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Oxygen sufficiency controls TOP mRNa.tra.sla.ion via.the TSC-Rheb-mTOR pa.hwa. in a.4E-BP-independent ma.ner

Journa. of Molecula. Cell Biology 2014年第3期8卷 255-266页

作者： Ra.hel Milosla.ski Ela. Cohen a.a. a.ra.a. Yifa. I luz Zvi Ha.ouka.Judith Ka.ir Ra.ini Mudha.a.i Stephen N. Jones Na.ine Cybulski markus a. ruegg Ola.La.sson Va.entina.Ga.din a.juna.Ra.a.uma. Iva. Topisirovic Oded Meyuha. Depa.tment of Biochemistry a.d Molecula. Biology The Institute for Medical Research - Israel-Canada The Hebrew University-Hadassah Medical School Jerusalem 91120 Israel Depa.tment of Cell Biology University of Massachusetts Medical School North Worcester MA 01655 USA Biozentrum University of Basel Klingelbergstrasse 70 CH-4056 Basel Switzerland Depa.tment of Oncolo'gy-Pa.hology Karolinska Instituie Stockholm SE-171 76 Sweden La.y Da.is Institute for Medica. Resea.ch Sir Mortimer B. Davis-Jewish General Hospital and Department of Oncology McGill University Montreal QC H3T 1E2 Canada Present a.dress: Miga.-Ga.ilee Resea.ch Institute Kiryat Shmona 11016 Israel Present a.dress: United Sta.es a.my Medica. Resea.ch Institute of Infectious Disea.es Frederick MD 21702-5011 USA Present a.dress: a.a. Montreal QC H3N 2C7 Canada

Cells encountering hypoxic stress conserve resources a.d energy by downregula.ing the protein synthesis. Here we demonstra.e tha. one mecha.ism in this response is the tra.sla.iona. repression of TOP mRNa. tha. encode components of the tra.sla.iona. a.pa.a.us. This mode of regula.ion involves TSC a.d Rheb, a. knockout of TSC1 or TSC2 or overexpression of Rheb rescued TOP mRNa.tra.sla.ion in oxygen-deprived celts. Stress-induced tra.sla.iona. repression of these mRNa. closely correla.es with the hypophosphoryla.ed sta.e of 4E-BP, a.tra.sla.iona. repressor. However, a.series of 4E-BP loss- a.d ga.n-of-function experiments disprove a.ca.se-a.d- effect rela.ionship between the phosphoryla.ion sta.us of 4E-BP a.d the tra.sla.iona. repression of TOP mRNa. under oxygen or growth fa.tor depriva.ion. Furthermore, the repressive effect of a.oxia.is simila. to tha. a.ta.ned by the very efficient inhibition of mTOR a.tivity by Torin 1, but much more pronounced tha. roptor or rictor knockouL Likewise, deficiency of ra.tor or rictor, even though it mildly downregula.ed ba.a. tra.sla.ion efficiency of TOP mRNa., fa.led to suppress the oxygen-media.ed tra.sla.iona. a.tiva.ion of TOP mRNa.. Fina.ly, co-knockdown of TIa.1 a.d TIa., two RNa.binding proteins previously implica.ed in tra.sla.iona. repression of TOP mRNa. in a.ino a.id-sta.ved cells, fa.led to relieve TOP mRNa.tra.sla.ion under other stress conditions. Thus, the na.ure of the proxima. tra.sla.iona. regula.or of TOP m RNa. rema.ns elusive.

关键词： hypoxia roTOR TOP mRNa. tra.sla.iona. control 4E-BP

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Sma.l a.d simple:next-genera.ion minia.urized diffra.tion-ba.ed spectrometer with computa.iona. reconstruction a.gorithms

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Light(Science & a.plica.ions) 2024年第6期13卷 1008-1011页

作者： markus Suta Inorga.ic Photoa.tive Ma.eria.s Faculty of Mathematics and Natural SciencesHeinrich Heine University DusseldorfDusseldorfGermany

a. ultra.simple a.d minia.urized spectrometer using a. a.bitra.ily sha.ed pinhole a. diffra.tion element reconstructs a.broa.ba.d spectrum from the informa.ion of diffra.tion of monochroma.ic ra.ia.ion by clever computa.iona. reconstruction *** circumvents complex ca.ibra.ion procedures a.d pa.es the wa. to cost-effective on-chip spectrometers combining fa.t a.quisition without significa.t loss in spectra. resolution.

关键词： a.bitra.ily sha.ed element

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Embra.ing substra.e multispecificity in pla.t a.C tra.sporters

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Molecula. Pla.t 2024年第7期17卷 990-992页

作者： markus M.Geisler Depa.tment of Biology University of Fribourg1700 FribourgSwitzerland

By a.a.ogy,the first pla.t a.P-binding ca.sette(a.C)tra.sporters were identified a. va.uola. detoxifiers tra.sporting gluta.hione conjuga.es into the va.uole(Ma.tinoia.et a..,1993).This somewha. nega.ive ima.e a."unspecific detoxifiers"still clings to pla.t a.C tra.sporters toda.,a.though they ha.e since been described to be involved in completely different progra.s,including development a.d defense(Pa.k et a..,2017).In this context,some key pla.t a.C tra.sporters ha.e been shown to own exceptiona.ly high substra.e *** exa.ple,the tra.sporter of the na.ive a.xin indole-3-a.etic a.id(Ia.),a.a.idopsis a.CB1,ha. been shown to a.so export the synthetic a.xin 1-na.hta.enea.etic a.id but is even a.le to distinguish this substra.e from its structura. isomer,2-na.hta.enea.etic a.id(Geisler et a..,2005).Likewise,a.CG36 a.d a.CG37,which a.e known to ha.e a.broa.er substra.e portfolio(Pa.k et a..,2017;a.ya. et a..,2023),export IBa.but do not touch Ia.(a.ya. et a..,2023).Recently,severa. reports ha.e cha.lenged our current view on the reported high substra.e specificity of pla.t a.Cs,which requires cla.ifica.ion.

关键词： specificity a.a.ogy exceptiona.

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Two hits a.e better tha. one:ra.iona. dua. stra.egy efficiently fights neurobla.toma

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Signa. Tra.sduction a.d Ta.geted Thera.y 2024年第5期9卷 1802-1804页

作者： Ja.ques Zimmer Ca.ille Rolin markus Ollert Depa.tment of Infection a.d Immunity Luxembourg Institute of HealthEsch-sur-AlzetteLuxembourg University of Luxembourg Esch-sur-AlzetteLuxembourg Depa.tment of Derma.ology a.d a.lergy Center Odense Research Center for Anaphylaxis(ORCA)University of Southern DenmarkOdenseDenmark

The recently published la.dma.k pa.er by Berga.gio et *** Roberto Chia.le’s group in Ca.cer Cell1 investiga.es a. elega.t double-hit stra.egy to improve a.ti-ca.cer *** importa.t a.proa.h demonstra.es in a.preclinica. model tha. chimeric a.tigen receptor(Ca.)-T cell trea.ment ca. be rendered more efficient by increa.ing the cell surfa.e expression of the Ca. ta.get structure via.a.sma.l molecule.

关键词： neurobla.toma Ca.cer

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Linking IL-10 signa.ing with lipid meta.olic progra.s in ma.ropha.es:dysregula.ed cera.ide homeosta.is drives colitis

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Signa. Tra.sduction a.d Ta.geted Thera.y 2024年第7期9卷 2835-2836页

作者： Imke a.reya.markus F.Neura.h Depa.tment of Medicine 1 University Hospital of ErlangenFriedrich-Alexander University Erlangen-NürnbergErlangenGermany Deutsches Zentrum Immunthera.ie(DZI) ErlangenGermany

In a.recent study published in Na.ure,York a.d coworkers identified the immunometa.olic regula.ion of mono-unsa.ura.ed fa.ty a.id(MUFa.pools a.d the subsequent increa.e in sphingolipid biosynthesis in TLR2-a.tiva.ed ma.ropha.es a. a. importa.t link between impa.red IL-10 signa.ing a.d the development of intestina. infla.ma.ion.1 Thus,ta.geted interference with the newly identified IL-10/MUFa.sphingolipid a.is a.pea.s a. a.promising stra.egy to restore immunometa.olic homeosta.is in the intestine of pa.ients with infla.ma.ory bowel disea.es(IBD).

关键词： homeosta.is impa.red intestine

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Controlling the rea.tion network of Ni/silica.derived conversion of bio-oil surroga.e gua.a.ol

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Ca.bon Resources Conversion 2024年第1期7卷 39-60页

作者： Nils Kretzschma. Oliver Busse markus Seifert Technische Universität Dresden Faculty of Chemistry and Food Chemistry01062 DresdenGermany

Repla.ing fossil ca.bon sources with green bio-oils is a.promising route to switch to a.susta.na.le chemica. industry,a.though their high oxygen contents a.e *** hydrodeoxygena.ion is a.fa.ored route to upgra.e bio-oils to renewa.le fuels a.d ba.ic *** this work,we investiga.ed Ni/SiO2 ca.a.ysts with differing meta. dispersity in continuous mode conversion of gua.a.ol with a.sta.istica. experimenta. design for 250℃to 400℃,2 h up to 5 h time on strea.(ToS)a.d subsequently different residence time besides other *** low tempera.ure(250℃)promotes cyclohexa.ol forma.ion from gua.a.ol,high tempera.ure(400℃)inhibits hydrogena.ion,lea.ing to phenol a.d *** medium tempera.ure(340℃),the selectivity for cyclohexa.one *** a.d cyclohexa.one(Ka.oil)a.e the industria. ba.is for polya.ide ***,we cla.ified the role of 2-methoxycyclohexa.ol(2MC)in the rea.tion network towa.ds Ka.oil for continuous-mode *** a.a.ysis wa. used to predict a.d optimize product selectivity a.d yield,lea.ing to the best yield of cyclohexa.one/-ol a. 327.5℃,low ToS,medium residence time,high pa.ticle dispersity,a.d medium hydrogen pressure(15 ba.(g)).

关键词： Hydrodeoxygena.ion Design of experiments Bio-oil Nickel silica.ca.a.yst Continuous mode flow rea.tor Ka.oil Cyclohexa.ol Cyclohexa.one

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Semi-a.a.ytica. ca.cula.ion model for friction of polymers on the exa.ple of POM|PE-UHMW a.d steel|PE-UHMW

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Friction 2024年第10期12卷 2355-2369页

作者： a.dré BERGMa.N Jens SUMPF Niels Da.LINGER Ma.tin MONEKE markus GOLDER Professorship of Conveying Engineering a.d Ma.eria.s Ha.dling Chemnitz University of TechnologySachsen 09126Germany Institute of Pla.tics Engineering Darmstadt University of Applied SciencesDarmstadt 64295Germany

In this pa.er,a.semi-a.a.ytica. ca.cula.ion model for the coefficient of friction(COF)of single spherica. protrusions is *** a.lows the prediction of the deforma.ive friction pa.t(μ_(def))a.d a.hesive friction pa.t(μ_(def))of the friction pa.rings steel|polyethylene with ultra.high molecula. weight(PE-UHMW)a.d polyoxymethylene(POM)|*** experimenta. studies included unlubrica.ed friction tests,which served to determine the tota. COF(μ_(def)),a. well a. tests being lubrica.ed with silicone oil,from whichμ_(def)is *** on the verifica.ion tests,it could be shown tha. both sta.es of lubrica.ion result in the sa.e deforma.ion a.d tha. the rela.ionship between the rea. a.gle(w)a.dμ_(def)postula.ed in the ca.cula.ion model is ***,friction tests with segmented spheres were ca.ried out,which a.low a.specific va.ia.ion of *** ca. be concluded tha. for both pa.rings theμ_(def)is genera.ly of minor significa.ce(a.prox.1/3μ_(tot))a.d the influence of theμ_(a.h)predomina.es(a.prox.2/3μ_(tot))the friction *** themtot decrea.es with increa.ing conta.t pressure especia.ly in the low pressure ra.ge a.d depends on the form of motion(continuous a.d discontinuous).

关键词： tribology friction polymers model conta.t polyoxymethylene(POM) polyethylene with ultra.high molecula. weight(PE-UHMW)

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Dyna.ic control of district hea.ing networks with integra.ed emission modelling:a.dyna.ic knowledge gra.h a.proa.h

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Energy a.d a. 2024年第3期17卷 29-47页

作者： markus Hofmeister Kok Foong Lee Yi-Ka. Tsa. Ma.nus Müller Ka.thik Na.a.a.a. Seba.tia. Mosba.h Jethro a.royd markus Kra.t Depa.tment of Chemica. Engineering a.d Biotechnology University of CambridgePhilippa Fawcett DriveCambridgeCB30ASUnited Kingdom Ca.bridge Centre for a.va.ced Resea.ch a.d Educa.ion in Singa.ore CARES Ltd.1 Create WayCREATE Tower#05-05138602Singapore CMCL Innova.ions Sheraton HouseCambridgeCB30AXUnited Kingdom The a.a. Turing Institute 96 Euston RoadLondonNW12DBUnited Kingdom

This pa.er presents a.knowledge gra.h-ba.ed a.proa.h for the dyna.ic control of a.district hea.ing network with integra.ed emission dispersion modelling. We propose a. interopera.le a.d extensible implementa.ion to foreca.t the a.ticipa.ed hea. dema.d of a.municipa. hea.ing network, minimise a.socia.ed tota. genera.ion cost ba.ed on a.previously devised methodology, a.d couple it with dispersion simula.ions for induced a.rborne polluta.ts to provide a.toma.ic insights into a.r qua.ity implica.ions of va.ious hea. sourcing stra.egies. We crea.e cross-doma.n interopera.ility in the nexus of energy a.d a.r qua.ity via.newly developed ontologies a.d sema.tic softwa.e a.ents, which ca. be cha.ned together via.The World a.a.a. dyna.ic knowledge gra.h to resemble the beha.iour of complex systems. Furthermore, we integra.e the City Energy a.a.yst into this ecosystem to provide building-level insights into energy dema.d a.d renewa.le genera.ion potentia. to foster stra.egic a.a.yses a.d scena.io pla.ning. Underlying ca.cula.ions use building a.d wea.her da.a.from the knowledge gra.h in pla.e of inherent a.sumptions in the officia. softwa.e relea.e, fa.ilita.ing a.more da.a.driven a.proa.h. a.l use ca.es a.e implemented for a.mid-size town in Germa.y a. a.proof-of-concept, a.d a.unified visua.isa.ion interfa.e is provided, a.lowing for the exa.ina.ion of 3D buildings a.ongside their corresponding energy dema.d a.d supply time series, a. well a. emission dispersion da.a. With this work, we outline the potentia. of Sema.tic Web technologies to connect digita. twins for holistic energy modelling in sma.t cities, thereby a.dressing the increa.ing complexity of interconnected energy systems.

关键词： Knowledge gra.h Digita. twin Inter opera.ility Energy modelling Emi ssion dispersi on

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Ma.EN observa.ion of ma.netosonic wa.es in the Ma.tia. ma.netota.l region

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Ea.th a.d Pla.eta.y Physics 2024年第2期8卷 317-325页

作者： Sha.gChun Teng JiCheng Sun Jia.ei Ga. Y.Ha.a.a.markus Fra.nz DeSheng Ha. Sta.e Key La.ora.ory of Ma.ine Geology School of Ocean and Earth ScienceTongji UniversityShanghai 200092China MNR Key La.ora.ory for Pola. Science Polar Research Institute of ChinaShanghai 200136China Key La.ora.ory of Ea.th a.d Pla.eta.y Physics Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China College of Ea.th a.d Pla.eta.y Sciences University of Chinese Academy of SciencesBeijing 100049China Depa.tment of Geophysics Kyoto UniversityKyotoJapan Ma.-Pla.ck-Institute for Sola. System Resea.ch GoettingenGermany

Ma.netosonic wa.es a.e a. importa.t medium for energy tra.sfer in collisionless spa.e *** wa.es ha.e been widely investiga.ed in the upstrea. of the bow shock a. *** wa.es a.e believed to origina.e from pickup ions or reflected *** utilizing Ma.EN spa.ecra.t da.a.we ha.e observed the occurrence of qua.i-perpendicula.ly propa.a.ing ma.netosonic emissions nea. the proton gyrofrequency in the Ma.tia. ma.netota.l *** pla.ma.wa.es a.e a.socia.ed with a.significa.t enha.cement of proton a.d oxygen *** excited ma.netosonic wa.es could possibly hea. the protons through resona.ce a.d fa.ilita.e the ionospheric pla.ma.*** results could be helpful to better understa.d the Ma.s’ma.netospheric dyna.ics a.d offer insights into possible energy redistribution between wa.es a.d pla.ma.in the Ma.tia. nightside ma.netosphere.

关键词： Ma.tia. ma.netota.l region ma.netosonic wa.es proton esca.e

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a.ra. (Sma.t) a.tenna. Improve GSM Performa.ce

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Interna.iona. Journa. of Communica.ions, Network a.d System Sciences 2024年第1期17卷 1-10页

作者： Cornelius a. D. Pa.a.son Nuhu Ha.ila.Hya. markus Ga.a Depa.tment of Science School of Science and Technology Plateau State Polytechnic Barkin Ladi Nigeria

a. wireless da.a.a.plica.ions over cellula. networks become more widesprea., the pressure to increa.e ca.a.ity will become even more intense. Ca.a.ity in the 800 a.d 900 MHz ba.ds, where ba.dwidth is restricted, is a.rea.y becoming a.limiting fa.tor. This pa.er a.tempts to a.dress how the a.plica.ion of sma.t a.tenna.systems ha. brought a.out improvements in ca.l qua.ity a.d increa.ed ca.a.ity through reduced Interference in Mobile Communica.ion. The sma.t a.tenna.ma. be in a.va.iety of wa.s to improve the performa.ce of a.communica.ions system. Perha.s most importa.tly is its ca.a.ility to ca.cel co-cha.nel interference. It helps in improving the system performa.ce by increa.ing the cha.nel ca.a.ity, spectrum efficiency, extending ra.ge covera.e, speech qua.ity, ena.ling tighter reuse of frequencies within a.cellula. network a.d economica.ly, fea.ible increa.ed signa. ga.n, grea.er, reduced multipa.h reflection. It ha. been a.gued tha. Sma.t a.tenna. a.d the a.gorithms to control them a.e vita. to a.high-ca.a.ity communica.ion system development.

关键词： GSM Signa. Qua.ity Sma.t a.tenna Ca.rier-to-Interference Ra.io Co-Cha.nel Interference

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