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Unraveling the hydrothermal history of the Xinshuijing Na-metasomatite uranium deposit in the Longshoushan metallogenic belt， Northwest China by coupled hydrothermal zircon U–Pb and albite Ar–Ar dating

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Journal of Earth Science 2024年

作者： JUN ZHONG mark MIHALASKY MICHEL CUNEY SHENG HE JUN-JIE LI National Key Laboratory of Uranium Resource Exploration-Mining and Nuclear Remote Sensing， Beijing Research Institute of Uranium Geology International Atomic Energy Agency (IAEA)， Nuclear Fuel Cycle and Materials Section， Division of Nuclear Fuel Cycle and Waste Technology， Vienna International Center Université de Lorraine， GéoRessources CNRS State Key Laboratory of Lithospheric Evolution (SKLLE)， Institute of Geology and Geophysics， Chinese Academy of Sciences

Na-metasomatite uranium deposits are an important type of large-tonnage low-grade uranium deposit. They are characterized by an intimate association between uranium minerals and albite， and by the common development of syn-ore hydrothermal zircons. Similar to other types of uranium deposits， constraining an accurate age of mineralization remains a challenge for the Na-metasomatite type ones. In this study， we present for the first time， an approach that combines age dating results from the syn-ore albites (40Ar-39Ar) and hydrothermal zircons （U-Pb） for a typical Na-metasomatite uranium deposit， the Xinshuijing deposit in the Longshoushan metallogenic belt of northwest China. The hydrothermal zircon U-Pb and albite40Ar-39Ar ages are consistent with each other （378-366 Ma; within error）， but also identical to the previously reported uraninite chemical U-Pb ages （approximately 370 Ma）. The coupled application of hydrothermal zircon U-Pb and albite40Ar-39Ar age dating is thus regarded as a robust approach for constraining the age of mineralization for Na-metasomatite uranium deposits. An age gap of approximately 70 m.y. between uranium mineralization （～ 370 Ma） and host granitoid emplacement （about 440 Ma） suggests no direct genetic linkage between the two. Further exploration in the surrounding metamorphic units is therefore suggested， rather than only focusing on the host granitoids， especially where intensive wallrock alteration and structural features are pervasive. The varied hydrothermal zircon δ18O isotope compositions are attributed to the significant fluid-wallrock interaction during the uranium mineralization， which is consistent with our previous fluid inclusion and geochemical studies. Our study highlights the importance of selecting appropriate isotopic dating methods， which is informed by detailed paragenetic and geochemical analysis of dateable minerals formed before or coeval to the main-stage uranium mineralization. Moreover， it is underlined that the e

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A Simulation of the Dependence of Tidal Interaction on Galaxy Type in Compact Groups

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International Journal of Astronomy and Astrophysics 2024年第2期14卷 85-100页

作者： mark J. Henriksen Mateo Mejia Department of Physics University of Maryland Baltimore USA

We have investigated the role that different galaxy types have in galaxy-galaxy interactions in compact groups. N-body simulations of 6 galaxies consisting of a differing mixture of galaxy types were run to compare the relative importance of galaxy population demographic on evolution. Three different groups with differing galaxy content were tested: all spiral, a single elliptical and 50% elliptical. Tidal interaction strength and duration were recorded to assess the importance of an interaction. A group with an equal number of spiral and elliptical galaxies has some of the longest and strongest interactions with elliptical-elliptical interactions being most significant. These elliptical-elliptical interactions are not dominated by a single large event but consist of multiple interactions. Elliptical galaxies tidally interacting with spiral galaxies, have the next strongest interaction events. For the case when a group only has a single elliptical, the largest magnitude tidal interaction is an elliptical on a spiral. Spirals interact with each other through many small interactions. For a spiral only group, the interactions are the weakest compared to the other group types. These spiral interactions are not dominated by any singular event that might be expected to lead to a merger but are more of an ongoing harassment. These results suggest that within a compact group, early type galaxies will not form via merger out of an assemblage of spiral galaxies but rather that compact groups, in effect form around an early type galaxy.

关键词： Galaxy Groups Galaxy Clusters Galaxy Evolution N-Body Simulations

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Why Don’t We Adequately Identify and Manage Adverse Drug Reactions despite Having the Needed Information?

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Health 2024年第2期16卷 148-159页

作者： mark J. Kupersmith Karl Kieburtz Department of Neurology Ophthalmology and Neurosurgery Icahn School of Medicine at Mount Sinai New York NY USA SafeTherapeutics LLC New York NY USA Clintrex Research Corporation Sarasota FL USA

Importance/Objective: Adverse Drug Reactions (ADRs) are unavoidable, but recognizing and addressing ADRs early can improve wellness and prevent permanent injury. We suggest that available medical information and digital/electronic methods could be used to manage this major healthcare problem for individual patients in real time. Methods: We searched the available digital applications and three literature databases using the medical subject heading terms, adverse drug reaction reporting systems or management, filtered by clinical trial or systemic reviews, to detect publications with data about ADR identification and management approaches. We reviewed the reports that had abstract or summary data or proposed or implemented methods or systems with potential to identify or manage ADRs in clinical settings. Results: The vast majority of the 481 reports used retrospectively collected data for groups of patients or were limited to surveying one population group or class of medication. The reports showed potential and definite associations of ADRs for specific drugs and problems, mostly, but not exclusively, for patients in hospitals and nursing homes. No reports described complete methods to collect comprehensive data on ADRs for individual patients in a healthcare system. The digital applications have ADR information, but all are too cumbersome or incomplete for use in active clinical settings. Several studies suggested that providing information about potential ADRs to clinicians can reduce these problems. Conclusion and Relevance: Although investigators and government agencies agree with the need, there is no comprehensive ADR management program in current use. Informing the patient’s healthcare practitioners of potential ADRs at the point of service has the potential for reduction of these complications, which should improve healthcare and reduce unneeded costs.

关键词： Adverse Drug Reaction Medication Side Effect Identification Medication Complication Medication Safety

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基于丙烯酸-N-琥珀酰亚胺酯共聚物交联剂的壳聚糖水凝胶的生物相容性研究

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材料导报 2024年第12期38卷 234-243页

作者：杨水艳盛扬孙一新蔡仁钦 mark Bradley 张嵘常州大学材料科学与工程学院江苏常州213164 大博医疗科技有限公司基础研究院福建厦门361026 英国爱丁堡大学化学学院英国爱丁堡EH93JJ

壳聚糖作为一种天然的氨基多糖,拥有良好的生物相容性和资源可再生性,但是较差的力学性能限制了其更广泛的应用。本研究以丙烯酸、N-乙烯基吡咯烷酮和丙烯酸-N-琥珀酰亚胺酯为单体聚合得到三元共聚物大分子交联剂,然后将其与壳聚糖溶液... 详细信息

壳聚糖作为一种天然的氨基多糖,拥有良好的生物相容性和资源可再生性,但是较差的力学性能限制了其更广泛的应用。本研究以丙烯酸、N-乙烯基吡咯烷酮和丙烯酸-N-琥珀酰亚胺酯为单体聚合得到三元共聚物大分子交联剂,然后将其与壳聚糖溶液混合后制备壳聚糖水凝胶。采用红外、热重、SEM等对合成的聚合物及壳聚糖凝胶的组成、形貌和热稳定性进行了表征。结果表明,丙烯酸-N-琥珀酰亚胺酯共聚物的数均分子量为111900,具有一定的水溶性,与壳聚糖形成的水凝胶有良好的力学性能、溶胀性能和水蒸气渗透速率。在PBS(pH=7.4)中交联的凝胶膜与酸性条件下制备的凝胶膜相比,热分解温度提高,水接触角变大,力学性能得到较大提升。细胞毒性实验表明壳聚糖凝胶有良好的生物相容性,人脂肪干细胞在壳聚糖凝胶膜上会形成细胞簇并分泌外泌体。将壳聚糖凝胶膜覆盖在脂肪干细胞上,细胞能正常生长并分泌外泌体。因此,壳聚糖凝胶具有负载外泌体后应用于皮肤敷料的潜力。

关键词：壳聚糖丙烯酸-N-琥珀酰亚胺酯水凝胶外泌体

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Rationale and design of Tenecteplase Reperfusion Therapy in Acute Ischaemic Cerebrovascular Events III (TRACE III): a randomised, phase III, open- label, controlled trial

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Stroke & Vascular Neurology 2024年第1期9卷 82-89页

作者： Yunyun Xiong Bruce C V Campbell Marc Fisher Lee H Schwamm mark Parsons Hao Li Yuesong Pan Xia Meng Xingquan Zhao Yongjun Wang Neurology Beijing Tiantan HospitalBeijingChina China National Clinical Research Center for Neurological Diseases BeijingChina Department of Medicine and Neurology The University of MelbourneMelbourneVictoriaAustralia Neurology Beth Israel Deaconess Medical CenterBostonMassachusettsUSA Department of Neurology and Comprehensive Stroke Center Massachusetts General HospitalBostonMassachusettsUSA Department of Neurology University of New South Wales South Western Sydney Clinical SchoolLiverpoolNew South WalesAustralia

Background and purpose Recombinant human TNK tissue-type plasminogen activator(rhTNK-tPA)was not inferior to alteplase for ischaemic stroke within *** study aimed to investigate the efficacy and safety of rhTNK-tPA in patients who had an ischaemic stroke due to large vessel occlusion(LVO)of anterior circulation beyond *** and design Tenecteplase Reperfusion Therapy in Acute Ischaemic Cerebrovascular Events-III(TRACE III)is a multicentre,prospective,randomised,open-label,blind endpoint,controlled clinical *** who had an ischaemic stroke due to anterior circulation LVO(internal carotid artery,middle cerebral artery M1 and M2 segments)within 4.5–24hours from last known well(including wake-up stroke and no witness stroke)and with salvageable tissue(ischaemic core volume6s at 24 hours and NIHSS score change from baseline at *** outcomes are symptomatic intracerebral haemorrhage within 36 hours and mortality at 90 *** TRACE III will provide evidence for the efficacy and safety of rhTNK-tPA in patients who had an ischaemic strokes due to anterior circulation LVO beyond *** registration number NCT05141305.

关键词： Therapy random Rational

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Regioselective cation exchange reaction for photoelectrochemical water splitting

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Rare Metals 2024年第7期43卷 3400-3407页

作者： Mo-Yan Chen Tai-Song Zhang Zhi Yan Jiang-Nan Lv Xiao-Ting Sun Rui-Xia Yang mark TSwihart Xiao-Hong Xu Yang Liu Research Institute of Materials Science of Shanxi Normal University&Key Laboratory of Magnetic Molecules and Magnetic Information Materials of Ministry of Education Taiyuan 030031China Department of Chemical and Biological Engineering University at Buffalo(SUNY)NY 14260USA Department of Materials Science Fudan UniversityShanghai 200433China

Engineering copper sulfide-based heterostructures via cation exchange(CE)is an appealing approach,as it allows selective combination of distinct compositions and functions of metal *** heterostructures can play a significant role in photoelectrochemical applications,but the effect of the ratio between two or more domains in such heterostructures on the photoresponse has not been well explored.

关键词： exchange sulfide splitting

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An Improved Coupled Level Set and Continuous Moment-of-Fluid Method for Simulating Multiphase Flows with Phase Change

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Communications on Applied Mathematics and Computation 2024年第2期6卷 1034-1069页

作者： Zhouteng Ye Cody Estebe Yang Liu Mehdi Vahab Zeyu Huang mark Sussman Alireza Moradikazerouni Kourosh Shoele Yongsheng Lian Mitsuhiro Ohta M.Yousuff Hussaini ZJUI Institute Zhejiang UniversityHaining 314400ZhejiangChina Department of Mathematics Florida State UniversityTallahasseeUSA Department of Mechanical Engineering Florida State UniversityTallahasseeUSA Mechanical and Aerospace Engineering Mathworks NatickMAUSA School of Aerospace Engineering Tsinghua UniversityBeijing 100084China Department of Mechanical Engineering University of LouisvilleLouisvilleUSA Department of Mechanical Science Tokushima UniversityTokushimaJapan

An improved algorithm for computing multiphase flows is presented in which the multimaterial Moment-of-Fluid(MOF)algorithm for multiphase flows,initially described by Li et al.(2015),is enhanced addressing existing MOF difficulties in computing solutions to problems in which surface tension forces are crucial for understanding salient flow *** Continuous MOF(CMOF)method is motivated in this *** CMOF reconstruction method inherently removes the"checkerboard instability"that persists when using the MOF method on surface tension driven multiphase(multimaterial)*** CMOF reconstruction algorithm is accelerated by coupling the CMOF method to the level set method and coupling the CMOF method to a decision tree machine learning(ML)*** flow examples are shown in the two-dimensional(2D),three-dimensional(3D)axisymmetric"RZ",and 3D coordinate *** include two material and three material multiphase flows:bubble formation,the impingement of a liquid jet on a gas bubble in a cryogenic fuel tank,freezing,and liquid lens dynamics.

关键词： Moment-of-Fluid(MOF) Surface tension Two phase flow Phase change Deforming boundaries with change(s)in topology Two-dimensional(2D) Three-dimensional(3D)axisymmetric 3D

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基于概率的步行导致结构振动评估方法

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建筑结构 2024年第5期54卷 104-110页

作者：李兆凡潘斌 mark SARKISIAN 清华大学土木工程系北京100084 史基摩欧文美尔(上海)建筑设计事务所有限公司上海200031 Skidmore Owings&Merrill LLPSan FranciscoCA 94111

提出一种基于概率的步行导致结构振动评估方法。现有的评估方法大致有三类:简化方法、基于频域的方法和基于时域的方法,都可以得到步行导致结构共振时产生的峰值加速度,但都没有考虑步行频率的概率分布,因此无法给出加速度值对应的超越... 详细信息

提出一种基于概率的步行导致结构振动评估方法。现有的评估方法大致有三类:简化方法、基于频域的方法和基于时域的方法,都可以得到步行导致结构共振时产生的峰值加速度,但都没有考虑步行频率的概率分布,因此无法给出加速度值对应的超越概率。行人步行频率大部分分布在一个较窄的范围内,而且基本符合正态分布。该评估方法可以在计算结构竖向振动加速度的基础上,计算振动加速度的概率密度函数。从而可以确定各加速度值的超越概率,对结构振动的风险作出更准确的评估。在此基础上,可以选择具有一定保证率的结构振动加速度反应系数来代表结构的振动性能表现,建议办公建筑取95%保证率的反应系数,天桥结构取具有90%保证率的反应系数来代表结构的振动表现。

关键词：步行振动加速度反应系数概率正态分布保证率

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Adverse events associated with the gold probe and the injection gold probe devices used for endoscopic hemostasis:A MAUDE database analysis

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World Journal of Gastrointestinal Endoscopy 2024年第1期16卷 37-43页

作者： Vishnu Charan Suresh Kumar mark Aloysius Ganesh Aswath Division of Gastroenterology and Hepatology SUNY Upstate Medical UniversitySyracuseNY 13202United States

BACKGROUND Gastrointestinal(GI)bleeding accounts for over half a million admissions annually and is the most common GI diagnosis requiring hospitalization in the United *** electrocoagulation devices are used for the management of gastrointestinal *** is no data on device-related adverse events for gold probe(GP)and injection gold probe(IGP).AIM To analyze this using the Food and Drug Administration(FDA’s)Manufacturer and User Facility Device Experience(MAUDE)database from 2013 to *** We examined post-marketing surveillance data on GP and IGP from the FDA MAUDE database to report devicerelated and patient-related adverse events between *** MAUDE database is a publicly available resource providing over 4 million records relating to medical device *** analyses were performed using IBM SPSS Statistics V.27.0(IBM Corp.,Armonk,NY,United States).RESULTS Our search elicited 140 reports for GP and 202 reports for IGP,respec-tively,during the study period from January 2013 to August *** reportedly occurred in 130 cases for GP,and actual patient injury or event occurred in 10 patients.A total of 149 patients(74%)reported with Injection GP events suffered no significant consequences due to the device failure,but 53 patients(26%)were affected by an *** GP and IGP are critical in managing gastrointestinal *** study of the FDA MAUDE database revealed the type,number,and trends of reported device-related adverse *** endoscopist and support staff must be aware of these device-related events and be equipped to manage them if they occur.

关键词： Hemostasis Gastrointestinal bleeding Endoscopy Device failure Bipolar coagulation Cautery Risks

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A Bayesian hierarchical model for the inference between metal grade with reduced variance:Case studies in porphyry Cu deposits

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Geoscience Frontiers 2024年第2期15卷 304-314页

作者： Yufu Niu mark Lindsay Peter Coghill Richard Scalzo Lequn Zhang CSIRO Mineral Resources Lucas HeightsNew South Wales 2234Australia Mineral Exploration Cooperative Research Centre Centre for Exploration TargetingSchool of Earth ScienceThe University of Western AustraliaPerthWA 6009Australia ARC centre for Data Analytics for Resources and Environments(DARE) Perth and SydneyAustralia CSIRO Mineral Resources Australian Resources Research CentreWA 6151Australia CSIRO Data61 ClaytonVIC 3168Australia

Ore sorting is a preconcentration technology and can dramatically reduce energy and water usage to improve the sustainability and profitability of a mining *** porphyry Cu deposits,Cu is the primary target,with ores usually containing secondary‘pay’metals such as Au,Mo and gangue elements such as Fe and *** to sensing technology limitations,secondary and deleterious materials vary in correlation type and strength with Cu but cannot be detected simultaneously via magnetic resonance(MR)ore *** the relationships between Cu and other elemental abundances is particularly critical for mineral *** variations in metal grade relationships occur due to the transition into different geological *** raises two questions-how to define these geological domains and how the metal grade relationship is influenced by these geological *** this paper,linear relationship is assumed between Cu grade and other metal *** applies a Bayesian hierarchical(partial-pooling)model to quantify the linear relationships between Cu,Au,and Fe grades from geochemical bore core *** hierarchical model was compared with two other models-‘complete-pooling’model and‘nopooling’*** blocks were split based on spatial domain to construct hierarchical *** bore core data records metal grades measured from laboratory assay with spatial coordinates of sample *** case studies from different porphyry Cu deposits were used to evaluate the performance of the hierarchical *** chain Monte Carlo(MCMC)was used to sample the posterior *** results show that the Bayesian hierarchical model dramatically reduced the posterior predictive variance for metal grades regression compared to the no-pooling *** addition,the posterior inference in the hierarchical model is insensitive to the choice of *** data is wellrepresented in the posterior which indicates a robust *** results show that the spatial dom

关键词： Bayesian hierarchical model Porphyry Cu deposit Ore sorting Metal grade Linear regression

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