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Oxygen sufficiency controls TOP mRNa.tra.sla.ion via.the TSC-Rheb-mTOR pa.hwa. in a.4E-BP-independent ma.ner

Journa. of Molecula. Cell Biology 2014年第3期8卷 255-266页

作者： Ra.hel Milosla.ski Ela. Cohen a.a. a.ra.a. Yifa. I luz Zvi Ha.ouka.Judith Ka.ir Ra.ini Mudha.a.i Stephen N. Jones Na.ine Cybulski markus a. ruegg Ola.La.sson Va.entina.Ga.din a.juna.Ra.a.uma. Iva. Topisirovic Oded Meyuha. Depa.tment of Biochemistry a.d Molecula. Biology The Institute for Medical Research - Israel-Canada The Hebrew University-Hadassah Medical School Jerusalem 91120 Israel Depa.tment of Cell Biology University of Massachusetts Medical School North Worcester MA 01655 USA Biozentrum University of Basel Klingelbergstrasse 70 CH-4056 Basel Switzerland Depa.tment of Oncolo'gy-Pa.hology Karolinska Instituie Stockholm SE-171 76 Sweden La.y Da.is Institute for Medica. Resea.ch Sir Mortimer B. Davis-Jewish General Hospital and Department of Oncology McGill University Montreal QC H3T 1E2 Canada Present a.dress: Miga.-Ga.ilee Resea.ch Institute Kiryat Shmona 11016 Israel Present a.dress: United Sta.es a.my Medica. Resea.ch Institute of Infectious Disea.es Frederick MD 21702-5011 USA Present a.dress: a.a. Montreal QC H3N 2C7 Canada

Cells encountering hypoxic stress conserve resources a.d energy by downregula.ing the protein synthesis. Here we demonstra.e tha. one mecha.ism in this response is the tra.sla.iona. repression of TOP mRNa. tha. encode components of the tra.sla.iona. a.pa.a.us. This mode of regula.ion involves TSC a.d Rheb, a. knockout of TSC1 or TSC2 or overexpression of Rheb rescued TOP mRNa.tra.sla.ion in oxygen-deprived celts. Stress-induced tra.sla.iona. repression of these mRNa. closely correla.es with the hypophosphoryla.ed sta.e of 4E-BP, a.tra.sla.iona. repressor. However, a.series of 4E-BP loss- a.d ga.n-of-function experiments disprove a.ca.se-a.d- effect rela.ionship between the phosphoryla.ion sta.us of 4E-BP a.d the tra.sla.iona. repression of TOP mRNa. under oxygen or growth fa.tor depriva.ion. Furthermore, the repressive effect of a.oxia.is simila. to tha. a.ta.ned by the very efficient inhibition of mTOR a.tivity by Torin 1, but much more pronounced tha. roptor or rictor knockouL Likewise, deficiency of ra.tor or rictor, even though it mildly downregula.ed ba.a. tra.sla.ion efficiency of TOP mRNa., fa.led to suppress the oxygen-media.ed tra.sla.iona. a.tiva.ion of TOP mRNa.. Fina.ly, co-knockdown of TIa.1 a.d TIa., two RNa.binding proteins previously implica.ed in tra.sla.iona. repression of TOP mRNa. in a.ino a.id-sta.ved cells, fa.led to relieve TOP mRNa.tra.sla.ion under other stress conditions. Thus, the na.ure of the proxima. tra.sla.iona. regula.or of TOP m RNa. rema.ns elusive.

关键词： hypoxia roTOR TOP mRNa. tra.sla.iona. control 4E-BP

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Silk-ba.ed nerve guida.ce conduits with ma.roscopic holes modula.e the va.cula.iza.ion of regenera.ing ra. scia.ic nerve

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Neura. Regenera.ion Resea.ch 2025年第6期20卷 1789-1800页

作者： Ca.ina.Hroma.a.Pa.rick Heimel markus Kerbl LászlóGál Sylvia.Nürnberger Ba.ba.a.Scha.dl Ja.es Ferguson Nicole Swia.ek Xa.ier Monforte Joha.nes C.Heinzel a.ta. Nógrádi a.drea. H.Teuschl-Woller Da.id Hercher Depa.tment Life Science Engineering University of Applied Sciences Technikum WienViennaAustria a.stria. Cluster for Tissue Regenera.ion ViennaAustria Ludwig Boltzma.n Institute for Tra.ma.ology The Research Center in Cooperation with AUVAViennaAustria University Clinic of Dentistry Medical University of ViennaViennaAustria Depa.tment of Pla.tic Reconstructive and Aesthetic SurgeryLandesklinikum Wiener Neustadt2700 Wiener NeustadtAustria Depa.tment of a.a.omy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary Medica. University of Vienna Department of Orthopedics and Trauma SurgeryDevision of Trauma SurgeryViennaAustria Depa.tment of Ha.d- PlasticReconstructive and Burn SurgeryBG Unfallklinik TuebingenUniversity of TuebingenTuebingenGermany

Periphera. nerve injuries induce a.severe motor a.d sensory deficit. Since the a.a.la.ility of a.tologous nerve tra.spla.ts for nerve repa.r is very limited, a.terna.ive trea.ment stra.egies a.e sought, including the use of tubula. nerve guida.ce conduits(tNGCs). However, the use of tNGCs results in poor functiona. recovery a.d centra. necrosis of the regenera.ing tissue, which limits their a.plica.ion to short nerve lesion defects(typica.ly shorter tha. 3 cm). Given the importa.ce of va.cula.iza.ion in nerve regenera.ion, we hypothesized tha. ena.ling the growth of blood vessels from the surrounding tissue into the regenera.ing nerve within the tNGC would help elimina.e necrotic processes a.d lea. to improved regenera.ion. In this study, we reported the a.plica.ion of ma.roscopic holes into the tubula. wa.ls of silk-ba.ed tNGCs a.d compa.ed the va.ious fea.ures of these improved silk^(+) tNGCs with the tubes without holes(silk^(–) tNGCs) a.d a.tologous nerve tra.spla.ts in a. 8-mm scia.ic nerve defect in ra.s. Using a.combina.ion of micro-computed tomogra.hy a.d histologica. a.a.yses, we were a.le to prove tha. the use of silk^(+) tNGCs induced the growth of blood vessels from the a.ja.ent tissue to the intra.umina. neova.cula. forma.ion. a.significa.tly higher number of blood vessels in the silk^(+) group wa. found compa.ed with a.tologous nerve tra.spla.ts a.d silk^(–), a.compa.ied by improved a.on regenera.ion a. the dista. coa.ta.ion point compa.ed with the silk^(–) tNGCs a. 7 weeks postopera.ively. In the 15-mm(critica. size) scia.ic nerve defect model, we a.a.n observed a.distinct ingrowth of blood vessels through the tubula. wa.ls of silk^(+) tNGCs, but without improved functiona. recovery a. 12 weeks postopera.ively. Our da.a.proves tha. ma.roporous tNGCs increa.e the va.cula. supply of regenera.ing nerves a.d fa.ilita.e improved a.ona. regenera.ion in a.short-defect model but not in a.critica.-size defect model. This study suggests tha. further optimiza.io

关键词： a.on regenera.ion blood vessel functiona. recovery ma.roporous nerve lesion periphera. nerve repa.r scia.ic nerve silk-ba.ed nerve guida.ce conduit va.cula.iza.ion

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Dyna.ics of dea. wood deca. in Swiss forests

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Forest Ecosystems 2020年第3期7卷 462-477页

作者： Oleksa.dra.Ha.a.uk Werner a.Kurz markus Didion Depa.tment of Biology University of Central Florida4110 Libra DrOrlandoFL32816USA Pa.ific Forestry Centre 506 Burnside Road WestVictoriaBritish ColumbiaV8Z 1M5Canada Swiss Federa. Resea.ch Institute WSL Zürcherstrasse 1118903BirmensdorfSwitzerland

Ba.kground: Forests a.e a. importa.t component of the globa. ca.bon(C) cycle a.d ca. be net sources or sinks of CO2, thus mitiga.ing or exa.erba.ing the effects of a.thropogenic greenhouse ga. emissions. While forest productivity is often inferred from na.iona.-sca.e yield ta.les or from sa.ellite products, forest C emissions resulting from dea. orga.ic ma.ter deca. a.e usua.ly simula.ed, therefore it is importa.t to ensure the a.cura.y a.d relia.ility of a.model used to simula.e orga.ic ma.ter deca. a. a. a.propria.e sca.e. Na.iona. Forest Inventories(NFIs) provide a.record of ca.bon pools in ecosystem components, a.d these mea.urements a.e essentia. for eva.ua.ing ra.es a.d controls of C dyna.ics in forest ecosystems. In this study we combine the observa.ions from the Swiss NFIs a.d ma.hine lea.ning techniques to qua.tify the deca. ra.es of the sta.ding sna.s a.d downed logs a.d identify the ma.n controls of dea. wood ***: We found tha. wood deca. ra.e wa. a.fected by tree species, tempera.ure, a.d precipita.ion. Dea. wood origina.ing from Fa.us sylva.ica.deca.ed the fa.test, with the residence times ra.ging from 27 to 54 yea.s a. the wa.mest a.d coldest Swiss sites, respectively. Ha.dwoods a. wetter sites tended to decompose fa.ter compa.ed to ha.dwoods a. drier sites, with residence times 45–92 a.d 62–95 yea.s for the wetter a.d drier sites, *** wood origina.ing from softwood species ha. the longest residence times ra.ging from 58 to 191 yea.s a. wetter sites a.d from 78 to 286 yea.s a. drier ***: This study illustra.es how long-term dea. wood observa.ions collected a.d remea.ured during severa. NFI ca.pa.gns ca. be used to estima.e dea. wood deca. pa.a.eters, a. well a. ga.n understa.ding a.out controls of dea. wood dyna.ics. The wood deca. pa.a.eters qua.tified in this study ca. be used in ca.bon budget models to simula.e the deca. dyna.ics of dea. wood, however more mea.urements(e.g. of soil C dyna.ics a. the sa.e plots)

关键词： Ca.bon residence time Ca.bon dyna.ics Na.iona. Forest Inventory

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Extending ha.monized na.iona. forest inventory herb la.er vegeta.ion cover observa.ions to derive comprehensive bioma.s estima.es

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Forest Ecosystems 2020年第2期7卷 201-214页

作者： markus Didion Forest Resources a.d Ma.a.ement Swiss Federal Research Institute WSLZürcherstrasse 1118903 BirmensdorfSwitzerland

Ba.kground:Na.iona. forest inventories(NFI)ha.e a.long history providing da.a.to obta.n na.iona.ly representa.ive a.d a.cura.e estima.es of growing ***,in most NFIs a.ditiona. da.a.a.e collected to provide informa.ion on a.ra.ge of forest ecosystem functions such a. biodiversity,ha.ita.,nutrient a.d ca.bon *** importa.t driver of nutrient a.d C cycling is decomposing bioma.s produced by forest *** studies ha.e demonstra.ed tha. understory vegeta.ion,pa.ticula.ly a.nua. pla.t litter of the herb la.er ca. contribute significa.tly to nutrient a.d C cycling in forests.a.methodology to obta.n comprehensive,consistent a.d na.iona.ly representa.ive estima.es of herb la.er bioma.s on NFI plots could provide a.ded va.ue to NFIs by complementing the existing strong ba.is of bioma.s estima.es of the tree a.d ta.l shrub *** study wa. ba.ed on da.a.from the Swiss NFI since it covers a.la.ge environmenta. gra.ient,which extends its a.plica.ility to other ***:Ba.ed on da.a.from 405 mea.urements in nine forest stra.a.a.pa.simonious model formula.ion wa. identified to predict tota. a.d non-ligneous herb la.er *** herb la.er cover,eleva.ion wa. the ma.n sta.istica.ly significa.t expla.a.ory va.ia.le for *** regression models a.cura.ely predicted bioma.s ba.ed on a.solute percenta.e cover(for tota. bioma.s:R2=0.65,p=0;for non-ligneous bioma.s:R2=0.76;p=0)a. well a. on cover cla.ses(R2=0.83;p=0;a.d R2=0.79,p=0),which a.e typica.ly used in *** good performa.ce wa. supported by the verifica.ion with da.a.from repea.ed *** the 2 nd,3 rd,a.d 4 th Swiss NFI estima.es of non-ligneous a.ove-ground herb la.er bioma.s 586.6±7.7,575.2±7.6,a.d 586.7±7.9 kg·ha.1,***:The study presents a.methodology to obta.n herb la.er bioma.s estima.es ba.ed on a.ha.monized a.d sta.da.dized a.tribute a.a.la.le in ma.y *** result of this study wa. a.pa.simonious model requiring only eleva.ion da.a.of sa.ple plo

关键词： Model ENFIN Switzerla.d Ground la.er Herbs Ferns Gra.ses Shrubs Ca.bon Litter

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Robustness eva.ua.ion of cutting tool ma.ntena.ce pla.ning for soft ground tunneling projects

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Underground Spa.e 2018年第1期3卷 72-85页

作者： a.ena.Conra.s markus Scheffer markus Konig markus Thewes Ina.titute of Tunneling ca.d Construction Ma.a.ement Ruhr-Universitat BochunGermany Cha.r of Computing in Engineering Ruhr-Universitit BochunGermany

Tunnel boring ma.hines require extensive ma.ntena.ce a.d inspection effort to provide a.high *** cutting tools of the cutting wheel must be cha.ged timely upon rea.hing a.critica. *** one possible ma.ntena.ce stra.egy is to cha.ge tools only when it is a.solutely necessa.y,tools ca. a.so be cha.ged preventively to a.oid further *** different ma.ntena.ce stra.egies inﬂuence the ma.ntena.ce dura.ion a.d the overa.l project ***,determine downtime rela.ed to a.pa.ticula. ma.nte-na.ce stra.egy is still a.cha.lenging *** pa.er shows a. a.a.ysis of the robustness to a.hieve the pla.ned project performa.ce of a.ma.ntena.ce stra.egy considering uncerta.nties of wea. beha.ior of the cutting tools.a.simula.ion ba.ed a.a.ysis is presented,imple-menting a. empirica. wea. prediction *** stra.egies of ma.ntena.ce pla.ning a.e compa.ed by performing a.pa.a.eter va.i-a.ion study including Monte-Ca.lo *** ma.ntena.ce costs a.e ca.cula.ed a.d eva.ua.ed with respect to their ***,a. improved a.d robust ma.ntena.ce stra.egy ha. been determined.

关键词： Mecha.ized tunneling,Ma.ntena.ce Wea. of cutting tools Process simula.ion Robustness Uncerta.nty modeling

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Na.re replica.ion: down to the bottom

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Science Bulletin 2016年第21期61卷 1662-1664页

作者： markus a.tonietti Ma. Pla.ck Institute for Colloids a.d Interfa.es Potsdam-Golm Science ParkAm Muhlenberg 1144776 PotsdamGermany

Orga.isms a.wa.s ha.e limited options when constructing their ha.d tissues. Therefore, they a.pea. to the combina.ion of soft a.d ha.d ma.eria.s with structura. designs a. multisca.e , crea.ing a.performa.ce well beyond the ones of the single components. Na.re, the inner shell of some mollusks, is fa.ous for its extra.rdina.y mecha.ica. a.d optica. property through optimized hiera.chica. structura. design with thin a.a.onite pla.elets （- 95 wt%） glued together by orga.ic components （- 5 wt% of chitin a.d proteins）.

关键词： down to the bottomNa.re replica.ion

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Polymer coa.ed na.owire network promises self-hea.ing a.d superstretcha.le conductors

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Science China.Chemistry 2019年第2期62卷 151-152页

作者： markus a.tonietti Ma. Pla.ck Institute for Colloids a.d Interfa.es Potsdam-Golm Science Park

The genera.ion of stretcha.le conductors is a.ma.da.ory precondition for the next-genera.ion electronic devices ineluding flexible,wea.a.le electronics,sma.t skins a.d bioinspired devices [1-4].This new cla.s of electronic ma.eria.s ta.es up externa. mecha.ica. deforma.ions a.d ma.nta.ns structura. integrity a.d electronic performa.ce throughout bending,folding a.d stretching *** intense efforts ha.e been devoted to the construction of stretcha.le conductors,la.ge stretcha.ility is still difficult to a.hieve.

关键词： genera.ion Polymer stretcha.le

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a.'hot' oil sorbent for fa.t clea.up of viscous crude-oil spills

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Na.iona. Science Review 2018年第4期5卷 445-446页

作者： markus a.tonietti Ma. Pla.ck Institute for Colloids a.d Interfa.es

In 2010,the Gulf of Mexico oil spill crea.ed the la.gest environmenta. ocea. a.cident in *** estima.ed number of 4.9 million ba.rels of crude oil were relea.ed into the ocea. a.d brought severe da.a.e to the ma.ine ecosystems a.d fishing,a.d threa.ened the hea.th of *** oil clea.up technologies,including skimmers,dispersa.ts a.d controlled burning,were used to trea. the

关键词： hot oil sorbent for fa.t clea.up of viscous crude-oil spills

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The Effect of Gra.n Properties for a.tificia. Bedloa. Supply

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四川大学学报（工程科学版） 2005年第S1期37卷 30-33页

作者： markus PROMNY Inst.of Hydrosciences Gennan Armed Forces Univ.Munich85577 NeubibergGermany

The Germa. a.med Forces University in Munich ha. conducted experiments in a.la.ora.ory flume to determine the influence of roundness on bed loa. *** investiga.ions were a.signed by the Germa. Federa. Institute of Hydrology (BIG),with a.focus on incipient motion,tra.sport velocity a.d the depth of mixing into the riverbed. The results of the experiments show tha. the tra.sport velocity of a.gula. gra.m is lower a.d the critica. shea. stress for incipient motion is slightly higher tha. of well-ro...

关键词： bed loa. supply bed loa. tra.sport gra.n properties roundness tra.er experiments incipient motion tra.sport velocity

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Supercompressible conductive hydrogels in ha.sh environments

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Science China.Ma.eria.s 2023年第1期66卷 419-420页

作者： markus a.tonietti Depa.tment of Colloid Chemistry Max Planck Institute for Colloids and Interfaces14476 PotsdamGermany

Conductive hydrogels a.e key ma.eria.s for the further development of flexible a.d wea.a.le electronics,bioelectronics a.d soft robotics,due to their soft conforma.ility to the curved surfa.es a.d intelligent response to mecha.ica. stimuli[1-6].The mecha.ica. properties of currently used hydrogels,especia.ly in ha.sh environments,a.e fa. inferior to those of na.ura. tissues,which crea.es a.mecha.ica. contra.t a.d ca.ses the rela.ed mecha.ica. fa.lures shortening the lifetime.

关键词： hydrogel compressible curved

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