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Genotype specific peripheral lipid profile changes with hepatitis C therapy

World Journal of Gastroenterology 2016年第46期22卷 10226-10231页

作者： mark r pedersen Amit Patel David Backstedt Myunghan Choi Anil B Seetharam Department of Internal Medicine Banner University Medical Center University of Arizona College of Medicine Phoenix AZ 85006 United States Department of Gastroenterology Banner University Medical Center University of Arizona College of Medicine Phoenix AZ 85006 United States Arizona State University College of Nursing and Health Care Innovation Banner Phoenix AZ 85006 United States Transplant and Advanced Liver Disease Center University of Arizona College of Medicine Phoenix AZ 85006 United States

AIM To evaluate magnitude/direction of changes in peripheral lipid profiles in patients undergoing direct acting therapy for hepatitis C by *** Mono-infected patients with hepatitis C were treated with guideline-based DAAs at a university-based liver clinic. Patient characteristics and laboratory values were collected before and after the treatment period. Baseline demographics included age, ethnicity, hypertension, diabetes, hyperlipidemia, treatment regimen, and fibrosis stage. Total cholesterol(TCHOL), high density lipoprotein(HDL), low density lipoprotein(LDL), triglycerides(TG), and liver function tests were measured prior to treatment and ETr. Changes in lipid and liver function were evaluated by subgroups with respect to genotype. Mean differences were calculated for each lipid profile and liver function component(direction/magnitude). The mean differences in lipid profiles were then compared between genotypes for differences in direction/magnitude. Lipid profile and liver function changes were evaluated with Levene's test and student's t test. Mean differences in lipid profiles were compared between genotypes using ANOVA, post hoc analysis via the Bonferroni correction or Dunnett *** Three hundred and seventy five patients enrolled with 321(85.6%) achieving sustained-viral response at 12 wk. 72.3% were genotype 1(GT1), 18.1% genotype 2(GT2), 9.7% genotype 3(GT3). Baseline demographics were similar. Significant change in lipid profiles were seen with GT1 and GT3(ΔGT1, p and ΔGT3, p), with TCHOL increasing(+5.3, P = 0.005 and +16.1, P reasing(+12.5, P reasing(+7.4, P = 0.058 and +12.5, P reasing(-5.9, P = 0.044 and-9.80 P = 0.067). Among genotypes(ΔGT1 v. ΔGT2 v. ΔGT3, ANOVA), significant mean differences were seen with TCHOL(+5.3 v. +0.1 v. +16.1, P = 0.017) and HDL(+12.3 v. +2 v. +7.9, P = 0.040). Post-hoc, GT3 was associated with a greater increase in TCHOL than GT

关键词： Hepatitis C genotypes Lipids Metabolic syndrome

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Two-stage liver transplant for ruptured hepatic adenoma:A case report

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World Journal of Hepatology 2019年第2期11卷 242-249页

作者： Marc Salhanick Malcolm P MacConmara mark r pedersen Lafaine Grant Christine S Hwang Justin r Parekh Division of Vascular Surgery Department of Surgerythe University of Texas Southwestern Medical Center Division of Surgical Transplantation Department of Surgerythe University of Texas Southwestern Medical Center Division of Digestive and Liver Diseases Department of Internal Medicinethe University of Texas Southwestern Medical Center

BACKGrOUND Only one case of liver transplantation for hepatic adenoma has previously been reported for patients with rupture and uncontrolled *** present the case of a massive ruptured hepatic adenoma with persistent hemorrhagic shock and toxic liver syndrome which resulted in a two-stage liver *** is the first case of a two-stage liver transplantation performed for a ruptured hepatic *** SUMMArY A 23 years old African American female with a history of pre-diabetes and oral contraceptive presented to an outside facility complaining of right-sided chest pain and emesis for one *** was found to be in hemorrhagic shock due to a massive ruptured hepatic hepatic *** underwent repeated embolizations with interventional radiology with ongoing hemorrhage and the development of renal failure,hepatic failure,and hemodynamic instability,known as toxic liver *** the setting of uncontrolled hemorrhage and toxic liver syndrome,a hepatectomy with porto-caval anastomosis was performed with liver transplantation 15 h *** tolerated the anhepatic stage well,and has done well over one year *** When toxic liver syndrome is recognized,liver transplantation with or withouthepatectomy should be considered before the patient becomes unstable.

关键词： Hepatic adenoma Toxic liver syndrome Two-stage liver transplantation Hepatectomy ruptured adenoma Case report

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Surveillance for highly pathogenic avian influenza in wild birds in the USA

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Integrative Zoology 2009年第4期4卷 426-439页

作者： Thomas J.DELIBErTO Seth r.SWAFFOrD Dale L.NOLTE Kerri pedersen mark W.LUTMAN Brandon B.SCHMIT John A.BArOCH Dennis J.KOHLEr Alan FrANKLIN United States Department of Agriculture Animal and Plant Health Inspection ServiceWildlife ServicesNational Wildlife Disease ProgramFort CollinsUSA United States Department of Agriculture Animal and Plant Health Inspection ServiceWildlife ServicesNational Wildlife Research CenterFort CollinsColoradoUSA

As part of the USA’s National Strategy for Pandemic Influenza,an Interagency Strategic Plan for the Early Detection of Highly Pathogenic H5N1 Avian Influenza in Wild Migratory Birds was developed and ***1April2006 through 31 March 2009,261946 samples fromwild birds and 101457 wild bird fecalsamples were collected in the USA;no highly pathogenic avian influenza was *** United States Department of Agriculture,and state and tribal cooperators accounted for 213115(81%)of the wild bird samples collected;31,27,21 and 21%of the samples were collected from theAtlantic,Pacific,Central and Mississippi flyways,*** than 250 species of wild birds in all 50 states were *** majority of wild birds(86%)were dabbling ducks,geese,swans and *** apparent prevalence of low pathogenic avian influenza viruses during biological years 2007 and 2008 was 9.7 and 11.0%,*** apparent prevalence of H5 and H7 subtypes across all species sampled were 0.5 and 0.06%,*** pooled fecal samples(n=101539)positive for low pathogenic avian influenza were 4.0,6.7 and 4.7%for biological years 2006,2007 and 2008,*** highly pathogenic early detection system for wild birds developed and implemented in the USA represents the largest coordinated wildlife disease surveillance system ever *** effort provided evidence that wild birds in the USA were free of highly pathogenic avian influenza virus(given the expected minimum prevalence of 0.001%)at the 99.9%confidence level during the surveillance period.

关键词： disease surveillance highly pathogenic avian influenza H5N1 morbidity and mortality wild bird.

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