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Emerging role of A-kinase anchoring protein 5 signaling in reward circuit function

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Neural Regeneration Research 2025年第10期20卷 2913-2914页

作者： William J.Flerlage mark L.Dell’Acqua Brian M.Cox Fereshteh S.Nugent Uniformed Services University of the health Sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Department of Pharmacology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a strong evidence supporting the hypothesis of synaptic dysfunction as a major contributor to neural circuit and network disruption underlying emotional and mood dysregulation in psychiatric disorders(Simmons et al.,2024).Diverse sets of distinct molecular signaling pathways converge on the synapse to regulate synaptogenesis,synaptic function,and synaptic plasticity in brain regions and circuits through complex interactions organized by numerous multivalent protein scaffolds,including the family of proteins known as A-kinase anchoring proteins(AKAPs).

关键词： function supporting

Upper and Lower Bounds of Table Sums

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Algebra Colloquium 2021年第4期28卷 555-560页

作者： Xiaoyou Chen mark L.lewis hung P.Tong-Viet School of Sciences Henan University of TechnologyZhengzhou 450001China Department of Mathematical Sciences Kent State UniversityKentOH 44242USA Department of Mathematical Sciences Binghamton University 4400 Vestal Parkway EastBinghamtonNY 13902-6000USA

For a group G,we produce upper and lower bounds for the sum of the entries of the Brauer character table of G and the projective indecomposable character table of *** G is aπ-separable group,we show that the sum of the entries in the table of Isaacs'partial characters is a real number,and we obtain upper and lower bounds for this sum.

关键词： character table Brauer characters projective indecomposable characters π-paxtial characters

Groups with One or Two Super-Brauer Character Theories

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Acta Mathematica Sinica,English Series 2020年第4期36卷 379-394页

作者： Xiao You ChEN mark Llewis College of Science Henan University of TechnologyZhengzhou 450001P.R.China Department of Mathematical Sciences Kent State UniversityKent 44242USA

A super-Brauer character theory of a group G and a prime p is a pair consisting of a partition of the irreducible p-Brauer characters and a partition of the p-regular elements of G that satisfy certain *** classify the groups and primes that have exactly one super-Brauer character *** discuss the groups with exactly two super-Brauer character theories.

关键词： Super character theory super-Brauer character theory Brauer characters

Stepping up to meet the challenge of freezing of gait in Parkinson’s disease

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Translational Neurodegeneration 2022年第1期11卷 589-600页

作者： Simon lewis Stewart Factor Nir Giladi Alice Nieuwboer John Nutt mark hallett ForeFront Parkinson’s Disease Research Clinic Brain and Mind CentreSchool of Medical SciencesUniversity of SydneySydneyNSWAustralia Jean and Paul Amos Parkinson’s Disease and Movement Disorders Program Emory University School of MedicineAtlantaGAUSA Movement Disorders Unit Department of NeurologyTel-Aviv Sourasky Medical CenterSackler School of Medicine and Sagol School of NeuroscienceTel Aviv UniversityTel AvivIsrael Department of Rehabilitation Sciences KU LeuvenLeuvenBelgium Movement Disorder Section Department of NeurologyOregon Health&Science UniversityPortlandORUSA human Motor Control Section National Institute of Neurological Disorders and StrokeNational Institutes of HealthBethesdaMDUSA.

There has been a growing appreciation for freezing of gait as a disabling symptom that causes a significant burden in Parkinson’s disease. Previous research has highlighted some of the key components that underlie the phenomenon, but these reductionist approaches have yet to lead to a paradigm shift resulting in the development of novel treatment strategies. Addressing this issue will require greater integration of multi-modal data with complex computational modeling, but there are a number of critical aspects that need to be considered before embarking on such an approach. This paper highlights where the field needs to address current gaps and shortcomings including the standardization of definitions and measurement, phenomenology and pathophysiology, as well as considering what available data exist and how future studies should be constructed to achieve the greatest potential to better understand and treat this devastating symptom.

关键词： Freezing of gait Computational modeling Standardized definitions and assessments Novel paradigms Phenomenology Pathophysiology Treatment

Could zinc dipicolinate be used to“smuggle”zinc into prostate cancer cells?

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Journal of Cancer Metastasis and Treatment 2020年第1期6卷 209-213页

作者： mark F.McCarty Simon Iloki Assanga Lidianys lewis Lujan Catalytic Longevity Foundation San DiegoCA 92109USA Department of Research and Postgraduate in Food University of SonoraHermosillo 83210Mexico

Although prostate epithelium concentrates zinc for the purpose of promoting citrate secretion,it loses its capacity to import zinc while undergoing malignant *** exclusion of zinc may be necessary for the viability of prostate cancer,as measures which increase the intracellular zinc content of prostate cancers lead to cell death,oxidative stress,and a marked reduction in ATP,suggestive of mitochondrial *** anti-fungal drug clioquinol,which can act as a zinc ionophore,can markedly slow the growth of human prostate cancer in nude mice,and has been proposed as a clinical therapy for prostate ***,clioquinol is currently only available as a topical agent,as it was linked to subacute myelo-optic neuropathy with oral use.A more practical option for promoting zinc transport may be offered by the nutraceutical zinc dipicolinate,a stable chelate in which four coordination positions of zinc are occupied by two molecules of the tryptophan metabolite picolinic *** dipicolinate is a highly effective supplemental source of zinc that has been shown to be more potent than soluble zinc salts for alleviating the symptoms of acrodermatitis enteropathica,a genetic zinc deficiency disorder reflecting homozygous loss of functional ZIP4 zinc importers in *** suggests that the zinc dipicolinate complex is sufficiently stable and lipophilic to transfer zinc across cellular *** so,it may have potential for“smuggling”zinc into prostate cancer ***,cell culture and rodent studies to evaluate the impact of zinc dipicolinate on human prostate cancer are warranted.

关键词： Prostate cancer zinc clioquinol picolinic acid ZIP4

Update on the management of sigmoid diverticulitis

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World Journal of Gastroenterology 2021年第9期27卷 760-781页

作者： mark h hanna Andreas M Kaiser Division of Colorectal Surgery Department of SurgeryCity of Hope National Medical CenterDuarteCA 91010-3000United States

Diverticular disease and diverticulitis are the most common non-cancerous pathology of the *** has traditionally been considered a disease of the elderly and associated with cultural and dietary *** has been a growing evolution in our understanding and the treatment guidelines for this *** provide an updated review of the epidemiology,pathogenesis,classification and highlight changes in the medical and surgical management of *** is increasingly being seen in young patients(han previously *** similarities and overlap with inflammatory bowel disease and irritable bowel syndrome *** tomography imaging represents the standard to classify the severity of *** to the traditional hinchey classification might serve to better delineate mild and intermediate forms as well as better classify chronic presentations of ***-operative management is primarily based on antibiotics and supportive measures,but antibiotics may be omitted in mild *** colonoscopy remains advisable after an acute attack,particularly after a complicated *** surgery is needed for the most severe as well as refractory cases,whereas elective resections are individualized and should be considered for chronic,smoldering,or recurrent forms and respective complications(stricture,fistula,etc.)and for patients with factors highly predictive of recurrent *** is no longer a disease of the *** evolving understanding of diverticulitis as a clinical entity has led into a more nuanced approach in both the medical and surgical management of this common ***-surgical management remains the appropriate treatment for greater than 70%of *** individuals with non-relenting,persistent,or recurrent symptoms and those with complicated disease and sequelae,a segmental colectomy remains the most effec

关键词： Diverticulitis Epidemiology Antibiotics Surgical resection Laparoscopic lavage Classification

Evaluation of seismic potential in a longwall mine with massive sandstone roof under deep overburden

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International Journal of Mining Science and Technology 2018年第1期28卷 115-119页

作者： mark A.Van Dyke Wen h.Su Joe Wickline Ground Control Branch NIOSHPittsburgh15236 PAUSA Coronado Coal LLC BeckleyWVUSA

A recent seismic event was recorded by a deep longwall mine in Virginia at 3.7 ML on the local magnitude scale and 3.4 MMS by the United States Geological Survey(USGS) in *** investigations by the National Institute for Occupational Safety and health(NIOSh) and Coronado Coal researchers have shown that this event was associated with geological features that have also been associated with other, similar seismic events in *** mapping and geological exploration in the mining area has made it possible to forecast possible locations for future seismic *** order to use the geology as a forecaster of mining-induced seismic events and their energy potential, two primary components are *** first component is a long history of recorded seismic events with accurately plotted *** second component is a high density of geologic data within the mining *** this case, 181 events of 1.0 MLor greater were recorded by the mine's seismic network between January, 2009, and October, *** the mining area, 897 geophysical logs, 224 core holes, and 1031 fiberscope holes were examined by mine *** this information, it was found that overburden thickness, sandstone thickness, and sandstone quality contributed greatly to seismic *** the data was analyzed, a pattern became apparent indicating that the majority of seismic events occurred under specific *** forecast maps were created based on geology of previous seismic *** forecast maps have shown an accuracy of within 74%–89% when compared to the recorded 181 events that were1.0 MLor greater when considering three major geological criteria of overburden thickness of 579.12 m or greater, 6.096–12.192 m of sandstone within 15.24 m of the Pocahontas number 3 seam, and a longwall caving height of 4.572 m or less.

关键词： Seismic Mapping Deep overburden Massive sandstone

Prestroke selective serotonin reuptake inhibitor use and functional outcomes after ischaemic stroke

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Stroke & Vascular Neurology 2018年第1期3卷 9-16页

作者： mark R Etherton Khawja A Siddiqui Lee h Schwamm Department of Neurology Harvard Medical SchoolBostonMassachusettsUSA Department of Neurology Massachusetts General HospitalBostonMassachusettsUSA

background Selective serotonin reuptake inhibitors(SSRIs)have been implicated in contributing to recovery after acute ischaemic *** particular,poststroke initiation of an SSRI has been demonstrated to improve motor *** role of prestroke SSRI use on functional outcomes and stroke recovery is less *** aimed to examine the effect of prestroke SSRI use on metrics of hospitalisation and functional *** We included 4968 consecutive patients from January 2006 to June 2015 in our local Get With The Guidelines-Stroke registry in whom a preadmission drug list could be extracted from an administrative research data *** and multivariate analyses were performed to identify predictors of functional *** On univariate analysis,among 4698 ischaemic strokes(740 SSRI users and 3948 non-users),SSRI use before acute ischaemic stroke did not impact the National Institutes of health Stroke Scale(NIhSS)admission score,length of stay or rate of symptomatic *** using SSRIs prior to their stroke were more likely to present with weakness(57% vs 47.3%;Phave hospitalisations complicated by pneumonia(7.6% vs 5.7%;Ph a negative impact on ambulatory status at discharge and discharge to *** multivariate regression analysis,SSRI use was associated with lower likelihood of discharge to home(adjusted OR 0.79,95% CI 0.62 to 0.997,Phaemic stroke is associated with lower rates of discharge to home despite no significant increase in length of stay or NIhSS score.

关键词： functional likely stroke

Talin and kindlin： the one-two punch in integrin activation

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Frontiers of Medicine 2014年第1期8卷 6-16页

作者： Feng Ye Adam K. Snider mark h. Ginsberg Department of Medicine University of California San Diego La Jolla CA 92093 USA

Proper cell-cell and cell-matrix contacts mediated by integrin adhesion receptors are important for development, immune response, hemostasis and wound healing. Integrins pass trans-membrane signals bidirectionally through their regulated affinities for extracellular ligands and intracellular signaling molecules. Such bidirectional signaling by integrins is enabled by the conformational changes that are often linked among extracellular, transmembrane and cytoplasmic domains. here, we review how talin-integrin and kindlin-integrin interactions, in cooperation with talin-lipid and kindlin-lipid interactions, regulate integrin affinities and how the progress in these areas helps us understand integrin-related diseases.

关键词： signal transduction transmembrane domain nanodisc integrin talin kindling cell adhesion