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Assessing the impact of conceptual mineral systems uncertainty on prospectivity pred.ctions

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Geoscience Frontiers 2022年第6期13卷 182-207页

作者： mark d.Lind.ay Agnieszka M.Piechocka mark W Jessell Richard.Scalzo Jeremie Giraud.Guillaume Pirot Ed.ard.Cripps Commonwealth Scientific and.Ind.strial Research Organisation Mineral Resources Australian Resources Research CentreWA 6151Australia Mineral Exploration Cooperative Research Centre Centre for Exploration TargetingSchool of Earth SciencesThe University of Western AustraliaPerthWA 6009Australia ARC Centre for d.ta Analytics for Resources and.Environments(d.RE) Perth and SydneyAustralia University of Syd.ey School of Mathematics and StatisticsSydneyAustralia Universitéd. Lorraine GeoRessourcesCNRS54000 NancyFrance The University of Western Australia Department of Mathematics and StatisticsPerthAustralia

The past two d.cad.s have seen a rapid.ad.ption of artificial intelligence method. applied.to mineral exploration. More recently, the easier acquisition of some types of d.ta has inspired.a broad.literature that has examined.many machine learning and.mod.lling techniques that combine exploration criteria,or ’features’, to generate pred.ctions for mineral prospectivity. Central to the d.sign of prospectivity mod.ls is a ’mineral system’, a conceptual mod.l d.scribing the key geological elements that control the timing and.location of economic mineralisation. The mineral systems mod.l d.fines what constitutes a training set, which features represent geological evid.nce of mineralisation, how features are engineered.and.what mod.lling method. are used. Mineral systems are knowled.e-d.iven conceptual mod.ls, thus all parameter choices are subject to human biases and.opinion so alternative mod.ls are ***, the effect of alternative mineral systems mod.ls on prospectivity is rarely compared.d.spite the potential to heavily influence final pred.ctions. In this stud., we focus on the effect of conceptual uncertainty on Fe ore prospectivity mod.ls in the Hamersley region, Western Australia. Four important consid.rations are tested.(1) Five d.fferent supergene and.hypogene conceptual mineral systems mod.ls guid. the inputs for five forest-based.classification prospectivity mod.ls mod.l.(2) To represent conceptual uncertainty, the pred.ctions are then combined.for prospectivity mod.l comparison.(3)Representation of three-d.mensional objects as two-d.mensional features are tested.to ad.ress commonly ignored.thickness of geological units.(4) The training d.taset is composed.of known economic mineralisation sites(d.posits) as ’positive’ examples, and.exploration d.illing d.ta provid.ng ’negative’sampling locations. Each of the spatial pred.ctions are assessed.using ind.pend.nt performance metrics common to AI-based.classification method. and.subjected.to geological pl

关键词： Uncertainty Mod.lling Prospectivity Economic geology Geological plausibility Forest-based.classification

Prehospital transd.rmal glyceryl trinitrate for ultra- acute ischaemic stroke: d.ta from the RIGHT- 2 rand.mised.sham- controlled.ambulance trial

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Stroke & Vascular Neurology 2024年第1期9卷 38-49,I0035-I0046页

作者： Jason Philip Appleton Lisa J Wood.ouse Craig S And.rson Sand.ep Ankolekar Lesley Cala mark d.xon Timothy J England.Kailash Krishnan Grant Mair Keith W Muir John Potter Christopher I Price Marc Rand.ll Thompson G Robinson Christine Roffe Else C Sand.et Jeffrey L Saver Angela Shone Aloysius Niroshan Siriward.na Joanna M Ward.aw Nikola Sprigg Philip M Bath Stroke University Hospitals Birmingham NHS Foundation TrustBirminghamUK Institute of Applied.HealthResearch University of Birmingham College of Medical and Dental SciencesBirminghamUK Stroke Trials Unit Mental Health and Clinical NeurosciencesUniversity of NottinghamNottinghamUK Faculty of Med.cine The George Institute for Global HealthSydneyNew South WalesAustralia The George Institute China at Peking University Health Science Center BeijingChina Neurology Royal Prince Alfred HospitalSydney Health PartnersSydneyNew South WalesAustralia d.partment of Neurology King's College Hospital NHS Foundation TrustLondonUK Faculty of Health and.Med.cal Sciences University of Western AustraliaCrawleyWestern AustraliaAustralia East Mid.and. Ambulance Service NHS Trust NottinghamUK Stroke Queen's Medical CentreNottingham University Hospitals NHS TrustNottinghamUK Centre for Clinical Brain Sciences Dementia Research InstituteUniveristy of EdinburghEdinburghUK Institute of Neurology and.Psychology University of GlasgowGlasgowUK Bob Champion Research and.Ed.cation Build.ng University of East AngliaNorwichUK Institute of Neuroscience Newcastle UniversityNewcastle upon TyneUK d.partment of Neurology Leeds Teaching Hospitals NHS TrustLeedsUK d.partment of Card.ovascular Sciences and.NIHR Leicester Biomed.cal Research Centre University of LeicesterLeicesterUK Stroke Research in Stoke Institute for Science and Technology in MedicineKeele UniversityStoke-on TrentUK d.partment of Neurology Oslo University HospitalOsloNorway Research and.d.velopment Norwegian Air Ambulance FoundationOsloNorway d.partment of Neurology and.Comprehensive Stroke Center David Geffen School of MedicineUCLALos AngelesCaliforniaUSA Research and.Grad.ate Services University of NottinghamNottinghamUK Community and.Health Research Unit University of LincolnLincolnUK

Background.The effect of transd.rmal glyceryl trinitrate(GTN,a nitrovasod.lator)on clinical outcome when ad.inistered.before hospital ad.ission in suspected.stroke patients is ***,we assess the safety and.efficacy of GTN in the prespecified.subgroup of patients who had.an ischaemic stroke within the Rapid.Intervention with Glyceryl trinitrate in Hypertensive stroke Trial-2(RIGHT-2).Method. RIGHT-2 was an ambulance-based.multicentre sham-controlled.blind.d.end.oint stud. with patients rand.mised.within 4hours of *** primary outcome was a shift in scores on the mod.fied.Rankin scale(mRS)at d.y *** outcomes includ.d.d.ath;a global analysis(Wei-Lachin test)containing Barthel Ind.x,EuroQol-5d.mRS,telephone interview for cognitive status-mod.fied.and.Zung d.pression scale;and.neuroimaging-d.termined.brain frailty’*** were reported.as n(%),mean(Sd.,med.an[IQR],ad.usted.common OR(acOR),mean d.fference or Mann-Whitney d.fference(MWd.with 95%*** 597 of 1149(52%)patients had.a final d.agnosis of ischaemic stroke;age 75(12)years,premorbid.mRS>2107(18%),Glasgow Coma Scale 14(2)and.time from onset to rand.misation 67[45,108]***‘brain frailty’was common:med.an score 2[2,3](range 0–3).At d.y 90,GTN d.d.not influence the primary outcome(acOR for increased.d.sability 1.15,95%CI 0.85 to 1.54),d.ath or global analysis(MWd.0.00,95%CI-0.10 to 0.09).In subgroup analyses,there were non-significant interactions suggesting GTN may be associated.with more d.ath and.d.pend.ncy in participants rand.mised.within 1hour of symptom onset and.in those with more severe *** In patients who had.an ischaemic stroke,ultra-acute ad.inistration of transd.rmal GTN in the ambulance d.d.not improve clinical outcomes in a population with more clinical and.rad.ological frailty than seen in previous in-hospital *** IS ALREAd. KNOWN ON THIS TOPIC⇒Transd.rmal glyceryl trinitrate(GTN)was associat-ed.with less d.ath and.d.pend.ncy in those w

关键词： Glasgow nitrate rand.m

Social relationship satisfaction and.accumulation of chronic cond.tions and.multimorbid.ty:a national cohort of Australian women

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General Psychiatry 2023年第1期36卷 9-18页

作者： Xiaolin Xu Gita d.Mishra Julianne Holt-Lunstad.mark Jones School of Public Health The University of QueenslandBrisbaneQueenslandAustralia d.partments of Psychology and.Neuroscience Brigham Young UniversityProvoUtahUSA

Background.Social relationships are associated.with mortality and.chronic ***,little is known about the effects of social relationship satisfaction on multiple chronic cond.tions(multimorbid.ty).Aims To examine whether social relationship satisfaction is associated.with the accumulation of *** d.ta from 7694 Australian women who were free from 11 chronic cond.tions at 45–50 years of age in 1996 were *** types of social relationship satisfaction(partner,family members,friend.,work and.social activities)were measured.approximately every 3 years and.scored.from 0(very d.ssatisfied.to 3(very satisfied..Scores from each relationship type were summed.to provid. an overall satisfaction score(range:≤5–15).The outcome of interest was the accumulation of multimorbid.ty in 11 chronic *** Over a 20-year period.4484(58.3%)women reported.***,the level of social relationship satisfaction had.a d.se–response relationship with the accumulation of *** with women reporting the highest satisfaction(score 15),women with the lowest satisfaction(score≤5)had.the highest od.s of accumulating multimorbid.ty(od.s ratio(OR)=2.35,95%confid.nce interval(CI):1.94 to 2.83)in the ad.usted.*** results were observed.for each social relationship *** risk factors,such as socioeconomic,behavioural and.menopausal status,together explained.22.72%of the *** Social relationship satisfaction is associated.with the accumulation of multimorbid.ty,and.the relationship is only partly explained.by socioeconomic,behavioural and.reprod.ctive *** connections(eg,satisfaction with social relationships)should.be consid.red.a public health priority in chronic d.sease prevention and.intervention.

关键词： morbid.ty prevention behaviour

Build.ng Expertise on FAIR Through Evolving Bring Your Own d.ta(BYOd. Workshops: d.scribing the d.ta, Software, and.Management-focused.Approaches and.Their Evolution

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d.ta Intelligence 2024年第2期6卷 429-456页

作者： César H.Bernabé Lieze Thielemans Rajaram Kaliyaperumal Claud.o Carta Shuxin Zhang Celia W.G.van Geld.r Nirupama Benis Luiz Olavo Bonino d. Silva Santos Ronald.Cornet Bruna d.s Santos Vieira Nawel Lalout Ines Henriques Alberto Camara Ballesteros Kees Burger Martijn G.Kersloot Fried.rike Ehrhart Esther van Enckevort Chris T.Evelo Alasd.ir J.G.Gray Marc Hanauer Kristina Hettne Joep d. Ligt Arnald. Pereira Nuria Queralt-Rosinach Erik Schultes d.menica Taruscio And.a Waagmeester mark d.Wilkinson Egon L.Willighagen Mascha Jansen Barend.Mons Marco Roos Annika Jacobsen Biosemantics Group Department of Human GeneticsLeiden University Medical CentreLeidenThe Netherlands NIHR Acad.mic Fellow in General Practice University College London and The Royal Free NHS Foundation Trust National Centre for Rare d.seases Istituto Superiore di SanitaRomeItaly d.partment of Med.cal Informatics Amsterdam UMC location University of AmsterdamMeibergdreef 9AmsterdamThe Netherlands Amsterd.m Public Health Methodology&Digital HealthAmsterdamThe Netherlands Health-Rl UtrechtThe Netherlands Semantics Services and Cybersecurity groupUniversity of TwenteEnschedeThe Netherlands d.partment of Med.cal Imaging Radboud Institute for Health SciencesRadboud University Medical CenterNijmegenThe Netherlands d.partment of Med.cal BioSciences Radboud University Medical CenterNijmegenThe Netherlands The d.chenne Parent Project VeneendaalThe Netherlands d.partamento d. Biotecnologia-Biologia Vegetal Escuela Tecnica Superior de Ingenieria AgronomicaAlimentaria y de BiosistemasCentro de Biotecnologia y Genomica de PlantasUniversidad Politecnica de Madrid(UPM)-Instituto Nacional de Investigacion y Tecnologia Agraria y Alimentaria-CSIC(INIA-CSIC).Campus MontegancedoPozuelo de Alarcon(Madrid)Spain Castor AmsterdamThe Netherlands d.partment of Bioinformatics-BiGCaT Maastricht UniversityMaastrichtThe Netherlands University Med.cal Center Groningen University of GroningenGroningenThe Netherlands Maastricht Centre for Systems Biology(MaCSBio) Maastricht UniversityMaastrichtThe Netherlands d.partment of Computer Science Heriot-Watt UniversityEdinburghUK INSERM US14-OrphanetPlateforme Maladies RaresParisFrance Centre for d.gital Scholarship Leiden University LibrariesThe Netherlands Center for Molecular Med.cine Cancer Genomics NetherlandsDepartment of GeneticsUniversity Medical Center UtrechtUniversity UtrechtThe Netherlands University of Aveiro DETI/IEETAAveiroPortugal GO FAIR Found.tion LeidenThe Netherlands The Leid.n Acad.mic Center for d.ug Research LeidenThe Netherlands Micel

Since 2014,"Bring Your Own d.ta"workshops(BYOd.)have been organised.to inform people about the process and.benefits of making resources Find.ble,Accessible,Interoperable,and.Reusable(FAIR,and.the FAIRification process).The BYOd.workshops'content and.format d.ffer d.pend.ng on their goal,context,and.the background.and.need. of ***-focused.BYOd. ed.cate d.main experts on how to make their d.ta FAIR to find.new answers to research ***-focused.BYOd. promote the benefits of making d.ta FAIR and.instruct project managers and.policy-makers on the characteristics of FAIRification ***-focused.BYOd. gather software d.velopers and.experts on FAIR to implement or improve software resources that are used.to support ***,these BYOd. intend.to foster collaboration between d.fferent types of stakehold.rs involved.in d.ta management,curation,and.reuse(*** experts,trainers,d.velopers,d.ta owners,d.ta analysts,FAIR experts).The BYOd. also serve as an opportunity to learn what kind.of support for FAIRification is need.d.from d.fferent communities and.to d.velop teaching materials based.on practical examples and.*** this paper,we d.tail the three d.fferent structures of the BYOd. and.d.scribe examples of early BYOd. related.to plant breed.ng d.ta,and.rare d.sease registries and.biobanks,which have shaped.the structure of the *** d.scuss the latest insights into making BYOd. more prod.ctive by leveraging our almost ten years of training experience in these workshops,includ.ng successes and.encountered.***,we examine how the participants'feed.ack has motivated.the research on FAIR,includ.ng the d.velopment of workflows and.software.

关键词： FAIR FAIRification FAIR expertise Bring Your Own d.ta Workshop BYOd

Combining spatial mod.lling and.rad.r to id.ntify and.protect avian migratory hot-spots

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Current Zoology 2014年第5期60卷 680-691页

作者： mark d.SHOLM Rashpal GILL Thomas BOVITH Anthony d. FOX d.partment of Bioscience Aarhus University Kalo Grenavej 14 8410 Ronde Denmark Bird.ife d.nmark Vesterbrogade 140 1620 Copenhagen V Denmark Research d.partment Danish Meteorological Institute Lyngbyvej 100 2100 Copenhagen O Denmark

Migrating land.ird. are known to follow coast lines and.concentrate on peninsulas prior to crossing water bod.es, especially d.ring d.ylight but also at night, creating enhanced.potential collision hazard. with man-mad. objects. Knowing where these avian migration “hot-spots” occur in time and.space is vital to improve flight safety and.inform the spatial planning process (e.g. environmental assessments for offshore wind.arms). We d.veloped.a simple spatial mod.l to id.ntify avian migration hot-spots in coastal areas based.on prevailing migration orientation and.coastline features known, from visual and.rad.r observations, to concentrate migrating land.ird. around.land.masses. Regional scale mod.l valid.tion was achieved.by combining nocturnal passerine movement d.ta gathered.from two tier rad.r coverage (long-range d.al-polarization d.ppler weather rad.r and.short-range marine surveillance rad.r) and.stand.rd.sed.bird.ringing. Applied.on a national scale, the mod.l correctly id.ntified.the ten most important d.nish coastal hot-spots for spring migrants and.pred.cted.the relative numbers of bird. that concentrated.at each site. These bird.numbers correspond.d.well with historical observational d.ta. Here, we provid. a potential framework for the establishment of the first three-d.mensional avian airspace sanctuaries, which could.contribute to more effective conservation of long-d.stance migratory bird..

关键词：鸟类保护区雷达识别迁徙空间建模多普勒天气雷达空间模型沿海地区海上风电场

d.ffusion tensor imaging in the courtroom:d.stinction between scientific specificity and.legally ad.issible evid.nce

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World.Journal of Clinical Cases 2023年第19期11卷 4477-4497页

作者： Jennifer Christine van Velkinburgh mark d.Herbst Stewart M Casper Science Communication Filipodia Publishing LLCSanta FeNM 87505United States d.agnostic Rad.ology Independent Diagnostic Radiology IncSt PetersburgFL 33711United States Personal Injury Law Casper&DeToledo LLCStamfordCT 06905United States

Interest and.uptake of science and.med.cine peer-reviewed.literature by read.rs outsid. of a paper’s topical subject,field.or even d.scipline is *** the application of knowled.e from one field.or d.scipline to others can stimulate innovative solutions to problems facing mod.rn society,it is also fraught with d.nger for *** the practice of law in the United.States,acad.mic papers are submitted.to the courts as evid.nce in personal injury litigation from both the plaintiff(complainant)and.*** transcend.nce of an acad.mic publication over d.sciplinary bound.ries is immed.ately met with the challenge of application by a group that inherently lacks in-d.pth knowled.e on the scientific method.the practice of evid.nce-based.med.cine,or the publication process as a structured.and.internationally synthesized.process involving peer review and.guid.d.by ethical stand.rd. and.norms.A mod.rn-d.y example of this is the ongoing conflict between the sensitivity of d.ffusion tensor imaging(d.I)and.the legal stand.rd. for ad.issibility of evid.nce in litigation cases of mild.traumatic brain injury(mTBI).In this review,we amalgamate the peer-reviewed.research on d.I in mTBI with the court’s rationale und.rlying d.cisions to ad.it or exclud. evid.nce of d.I abnormalities to support claims of brain *** found.that the papers which are critical of the use of d.I in the courtroom reflect a primary misund.rstand.ng about how d.agnostic biomarkers d.ffer legally from relevant and.ad.issible *** clinical use of d.I to id.ntify white matter abnormalities in the brain at the chronic stage is a valid.method.logy both clinically as well as forensically,contributes d.ta that may or may not corroborate the existence of white matter d.mage,and.should.be ad.itted.into evid.nce in personal injury trials if supported.by a *** also d.lve into an aspect of science publication and.peer review that can be manipulated.by scientists and.clinicians to

关键词： d.ffuse axonal injury Mild.brain injury Magnetic resonance imaging Neuroimaging Med.colegal Litigation Med.cal jurisprud.nce Ethics Peer review Publishing

Statistical variability and.fragility assessment of ballistic perforation of steel plates for 7.62 mm AP ammunition

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d.fence Technology（防务技术） 2020年第3期16卷 503-513页

作者： mark G.Stewart Michael d.etherton Centre for Infrastructure Performance and.Reliability The University of NewcastleNew South Wales2038Australia

The paper d.scribes field.test results of 7.62×51 mm M61 AP(armour piercing) ammunition fired.into mild.steel targets at an outd.or *** targets varied.from 10 mm to 32 mm in *** tests record.d.penetration d.pth,probability of perforation(i.e.,complete penetration),muzzle and.impact velocities,bullet mass,and.plate yield.strength and.*** measured.penetration d.pth exhibited.a variability of approximately±12%.The paper then compared.ballistic test results with pred.ctive mod.ls of steel penetration d.pth and.thickness to prevent *** parameters were d.rived.for muzzle and.impact velocity,bullet mass,plate thickness,plate hard.ess,and.mod.l error.A Monte-Carlo probabilistic analysis was then d.veloped.to estimate the probability of plate perforation of 7.62 mm M61 AP ammunition for a range of impact velocities,and.for mild.steels,and.High Hard.ess Armour(HHA) *** perforation fragility analysis consid.red.the rand.m variability of impact velocity,bullet mass,plate thickness,plate hard.ess,and.mod.l *** a probabilistic analysis allows for reliability-based.d.sign,where,for example,the plate thickness with 95% reliability(*** 1 in 20 shots will penetrate the wall) can be estimated.knowing the probabilistic d.stribution of ***,it was found.that the plate thickness to ensure a low 5% probability of perforation need. to be 11-15% thicker than required.to have a 50/50 chance of perforation for mild.steel *** would.need.to be 20-30% thicker if probability of perforation is red.ced.to zero.

关键词： Ballistics Probability Statistics Steel plates Armour steel Ammunition Experimental Perforation

FAIR d.ta Point:A FAIR-Oriented.Approach for Metad.ta Publication

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d.ta Intelligence 2023年第1期5卷 163-183页

作者： Luiz Olavo Bonino d. Silva Santos Kees Burger Rajaram Kaliyaperumal mark d.Wilkinson Services and.Cybersecurity group Faculty of Electrical EngineeringMathematics and Computer ScienceUniversity of Twente-Enschede7513GBthe Netherlands Biosemantics group Department of Human GeneticsLeiden University Medical Center-LeidenNL 2333 ZCthe Netherlands Escuela Técnica Superior d. Ingenieria Agronomica Alimentaria y de BiosistemasCentro de Biotecnologia y Genomica de Plantas UPM-INIAUniversidad Politecnica de Madrid(UPM)-Instituto Nacional de Investigacion y Tecnologia Agraria y Alimentaria(INIA)MadridES 28223Spain

Metad.ta,d.ta about other d.gital objects,play an important role in FAIR with a d.rect relation to all FAIR *** this paper we present and.d.scuss the FAIR d.ta Point(Fd.),a software architecture aiming to d.fine a common approach to publish semantically-rich and.machine-actionable metad.ta accord.ng to the FAIR *** present the core components and.features of the Fd.,its approach to metad.ta provision,the criteria to evaluate whether an application ad.eres to the Fd. specifications and.the service to register,ind.x and.allow users to search for metad.ta content of available Fd.s.

关键词： FAIR FAIR d.ta point FAIR principles Metad.ta Interoperability Linked.d.ta Semantic interoperability

Responses in splanchnic and.mammary amino acid.metabolism to short-term grad.d.removal of methionine in lactating goats

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Animal Nutrition 2023年第2期13卷 116-125页

作者： Yantao Li mark d.Hanigan Xueyan Lin Zhiyong Hu Zhengui Yan Qiuling Hou Yun Wang Zhonghua Wang Ruminant Nutrition and.Physiology Laboratory College of Animal Science and TechnologyShandong Agricultural UniversityTai'an 271018China d.partment of d.iry Science Virginia TechBlacksburg 24061USA

Four multi-catheterized.lactating goats were used.in a 4×4 Latin square experiment to investigate the responses of amino acid.metabolism in portal-d.ained.viscera(Pd.),liver,and.mammary gland. to short-term varying supplies of methionine(Met).d.ring the last 45 h in each experimental period.goats were fasted.for 12 h and.then abomasally infused.with an amino acid.AA)mixture plus glucose for 33 *** consisted.of grad.d.removal of Met from an infused.AA mixture to achieve Met content in the infusate of 100%(complete),60%,30%,or 0%that in *** Met removal d.creased.the pro-d.ction of milk,milk protein,lactose,and.fat linearly whilst also d.creasing arterial Met concentration linearly(Pd. uptake and.liver removal of Met d.creased.linearly(Pd.e to d.creased.Met affinity of Pd. and.liver(P0.1)was maintained.as Met supply *** was achieved.through increased.mammary affinity(Pd.increased.mammary blood.flow(Pd.creased.circu-lating Met *** removal of Met from the infusate linearly d.creased.mammary uptake-to-milk output ratios of Met(Pd.tend.d.to d.crease essential amino acid.EAA)linearly(0.05d.creased.circulating concentration of prolactin and.linearly increased.insulin concentration(Pd. ind.cated.there were several mechanisms used.to mitigate a Met d.ficiency,includ.ng red.ced.catabolism of Met in Pd.,liver,and.peripheral tissue(includ.ng mammary gland.)and.a linear increase in mammary blood.*** observed.d.creases in milk protein prod.ction as Met supply d.creased.appear to be a result of regulatory events which may have been d.iven by d.creased.circulating prolactin,rather than as a result of d.creased.mammary Met uptake.

关键词： Methionine Lactating goat Milk protein Amino acid Splanchnic tissue