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Insect Science 2011年第4期18卷 435-442页

作者： j. mark Scriber Brittany Sonke Department of Entomology Michigan State University East Lansing Michigan McGuire Center for Lepidoptera and Biodiversity Flonda Museum of Natural History University of Florida Gainesville Florida USA

With recent climate warming trends, both the increase in thermal variance （i.e., diurnal temperature range; DTR） as well as increased mean temperature may impact many different organisms, especially poikilothermic invertebrates. Predictions of insect developmental rates using degree-days （thermal unit accumulations above the developmental base threshold of the insect） are based on daily mean temperatures, regardless of DTR. However, non-linearity and variance in the means and extremes are often ignored. The role of thermal variance （e.g., daily temperature extremes and DTR） was evaluated experimentally for two swallowtail butterfly sister species using a common day/night photoperiod of 18 ： 6 h photo ： scoto-phase and corresponding daytime thermophase and nighttime cryophase periods of 22 ： 22℃ （constant 22℃）, 24 ： 16℃, and 26 ： 10℃（all three treatments had the same daily mean and the same degree-day accumulations）. Although developmental rates ofpost-diapause pupae were largely unaffected for both species, our results show that sizes in P canadensis females （but not males） were smaller in the treatments with more variance （26℃ ： 10℃） compared to constant 22℃. Such potentially significant impacts of size reduction in P canadensis females were not observed in P glaucus males or females under the same series ofthermo-period treatments.

关键词： climate warming degree-days diurnal temperature range (DTR) photoperiods swallowtail butterflies thermoperiods

Modulating p-type doping of two-dimensional material palladium diselenide

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Nano Research 2024年第4期17卷 3232-3244页

作者： j.ali Yang Yu Liu En-Yang Wang j.nbo Pang Shirong Huang Thomas Gemming j.nshun Bi Alicj. Bachmatiuk Hao j.a Shu-Xian Hu Chongyun j.ang Hong Liu Gianaurelio Cuniberti Weij.a Zhou mark H Rümmeli Institute for Advanced Interdisciplinary Research(iAIR) University of JinanJinan 250022China Institute for Materials Chemistry Leibniz Institute for Solid State and Materials Research Dresden(IFW Dresden)20 Helmholtz StrasseDresden 01069Germany State Key Lab of Transducer Technology Shanghai Institute of Microsystem and Information TechnologyChinese Academy of SciencesShanghai 200050China College of Energy Soochow Institute for Energy and Materials Innovations Soochow UniversitySuzhou 215006China Key Laboratory of Advanced Carbon Materials and Wearable Energy Technologies of j.angsu Province Soochow UniversitySuzhou 215006China School of Integrated Circuits University of Chinese Academy of SciencesBeijing 101408China Institute of Microelectronics of Tianj.n Binhai New Area Tianjin 300451China Institute of Microelectronics Chinese Academy of SciencesBeijing 100029China Lukasiewicz Research Network PORT Polish Center for Technology DevelopmentStablowicka 147Wroclaw 54-066Poland School of Mathematics and Physics University of Science and Technology BeijingBeijing 100083China College of electronic information and optical engineering Nankai UniversityTianjin 300350China Centre of Polymer and Carbon Materials Polish Academy of SciencesM.Curie Sklodowskiej 34Zabrze 41-819Poland Center for Energy and Environmental Technologies VŠB-Technical University of Ostrava17.Listopadu 15Ostrava 70833Czech Republic State Key Laboratory of Crystal Materials Center of Bio&Micro/Nano Functional MaterialsShandong UniversityJinan 250100China Dresden Center for Computational Materials Science Technische Universität DresdenDresden 01062Germany Dresden Center for Intelligent Materials(GCL DCIM) Technische Universität DresdenDresden 01062Germany Institute for Materials Science and Max Bergmann Center of Biomaterials Technische Universität DresdenDresden 01069Germany Center for Advancing Electronics Dresden Technische Universität DresdenDresden 01069Germany

The van der Waals heterostructures have evolved as novel materials for complementing the Si-based semiconductor ***-10 noble metal dichalcogenides(e.g.,PtS_(2),PtSe_(2),PdS_(2),and PdSe_(2))have been listed into two-dimensional(2D)materials toolkit to assemble van der Waals *** them,PdSe_(2) demonstrates advantages of high stability in air,high mobility,and wide tunable ***,the regulation of p-type doping of PdSe_(2) remains unsolved problem prior to fabricating p–n j.nction as a fundamental platform of semiconductor ***,a quantitative method for the controllable doping of PdSe_(2) is yet to be *** this study,the doping level of PdSe_(2) was correlated with the concentration of Lewis acids,for example,SnCl_(4),used for *** the transfer characteristics,the threshold voltage(the gate voltage corresponding to the minimum drain current)increased after SnCl_(4) soaking ***_(2) transistors were soaked in SnCl_(4) solutions with five different *** threshold voltages from the as-obtained transfer curves were extracted for linear fitting to the threshold voltage versus doping concentration correlation *** study provides in-depth insights into the controllable p-type doping of PdSe_(2).It may also push forward the research of the regulation of conductivity behaviors of 2D materials.

关键词： two-dimensional(2D)materials Lewis acid treatment p-type doping field-effect transistors transfer characteristic

Salicaceae detoxification abilities in Florida tiger swallowtail butterflies （Papilio glaucus maynardi Gauthier）＂ Novel ability or Pleistocene holdover？

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Insect Science 2012年第3期19卷 337-345页

作者： Matthew S. Lehnert j. mark Scriber McGuire Center for Lepidoptera and Biodiversity Florida Museum of Natural History University of Florida Gainesville Florida Department of Entomology Soils and Plant Sciences Clemson University Clemson South Carolina Department of Entomology Michigan State University East Lansing Michigan USA

Florida populations of the eastern tiger swallowtail butterfly, Papilio glaucus L., have unique morphological features and ecological adaptations that have contributed to their subspecies status （P. g. rnaynardi Gauthier）. We describe geographically unique abilities for detoxification of Carolina willow, Salix caroliniana Michx. （Salicaceae）, for several Florida populations of P. g. maynardi. Of all the approximately 570 worldwide species of the Papilionidae, such Salicaceae detoxification abilities exist only in the allopatric North American western and northernmost species （P. rutulus Lucas, R eurymedon Lucas and P. canadensis Rothschild ＆ j.rdan）. Females of P. glaucus collected from populations in southeastern USA were examined for oviposition preference in 5-choice assays, and displayed a low preference for Salicaceae （〈5%）, but larvae from Florida populations exhibited a high survival （〉 60%） on these plants. Detoxification abilities have previously shown to be autosomally inherited, and can be transferred via natural or hand-paired interspecific hybrid introgression. However, these Florida populations are at least 700-1 500 km from the nearest hybrids or the hybrid species, 17. appalachiensis Pavulaan ＆ Wright, which possess these detoxification abilities. In any case, the Z （ = X）-linked oviposition preferences for Salicaceae are lacking in these Florida populations, illustrating genetic independence ofoviposition preference determination and larval survival/performance abilities. The origins of detoxification abilities are unlikely to be due to recent climate-driven introgression, and may represent ancestral trait carry-overs from interglacial refugium populations of the Pleistocene epoch.

关键词： eastern tiger swallowtail genetic introgression interglacial island refugia,Papilio glaucus maynardi Papilionidae host plants Salicaceae detoxification

Reversible phosphorylation of the 26S proteasome

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Protein & Cell 2017年第4期8卷 255-272页

作者： Xing Guo Xiuliang Huang mark j. Chen The Life Sciences Institute of Zhej.ang University Hangzhou 310058 China Ministry of Education Key Laboratory of Protein Science School of Life Sciences Tsinghua University Beijinq 100084 China Department of Bioinformatics and Computational Biology Genentech Inc. South San Francisco CA 94080 USA

The 26S proteasome at the center of the ubiquitin- proteasome system （UPS） is essential for virtually all cellular processes of eukaryotes. A common miscon- ception about the proteasome is that, once made, it remains as a static and uniform complex with sponta- neous and constitutive activity for protein degradation. Recent discoveries have provided compelling evidence to support the exact opposite insomuch as the 26S proteasome undergoes dynamic and reversible phos- phorylation under a variety of physiopathological con- ditions. In this review, we summarize the history and current understanding of proteasome phosphorylation, and advocate the idea of targeting proteasome kinases/ phosphatases as a new strategy for clinical interven- tions of several human diseases.

关键词： proteasome phosphorylation kinase,phosphatase protein degradation

Encroachment drives facilitation at alpine shrublines

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Forest Ecosystems 2024年第1期11卷 62-72页

作者： Yafeng Wang Eryuan Liang j.j.lio Camarero College of Ecology and Environment Nanjing Forestry UniversityNanjing210037China State Key Laboratory of Tibetan Plateau Earth System Environment and Resources(TPESER)Institute of Tibetan Plateau ResearchChinese Academy of SciencesBeijing100101China Instituto Pirenaico de Ecología(IPE-CSIC) Zaragoza50080Spain

Ongoing encroachment is driving recent alpine shrubline dynamics globally,but the role of shrub-shrub interactions in shaping shrublines and their relationships with stem density changes remain poorly ***,the size and age of shrubs from 26 Salix shrubline populations along a 900-km latitudinal gradient(30°-38°N)were measured and mapped across the eastern Tibetan *** pattern analyses were used to quantify the spatial distribution patterns of j.veniles and adults,and to assess spatial associations between *** intensity of univariate and bivariate spatial patterns was related to biotic and abiotic *** mark correlation functions with a quantitative mark(shrub height,basal stem diameter,crown width)were also employed to investigate the spatial relationships between shrub traits of j.veniles and *** equation models were used to explore the relationships among conspecific interactions,patterns,shrub traits and recruitment dynamics under climate *** shrublines showed clustered patterns,suggesting the existence of conspecific *** patterns of j.veniles and conspecific interactions(potentially facilitation)tended to intensify with increasing soil moisture *** warming before 2010 triggered positive effects on population interactions and spatial patterns via increased shrub ***,summer warming after2010 triggered negative effects on interactions through reduced shrub ***,shrub recruitment shifts under rapid climate change could impact spatial patterns,alter conspecific interactions and modify the direction and degree of shrublines responses to *** changes would have profound implications for the stability of alpine woody ecosystems.

关键词： Alpine shrubline Positive interactions Facilitation Spatial clustering Point pattern analyses

Assessment of oxide nanoparticle stability in liquid phase transmission electron microscopy

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Nano Research 2019年第9期12卷 2355-2363页

作者： mark j. Meij.rink Krij. P. de j.ng j.vana Zecevic Inorganic Chemistry and Catalysis Debye Institute of Nanomaterials ScienceUtrecht UniversityUniversiteitsweg 993584 CG UtrechtThe Netherlands

Studying liquid phase nanoscale dynamic processes of oxide nanoparticles is of considerable interest to a wide variety of *** developed liquid phase transmission electron microscopy(LP-TEM)is a promising technique,but destabilization of oxides by solid-liquid?electron interactions remains an important *** this work we present a methodology to assess LP-TEM oxide stability in an aqueous phase,by subj.cti ng several oxides of tech no logical importa nee to a controlled electr on dose in *** show a correlati on based on the Gibbs free en ergy of oxide hydrati on that can be used to assess the stability of oxides and dem on strate the existenee of several remarkably stable oxides,with no observable structural changes after one hour of electron beam irradiation in *** such destabilization phenomena combined with the identification of stable oxides allows for designing LP-TEM experiments free from adverse beam effects and thus in vestigati ons of numerous releva ntnano scale processes in water.

关键词： liquid phase transmission electron microscopy(LP-TEM) transmission electron microscopy electron beam damage metal oxide nano materials oxide stability

Treatment and prevention of epilepsy in onchocerciasis-endemic areas is urgently needed

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Infectious Diseases of Poverty 2024年第1期13卷 85-89页

作者： Robert Colebunders j.seph Nelson Siewe Fodj. Olivia Kamoen Luis-j.rge Amaral Amber Hadermann Chiara Trevisan mark j.Taylor j.lia Gauglitz Achim Hoerauf Yasuaki Sato Katj. Polman Maria-Gloria Basanez Dan Bhwana Thomson Lakwo Gasim Abd-Elfarag Sebastien D.Pion Global Health Institute University of AntwerpAntwerpBelgium Department of Neurology Heilig Hart ZiekenhuisLierBelgium Department of Public Health Institute of Tropical MedicineAntwerpBelgium Liverpool School of Tropical Medicine LiverpoolUK Department of Computer Science University of AntwerpAntwerpBelgium Institute of Medical Microbiology Immunology and ParasitologyUniversity Hospital BonnBonnGermany German Center for Infection Research(DZIF) Partner Site Bonn-CologneBonnGermany School of Global Humanities and Social Sciences Nagasaki UniversityNagasakiJapan MRC Centre for Global Infectious Disease Analysis and London Centre for Neglected TropicalDisease Research Department of Infectious Disease EpidemiologySchool of Public HealthImperial College LondonLondonUK National Institute for Medical Research TangaTanzania Vector Control Division Ministry of HealthKampalaUganda School of Public Health University of JubaJubaSouth Sudan Access for Humanity JubaSouth Sudan French National Research Institute for Sustainable Development MontpellierFrance

Background There is increasing epidemiological evidence supporting the association between onchocerciasis and seizures, reinforcing the concept of onchocerciasis-associated epilepsy (OAE). The aim of this paper is to provide an update on the new knowledge about OAE and to propose recommendations to the World Health Organization how to address this public health *** text During the 2nd International Workshop on OAE held on 19-21 September, 2023, in Antwerp, Belgium, participants recognised OAE as a substantial yet neglected public health problem, particularly in areas of sub-Saharan Africa where onchocerciasis remains hyperendemic. Evidence from prospective population-based studies suggest that strengthening onchocerciasis elimination efforts leads to a significant reduction of OAE incidence. There is a need to validate an OAE case definition to estimate the burden of disease and identify onchocerciasis-endemic areas requiring intensification of onchocerciasis elimination programmes and integration of epilepsy care. It is expected that raising awareness about OAE will boost the population uptake of ivermectin. The implementation of a community-based epilepsy treatment programme offering free anti-seizure medications (ASMs) has shown high effectiveness in reducing the frequency of seizures and improving the overall quality of life of people with *** To reduce OAE burden, enhanced collaboration between onchocerciasis and mental health programmes at community, national, and international levels is required. Urgent efforts are needed to ensure the uninterrupted provision of free ASMs in onchocerciasis-endemic areas. Furthermore, OAE should be included in the quantification of the onchocerciasis disease burden.

关键词： Onchocerciasis Morbidity Burden of disease Prevention Ivermectin Epilepsy Nodding syndrome Treatment Children Policy

Differential effects of short term winter thermal stress on diapausing tiger swallowtail butterflies （Papilio spp.）

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Insect Science 2012年第3期19卷 277-285页

作者： j. mark Scriber Emily Maher Matthew L. Aardema Department of Entomology Michigan State University East Lansing MI McGuire Center for Lepidoptera and Biodiversity Florida Museum of Natural History University of Florida Gainesville FL Department of Ecology and Evolutionary Biology Princeton University Princeton N J USA

It is generally thought that insects inhabiting lower latitudes are more severely impacted by changes in their thermal environment than are high latitude species. This is attributed to the wider range of temperatures to which high-latitude species are exposed. By contrast, low-latitude species have typically evolved in more thermally stable environments with a narrower range of temperature variation. However, deviation from this pattern can occur and here we report that under variable winter conditions a higher latitude species may be more sensitive to thermal variation than its lower latitude sister species. Using split broods, we examined the survival and adult emergence success of diapausing pupae of Papilio canadensis and P. glaucus, as well as a unique, recombinant hybrid population （＂late-flight＂） to short periods of mid-winter cold and heat stress. Our results indicate that the higher latitude, univoltine populations （P. canadensis and late-flights） exhibit lower pupal survival than the lower latitude, facultative diapauser （P. glaucus） for all mid-winter thermal stress treatments, both high and low. Size differences alone do not appear to account for the observed differences in survival or metabolic costs in these three pheno- types, as late-flight individuals are similar in size to R glaucus. We attribute the observed differences in survival and weight loss to potential metabolic differences and variation in the intensity of diapause, in addition to divergent adaptation to winter precipitation levels （e.g. snow cover） and the influences this may have on microhabitat temperature moderation.

关键词： climate change developmental threshold incipient hybrid species metabolic cost Papilionidae post-diapause delays thermal stress

In Vivo and In Vitro Degradation Behavior of Magnesium Alloys as Biomaterials

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j.urnal of Materials Science & Technology 2012年第3期28卷 261-267页

作者： Dingchuan Xue Yeoheung Yun Zongqing Tan Zhongyun Dong mark j. Schulz Department of Chemical and Materials Engineering University of Cincinnati OH 45221 USA Department of Bioengineering North Carolina A ＆ T State University Greensboro NC 27411 USA Department of Internal Medicine University of Cincinnati OH 45221 USA Department of Mechanical Engineering University of Cincinnati OH 45221 USA

The corrosion behavior of pure Mg,AZ31,and AZ91D were evaluated in various in vitro and in vivo environments to investigate the potential application of these metals as biodegradable implant *** polarization tests and immersion tests were performed in different simulated body solutions,such as distilled（DI） water,simulated body fluid（SBF） and phosphate buffered solution（PBS）.Mg/Mg alloys were also implanted in different places in a mouse for in vivo weight loss and biocompatibility *** in vivo subcutis bio-corrosion rate was lower than the corrosion rate for all of the in vitro simulated corrosive *** Mg/Mg alloys were biocompatible based on histology results for the liver,heart,kidney,skin and lung of the mouse during the two months *** microscopy and scanning electron microscopy were carried out to investigate the morphology and topography of Mg/Mg alloys after immersion testing and implantation to understand the corrosion mechanisms.

关键词： Mg/Mg alloys In vitro/in vivo testing Bio-degradation rate Biocompatibility

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美股科技双杰崛起

商业周刊（中文版） 2024年第5期 48-49页

作者： Eric j.Weiner j.ran Wittenstein mark Gurman 孟洁冰(译) 不详

十多年来,少数几家科技巨头推动美国股市一路向前,带来了超高速增长的希望。你熟知这些家喻户晓的名字:比如谷歌的母公司Alphabet、亚马逊公司(***)、苹果公司、Facebook的母公司Meta、微软公司和特斯拉公司。这些公司的名号组成了各种... 详细信息

十多年来,少数几家科技巨头推动美国股市一路向前,带来了超高速增长的希望。你熟知这些家喻户晓的名字:比如谷歌的母公司Alphabet、亚马逊公司(***)、苹果公司、Facebook的母公司Meta、微软公司和特斯拉公司。这些公司的名号组成了各种首字母缩略词——FANG、FAANG、MAMAA——几乎成为每个投资组合的主要配置。

关键词：投资组合母公司 Amazon 苹果公司亚马逊公司美国股市 .com