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复仇之路不通俄克拉荷马城雷霆

NBA特刊 2024年第7期 72-77页

作者：二九 mark49(设计) 不详

2016年,杜兰特离开雷霆,加盟勇士。留给俄克拉荷马城的是无尽的失望和一套残阵。但他的老搭档威斯布鲁克并不打算放弃,他火力全开,连续三个赛季拿到三双数据。正因如此,雷霆队下决心以威斯布鲁克为核心进行补强,他们找来了保罗·乔治和... 详细信息

2016年,杜兰特离开雷霆,加盟勇士。留给俄克拉荷马城的是无尽的失望和一套残阵。但他的老搭档威斯布鲁克并不打算放弃,他火力全开,连续三个赛季拿到三双数据。正因如此,雷霆队下决心以威斯布鲁克为核心进行补强,他们找来了保罗·乔治和卡梅罗·安东尼,组成了华丽的巨头阵容。可惜,仇恨带不来总冠军,雷霆队的一系列操作最终也落了空。

关键词：总冠军俄克拉荷马杜兰特雷霆队安东尼

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洛杉矶湖人目标双冠王

NBA特刊 2024年第1期 20-25页

作者：二九 mark49(设计) 不详

湖人队在赛季开始时暴露了很多问题,但勒布朗·詹姆斯[LeBron James]和安东尼·戴维斯[Anthony Davis]用一座MVP奖杯和一座冠军奖杯提醒其他球队,他们已经建立了足够稳健的防守,本赛季,他们的新目标就是成为NBA历史上的第一支双冠王球队。

关键词：湖人队洛杉矶湖人 NBA 冠军奖杯戴维斯勒布朗防守安东尼

A new framework for reverse cholesterol transport: Non-biliary contributions to reverse cholesterol transport

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World Journal of Gastroenterology 2010年第47期16卷 5946-5952页

作者： Ryan e Temel J mark Brown Department of Pathology Section on Lipid SciencesWake Forest University School of Medicine

Reduction of low-density lipoprotein-cholesterol through statin therapy has only modestly decreased coronary heart disease (CHD)-associated mortality in developed countries, which has prompted the search for alternative therapeutic strategies for CHD. Major efforts are now focused on therapies that augment high-density lipoprotein (HDL)-mediated reverse cholesterol transport (RCT), and ultimately increase the fecal disposal of cholesterol. The process of RCT has long been thought to simply involve HDL-mediated delivery of peripheral cholesterol to the liver for biliary excretion out of the body. However, recent studies have revealed a novel pathway for RCT that does not rely on biliary secretion. This nonbiliary pathway rather involves the direct excretion of cholesterol by the proximal small intestine. Compared to RCT therapies that augment biliary sterol loss, modulation of non-biliary fecal sterol loss through the intestine is a much more attractive therapeutic strategy, given that excessive biliary cholesterol secretion can promote gallstone formation. However, we are at an early stage in understanding the molecular mechanisms regulating the non-biliary pathway for RCT, and much additional work is required in order to effectively target this pathway for CHD prevention. The purpose of this review is to discuss our current understanding of biliary and nonbiliary contributions to RCT with particular emphasis on the possibility of targeting the intestine as an inducible cholesterol secretory organ.

关键词： Cholesterol Intestine Bile Lipoprotein Reverse cholesterol transport

Behavioral effects of social challenges and genomic mechanisms of social priming： What＇s testosterone got to do with it？

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Current Zoology 2014年第6期60卷 791-803页

作者： Kimberly A. ROSVALL mark e PeTeRSON Indiana University Department of Biology and Center for the Integrative Study of Animal Behavior Bloomington IN 47405 USA Viterbo University Departments of Biology and Mathematics La Crosse WI 54601 USA

Social challenges from rival conspecifics are common in the lives of animals, and changes in an animal＇s social environment can influence physiology and behavior in ways that appear to be adaptive in the face of continued social instability （i.e. social priming）. Recently, it has become clear that testosterone, long thought to be the primary mediator of these effects, may not always change in response to social challenges, an observation that highlights gaps in our understanding of the proximate me- chanisms by which animals respond to their social environment. Here, our goal is to address the degree to which testosterone me- diates organismal responses to social cues. To this end, we review the behavioral and physiological consequences of social chal- lenges, as well as their underlying hormonal and gene regulatory mechanisms. We also present a new case study from a wild songbird, the dark-eyed junco Junco hyemalis, in which we find largely divergent genome-wide transcriptional changes induced by social challenges and testosterone, respectively, in muscle and liver tissue. Our review underscores the diversity of mechani- sms that link the dynamic social environment with an organisms＇ genomic, hormonal, and behavioral state. This diversity among species, and even among tissues within an organism, reveals new insights into the pattern and process by which evolution may alter proximate mechanisms of social priming.

关键词： Social priming Challenge hypothesis Aggression Hormonal mechanism Testosterone Genomics

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健康寿命概念变追捧初创公司争相入局

商业周刊（中文版） 2024年第12期 8-11页

作者： mark ellwood 汪泽(译) 不详

疫情后,人们健康意识增强,关注这一领域商机的公司不断涌现。但“健康寿命”概念被一部分人质疑为敛财手段一切从寄来的一个深绿色的盒子开始,装着满满的测试装备。里面有盛放唾液和呼气样本的小瓶子,还有一个监测设备,在预约的面诊时... 详细信息

疫情后,人们健康意识增强,关注这一领域商机的公司不断涌现。但“健康寿命”概念被一部分人质疑为敛财手段一切从寄来的一个深绿色的盒子开始,装着满满的测试装备。里面有盛放唾液和呼气样本的小瓶子,还有一个监测设备,在预约的面诊时间之前需要佩戴几天。说明书指示我带上所有这些东西前往一处咨询室,它位于伦敦市中心一条树林掩映的街道上。这个地方靠近私立医院集中的哈利街,而这家公司的名称Viavi在一个亮闪闪的黄铜蜂鸣器上面,很不显眼。根据具体的项目不同,面诊可能需要两个工作日。

关键词：私立医院初创公司健康寿命伦敦市中心监测设备深绿色蜂鸣器咨询室

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票房大卖好莱坞热衷拍电影续集

商业周刊（中文版） 2024年第11期 10-11页

作者： mark Leydorf 程玺(译) 不详

许多出色的续集不会费尽心思,只会加码更多大家第一部喜爱的内容。疫情过后,急于让观众重返影院的好莱坞全力投人成熟IP,这巩固了流媒体兴起后势不可挡的大片热潮。2020年以来,票房最高的20部影片中有16部是续集、前传或重拍片(又称翻拍... 详细信息

许多出色的续集不会费尽心思,只会加码更多大家第一部喜爱的内容。疫情过后,急于让观众重返影院的好莱坞全力投人成熟IP,这巩固了流媒体兴起后势不可挡的大片热潮。2020年以来,票房最高的20部影片中有16部是续集、前传或重拍片(又称翻拍片)。

关键词：好莱坞电影续集翻拍片流媒体票房重拍片大片

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降雪正在成为过去式相关产业将受影响

商业周刊（中文版） 2024年第2期 26-27页

作者： mark Gongloff 杨飞(译) 不详

如果你和我一样在下雪前志志不安,就像要迎来一场门诊手术,那么,美国最近几年的冬天几乎可以说是幸福的。我们东海岸的一些人近两年来都没有看到大雪。与我的个人感受正相反,这其实并不是什么好事。的确,越来越暖和的冬天和越来越少的... 详细信息

如果你和我一样在下雪前志志不安,就像要迎来一场门诊手术,那么,美国最近几年的冬天几乎可以说是幸福的。我们东海岸的一些人近两年来都没有看到大雪。与我的个人感受正相反,这其实并不是什么好事。的确,越来越暖和的冬天和越来越少的暴风雪意味着寒冷造成的死亡人数较少,而且不用燃烧那么多化石燃料来为房屋供暖。但是,严寒的冬季气候为人类带来了很多好处,随着气候变化和地球变暖,这些好处在逐渐消失。

关键词：个人感受地球变暖门诊手术死亡人数冬季气候化石燃料气候变化暴风雪

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苹果十年造车之旅夏然而止

商业周刊（中文版） 2024年第3期 52-53页

作者： mark Gurman 程玺(译) 不详

苹果此前的目标是生产一款完全自动驾驶的电动汽车,具有豪车内饰和语音导航功能。结束该项目的决定对苹果而言是一个重磅炸弹,但投资者松了一口气。据知情人士透露,苹果公司在经过了十年努力后决定终止电动汽车造车业务,放弃其历史上最... 详细信息

苹果此前的目标是生产一款完全自动驾驶的电动汽车,具有豪车内饰和语音导航功能。结束该项目的决定对苹果而言是一个重磅炸弹,但投资者松了一口气。据知情人士透露,苹果公司在经过了十年努力后决定终止电动汽车造车业务,放弃其历史上最雄心勃勃的开发项目之一。

关键词：电动汽车自动驾驶语音导航内饰苹果公司十年重磅炸弹

Tendency to Avoid Physical Activity and Sport:Associations with Weight Stigma,and Psychological Distress in a Two-Wave Longitudinal Study

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International Journal of Mental Health Promotion 2024年第8期26卷 633-641页

作者： Saffari Mohsen Yi-Ching Lin Po-Ching Huang Yu-Ting Huang Ru-Yi Huang Chi Hsien Huang Jung-Sheng Chen Wai Chuen Poon mark D.Griffiths Chung-Ying Lin Health Research Center Life Style InstituteBaqiyatallah University of Medical SciencesTehran***Iran Health education Department Faculty of HealthBaqiyatallah University of Medical SciencesTehran***Iran Department of early Childhood and Family education National Taipei University of EducationTaipei106TaiwanChina School of Physical Therapy Graduate Institute of Rehabilitation ScienceCollege of MedicineChang Gung UniversityTaoyuan333TaiwanChina Institute of Allied Health Sciences College of MedicineNational Cheng Kung UniversityTainan701TaiwanChina Division of Family Medicine Taipei Tzu Chi HospitalBuddhist Tzu Chi Medical Foundationand School of MedicineTzu Chi UniversityHualienTaiwanChina Data Science Degree Program National Taiwan University and Academia SinicaTaipeiTaiwanChina Department of Family Medicine and Community Medicine E-Da HospitalI-Shou UniversityKaohsiung824TaiwanChina College of Medicine I-Shou UniversityKaohsiung840Taiwan Department of Medical Research E-Da HospitalI-Shou UniversityKaohsiung840TaiwanChina Sunway Business School Sunway UniversitySelangor47500Malaysia International Gaming Research Unit Psychology DepartmentNottingham Trent UniversityNottinghamNG14BUUK Department of Public Health College of MedicineNational Cheng Kung UniversityTainan701TaiwanChina Biostatistics Consulting Center National Cheng Kung University HospitalCollege of MedicineNational Cheng Kung UniversityTainan704TaiwanChina Department of Occupational Therapy College of MedicineNational Cheng Kung UniversityTainan701TaiwanChina

Background:Physical inactivity is a major public health problem worldwide that results in physical and mental health *** major issue for physical inactivity is weight stigma(WS),especially perceived WS,which could lead to a tendency to avoid physical activity(PA).To better understand the association between perceived WS and PA,knowledge of the likely mediators in this association such as weight bias internalization(WBI)and psychological distress were investigated in the present ***:Using a two-wave longitudinal study and convenient sampling,388 Taiwan residents participants(55%females;mean age=29.7 years[SD±6.3])completed two surveys six months *** mass index(BMI),Perceived Weight Stigma Scale(PWSS),Weight Bias Internalization Scale(WBIS),Depression,Anxiety,Stress Scale(DASS-21),and Tendency to Avoid Physical Activity and Sport Scale(TAPAS)were ***:A mediation model controlling for age,gender,and BMI with 5000 bootstrapping resamples was *** WS exerted significant direct effects on WBI(β=0.25;pess(β=0.15;p=0.003),and tendency to avoid PA(β=0.10;p=0.027);WBI exerted a significant direct effect on tendency to avoid PA(β=0.47;ped indirect effects of WBI and psychological distress on the association between perceived WS and tendency to avoid PA were 0.12 and 0.01,***:Given the direct association of perceived WS on the tendency to avoid PA and the mediating role of WBI in this association,interventions addressing perceived WS and WBI may contribute to promoting ***,health interventionists(both when planning and executing PA programs)need to consider weight stigmawhen encouraging physical activity.

关键词： Mediation model physical activity psychological distress weight stigma young adults