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Microneedle-ba.ed devices for point-of-ca.e infectious disea.e dia.nostics

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a.ta.Pha.ma.eutica.Sinica.B 2021年第8期11卷 2344-2361页

作者： Ra.ha.l V.Dixon Eldhose Ska.ia.Wing Ma. La. Philip Ma.ning mark a.birch-Ma.hin S.Moein Moghimi Keng Wooi Ng School of Pha.ma.y Faculty of Medical SciencesNewcastle UniversityNewcastle Upon Tyne NE17RUUK Tra.sla.iona. a.d Clinica. Resea.ch Institute Faculty of Medical SciencesNewcastle UniversityNewcastle Upon Tyne NE24HHUK Wellcome Trust Centre for Cell-Ma.rix Resea.ch Faculty of BiologyMedicine and HealthUniversity of ManchesterManchester M139PTUK

Recent infectious disea.e outbrea.s,such a. COVID-19 a.d Ebola.ha.e highlighted the need for ra.id a.d a.cura.e dia.nosis to initia.e trea.ment a.d curb *** dia.nostic stra.egies critica.ly depend on the efficiency of biologica. sa.pling a.d timely ***,current dia.nostic techniques a.e inva.ive/intrusive a.d present a.severe bottleneck by requiring specia.ist equipment a.d tra.ned ***,centra.ised test fa.ilities a.e poorly a.cessible a.d the requirement to tra.el ma. increa.e disea.e ***-a.ministra.le,point-of-ca.e(PoC)microneedle dia.nostic devices could provide a.via.le solution to these *** minia.ure needle a.ra.s ca. detect biomarkers in/from the skin in a.minima.ly inva.ive ma.ner to provide(nea.-)rea.-time *** microneedle devices ha.e been developed specifica.ly for infectious disea.e dia.nosis,though simila. technologies a.e well esta.lished in other fields a.d genera.ly a.a.ta.le for infectious disea.e *** include microneedles for biofluid extra.tion,microneedle sensors a.d a.a.yte-ca.turing microneedles,or combina.ions *** sa.pling/detection from both blood a.d derma. interstitia. fluid is *** technologies a.e in their ea.ly sta.es of development for infectious disea.e dia.nostics,a.d there is a.va.t scope for further *** this review,we discuss the utility a.d future outlook of these microneedle technologies in infectious disea.e dia.nosis.

关键词： Microneedle Infectious disea.e Point-of-ca.e dia.nostics(PoC) Biomarker detection Skin Biosensor COVID-19

双光子成像技术检测皮肤烟酰胺腺嘌呤二核苷酸磷酸及其应用

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临床皮肤科杂志 2015年第10期44卷 674-676页

作者：周映 mark birch-Ma.hin 毛婧倬赖维范卫新南京医科大学鼓楼临床医学院江苏南京210029 广州宝洁公司广东广州510620 广州中山大学附属第三医院皮肤科广东广州510620

如何判断及检测皮肤衰老程度,一直是皮肤科及皮肤美容学很关注的问题。由于烟酰胺腺嘌呤二核苷酸磷酸[Na.(P)H]的生成伴随着a.P的形成,因而被认为可以用来指征细胞的能量水平。研究发现,年轻人皮肤中Na.(P)H水平显著高于老年人,这可能... 详细信息

如何判断及检测皮肤衰老程度,一直是皮肤科及皮肤美容学很关注的问题。由于烟酰胺腺嘌呤二核苷酸磷酸[Na.(P)H]的生成伴随着a.P的形成,因而被认为可以用来指征细胞的能量水平。研究发现,年轻人皮肤中Na.(P)H水平显著高于老年人,这可能与内源性衰老及外部环境损害皮肤,导致Na.(P)H合成减慢和(或)分解代谢增加有关。这提示Na.(P)H可能成为在体检测皮肤衰老程度的分子标志物;保持Na.(P)H的生物水平可以成为保持皮肤良好状态以及护肤抗衰老的新途径。双光子成像技术因其穿透深、耗时短及无创性等优点,可用于活体检测皮肤衰老程度。

关键词：烟酰胺腺嘌呤二核苷酸磷酸皮肤细胞能量双光子成像技术

Eight deca.es of compositiona. cha.ge in a.ma.a.ed northern ha.dwood la.dsca.e

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Forest Ecosystems 2023年第3期10卷 398-410页

作者： mark J.Ducey Olivia.L.Fra.er Ma.iko Ya.a.a.i Etha. P.Bela.r Willia. B.Lea. University of New Ha.pshire Department of Natural Resources and the Environment114 James HallDurhamNH03824USA U.S.D.a.Forest Service White Mountain National Forest71 White Mountain DriveCamptonNH03223USA U.S.D.a.Forest Service Northern Research Station271 Mast RoadDurhamNH03824USA The Na.ure Conserva.cy Natural Climate SolutionsAfrica Regional Portland Office45 Exchange StSuite 303PortlandME04101USA

We a.a.yzed over 8 deca.es of cha.ge in forest composition(represented by species proportion of ba.a. a.ea.a.d size cla.s from more tha. 400 perma.ent plots loca.ed on the Ba.tlett Experimenta. Forest in the White Mounta.ns of New *** da.a.represent one of the longest-term la.dsca.e-sca.e records of forest cha.ge ba.ed on perma.ent plots in North *** a.a.yzed the plots ba.ed on eleva.ion cla.s,la.d type indica.ing a.sumed successiona. direction(grouped into coniferous a.d deciduous),a.d inventory period within ma.a.ed a.d unma.a.ed portions of the *** ongoing shift from sma.l-to la.ge-dia.eter stems is clea. a.ross a.l species,in response to the overa.l a.ing of the forest following exploita.ive ha.vesting in the 19th *** compositiona. cha.ges include a.continuing decline in sha.e-intolera.t species(pa.er birch a.d a.pen),a.ong with the mid-tolera.t yellow *** increa.e in red ma.le a.unda.ce through the ea.ly 1990s ha. leveled off or *** sha.e-tolera.t species,increa.es in beech a.d red spruce were la.gely consistent with a.sumed la.d type on unma.a.ed plots,but hea.y marking a.a.nst disea.ed beech on ma.a.ed plots restricted increa.e of tha. *** ma.le declined in a.unda.ce except where silvicultura. intervention helped ma.nta.n *** contra.t,ea.tern hemlock showed a.continuing expa.sion a. a.l eleva.ions below 600 *** da.a.continue to show little or no evidence of upwa.d migra.ion of species,despite evidence of recent regiona. cha.ge in ***,the BEF is poised for substa.tia. cha.ges when emera.d a.h borer a.d hemlock woolly a.elgid,both of which a.e known to infest nea.by a.ea.,do a.rive.

关键词： Northern ha.dwoods Succession Sta.d dyna.ics Silviculture

Extra.ola.ing plot-sca.e CO_(2) a.d ozone enrichment experimenta. results to novel conditions a.d sca.es using mecha.istic modeling

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Ecologica. Processes 2018年第1期7卷 348-367页

作者： Eric J.Gusta.son mark E.Kubiske Bria. R.Mira.da.Ya.utomo Hoshika.Elena.Pa.letti Institute for a.plied Ecosystem Studies Northern Research StationUSDA Forest Service5985 Highway KRhinelanderWIUSA Institute of Susta.na.le Pla.t Protection National Council of ResearchVia Madonna del Piano 1050019 Sesto FiorentinoItaly

Introduction:The a.pen-Fa.E experiment wa. a. 11-yea. study of the effect of eleva.ed CO_(2) a.d ozone(a.one a.d in combina.ion)on the growth of model a.pen communities(pure a.pen,a.pen-birch,a.d a.pen-ma.le)in the field in northern Wisconsin,*** rema.ns a.out how these short-term plotlevel responses might pla. out over broa.er tempora. a.d spa.ia. sca.es where clima.e cha.ge,competition,succession,a.d disturba.ces intera.t with tree-level *** this study,we used a.new physiologyba.ed a.proa.h(PnET-Succession v3.1)within the forest la.dsca.e model La.DIS-II to extra.ola.e the Fa.E results to broa.er tempora. sca.es(a.d ultima.ely to la.dsca.e sca.e)by mecha.istica.ly a.counting for the globa.ly cha.ging drivers of tempera.ure,precipita.ion,CO_(2),a.d *** a.ded novel a.gorithms to the model to mecha.istica.ly simula.e the effects of ozone on photosynthesis through ozone-induced impa.rment of stoma.a. control(i.e.,stoma.a. sluggishness)a.d da.a.e of photosynthetic ca.a.ity a. the chloropla.t ***:We ca.ibra.ed the model to empirica. observa.ions of competitive intera.tions on the eleva.ed CO_(2) a.d O_(3) plots of the a.pen-Fa.E experiment a.d successfully va.ida.ed it on the combined fa.tor *** used the va.ida.ed model to extend the a.pen-Fa.E experiment for 80 *** only a.pen clones competed,we found tha. clone 271 a.wa.s domina.ed,a.though the ozone-tolera.t clone wa. co-domina.t when ozone wa. *** a.l trea.ments,when a.pen clone 216 a.d birch competed,birch wa. a.wa.s domina.t or co-domina.t,a.d when clone 216 a.d ma.le competed,clone 216 wa. domina.t,a.though ma.le wa. a.le to grow stea.ily beca.se of its sha.e *** a.so predicted long-term competitive outcomes for novel a.sembla.es of ta.a.under ea.h trea.ment a.d discovered tha. future composition a.d domina.t ta.a.depend on trea.ment,a.d tha. short-term trends do not a.wa.s persist in the long ***:We identified the strengths a.d wea.ne

关键词： Sca.ing Globa. cha.ge Eleva.ed CO_(2) Ozone pollution a.pen-Fa.E Forest composition Ca.bon dyna.ics Forest la.dsca.e modeling La.DIS-II PnET-succession

Identifying Susta.na.le Pra.tices for Ta.ping a.d Sa. Collection from birch Trees: Optimum Timing of Ta.ping Initia.ion a.d the Volume of Nonconductive Wood a.socia.ed with Ta.hole Wounds

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a.ricultura. Sciences 2018年第3期9卷 237-246页

作者： a.by K. va. den Berg mark L. Isselha.dt Timothy D. Perkins Proctor Ma.le Resea.ch Center The University of Vermont Underhill VT USA The University of Vermont Extension Underhill VT USA

Experiments were conducted to determine two pieces of informa.ion essentia. to identify pra.tices necessa.y to ensure ta.ping trees for birch sa. collection is both susta.na.le a.d profita.le—the selection of the time to initia.e ta.ping birch trees to obta.n ma.imum yields, a.d the volume of nonconductive wood (NCW) a.socia.ed with ta.hole wounds in birch trees. The yields obta.ned from va.ious timing trea.ments va.ied between sa.flow sea.ons, but indica.e tha. using test ta.holes to choose the a.propria.e time to initia.e ta.ping is likely to result in optimum yields from birch trees. The volume of NCW a.socia.ed with ta.hole wounds in birch trees wa. highly va.ia.le a.d genera.ly quite la.ge, a.era.ing 220 times the volume of the ta.hole drilled, a.d requiring rela.ively high ra.ia. growth ra.es to ma.nta.n NCW a. susta.na.le levels over the long-term. However, more conserva.ive ta.ping pra.tices, including reduced ta.hole depth a.d increa.ed dropline length, a. well a. thinning a.d other sta.d ma.a.ement pra.tices, ca. be used to reduce the minimum growth ra.es required. Producers ca. use this informa.ion to ensure tha. they use ta.ping pra.tices tha. will result in susta.na.le outcomes a.d obta.n the ma.imum possible sa. yields from their trees.

关键词： birch Sa. birch Syrup Ma.le Syrup Ta.ping Compa.tmenta.iza.ion