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Exercise-induced increase in brain-derived neurotrophic factor in human Parkinson's disease:a systematic review and metaanalysis

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Translational Neurodegeneration 2018年第1期7卷 63-74页

作者： mark A.h.rsch Erwin E.h.van Wegen mark A.Newman Patricia C.heyn Carolinas Medical Center Carolinas RehabilitationDepartment of Physical Medicine and Rehabilitation1100 Blythe BlvdCharlotteNC 28203USA Department of rehabilitation Medicine Amsterdam Movement Sciences/Amsterdam NeurosciencesVU University Medical CenterPO Box 70571007 AmsterdamMBThe Netherlands Department of Physical Medicine and rehabilitation Anschutz Medical CampusUniversity of ColoradoDenverUSA

Background:Animal models of exercise and Parkinson’s disease(PD)have found that the physiologic use of exercise may interact with the neurodegenerative disease process,likely mediated by brain derived neurotrophic factor(BDNF).No reviews so far have assessed the methodologic quality of available intervention studies or have bundled the effect sizes of individual studies on exercise-induced effects on BDNF blood levels in human *** design and methods:We searched MEDLINE,EMBASE,Cochrane Library,PsycINFO and PubMed from inception to June ***:Data aggregated from two randomized controlled trials and four pre-experimental studies with a total of 100 ambulatory patients with idiopathic PD(hoehn/Yahr≤3)found improvements in BDNF blood concentration levels in all 6 studies(two rCTs and 4 pre-experimental studies).Pooled BDNF level change scores from the 2 rCTs resulted in a significant homogeneous summary effect size(Standardized Mean Difference 2.06,95% CI 1.36 to 2.76),and a significant heterogeneous SES for the motor part of the UPDrS-Ⅲ examination(MD-5.53,95% CI-10.42 to-0.64).Clinical improvements were noted in all studies using a variety of outcome ***:The evidence-base consists primarily of small studies with low to moderate methodological ***:This review provides preliminary evidence for the effectiveness of physical exercise treatments for persons with PD on BDNF blood *** research is needed.

关键词： Brain derived neurotrophic factor Exercise rehabilitation Systematic review Parkinson’s disease

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A simplified LC-MS/MS method for the quantification of the cardiovascular disease biomarker trimethylamine-N-oxide and its precursors

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Journal of Ph.rmaceutical Analysis 2021年第4期11卷 523-528页

作者： Kath.rina rox Silke rath Dietmar h.Pieper Marius Vital mark Bronstrup Department of Chemical Biology(CBIO) Helmholtz Centre for Infection Research(HZI)38124BraunschweigGermany German Center for Infection research(DZIF) Partner Site Hannover-Braunschweig38124BraunschweigGermany research Group Microbial Interactions and Processes(MINP) Helmholtz Centre for Infection Research(HZI)38124BraunschweigGermany Institute for Medical Microbiology and hospital Epidemiology Hannover Medical School(MHH)30625HannoverGermany

Trimethylamine-N-oxide(TMAO)has emerged as a potential biomarker for ath.rosclerosis and the development of cardiovascular diseases(CVDs).Although several clinical studies have shown striking associations of TMAO levels with ath.rosclerosis and CVDs,TMAO determinations are not clinical routine *** current methodology relies on isotope-labeled internal standards,which adds to pre-analytical complexity and costs for the quantification of TMAO and its precursors carnitine,betaine or ***,we report a liquid chromatography-tandem mass spectrometry based method that is fast(throughput up to 240 samples/day),consumes low sample volumes(e.g.,from a finger prick),and does not require isotope-labeled *** circumvented the analytical problem posed by the presence of endogenous TMAO and its precursors in human plasma by using an artificial plasma matrix for *** cross-validated the results obtained using an artificial matrix with those using mouse plasma matrix and demonstrated that TMAO,carnitine,betaine and choline were accurately quantified in’reallife’human plasma samples from healthy volunteers,obtained eith.r from a finger prick or from venous ***,we assessed the stability of samples stored at-20℃and room *** all metabolites were stable at-20℃,increasing concentrations of choline were determined when stored at room *** method will facilitate the establishment of TMAO as a routine clinical biomarker in hematology in order to assess the risk for CVDs development,or to monitor disease progression and intervention effects.

关键词： TMAO Ath.rosclerosis Biomarker Carnitine Choline Betaine LC-MS/MS

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The Chapman-rich.rds Distribution and its relationship to the Generalized Beta

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Forest Ecosystems 2019年第3期6卷 219-235页

作者： Jeffrey h.Gove Thomas B.Lynch mark J.Ducey USDA Forest Service Northern Research Station271 Mast Road Durham 03824NHUSA Professor Emeritus Department of Natural Resource Ecology and ManagementOklahoma State UniversityAg Hall Room 008CStillwater 74078OKUSA Department of Natural resources and the Environment University of New Hampshire114 James Hall Durham 03824NHUSA

Background: The Chapman-rich.rds distribution is developed as a special case of the equilibrium solution to the McKendrick-Von Foerster equation. The Chapman-rich.rds distribution incorporates the vital rate assumptions of the Chapman-rich.rds growth function, constant mortality and recruitment into the mathematical form of the distribution. Th.refore, unlike 'assumed' distribution models, it is intrinsically linked with the underlying vital rates for the forest area under consideration. Methods: It is shown that the Chapman-rich.rds distribution can be recast as a subset of the generalized beta distribution of the first kind, a rich family of assumed probability distribution models with known properties. These known properties for the generalized beta are then immediately available for the Chapman-rich.rds distribution, such as the form of the compatible basal area-size distribution. A simple two-stage procedure is proposed for the estimation of the model parameters and simulation experiments are conducted to validate the procedure for four different possible distribution shapes. results: The simulations explore the efficacy of the two-stage estimation procedure;these cover the estimation of the growth equation and mortality-recruitment derives from the equilibrium assumption. The parameter estimates are shown to depend on both the sample size and the amount of noise imparted to the synthetic measurements. The results vary somewhat by distribution shape, with the smaller, noisier samples providing less reliable estimates of the vital rates and final distribution forms. Conclusions: The Chapman-rich.rds distribution in its original form, or recast as a generalized beta form, presents a potentially useful model integrating vital rates and stand diameters into a flexible family of resultant distributions shapes. The data requirements are modest, and parameter estimation is straightforward provided the minimal recommended sample sizes are obtained.

关键词： Diameter distributions Chapman-rich.rds growth Generalized beta distribution of the first kind Maximum likelihood McKendrick-Von Foerster equation Physiologically structured population model Size-structured distributions

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Effect of process parameters on the density and porosity of laser melted AlSi10Mg/SiC metal matrix composite

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Frontiers of Mechanical Engineering 2018年第4期13卷 520-527页

作者： Omotoyosi h. FAMODIMU mark STANFOrD Chike F. ODUOZA Lijuan ZhANG Faculty of Science and Engineering School of Engineering Telford Campus University of Wolverhampton WV1 1LY Wolverhampton UK

Laser melting of aluminium alloy-AlSi10Mg has increasingly been used to create specialised products in various industrial applications, however, research on utilising laser melting of aluminium matrix composites in replacing specialised parts have been slow on the uptake. This has been attributed to the complexity of the laser melting process, metal/ceramic feedstock for the process and the reaction of the feedstock material to the laser. Thus, an understanding of the process, material microstructure and mechanical properties is important for its adoption as a manufacturing route of aluminium metal matrix composites. The effects of several parameters of the laser melting process on the mechanical blended composite were thus investigated in this research. This included single track formations of the matrix alloy and the composite alloyed with 5% and 10% respectively for their reaction to laser melting and the fabrication of density blocks to investigate the relative density and porosity over different scan speeds. The results from these experiments were utilised in determining a process window in fabricating near-fully dense parts.

关键词： selective laser melting additive manufacturing mechanical alloying powder metallurgy aluminium metal matrix composite

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Validity,reliability,and Measurement Invariance of the Thai Smartphone Application-Based Addiction Scale and Bergen Social Media Addiction Scale

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International Journal of Mental health Promotion 2024年第4期26卷 293-302页

作者： Kamolthip ruckwongpatr Ch.rawat Paratthakonkun Usanut Sangtongdee Iqbal Pramukti Ira Nurmala Kanokwan Angkasith Weena Thanachaisakul Jatuphum Ketchatturat mark DGriffiths Yi-Kai Kao Chung-Ying Lin Institute of Allied health Sciences College of MedicineNational Cheng Kung UniversityTainan701401Taiwan College of Sports Science and Technology Mahidol UniversityNakhon Pathom73170Thailand Department of Forensic Science Royal Police Cadet AcademyNakhon Pathom73110Thailand School of Computing Engineeringand Digital TechnologyTeesside UniversityMiddlesbroughUK Faculty of Nursing Universitas PadjadjaranWest Java45363Indonesia Division of health Promotion and Behavioral Sciences Faculty of Public HealthUniversitas AirlanggaSurabaya60115Indonesia Faculty of Education Chiang Mai UniversityChiang Mai50200Thailand Faculty of Education Khon Kaen UniversityKhon Kaen40002Thailand International Gaming research Unit Psychology DepartmentNottingham Trent UniversityNottinghamNG14FQUK Division of Colorectal Surgery E-DA HospitalKaohsiung82445Taiwan College of Medicine National Cheng Kung UniversityTainan701401Taiwan Biostatistics Consulting Center National Cheng Kung University HospitalTainan701401Taiwan

Background:In recent years,th.re has been increased research interest in both smartphone addiction and social media addiction as well as the development of psychometric instruments to assess these ***,th.re is a lack of psychometric evaluation for instruments assessing smartphone addiction and social media addiction in *** present study evaluated the psychometric properties and gender measurement invariance of the Thai version of the Smartphone Application-Based Addiction Scale(SABAS)and Bergen Social Media Addiction Scale(BSMAS).Method:A total of 801 Thai university students participated in an online survey from January 2022 to July 2022 which included demographic information,SABAS,BSMAS,and the Internet Gaming Disorder Scale-Sh.rt Form(IGDS9-SF).results:Confirmatory Factor Analyses(CFAs)found that both the SABAS and BSMAS had a one-factor *** demonstrated adequate psychometric properties of both instruments and also supported measurement invariance across ***,scores on the SABAS and BSMAS were correlated with scores on the ***:The results indicated that the SABAS and BSMAS are useful psychometric instruments for assessing the risk of smartphone addiction and social media addiction among Thai young adults.

关键词： Factor analysis smartphone addiction social media addiction smartphone application-based addiction scale bergen social media addiction scale psychometric validation

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A comparative study of the role of solute,potent particles and ultrasonic treatment during solidification of pure Mg,Mg-Zn and Mg-Zr alloys

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Journal of Magnesium and Alloys 2021年第3期9卷 829-839页

作者： Nagasivamuni Balasubramani Gui Wang mark A.Easton David h.St John Matthew S.Dargusch Centre for Advanced Materials Processing and Manufacturing(AMPAM) School of Mechanical and Mining EngineeringThe University of QueenslandBrisbane 4072Australia School of Engineering RMIT UniversityCarlton3053 VICAustralia

Ultrasonic treatment(UST)applied during the solidification of pure Mg,eutectic(Mg-Zn)and peritectic(Mg-Zr)alloys was investigated in order to explore the grain refinement *** dependent grain refinement is observed in pure Mg wh.re decreasing the superheat temperature(at which UST is applied from above the melting temperature,TM)from 100℃to 40℃produces significant refinement with a uniform grain *** presence of solute reduces the temperature dependence of the UST refinement and excellent grain refinement is obtained regardless of the superheat temperature(100℃or 40℃)and even with the use of preheated sonotrode in the Mg-6 wt.%Zn alloy.A furth.r improvement in grain refinement is achieved when the alloy contains potent particles that introduce additional nucleation of grains in Mg-0.5 and 1.0 wt.%Zr alloys(producing an average grain size of≤100μm).At 40℃superheat,UST of Mg-Zn alloys produces excellent refinement(average grain sizeh non-dendritic grains,which is normally achieved only with the addition of grain refining master alloy in the as-cast *** enhanced refinement observed in the eutectic alloy is explained through the undercooling imposed by a relatively cold sonotrode combined with high frequency vibrations and acoustic *** advantages of using a cold sonotrode,a low superheat and solute are demonstrated for achieving significant refinement during solidification of Mg alloys under UST without or with a lower addition of grain refining master alloys.

关键词： Grain refinement Mg-Zn alloy Mg-Zr alloy Ultrasonic treatment Interdependence Model Solidification

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Through-polymer,via technology-enabled,flexible,lightweight,and integrated devices for implantable neural probes

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Microsystems & Nanoengineering 2024年第2期10卷 279-291页

作者： Cunkai Zhou Ye Tian Gen Li Yifei Ye Lusha Gao Jiazhi Li Ziwei Liu haoyang Su Yunxiao Lu Meng Li Zhitao Zhou Xiaoling Wei Lunming Qin Tiger h.Tao Liuyang Sun College of Electronics and Information Engineering Shanghai University of Electric PowerShanghaiChina 2020 X-Lab Shanghai Institute of Microsystem and Information TechnologyChinese Academy of SciencesShanghaiChina School of Graduate Study University of Chinese Academy of SciencesBeijingChina State Key Laboratory of Transducer Technology Shanghai Institute of Microsystem and Information TechnologyChinese Academy of SciencesShanghaiChina Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijingChina School of Physical Science and Technology ShanghaiTech UniversityShanghaiChina Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of SciencesShanghaiChina Neuroxess Co. Ltd.(Jiangxi)NanchangJiangxiChina Guangdong Institute of Intelligence Science and Technology HengqinZhuhaiGuangdongChina Tianqiao and Chrissy Chen Institute for Translational research ShanghaiChina

In implantable electrophysiological recording systems,the headstage typically comprises neural probes that interface with brain tissue and integrated circuit chips for signal *** advancements in MEMS and CMOS technology have significantly improved these components,their interconnection still relies on conventional printed circuit boards and sophisticated *** conventional approach adds considerable weight and volume to the package,especially for high channel count *** address this issue,we developed a through-polymer via(TPV)method inspired by the through-silicon via(TSV)technique in advanced three-dimensional *** innovation enables the vertical integration of flexible probes,amplifier chips,and PCBs,realizing a flexible,lightweight,and integrated device(FLID).The total weight of the FLIDis only 25%that of its conventional counterparts relying on adapters,which significantly increased the activity levels of animals wearing the FLIDs to nearly match the levels of control animals without ***,by incorporating a platinum-iridium alloy as the top layer material for electrical contact,the FLID realizes exceptional electrical performance,enabling in vivo measurements of both local field potentials and individual neuron action *** findings showcase the potential of FLIDs in scaling up implantable neural recording systems and mark a significant advancement in the field of neurotechnology.

关键词： alloy neural recording

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The mating system of the true fruit fly Bactrocera tryoni and its sister species, Bactrocera neohumeralis

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Insect Science 2017年第3期24卷 478-490页

作者： Wasala M. T. D. Ekanayake Mudalige S. h. Jayasundara Thelma Peek Anthony r. Clarke mark K. Schutze School of Earth Environmental and Biological Sciences Science and Engineering Faculty Queensland University of Technology (QUT)Bdsbane Queensland Department of Agriculture and Fish.ries Ecosciences Precinct Dutton Park Queensland Plant Biosecudty Cooperative research Centre Bruce ACT Australia

The frugivorous ＂true＂ fruit fly, Bactrocera tryoni （Queensland fruit fly）, is presumed to have a nonresourced-based lek mating system. This is largely untested, and contrary data exists to suggest Bactrocera tryoni may have a resource-based mating system focused on fruiting host plants. We tested the mating system ofBactrocera tryoni, and its close sibling Bactrocera neohumeralis, in large field cages using laboratory reared flies. We used observational experiments that allowed us to determine if：（i） mating pairs were aggregated or nonaggregated; （ii） mating system was resource or nonresource based; （iii） flies utilized possible landmarks （tall trees over sh.rt） as mate-rendezvous sites; and （iv） males called females from male-dominated leks. We recorded nearly 250 Bactrocera tryoni mating pairs across all experiments, revealing that：（i） mating pairs were aggregated; （ii） mating nearly always occurred in tall trees over sh.rt; （iii） mating was nonresource based; and （iv） that males and females arrived at the mate-rendezvous site togeth.r with no evidence that males preceded females. Bactrocera neohumeralis copulations were much more infrequent （only 30 mating pairs in total）, but for those pairs th.re was a similar preference for tall trees and no evidence of a resource-based mating system. Some aspects of Bactrocera tryoni mating behavior align with theoretical expectations of a lekking system, but oth.rs do not. Until evidence for unequivocal female choice can be provided （as predicted under a true lek）, the mating system ofBactrocera tryoni is best described as a nonresource based, aggregation system for which we also have evidence that land-marking may be involved.

关键词： aggregation Bactrocera tryoni Dacinae leks nonresourced mating system Tephritidae

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Gold nanoparticles as dehydrogenase mimicking nanozymes for estradiol degradation

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Chinese Chemical Letters 2019年第9期30卷 1655-1658页

作者： Zijie Zhang Leslie M. Bragg mark r. Servos Juewen Liu Department of Chemistry Waterloo Institute for Nanotechnology University of Waterloo Waterloo Ontario N2L 3G1 Canada Department of Biology University of Waterloo Waterloo Ontario N2L 3G1 Canada

Nanozyme catalysis has been mainly focused on a few chromogenic and fluorogenic substrates, while environmentally and biologically important compounds need to be tested to advance the field. In this work, we studied oxidation of estradiol(E2) in the presence of various nanomaterials including gold nanoparticles(AuNPs), nanoceria(CeO2), Fe3O4, Fe2O3, MnO2 and Mn2O3, and found that AuNPs had a dehydrogenase-mimicking activity to convert E2 to estrone(E1). This conversion was monitored using hPLC. The reaction was faster at high.r ph and reached saturation at ph 8. Smaller AuNPs had a high.r catalytic efficiency and 5 nm AuNPs were 4.8-fold faster than 13 nm at the same total surface area. Finally,we tried 17α-ethinylestradiol(EE2) as a substrate and found that 5 nm AuNPs can catalyze EE2 oxidation in the presence of h2O2. This work indicated that some nanomaterials can affect environmentally important h.rmones via oxidation reactions, and this study has expanded the scope of substrate of nanozymes.

关键词： Nanozymes Estradiol Gold nanoparticles Catalysis Environment hPLC

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Practical strategies for modulating foam cell formation and behavior

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World Journal of Clinical Cases 2014年第10期2卷 497-506页

作者： Elisabeth Uitz Babak Bahadori mark F McCarty Mohammed h Moghadasian Department of Internal Medicine 2 University Hospital of St. Poelten Karl Landsteiner Private University of Health and Life Sciences Catalytic Longevity Carlsbad CA 92009 United States Department of human Nutritional Sciences University of Manitoba Winnipeg R2H 2A6 Manitoba Canada

Although high density lipoprotein(hDL)-mediated reverse cholesterol transport is crucial to the prevention and reversal of ath.roma, a recent meta-analysis makes evident that current ph.rmaceutical strategies for modulating hDL cholesterol levels lower cardiovascular risk only to the extent that they concurrently decrease low density lipoprotein(LDL) cholesterol. This corresponds well with findings of a recent Mendelian randomization analysis, in which genetic polymorphisms associated with hDL cholesterol but no oth.r known cardiovascular risk factors failed to predict risk for myocardial infarction. Although it is still seems appropriate to search for th.rapies that could improve the efficiency with which hDL particles induce reverse cholesterol transport, targeting hDL cholesterol levels per se with current measures appears to be futile. Itmay th.refore be more promising to promote reverse cholesterol transport with agents that directly target foam cells. Macrophage expression of the cholesterol transport proteins adenosine triphosphate binding cassette transporter A1, adenosine triphosphate binding cassette transporter G1, and scavenger receptor class B member 1 is transcriptionally up-regulated by activated liver X receptors(LXr), wh.reas nuclear factor(NF)-kappa B antagonizes their expression. Taurine, which inhibits ath.rogenesis in rodent studies, has just been discovered to act as a weak agonist for LXralpha. Conversely, it may be possible to oppose NF-kappa B activation in macrophages with a range of measures. Induction of heme oxygenase-1, which can be attained with phase 2 inducer phytochemicals such as lipoic acid and green tea catechins, promotes reverse cholesterol transport in macrophages and inhibits ath.rogenesis in rodents, likely due to, in large part, NF-kappa B antagonism. Inhibition of macrophage nicotinamide adenine dinucleotide phosphate(NADPh) oxidase activity with the spirulina-derived bilirubin-mimetic phycocyanobilin may also oppose NF-ka

关键词： Ath.rosclerosis Cholesterol Inflammation Phytochemical Nutraceutical Ath.rogenesis Plaque Cytokine Antioxidant

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