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Improved thromboresistance and analytical performance of intravascular amperometric glucose sensors using optimized nitric oxide release coatings

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Chinese Chemical Letters 2015年第4期26卷 464-468页

作者： Alexander K.Wolf Yu Qin Terry C.Major mark e.Meyerhoff Department of Chemistry University of Michigan Department of Chemistry Nanjing University Department of Surgery University of Michigan

In this work, nitric oxide （NO） release coatings designed for intravenous amperometric glucose sensors are optimized through the use ofa polylactic acid （PLA） layer doped with a lipophilic diazeniumdiolated species that releases NO through a proton-driven mechanism. An elast-eon e2As polyurethane coating is used to both moderate NO release from the sensor surface and increase the sensor＇s linear detection range toward glucose. These sensors were evaluated for thromboresistance and in vivo glucose performance through implantation in rabbit veins. By maintaining NO flux on a similar scale to endogenous endothelial cells, implanted glucose sensors exhibited reduced surface clot formation which enables more accurate quantitative glucose measurements continuously. An in vivo time trace of implanted venous sensors demonstrated glucose values that correlated well with the discrete measurements of blood samples on a benchtop point-of-care sensor-based instrument. The raw measured currents from the implanted glucose sensors over 7 h time periods were converted to glucose concentration through use of both a one-point in vivo calibration and a calibration curve obtained in vitro within a bovine serum solution. Control sensors, assembled without NO release functionality, exhibit distinctive surface clotting over the 7 h in vivo implantation period.

关键词： Nitric oxide release coatingsGlucose sensorsPolylactic acid layerQuantitative glucose measurements

Heart healthy=prostate healthy： SeLeCT, the symbolic end of preventing prostate cancer via heart unhealthy and over anti-oxidation mechanisms？

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Asian Journal of Andrology 2012年第2期14卷 243-244页

作者： mark A Moyad Department of Urology University of Michigan Medical Center Ann Arbor MI 48109-0330 USA

The Selenium and Vitamin e Cancer Prevention Trial （SeLeCT） randomized over 35 000 men into four groups： high-dose vitamin e （400 IU day-1）, high-dose selenium （200 mcg day-1）, combination of vitamin e and sele... 详细信息

关键词： prostate cancer Heart healthy prostate healthy anti-oxidation

Rangeland hillslope lengths:A case study at the Walnut Gulch experimental Watershed,southeastern Arizona

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International Soil and Water Conservation Research 2022年第4期10卷 597-609页

作者： Li Li mark A.Nearing Philip Heilman Mary H.Nichols D.P.Guertin C.J.Williams School of Natural Resources and the environment University of ArizonaTucsonAZ85705USA USDA-Agricultural Research Service Southwest Watershed Research CenterTucsonAZ85719USA

Rangeland hillslopes provide much of the sediment supplied to channel systems and their lengths exert a fundamental constraint on hillslope diffusive ***,information regarding lengths of rangeland hillslopes,and how best to estimate them,is *** this study,three groups of watersheds(10 in total)were selected from the Walnut Gulch experimental Watershed according to their geology,soil and vegetation *** 1 watersheds were at lower elevations dominated by shrubs,Group 3 were at high elevations dominated by grass,and Group 2 were mixed shrub and *** hillslope lengths were calculated from 1 m-resolution DeMs using three methods:a flow routing algorithm,slope-area relationships,and inverted relationship with drainage *** that characterize the current watersheds,including Hack's exponent and coefficient,watershed shape coefficient,channel concavity and steepness,and surface roughness,were quantified and related to hillslope *** shows:(1)estimated hillslope lengths were different for the three methods and between the three groups of watersheds;(2)hillslope lengths that measured from the flow routing algorithm for the ten selected watersheds primarily ranged from 30 to 100 m,with a median value of 63.0 m,which was 20%e50%greater than those derived from slope-area plots or drainage densities;(3)hillslope lengths estimated from the flow routing method were greater in Group 3 watersheds than in Group 2 and then in Group 1 *** attributed these differences in hillslope lengths to the historic epeirogenic pulses,watershed and drainage network morphology,and differences in vegetation characteristics;(4)measured hillslope lengths from the flow routing algorithm were best correlated with hillslope relief,then surface roughness,channel steepness and *** results would benefit the applications of hydrological and erosion models in rangelands.

关键词： Rangeland hillslope Slope length Drainage density Slope-area relationship Hillslope hydrology

Detecting prostate cancer and prostatic calcifications using advanced magnetic resonance imaging

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Asian Journal of Andrology 2017年第4期19卷 439-443页

作者： Shewei Dou Yan Bai Ankit Shandil Degang Ding Dapeng Shi e mark Haacke Meiyun Wang Department of Radiology Henan Provincial People's Hospital and The People's Hospital of Zhengzhou University Zhengzhou 450003 Henan China Department of Postgraduate education School of International Education Zhengzhou University Zhengzhou 450001 Henan China Department of Urology Henan Provincial People's Hospital and The People's Hospital of Zhengzhou University Zhengzhou 450003 Henan China Department of Radiology Wayne State University Detroit 48202 MI USA Department of Administration Magnetic Resonance Innovations Inc. Detroit 48202 USA.

Prostate cancer and prostatic calcifications have a high incidence in elderly men. We aimed to investigate the diagnostic capabilities of susceptibility-weighted imaging in detecting prostate cancer and prostatic calcifications. A total number of 156 men, including 34 with prostate cancer and 122 with benign prostate were enrolled in this study. Computed tomography, conventional magnetic resonance imaging, diffusion-weighted imaging, and susceptibility-weighted imaging were performed on all the patients. One hundred and twelve prostatic calcifications were detected in 87 patients. The sensitivities and specificities of the conventional magnetic resonance imaging, apparent diffusion coefficient, and susceptibility-filtered phase images in detecting prostate cancer and prostatic calcifications were calculated. McNemar＇s Chi-square test was used to compare the differences in sensitivities and specificities between the techniques. The results showed that the sensitivity and specificity of susceptibility-filtered phase images in detecting prostatic cancer were greater than that of conventional magnetic resonance imaging and apparent diffusion coefficient （P 〈 0.05）. In addition, the sensitivity and specificity of susceptibility-filtered phase images in detecting prostatic calcifications were comparable to that of computed tomography and greater than that of conventional magnetic resonance imaging and apparent diffusion coefficient （P 〈 0.05）. Given the high incidence of susceptibility-weighted imaging （SWl） abnormality in prostate cancer, we conclude that susceptibility-weighted imaging is more sensitive and specific than conventional magnetic resonance imaging, diffusion-weighted imaging, and computed tomography in detecting prostate cancer. Furthermore, susceptibility-weighted imaging can identify prostatic calcifications similar to computed tomography, and it is much better than conventional magnetic resonance imaging and diffusion-weighted imaging.

关键词： calcification computed tomography diffusion-weighted imaging magnetic resonance imaging prostate cancer susceptibility-weighted imaging

Novel in-capsule synthesis of metal-organic framework for innovative carbon dioxide capture system

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Green energy & environment 2023年第3期8卷 767-774页

作者： Wei Yu Ming Gao Guanhe Rim Tony G.Feric mark L.Rivers Ammar Alahmed Aqil Jamal Ah-Hyung Alissa Park State Key Laboratory of Clean energy Utilization Zhejiang UniversityHangzhou310027China Lenfest Center for Sustainable energy The Earth InstituteColumbia University918 S.W.Mudd HallMail Code 4711500 W 120th St.New YorkNY10027USA Department of earth and environmental engineering 918 S.W.Mudd HallMail Code 4711500 W 120th St.New YorkNY10027USA Department of Chemical engineering Columbia UniversityNew YorkNY10027USA University of Chicago ChicagoIL60637USA Research and Development Center Saudi AramcoDhahran31311Saudi Arabia

Metal-Organic Frameworks(MOFs)have been developed as solid sorbents for CO_(2) capture applications and their properties can be controlled by tuning the chemical blocks of their crystalline units.A number of MOFs(e.g.,HKUST-1)have been developed but the question remains how to deploy them for gas-solid ***,the direct use of MOFs as nanocrystals would lead to serious problems and ***,for the first time,we report a novel MOF-based hybrid sorbent that is produced via an innovative in-situ microencapsulated *** a custom-made double capillary microfluidic assembly,double emulsions of the MOF precursor solutions and UV-curable silicone shell fluid are ***,HKUST-1 MOF is successfully synthesized within the droplets enclosed in the gas permeable *** developed MOF-bearing microcapsules uniquely allow the deployment of functional nanocrystals without the challenge of handling ultrafine particles,and further,can selectively reject undesired compounds to protect encapsulated MOFs.

关键词： encapsulation Metal-Organic Frameworks(MOFs) Carbon capture In-situ microencapsulated synthesis

An updated isoerodent map of the conterminous United States

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International Soil and Water Conservation Research 2022年第1期10卷 1-16页

作者： Ryan P.McGehee Dennis C.Flanagan Puneet Srivastava Bernard A.engel Chi-Hua Huang mark A.Nearing Purdue University Agricultural and Biological Engineering225 South University StreetWest LafayetteIN47907USA United States Department of Agriculture-Agricultural Research Service National Soil Erosion Research Laboratory275 S Russell StWest LafayetteIN47907USA University of Maryland Agricultural Experiment StationSymons Hall7998 Regents DriveCollege ParkMD20742-3131USA Purdue University Agricultural Administration Building615 West State StreetWest LafayetteIN47907-2053USAUnited States Department of Agriculture-Agricultural Research ServiceNational Soil Erosion Research Laboratory275 S Russell StWest LafayetteIN47907USA United States Department of Agriculture-Agricultural Research Service Southwest Watershed Research Center2000 E Allen RdTucsonAZ85719USA

Maps of erosivity,which are also commonly referred to as isoerodent maps,have played a critical role in soil conservation efforts in the United States and around the *** available erosivity maps for the United States are either outdated,conflict with erosivity benchmarking studies,or utilized less advanced spatial mapping ***,it is possible that the same underlying issues with US maps are impacting global maps as *** this study,we used more than 340015-min,fixed-interval precipitation gauges to update the isoerodent map of the conterminous United *** values were interpolated using universal kriging under several spatial model configurations and *** optimal spatial model was selected based on which result had the lowest sample variogram ***,erosivity,and erosivity density maps were compared to existing *** average annual and annual erosivity results were compared to high-quality erosivity benchmarking *** values from both RUSLe2 and Panagos et al.(2017)were generally lower in the eastern United States and mixed in the western United States compared to our *** effects resulted in much greater erosivity differences in this study as compared to prior *** comparisons revealed that erosivity maps from this study and others were lower than the benchmark by 14%or more(up to 38%).These findings suggest current practices of storm omission and intensity dampening correction need to be revisited,especially in locations with relatively low-to-moderate rainfall erosivity such as the Midwest or Northeast United States,for example.

关键词： erosion index erosivity United States USLe RUSLe2 Soil loss

Microstructural evolution of Nb–V–Mo and V Containing TRIP-assisted Steels during Thermomechanical Processing

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Journal of Materials Science & Technology 2017年第4期33卷 311-320页

作者： erfan Abbasi William mark Rainforth Department of Materials Science and engineering The University of Sheffield

The microstructural evolution and precipitation behaviour of Nb–V–Mo and single V containing transformation induced plasticity assisted steels were investigated during thermomechanical processing. A plane strain compression testing machine was used to simulate the thermomechanical processing. Microstructures were characterised by optical microscopy, scanning-transmission electron microscopy and microanalysis, and X-ray diffraction analysis, and Vickers hardness was obtained from the deformed specimens. The resulting microstructure of both Nb–V–Mo and V steels at room temperature primarily consisted of an acicular/bainitic ferrite, retained austenite and martensite surrounded by allotriomorphic *** TeM analysis showed that a significant number of Nb（V,Mo）（C,N） precipitates were formed in the microstructure down to the finishing stage in Nb–V–Mo steel（i.e. 830℃）. It was also found that the V（C,N）precipitation primarily occurred in both ferrite and deformed austenite below the finishing stage. The results suggested that Nb–Mo additions considerably increased the temperature stability of microalloy precipitates and controlled the microstructural evolution of austenite. However, the microalloy precipitation did not cause a significant precipitation strengthening in both Nb–V–Mo and V steels at room temperature.

关键词： Microalloyed TRiP-assisted steel Thermomechanical processing Precipitation behaviour Microstructural evolution

Conductive hearing loss in chronic inflammatory demyelinating polyneuropathy(CIDP):A case report

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Journal of Otology 2018年第4期13卷 141-144页

作者： mark A.Fadel Kevin Y.Zhan edward e.Dodson University of Toledo College of Medicine&Life Sciences 3000 Arlington AveToledoOH43614USA The Ohio State University Wexner Medical Center Department of Otolaryngology-Head&Neck Surgery915 Olentangy River RdColumbusOH43212USA

Chronic inflammatory demyelinating polyneuropathy(CIDP) is a progressive autoimmune disorder that targets peripheral nerves. It commonly presents with motor-predominant dysfunction and enlargement of cranial nerves. With regards to hearing loss, a few cases of sensorineural loss have been described. We present a novel case of conductive hearing loss caused by a mass on the tympanic segment of the facial nerve in the setting of CIDP.

关键词： Chronic inflammatory demyelinating polyneuropathy Hearing loss Ossicular erosion Cranial neuropathy

Assessing risks from mining-induced ground movements near gas wells

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International Journal of Mining Science and Technology 2020年第1期30卷 11-16页

作者： Christopher mark Gregory M.Rumbaugh Mine Safety and Health Administration PittsburghPAUSA

The proliferation of unconventional gas well development in the Northern Appalachian coalfields has raised a number of mine safety *** wells,which extract gas from deep shale formations,are characterized by gas volumes and pressures that are significantly higher than those observed at many conventional *** gas is composed largely of methane as well as other *** of planned and actively producing wells penetrate protective coal pillars or barriers within active mine boundaries,including chain pillars located between longwall *** released from a well damaged by mining-induced ground movements could pose a risk to miners by flowing into the mine *** mining-induced ground movements that may cause well damage include conventional subsidence,non-conventional subsidence(*** plane slip),pillar failure,and floor *** paper describes the known risk factors for each of the four failure *** includes a framework that can guide the risk assessment process when mining takes place near gas or oil wells.

关键词： Gas well Subsidence Coal protection pillar Risk matrix Longwall mining