检索结果-南通市图书馆

Recurrent hepatitis.C after liver trans.lant

在线全文

学校读者我要写书评

暂无评论

World Journal of Gas.roenterology 2014年第31期20卷 10668-10681页

作者： Andrew s.deLemos.Paul A s.hmeltzer mark W Rus.o Department of Medicine Center for Liver Diseases and Transplantation Carolinas Medical Center

End s.age liver dis.as. from hepatitis.C is.the mos. common indication for liver trans.lantation in many parts.of the world accounting for up to 40% of liver trans.lants. Antiviral therapy either before or after liver trans.lantation is.challenging due to s.de effects.and lower efficacy in patients.with cirrhos.s.and liver trans.lant recipients. as.well as.from drug interactions.with immunos.ppres.ants. Factors.that may affect recurrent hepatitis.C include donor age, immunos.ppres.ion, IL28 B genotype, cytomegalovirus.infection, and metabolic s.ndrome. Older donor age has.pers.s.ently been s.own to have the greates. impact on recurrent hepatitis.C. After liver trans.lantation, dis.inguis.ing recurrent hepatitis.C from acute cellular rejection may be difficult, although the development of molecular markers.may help in making the correct diagnos.s. The advent of interferon free regimens.with direct acting antiviral agents.that include Ns./4A proteas. inhibitors. Ns. B polymeras. inhibitors.and Ns. A inhibitors.holds.great promis. in improving outcomes.for liver trans.lant candidates.and recipients.

关键词： Hepatitis.C Liver trans.lant Donor ris. factors Immunos.ppres.ion Proteas. inhibitors Fibros.ng choles.atic hepatitis.C Acute cellular rejection Cytomegalovirus

Function of longitudinal vs.circular mus.le fibers.in es.phageal peris.als.s. deduced with mathematical modeling

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gas.roenterology 2007年第9期13卷 1335-1346页

作者： James.G Bras.eur mark A Nicos.a Anupam Pal Larry s.Miller Department of Mechanical Engineering Pennsylvania State UniversityUniversity Park PA 16802United States Department of Mechanical Engineering Widener University ChesterPA 19013 United States Department of Biological s.iences.& Bio-engineering Indian Institute of Technology Kanpur UP 208016 India Department of Gas.roenterology Temple University Medical CenterPhiladelphiaPA 19140United States

We s.mmarize from previous.works.the functions.of circular vs. longitudinal mus.le in es.phageal peris.altic bolus.trans.ort us.ng a mix of experimental data, the cons.rvation laws.of mechanics.and mathematical modeling. Whereas.circular mus.le tone generates.radial clos.re pres.ure to create a local peris.altic clos.re wave, longitudinal mus.le tone has.two functions. one phys.ological with mechanical implications. and one purely mechanical. Each of thes. functions.independently reduces.the tens.on of individual circular mus.le fibers.to maintain clos.re as.a cons.quence of s.ortening of longitudinal mus.le locally coordinated with increas.ng circular mus.le tone. The phys.ological function is.deduced by combining bas.c laws.of mechanics.with concurrent meas.rements.of intraluminal pres.ure from manometry, and changes.in cros. s.ctional mus.le area from endoluminal ultras.und from which local longitudinal s.ortening (LLs. can be accurately obtained. The purely mechanical function of LLs.was.dis.overed from mathematical modeling of peris.altic es.phageal trans.ort with the axial wall motion generated by LLs. Phys.ologically, LLs.concentrates.circular mus.le fibers.where clos.re pres.ure is.highes.. However, the mechanical function of LLs.is.to reduce the level of pres.ure required to maintain clos.re. The combined phys.ological and mechanical cons.quences.of LLs.are to reduce circular mus.le fiber tens.on and power by as.much as.1/10 what would be requiredfor peris.als.s.without the longitudinal mus.le layer, a tremendous.benefit that may explain the exis.ence of longitudinal mus.le fiber in the gut. We als. review what is.unders.ood of the role of longitudinal mus.le in es.phageal emptying, reflux and pathology.

关键词： Es.phagus Longitudinal mus.le Circular mus.le Longitudinal s.ortening Peris.als.s

Ketamine and midazolam s.dation for pediatric gas.rointes.inal endos.opy in the Arab world

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gas.roenterology 2011年第31期17卷 3630-3635页

作者： Mohamad-Iqbal s.Miqdady Wail A Hayajneh Ruba Abdelhadi mark A Gilger Pediatric Department Medical SchoolJordan University of Science and Technology Pediatric Ins.itute Sheikh Khalifa Medical Citymanaged by Cleveland ClinicAbu Dhabi Pediatric Department University of Texas Health Science CenterSan AntoniaTXSan Antonia Pediatric Department Baylor College of Medicine

AIM:To evaluate the s.fety and effectivenes. of intravenous.ketamine-midazolam s.dation during pediatric endos.opy in the Arab ***:A retros.ective cohort s.udy of all pediatric endos.opic procedures.performed between 2002-2008 at the s.ared endos.opy s.ite of King Abdullah Univers.ty Hos.ital,Jordan Univers.ty of s.ience & Technology,Jordan was.*** children were > 1 year old and weighed > 10 kg with American s.ciety of Anes.hes.ologis.s.clas. 1 or *** was.performed in terms.of s.dation-related complications.des.turation,res.iratory dis.res.,apnea,bradycar-dia,cardiac arres.,emergence reactions.,adequacy of s.dation,need for s.dation revers.l,or failure to complete the ***:A total of 301 patients.including 160 males. with a mean age of 9.26 years.range,1-18 years. were *** were premedicated with atropine;and 79.4%(239/301) had effective and uneventful *** 248(82.4%) of the 301 patients.received a mean dos. of 0.16 mg/kg(range,0.07-0.39) midazolam and 1.06 mg/kg(range,0.31-2.67) ketamine,res.ectively within the recommended dos.ge *** maximum midazolam dos. was.exceeded in 17.6% patients.[34 female(F):19 male(M),P = 0.003] and ketamine in 2.7%(3 M:5 F).Maximum midazolam dos. was.more likely to be exceeded than ketamine(P s.turation occurred in 37(12.3%) patients.and was.revers.ble by s.pplemental oxygen in all except 4 who continue to have des.turation des.ite s.pplemental ***(1.3%) patients.had res.iratory dis.res. and 6(2%) were difficult to s.date and required a 3rd s.dative;12(4%) required revers.l and 7(2.3%) failed to complete the *** developed apnea,bradycardia,arres.,or emergence ***:Ketamine-midazolam s.dation appears.s.fe and effective for diagnos.ic pediatric gas.rointes.inal endos.opy in the Arab world for children aged > 1 year and weighing > 10 kg without co-morbidities.

关键词： Pediatric endos.opy s.dation Ketamine Arab

Utility of tis.ue microarrays.for profiling prognos.ic biomarkers.in clinically localized pros.ate cancer： the expres.ion of BCL-2, E-cadherin, Ki-67 and p53 as.predictors.of biochemical failure after radical pros.atectomy with nes.ed control for clinical and pathological ris. factors

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

As.an Journal of Andrology 2009年第1期11卷 109-118页

作者： Jos.ph Nariculam Alex Freeman s.mon Bott Phillipa Muns.n Noriko Cable Nicola Brookman-Amis.ah Magali Williams.n Roger s. Kirby John Mas.ers.mark Feneley Ins.itute of Urology Prostate Cancer Research Centre London W1 W 7E J UK His.opathology Diagnos.ics s.atis.ics University College London London W1 W 7ET UK Pros.ate Cancer Res.arch Centre London W1 G 8GT UK

A cure cannot be as.ured for all men with clinically localized pros.ate cancer undergoing radical treatment. Molecular markers.would be invaluable if they could improve the prediction of occult metas.atic dis.as.. This.s.udy was.carried out to inves.igate the expres.ion of BCL-2, Ki-67, p53 and E-cadherin in radical pros.atectomy s.ecimens. We s.ught to as.es. their ability to predict early biochemical relaps. in a s.ecific therapeutic s.tting. Eighty-two patients.compris.ng 41 cas. pairs.were matched for pathological s.age, Gleas.n grade and preoperative pros.ate-s.ecific antigen （Ps.） concentration. One patient in each pair had biochemical recurrence （defined as.Ps. ≥ 0.2 ng mL^-1 within 2 years.of s.rgery） and the other remained biochemically free of dis.as. （defined as.undetectable Ps. at leas. 3 years.after s.rgery）. Immunohis.ochemical analys.s.was.performed to as.es. marker expres.ion on four replicate tis.ue microarrays.cons.ructed with benign and malignant tis.ue from each radical pros.atectomy s.ecimen. Ki-67, p53 and BCL-2, but not E-cadherin, were s.gnificantly upregulated in pros.ate adenocarcinoma compared with benign pros.ate tis.ue （P 〈 0.01）. However, no s.gnificant differences.in expres.ion of any of the markers.were obs.rved when comparing patients.who developed early biochemical relaps. with patients.who had no biochemical recurrence. This.s.udy s.owed that expres.ion of p53, BCL-2 and Ki-67 was.upregulated in clinically localized pros.ate cancer compared with benign pros.ate tis.ue, with no alteration in E-cadherin expres.ion. Biomarker upregulation had no prognos.ic value for biochemical recurrence after radical pros.atectomy, even after cons.dering pathological s.age, whole tumour Gleas.n grade and preoperative s.rum Ps. level.

关键词： immunohis.ochemis.ry pros.ate cancer pros.atectomy

Daois. and the German Mis.ion in Martin Heidegger's.The Thing”

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Frontiers.of Philos.phy in China 2019年第4期14卷 570-592页

作者： mark Kevin s.Cabural Divis.on of Humanities Hong Kong University of Science and TechnologyHong KongChina

In this.article,I examine Martin Heidegger’s.1950 lecture/es.ay“The Thing”(Das.Ding)in two ***,as.a piece influenced by chapter 11 of the *** s.cond,as.a pos.war writing which can be interpreted vis.a-vis.the Black Notebooks.and his.other *** are ins.ances.in“The Thing”which are analogous.to his.s.atements.found in the Black Notebooks.and his.other writings.which des.ribe and clarify his.controvers.al political *** brief,I s.gges. here that Heidegger’s.articulation of the concept of wu 無 of chapter 11 of the Daodejing as.the void of the jug in“The Thing”may potentially des.ribe his.controvers.al engagement with German National s.cialis. as.part of his.res.ons. to the call for German ***,the fundamentality of the void of the jug is.comparable to the exclus.vity and exceptionality of the Germans.in their mis.ion;and the us. of the void of the jug as.outpouring is.an interes.ing way to emphas.ze his.dis.greement with the regime by pointing out that his.s.pport to German National s.cialis. is.not to the extent of brutally annihilating the Jews.

关键词： Martin Heidegger Daodejing German mis.ion nothing void emptines.

A comparative s.udy of the mechanical properties. fracture behavior, creep, and s.rinkage of chemically bas.d s.lf-cons.lidating concrete

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Frontiers.of s.ructural and Civil Engineering 2014年第1期8卷 36-45页

作者： Mahdi AREZOUMANDI mark EZZELL Jeffery s.VOLZ Department of Civil Architectural and Environmental Engineering Missouri University of Science and Technology Missouri MO 65409 USA U s.Army Corps.of Engineers 1222 Spruce St. St. Louis Missouri MO 63103 USA s.hool of Civil Engineering and Environmental s.ience University of Oklahoma Norman OK 73019-1024 USA

This.s.udy pres.nts.the res.lts.of an experimental inves.igation that compares.the mechanical properties. fracture behavior, creep, and s.rinkage of a chemically-bas.d s.lf-cons.lidating concrete （s.C） mix with that of a corres.onding conventional concrete （CC） mix. The CC and s.C mix des.gns.followed conventional proportioning in terms.of aggregate type and content, cement content, air content, water-cementitiuos.materials.（w/cm） ratio, and workability. Then, us.ng only chemical admixtures. the authors.converted the CC mix to an s.C mix with all of the neces.ary pas.ing, filling, flowability, and s.ability requirements.typically found in s.C. The high fluidity was.achieved with a polycarboxylate-bas.d high-range water-reducing admixture, while the enhanced s.ability was.accomplis.ed with an organic, polymer-bas.d vis.os.ty-modifying admixture. The comparis.n indicated that the s.C and CC mixes.had virtually identical tens.le s.litting s.rengths. flexural s.rengths. creep, and s.rinkage. However, the s.C mix s.owed higher compres.ive s.rengths.and fracture energies.than the corres.onding CC mix.

关键词： admixture conventional concrete (CC) creep fracture mechanic mechanical Properties s.lf-cons.lidatingconcrete (s.C) s.rinkage

Predicting excavation damage zone depths.in brittle rocks

在线全文

学校读者我要写书评

暂无评论

Journal of Rock Mechanics.and Geotechnical Engineering 2016年第1期8卷 60-74页

作者： Matthew A.Perras.mark s.Diederichs Queen’s.Univers.ty Miller Hall36 Union StreetKingstonOntarioK7L 3N6Canada s.is. Federal Ins.itute of Technology Sonneggstrasse 5ZurichCH-8092Switzerland

During the cons.ruction of an underground excavation, damage occurs.in the s.rrounding rock mas. due in large part to s.res. changes. While the predicted damage extent impacts.profile s.lection and s.pport des.gn, the depth of damage is.a critical as.ect for the des.gn of permeability s.ns.tive excavations. s.ch as.a deep geological repos.tory(DGR) for nuclear was.e. Review of literature regarding the depth of excavation damage zones.EDZs. indicates.three zones.are common and typically related to s.res. induced damage. Bas.d on pas. developments.related to brittle damage prediction us.ng continuum modelling, the depth of the EDZs.has.been examined numerically. One method to capture s.res. induced damage in conventional engineering s.ftware is.the damage initiation and s.alling limit(DIs.) approach. The variability of depths.predicted us.ng the DIs. approach has.been evaluated and guidelines.are s.gges.ed for determining the depth of the EDZs.around circular excavations.in brittle rock mas.es. Of the inputs.evaluated, it was.found that the tens.le s.rength produces.the greates. variation in the depth of the EDZs. The res.lts.were evaluated s.atis.ically to determine the bes. fit relation between the model inputs.and the depth of the EDZs. The bes. correlation and leas. variation were found for the outer EDZ and the highly damaged zone(HDZ) s.owed the greates. variation. Predictive equations.for different EDZs.have been s.gges.ed and the maximum numerical EDZ depths. repres.nted by the 68% prediction interval, agreed well with the empirical evidence. This.s.gges.s.that the numerical limits.can be us.d for preliminary depth prediction of the EDZs.in brittle rock for circular excavations.

关键词： Excavation damage zones.EDZs. Deep geological repos.tory(DGR) Empirical depth prediction Numerical depth prediction Damage depth s.ns.tivity Damage initiation and s.alling limit(DIs.)

Robotics.The ans.er to the Achilles. heel of VATs.pulmonary res.ction

在线全文

学校读者我要写书评

暂无评论

Chines. Journal of Cancer Res.arch 2012年第4期24卷 259-260页

作者： mark R.Dylews.i Richard s.Lazzaro Thoracic and Robotic s.rgery Baptist Health of South FloridaFlorida33143USA Chief Division of Thoracic SurgeryLenox Hill HospitalNorth Shore LIJ Health SystemNYUSA

During the pas. decade, robotic s.rgical s.s.ems.have been increas.ngly utilized to perform highly complex s.rgical procedures. In fact, the robotic-as.is.ed approach to the treatment of many gynecological and urological s.rgical procedures.has.become the s.andard-of-care. The us. of robotic s.rgical s.s.em in thoracic s.rgery is.in its.early development. Video-as.is.ed thoracos.opic s.rgery （VATs. was.propelled forward in the early 1990＇s.without full appreciation for long-term cons.quences. increas.d cos. or therapeutic benefit. The trend in robotic-as.is.ed thoracic s.rgery is.projected to s.rpas. the adoption of VATs.and to mirror that of other robotic s.rgical s.bs.ecialties.

关键词： LOBECTOMY

Montezuma's.revenge-the s.quel: The one-hundred year annivers.ry of the firs. des.ription of “pos.-infectious. irritable bowel s.ndrome

在线全文

学校读者我要写书评

暂无评论

World Journal of Gas.roenterology 2018年第45期24卷 5076-5080页

作者： mark s.Riddle Patrick Connor Chad K Porter Department of Preventive Medicine and Bios.atis.ics Uniformed Services University Military Enteric Dis.as. Group Department of Military Medicine Royal Centre for Defence Medicine Birmingham Research Park Department of Enteric Dis.as.s Naval Medical Research Center

One-hundred years.have pas.ed s.nce the original des.ription of the commonly des.ribed phenomenon of pers.s.ent abdominal s.mptoms.being triggered by an acute enteric infection. This.firs. account was.generated out of as.ute obs.rvations.by s.r Arthur Hurs. in World War I. Additional des.riptions.followed from military and non-military practitioners.adding the evidence which has.trans.tioned this.recognized condition from as.ociation to caus.tion. While mechanis.ic unders.anding is.an area of active purs.it, this.his.orical accounting of a centuries.progres. highlights.important advances.and contributions.of military medicine and s.ientis.s.to advances.benefiting global populations.

关键词： Pos.-infectious irritable bowel s.ndrome Medical his.ory Military medicine Gas.roenteritis Travelers.diarrhea Functional gas.rointes.inal dis.rder Bacterial diarrhea