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被拜登遗忘的美国铁锈带

商业周刊（中文版） 2024年第6期 26-30页

作者： Shawn Donnan with mark Niquette 汪泽(译) 不详

就业人数大幅减少,拜登制造业复兴政策略过了美国铁锈带的摇摆州在密尔沃基的Master Lock Co.工厂,仅仅十年前,工人们每年的薪水至少达到10万美元,他们制造的挂锁确保了美国学校仓库和后院小屋的安全。然而现在,这座工厂显示出了美国总... 详细信息

就业人数大幅减少,拜登制造业复兴政策略过了美国铁锈带的摇摆州在密尔沃基的Master Lock Co.工厂,仅仅十年前,工人们每年的薪水至少达到10万美元,他们制造的挂锁确保了美国学校仓库和后院小屋的安全。然而现在,这座工厂显示出了美国总统乔·拜登(Joe Biden)竞选连任的经济宣传的一个弱点。

关键词：密尔沃基就业人数制造业复兴铁锈薪水

Recurrent hepatitis C after liver transplant

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world Journal of Gastroenterology 2014年第31期20卷 10668-10681页

作者： Andrew S deLemos Paul A Schmeltzer mark w Russo Department of Medicine Center for Liver Diseases and Transplantation Carolinas Medical Center

End stage liver disease from hepatitis C is the most common indication for liver transplantation in many parts of the world accounting for up to 40% of liver transplants. Antiviral therapy either before or after liver transplantation is challenging due to side effects and lower efficacy in patients with cirrhosis and liver transplant recipients, as well as from drug interactions with immunosuppressants. Factors that may affect recurrent hepatitis C include donor age, immunosuppression, IL28 B genotype, cytomegalovirus infection, and metabolic syndrome. Older donor age has persistently been shown to have the greatest impact on recurrent hepatitis C. After liver transplantation, distinguishing recurrent hepatitis C from acute cellular rejection may be difficult, although the development of molecular markers may help in making the correct diagnosis. The advent of interferon free regimens with direct acting antiviral agents that include NS3/4A protease inhibitors, NS5 B polymerase inhibitors and NS5 A inhibitors holds great promise in improving outcomes for liver transplant candidates and recipients.

关键词： Hepatitis C Liver transplant Donor risk factors Immunosuppression Protease inhibitors Fibrosing cholestatic hepatitis C Acute cellular rejection Cytomegalovirus

Effect of longwall-induced subsurface deformations on shale gas well casing stability under deep covers

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International Journal of Mining Science and Technology 2019年第1期29卷 3-8页

作者： Daniel w.H.Su Peter Zhang mark Van Dyke Todd Minoski Center for Disease Control and Prevention(CDC) National Institute for Occupational Safety and Health(NIOSH)Pittsburgh Mining Research Division(PMRD)

This paper presents the results of a 2017 study conducted by the National Institute for Occupational Safety and Health(NIOSH), Pittsburgh Mining Research Division(PMRD), to evaluate the effects of longwall-induced subsurface deformations within a longwall abutment pillar under deep cover. The 2017 study was conducted in a southwestern Pennsylvania coal mine, which extracts 457 m-wide longwall panels under 361 m of cover. One 198 m-deep, in-place inclinometer monitoring well was drilled and installed over a 45 m by 84 m center abutment pillar. In addition to the monitoring well, surface subsidence measurements and underground coal pillar pressure measurements were conducted as the 457 m-wide longwall panel on the south side of the abutment pillar was being mined. Prior to the first longwall excavation, a number of simulations using FLAC3D^(TM) were conducted to estimate surface subsidence, increases in underground coal pillar pressure, and subsurface horizontal displacements in the monitoring well. Comparisons of the pre-mining FLAC3D simulation results and the surface, subsurface,and underground instrumentation results show that the measured in-place inclinometer casing deformations are in reasonable agreement with those predicted by the 3D finite difference models. The measured surface subsidence and pillar pressure are in excellent agreement with those predicted by the 3D *** from this 2017 research clearly indicate that, under deep cover, the measured horizontal displacements within the abutment pillar are approximately one order of magnitude smaller than those measured in a 2014 study under medium cover.

关键词： Longwall Deformations Shale gas wells Casing Safety and health

The variable codons of H5N1 avian influenza A virus haemagglutinin genes

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Science China(Life Sciences) 2008年第11期51卷 987-993页

作者： mark J.GIBBS Robert w.MURPHY School of Botany and Zoology Faculty of ScienceAustralian National UniversityACT 0200Australia Department of Natural History Royal Ontario MuseumTorontoON M5S 2C6Canada

we investigated the selection pressures on the haemagglutinin genes of H5N1 avian influenza viruses using fixed effects likelihood models. we found evidence of positive selection in the sequences from isolates from 1997 to 2007, except viruses from 2000. The haemagglutinin sequences of viruses from southeast Asia, Hong Kong and China's Mainland were the most polymorphic and had similar nonsyn-onymous profiles. Some sites were positively selected in viruses from most regions and a few of these sites displayed different amino acid patterns. Selection appeared to produce different outcomes in vi-ruses from Europe, Africa and Russia and from different host types. One position was found to be positively selected for human isolates only. Although the functions of some positively selected posi-tions are unknown, our analysis provided evidence of different temporal, spatial and host adaptations for H5N1 avian influenza viruses.

关键词： positive selection pressure H5N1 avian influenza virus HA codon

Exercise intolerance in heart failure with preserved ejection fraction： more than a heart problem

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Journal of Geriatric Cardiology 2015年第3期12卷 294-304页

作者： Bharathi Upadhya mark J Haykowsky Joel Eggebeen Dalane w Kitzman Cardiology and Geriatrics Wake Forest School of Medicine Medical Center Blvd Winston Salem NC USA Faculty of Rehabilitation Medicine University of Alberta Edmonton AB Canada

Heart failure （HF） with preserved ejection fraction （HFpEF） is the most common form of HF in older adults, and is increasing in preva- lence as the population ages. Furthermore, HFpEF is increasing out of proportion to HF with reduced EF （HFrEF）, and its prognosis is worsening while that of HFrEF is improving. Despite the importance of HFpEF, our understanding of its pathophysiology is incomplete, and optimal treatment remains largely undefined. A cardinal feature of HFpEF is reduced exercise tolerance, which correlates with symptoms as well as reduced quality of life. The traditional concepts of exercise limitations have focused on central dysfimction related to poor cardiac pump function. However, the mechanisms are not exclusive to the heart and lungs, and the understanding of the pathophysiology of this dis- ease has evolved. Substantial attention has focused on defining the central versus peripheral mechanisms underlying the reduced functional capacity and exercise tolerance among patients with HF. In fact, physical training can improve exercise tolerance via peripheral adaptive mechanisms even in the absence of favorable central hemodynamic function. In addition, the drug trials performed to date in HFpEF that have focused on influencing cardiovascular function have not improved exercise capacity. This suggests that peripheral limitations may play a significant role in HF limiting exercise tolerance, a hallmark feature of HFpEF.

关键词： Exercise intolerance Heart failure Perioheral limitations Skeletal muscle

英国听力学教育概况--兼谈南安普顿大学的听力学教育

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听力学及言语疾病杂志 2011年第2期19卷 107-108页

作者：李国平郭莹胡红梅 mark lutman 英国南安普敦大学声学与振动研究所

各个国家的听力学教育实施有所不同。英国最早的听力学硕士教学1970年始于南安普敦大学，曼彻斯特大学、伦敦大学随后分别开展了听力学硕士教育。随着听力学工作的发展，英国听力学家协会（BritishAssociationofAudiolog-icalScientist... 详细信息

各个国家的听力学教育实施有所不同。英国最早的听力学硕士教学1970年始于南安普敦大学，曼彻斯特大学、伦敦大学随后分别开展了听力学硕士教育。随着听力学工作的发展，英国听力学家协会（BritishAssociationofAudiolog-icalScientist，BAAS）于1978年正式成立[后来和其他机构合并为英国听力学学会BAA（britishAcademyofAudiolo-gy）]，与此同时为了规范听力学从业人员的执业，

关键词：听力学教育英国伦敦大学从业人员硕士

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华盛顿地铁设计风格和导引系统的时代变迁

商业周刊（中文版） 2024年第6期 41-43页

作者： mark Byrnes 孟洁冰(译) 程玺(译) 不详

华盛顿地铁的新标识旨在帮助人们更方便地出行,从而提高客流,但地铁系统最初的设计者可能不会赞同这种改变。在建筑师哈里·威斯(Harry weese)设计的华盛顿特区地铁网络中,车站采用了野兽派(Brutalist)风格的高笃混凝土拱顶,像快捷的地... 详细信息

华盛顿地铁的新标识旨在帮助人们更方便地出行,从而提高客流,但地铁系统最初的设计者可能不会赞同这种改变。在建筑师哈里·威斯(Harry weese)设计的华盛顿特区地铁网络中,车站采用了野兽派(Brutalist)风格的高笃混凝土拱顶,像快捷的地铁系统每天运送乘客往返的旅游景点一样,这些拱顶也具有重大的意义。

关键词：地铁系统地铁设计华盛顿特区地铁网络导引系统野兽派时代变迁旅游景点

2023年美国麻醉医师学会神经肌肉阻滞监测与拮抗实践指南:美国麻醉医师学会工作组关于神经肌肉阻滞的报告

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中华麻醉学杂志 2024年第5期44卷 518-542页

作者： Stephan R.Thilen wade A.weigel Michael M.Todd Richard P.Dutton Cynthia A.Lien Stuart A.Grant Joseph w.Szokol Lars I.Eriksson Myron Yaster mark D.Grant Madhulika Agarkar Anne M.Marbella Jaime F.Blanck Karen B.Domino 西雅图华盛顿州明尼阿波里斯明尼苏达州达拉斯得克萨斯州密尔沃基威斯康星州教堂山北卡罗来纳州洛杉矶加利福尼亚州斯德哥尔摩瑞典丹佛科罗拉多州绍姆堡伊利诺斯州巴尔的摩马里兰州

本实践指南基于证据提供了全身麻醉期间及术后神经肌肉功能监测与阻滞拮抗的管理推荐。主要关注神经肌肉功能监测的类型与部位及阻滞拮抗的过程,以减少肌肉松弛药残留阻滞。

关键词：神经肌肉阻滞肌肉松弛药神经肌肉功能监测舒更葡糖钠新斯的明

BAS-PSO算法优化的无传感器轮毂电机转速控制

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江苏理工学院学报 2024年第4期30卷 16-27页

作者：彭倩吴浪徐笑韩锋钢 mark Robinson 厦门理工学院机械与汽车工程学院福建厦门361024 福建省客车先进设计与制造重点实验室福建厦门361024 纽卡斯尔大学工程学院纽卡斯尔英国NE17RU

针对无位置传感器轮毂电机比例积分(Proportion Integration,PI)控制中常见的抗干扰能力差、计算量大、控制精度不高等问题,提出一种粒子群-天牛须(Beetle Antennae Search-Particle Swarm Optimization,BAS-PSO)算法,在模型参考自适应... 详细信息

针对无位置传感器轮毂电机比例积分(Proportion Integration,PI)控制中常见的抗干扰能力差、计算量大、控制精度不高等问题,提出一种粒子群-天牛须(Beetle Antennae Search-Particle Swarm Optimization,BAS-PSO)算法,在模型参考自适应系统(Model Reference Adaptive System,MRAS)观测电机转速与位置的基础上,实现转速控制器的PI参数自整定。建立永磁同步轮毂电机(Permanent Magnet Synchronous Motor,PMSM)的数学模型,以转速环传递函数的时间绝对误差积分指标(Integrated Time Absolute Error,ITAE)作为适应度函数,通过BAS-PSO算法优化转速控制器的PI参数;MRAS将电机本身作为参考模型,将含有待估计参数的定子电流方程作为可调模型,基于Popov超稳定理论,设计合适的自适应律,估计电机的转速与位置;利用Matlab/Simulink进行仿真对比,并在HIL平台进行硬件测试验证。结果表明:与传统方法相比,BAS-PSO算法能够提高电机的运行响应速度,降低转速超调量,提高系统的鲁棒性。

关键词：轮毂电机模型参考自适应系统 BAS-PSO算法无位置传感器