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Residual feed intake phenotype and gender affect the expression of key genes of the lipogenesis pathway in subcutaneous adipose tissue of beef cattle

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Journal of Animal Science and Biotechnology 2019年第1期10卷 208-217页

作者： Clare McKenna Richard K.Porter Kate A.Keogh Sinead M.Waters mark mcgee David A.Kenny Animal and Bioscience Research Department Teagasc Grange School of Biochemistry & Immunology Trinity College Dublin

Background: Feed accounts for up to 75% of costs in beef production systems,thus any improvement in feed efficiency(FE) will benefit the profitability of this *** feed intake(RFI) is a measure of FE that is independent of level of *** tissue(AT) is a major endocrine organ and the primary metabolic energy *** modulates a variety of processes related to FE such as lipid metabolism and glucose homeostasis and thus measures of inter-animal variation in adiposity are frequently included in the calculation of the RFI *** aim of this study was to determine the effect of phenotypic RFI status and gender on the expression of key candidate genes related to processes involved in energy metabolism within *** matter intake(DMI) and average daily gain(ADG) were measured over a period of 70 d for 52 purebred Simmental heifers(n = 24) and bulls(n = 28) with an initial BW±SD of 372±39.6 kg and 387±50.6 kg,*** feed intake was calculated and animals were ranked within gender by RFI into high(inefficient; n = 9 heifers and n = 8 bulls)and low(efficient; n = 9 heifers and n = 8 bulls) ***: Average daily gain ±SD and daily DMI ±SD for heifers and bul s were 1.2±0.4 kg and 9.1±0.5 kg,and 1.8±0.3 kg and 9.5±1 kg *** RFI heifers and bulls consumed 10% and 15% more(P < 0.05) than their low RFI counterparts,*** had a higher expression of all genes measured than bulls(P < 0.05).A gender × RFI interaction was detected for HMGCS2(P < 0.05) in which high RFI bulls tended to have lower expression of HMGCS2 than low RFI bulls(P < 0.1),whereas high RFI heifers had higher expression than low RFI heifers(P < 0.05) and high RFI bulls(P < 0.05).SLC2 A4 expression was consistently higher in subcutaneous AT of low RFI animals across ***: The findings of this study indicate that low RFI cattle exhibit upregulation of the molecular mechanisms governing glucose metabolism in adipose tiss

关键词： Adipose Cattle RFI SLC2A4

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Network Analysis Reveals A Signaling RegulatoryLoop in PIK3CA-mutated Breast Cancer Predicting Survival Outcome

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Genomics, Proteomics & Bioinformatics 2017年第2期15卷 121-129页

作者： Shauna R. mcgee Chabane Tibiche mark Trifiro Edwin Wang National Research Council Canada Montreal QC H4P 2R2 Canada Department of Experimental Medicine McGill University Montreal QC H3A 2B2 Canada Center for Bioinformatics McGill University Montreal QC H3G OB1 Canada Lady Davis Institute for Medical Research of the Jewish General Hospital Montreal QC H3T 1E2 Canada Center for Health Genomics and Informatics Calgary AB T2N 4N1 Canada Department of Biochemistry & Molecular Biology/Medical Genetics/Oncology University of Calgary Cumming School of Medicine Calgary AB T2N 4N1 Canada Alberta Children's Hospital Research Institute Calgary AB T2N 4N1 Canada Arnie Charbonneau Cancer Research Institute Calgary AB T2N 4N1 Canada O'Brien Institute for Public Health Calgary AB T2N 4N1 Canada

Mutated genes are rarely common even in the same pathological type between cancer patients and as such, it has been very challenging to interpret genome sequencing data and difficult to predict clinical outcomes. PIK3 CA is one of a few genes whose mutations are relatively popular in tumors. For example, more than 46.6% of luminal-A breast cancer samples have PIK3 CA mutated, whereas only 35.5% of all breast cancer samples contain PIK3 CA mutations. To understand the function of PIK3 CA mutations in luminal A breast cancer, we applied our recentlyproposed Cancer Hallmark Network Framework to investigate the network motifs in the PIK3CA-mutated luminal A tumors. We found that more than 70% of the PIK3CA-mutated luminal A tumors contain a positive regulatory loop where a master regulator(PDGF-D), a second regulator(FLT1) and an output node(SHC1) work together. Importantly, we found the luminal A breast cancer patients harboring the PIK3 CA mutation and this positive regulatory loop in their tumors have significantly longer survival than those harboring PIK3 CA mutation only in their tumors. These findings suggest that the underlying molecular mechanism of PIK3 CA mutations in luminal A patients can participate in a positive regulatory loop, and furthermore the positive regulatory loop(PDGF-D/FLT1/SHC1) has a predictive power for the survival of the PIK3 CAmutated luminal A patients.

关键词： Network analysis PIK3CA mutation Network motif Breast cancer Genome sequencing Survival

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腺苷酸活化蛋白激酶与运动研究进展

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中国运动医学杂志 2005年第2期24卷 238-243,224页

作者：李良刚 mark Hargreaves Sean mcgee School of Exercise and Nutrition Science Deakin University

运动能刺激骨骼肌对葡萄糖摄取 ,提高对胰岛素的敏感性 ,促进脂肪酸的氧化等 ,即使是一次训练课就能够引起许多代谢基因显著变化。腺苷酸活化蛋白激酶 (5’ -AMP -activatedpro teinkinase ,AMPK)作为能量代谢变化的感受器能够被运动中A... 详细信息

运动能刺激骨骼肌对葡萄糖摄取 ,提高对胰岛素的敏感性 ,促进脂肪酸的氧化等 ,即使是一次训练课就能够引起许多代谢基因显著变化。腺苷酸活化蛋白激酶 (5’ -AMP -activatedpro teinkinase ,AMPK)作为能量代谢变化的感受器能够被运动中ATP/AMP的比值变化所激活 ,在调节这些对健康有利的代谢适应过程中起着十分重要的作用。许多研究表明AMPK与运动关系密切 :一方面运动能够对AMPK的活性、磷酸化以及基因和蛋白表达等产生多种影响 ;另一方面AMPK自身的变化 ,特别是一些重要位点的突变也会对运动能力产生深刻影响。本文总结了AMPK与运动相互影响的最新研究成果。

关键词： AMPK 运动能力腺苷酸活化蛋白激酶基因葡萄糖摄取比值变化代谢训练课运动关系适应

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Coagulase-negative Staphylococci in Conjunctivitis and Blepharitis

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眼科学报 1993年第3期9卷 129-135页

作者： Yue-Kong Au Harold GJensen James Rowsey mark Reynolds Department of Ophthalmology Louisiana State UniversityShreveportLouisianaUSA Dean mcgee Eye Institute Oklahoma CityOklahomaUSA

Coagulase-negative staphylococcus(C-NS)are regarded as normal flora of the lids and *** ability of these organisms to cause conjunctivitis and blepharitis can be overlooked or *** elucidate the role of individual C-NS species in these eye diseases we compared Staphylococcus *** from the conjunctiva and lids of 50 healthy volunteers with 248 strains of Staphylococcus isolated from patients with staphylococcal conjunctivitis or *** was the most frequent species isolated from the conjunctiva and lids of both *** was isolated only from infected *** individual C-NS species was found to be significantly associated with eye disease,but the colony count of C-NS after isolation was a useful indicator of conjunctivitis and *** ability of Staphylococcus to ferment mannitol or mannose was associated with isolates only from infected patients.

关键词： Staphylococcus aureus coagulase-negative Staphylococcus Staphylococcus epidermidis conjunctivitis blepharitis

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