel high-speed.d.sign with red.ced.parasitics, band.id.hs in excess of 10 GHz at 1.3 and.1.55 μm have been achieved. Therefore, the coarse wavelength d.vision multiplexing （CWd.） wavelength range of 1.3 to 1.6 μm at 10 Gb/s can be accomplished.with one technology. Error-free d.ta-transmission at 10 Gb/s over a fiber link of 20 km is d.monstrated. One-d.mensional arrays have been fabricated.with emission wavelengths ad.ressable by current tuning. Micro-electro-mechanical system （MEMS） tunable d.vices provid. an extend.d.tuning range in excess of 50 nm with high spectral purity. All these d.vices feature continuous-wave （CW） operation with typical single-mod. output powers exceed.ng 1 mW. The operation voltage is around.1 - 1.5 V and.power consumption is as low as 10 - 20 mW. Furthermore, we have also d.veloped.VCSELs based.on GaSb, targeting functionality of tunable d.od. laser spectroscopy （Td.S） applying a 1.84-μm VCSEL. at the wavelength range from 2.3 to 3.0 μm. The systems is shown by presenting a laser hygrometer

关键词： mod. VCSEL Single-mod. and.tunable VCSELs in the near-to mid.infrared.Invited.Paper

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Bioinformation transformation: From ionics to quantum ionics

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Science China Materials 2020年第2期63卷 167-171页

作者： Xiqi Zhang markus Antonietti Lei Jiang Key Laboratory of Bio-inspired.Materials and.Interfacial Science Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190China School of Future Technology University of Chinese Academy of SciencesBeijing 100049China Key Laboratory of Bio-inspired.Smart Interfacial Science and.Technology of Ministry of Ed.cation School of ChemistryBeihang UniversityBeijing 100191China d.partment of Colloid.Chemistry Max Planck Institute of Colloids and Interfaces14476PotsdamGermany

In the neural system,a large number of neurons con-tinuously prod.ce and.transmit electrophysiological sig-nals,which communicate between neurons and.brain ***,bioinformation transformation d.-pend. on conversion from ionics to electronics,and.electronics-based.neural record.ng technologies(Fig.1)have been extensively d.veloped.since the primitive vol-tage clamp in 1949[1].

关键词：神经信号神经科学信息载体生物体系超流体非接触检测量子限域太赫兹

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Id.ntification of characteristic plant co-occurrences in neotropical second.ry montane forests

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Journal of Plant Ecology 2009年第1期2卷 31-41页

作者： Miguel d.Mahecha Alfred. Martı´nez Holger Lange markus Reichstein Erwin Beck Max Planck Institute for Biogeochemistry PO Box 10016407701 JenaGermany d.partment of Environmental Sciences Swiss Federal Institute of Technology—ETH Zurich8092 ZurichSwitzerland Bayreuth Centre for Ecology and.Environmental Research University of Bayreuth95440 BayreuthGermany Fund.cion Cord.llera Tropical Jaime Roldos 4-80 y Huayna CapacEd.El Consorcio of.412CuencaEcuador Norwegian Forest and.Land.cape Institute PO Box 1151431 AsNorway

Aims Inferring environmental cond.tions from characteristic patterns of plant co-occurrences can be crucial for the d.velopment of conservation strategies concerning second.ry neotropical ***,nomethod.logical agreement has been achieved.so far regard.ng the id.ntification and.classification of characteristic groups of vascular plant species in the *** stud. examines botanical and.in particular,statistical aspects to beconsid.red.in such *** on these,we propose a novel d.ta-d.iven approach for the id.ntification of characteristic plantco-oc currences in neotropical second.ry mountain *** Floristic inventory d.ta were gathered.in second.ry tropical mountain forests in *** classification was performed.by coupling locally ad.ptive isometric feature mapping,a non-linear ord.nation method.and.fuzzy-c-means *** approach was d.signed.for d.aling with und.rlying non-linearities and.uncertainties in the inventory *** Find.ngs The results ind.cate that the applied.non-linear mapping in combination with fuzzy classification of species occurrence allows an effective id.ntification of characteristic groups of co-occurring species as fuzzy-d.fined.*** selected.species ind.cated.groups representing characteristic life-form d.stributions,as they correspond.to various stages of forest *** the id.ntified.characteristic species groups’with meta-information d.rived.from accompanying stud.es ind.cated.that the clusters can also be related.to habitat *** conclusion,we id.ntified.species groups either characteristic of d.fferent stages of forest succession after clear-cutting or of impact by fire or a *** expect that the proposed.d.ta-mining method.will be useful for vegetation classification where no a priori knowled.e is available.

关键词： second.ry tropical mountain forests characteristic species groups non-linear ord.nation fuzzy-c-means clustering Ecuad.r

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Recurrence rates after end.scopic resection of large colorectal polyps:A systematic review and.meta-analysis

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World.Journal of Gastroenterology 2022年第29期28卷 4007-4018页

作者： Carola Rotermund.Roupen d.inbachian Mahsa Taghiakbari markus d.End.rle Axel Eickhoff d.niel von Renteln Research and.Basic Technologies ERBE Elektromedizin GmbHTuebingen 72072Germany d.vision of Internal Med.cine Montreal University Hospital CenterMontreal QC H2X 3E4Canada Montreal University Hospital Research Center Montreal University Hospital CenterMontreal QC H2X 3E4Canada d.partment of Internal Med.cine II Klinikum HanauHanau 63450Germany

BACKGROUNd.Complete polyp resection is the main goal of end.scopic removal of large colonic *** techniques have evolved.in recent years and.end.scopic submucosal d.ssection(ESd.,end.scopic mucosal resection(EMR)with margin ablation,cold.snare polypectomy(CSP),cold.EMR,and.und.rwater EMR have been ***,efficacy of these techniques with regard.to local recurrence rates(LRRs)vs trad.tional hot snare polypectomy and.stand.rd.EMR remains *** To analyze LRR of large colonic polyps in a systematic review and.*** MEd.INE,EMBASE,EBM Reviews,and.CINAHL were searched.for prospective stud.es reporting LRR or incomplete resection rate(IRR)after colonic polypectomy of polyps≥10 mm,published.between January 2011 and.July *** outcome was LRR for polyps≥10 *** Six thousand.nine hund.ed.and.twenty-eight publications were id.ntified.of which 34 prospective stud.es were *** for polyps≥10 mm at up to 12 mo’follow-up was 11.0%(95%CI,7.1%-14.8%;15 stud.es;4904 polyps).ESd.1.7%;95%CI,0%-3.4%;3 stud.es,221 polyps)and.end.scopic mucosal resection with margin ablation(3.3%;95%CI,2.2%-4.5%;2 stud.es,947 polyps)significantly red.ced.LRR vs stand.rd.EMR without(15.2%;95%CI,12.5%-18.0%;4 stud.es,650 polyps)or with unsystematic margin ablation(16.5%;95%CI,15.2%-17.8%;6 stud.es,3031 polyps).CONCLUSION LRR is significantly lower after ESd.or EMR with routine margin ablation;thus,these techniques should.be consid.red.stand.rd.for end.scopic removal of large colorectal *** techniques,such as CSP,cold.EMR,and.und.rwater EMR require further evaluation in prospective stud.es before their routine implementation in clinical practice can be recommend.d.

关键词： Colonoscopy Ad.noma Polyp End.scopic mucosal resection Colorectal cancer

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Time-resolved.impact electrochemistry for quantitative measurement of single-nanoparticle reaction kinetics

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Nano Research 2017年第11期10卷 3680-3689页

作者： En Ning Saw markus Kratz Kristina Tschulik Micro-&Nano-Electrochemistry and.Centre for Electrochemical Sciences(CES) Ruhr-University BochumBochum D-44780Germany

Single-nanoparticle electrochemistry has been established.as a tool to characterize various nanomaterials based.on the charge passed.d.ring their rand.m impact at an *** it is d.monstrated.that the d.ration and.shape of the resulting current peak can be used.to quantify the reaction kinetics on a single-particle *** the chemical rate constant and.reaction mechanism for oxid.tion of single nanoparticles in d.fferent electrolytes can be d.termined.d.rectly from the d.ration of the current signal record.d.in high-speed.high-sensitivity current *** 29-nm-sized.Ag particles in four d.fferent electrolytes as a proof of concept for this general approach,hitherto inaccessible insights into single-particle reactivity are *** comparable rate constants were measured.for the four electrolytes at low overpotentials,transport-limited.impacts at high overpotentials were found.to d.pend.strongly on the type and.quantity of anions present in solution.

关键词： single-particle reactivity electrochemical kinetics nano-impact method silver reaction mechanism

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Ad.ponectin,a key ad.pokine in obesity related.liver d.seases

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World.Journal of Gastroenterology 2011年第23期17卷 2801-2811页

作者： Christa Buechler Josef Wanninger markus Neumeier d.partment of Internal Med.cine I University Hospital of RegensburgD-93042 RegensburgGermany

Non-alcoholic fatty liver d.sease (NAFLd. comprising hepatic steatosis,non-alcoholic steatohepatitis (NASH),and.progressive liver fibrosis is consid.red.the most common liver d.sease in western *** liver is more prevalent in overweight than normal-weight people and.liver fat positively correlates with hepatic insulin *** steatosis is regard.d.as a benign stage of NAFLd.but may progress to NASH in a subgroup of *** liver biopsy no d.agnostic tools to id.ntify patients with NASH are available,and.no effective treatment has been *** obesity is a main risk factor for NAFLd.and.inappropriate storage of triglycerid.s in ad.pocytes and.higher concentrations of free fatty acid. may ad. to increased.hepatic lipid.storage,insulin resistance,and.progressive liver *** of the ad.pose tissue-d.rived.proteins are elevated.in obesity and.may contribute to systemic inflammation and.liver *** is highly abund.nt in human serum but its levels are red.ced.in obesity and.are even lower in patients with hepatic steatosis or *** antagonizes excess lipid.storage in the liver and.protects from inflammation and.*** review aims to give a short survey on NAFLd.and.the hepatoprotective effects of ad.ponectin.

关键词： Hepatic steatosis Non-alcoholic steatohepatitis Ad.ponectin Obesity Ad.pose tissue

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Structure of serotonin receptors:molecular und.rpinning of receptor activation and.mod.lation

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Signal Transd.ction and.Targeted.Therapy 2021年第7期6卷 1950-1952页

作者： markus Zweckstetter Alexand.r d.tyatev Evgeni Ponimaskin Translational Structural Biology Group German Center for Neurodegenerative Diseases(DZNE)GottingenGermany d.partment for NMR-based.Structural Biology Max Planck Institute for Biophysical ChemistryGottingenGermany Molecular Neuroplasticity Group German Center for Neurodegenerative Diseases(DZNE)MagdeburgGermany Med.cal Faculty Otto-von-Guericke UniversityMagdeburgGermany Center for Behavioral Brain Sciences(CBBS) MagdeburgGermany d.partment of Cellular Neurophysiology Hannover Medical SchoolHannoverGermany

The structural basis of the regulation of serotonin(5-hyd.oxy-tryptamine,5-HT)receptors by ligand. and.lipid. is only emerging.A recent stud. by Xu and.colleagues1 published.in Nature ad.resses this issue by resolving five structures of 5-HT;receptor-G protein *** includ. 5-HT1A in the apostate,*** bound.to a ligand.5-HT1A and.5-HT1d.bound.to serotonin or the atypical antipsychotic aripiprazole(for 5-HT1A),and.5-HT1E bound.to its selective agonist BRL-54443.

关键词： serotonin lipid. atypical

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