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World Journal of Gastrointestinal Oncology 2016年第5期8卷 474-480页

作者： Ming Zeng Fernando N Aguila Taral Patel mark Knapp XueQiang Zhu XiLin Chen Phillip d Price department of Radiation Oncology Mount Carmel Health System Cancer Center Sichuan Academy of Medical SciencesSichuan Provincial Hospital Central Ohio Surgical Associates Inc. department of Hematology and Oncology Zangmeister Cancer CenterMount Carmel Health System department of Oncology 307 Hospital

AIM:To evaluate impact of radiation therapy dose escalation through intensity modulated radiation therapy with simultaneous integrated boost(IMRT-SIB).METHOdS:We retrospectively reviewed the patients who underwent four-dimensional-based IMRT-SIBbased neoadjuvant chemoradiation *** the concurrent chemoradiation therapy,radiation therapy was through IMRT-SIB delivered in 28 consecutive daily fractions with total radiation doses of 56 Gy to tumor and 5040 Gy dose-painted to clinical tumor volume,with a regimen at the discretion of the treating medical *** was followed by surgical tumor *** analyzed pathological completion response(p CR) rates its relationship with overall survival and ***:Seventeen patients underwent dose escalation with the IMRT-SIB protocol between 2007 and 2014 and their records were available for *** the IMRT-SIB-treated patients,the toxicity appeared mild,the most common side effects were grade 1-3 esophagitis(46%) and pneumonitis(11.7%).There were no cardiac *** Ro resection rate was 94%(n = 16),the p CR rate was 47%(n = 8),and the postoperative morbidity was *** was one mediastinal failure found,one patient had local failure at the anastomosis site,and the majority of failures were distant in the lung or *** 3-year diseasefree survival and overall survival rates were 41%(n = 7) and 53%(n = 9),***:The dose escalation through IMRT-SIB in the chemoradiation regimen seems responsible for down-staging the distal esophageal with well-tolerated complications.

关键词： Intensity modulated radiation therapy Esophageal adenocarcinoma Simultaneous integrated boost Neoadjuvant chemoradiation dose escalation Resection rate

A novel technique for sacropelvic fixation using image-guided sacroiliac screws:a case series and biomechanical study

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The Journal of Biomedical Research 2019年第3期33卷 208-216页

作者： Kee d.Kim Huy duong Aditya Muzumdar Mir Hussain mark Moldavsky Bandon Bucklen department of Neurological Surgery University of California davis department of Neurosurgery Kaiser Permanente Medical Group Musculoskeletal Education and Research Center(MERC) Globus Medical Inc

In this study, we sought to assess the safety and accuracy of sacropelvic fixation performed with image-guided sacroiliac screw placement using postoperative computed tomography and X-rays. The sacroiliac screws were placed with navigation in five patients. Intact specimens were mounted onto a six-degrees-of-freedom spine motion simulator. Long lumbosacral constructs using bilateral sacroiliac screws and bilateral S1 pedicle and iliac screws were tested in seven cadaveric spines. Nine sacroiliac screws were well-placed under an image guidance system(IGS);one was placed poorly without IGS with no symptoms. Both fixation techniques significantly reduced range of motion(Pded that rigid lumbosacral fixation can be achieved with sacroiliac screws,and image guidance improves its safety and accuracy. This new technique of image-guided sacroiliac screw insertion should prove useful in many types of fusion to the sacrum, particularly for patients with poor bone quality,complicated anatomy, infection, previous failed fusion and iliac harvesting.

关键词： lumbosacral fixation sacropelvic fixation sacroiliac screw computer-assisted surgery image-guided surgery

Quantification of soluble epoxide hydrolase inhibitors in experimental and clinical samples using the nanobody-based ELISA

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Journal of Pharmaceutical Analysis 2023年第9期13卷 1013-1023页

作者： Huiyi Yang Meng Qi Qiyi He Sung Hee Hwang Jun Yang mark McCoy Christophe Morisseau Suqing Zhao Bruce d.Hammock department of Pharmaceutical Engineering School of Biomedical and Pharmaceutical SciencesGuangdong University of TechnologyGuangzhouChina department of Entomology and Nematology and UCd Comprehensive Cancer Center University of CaliforniaDavisCA 95616USA Langfang Normal University LangfangHebei065000China

To ensure proper dosage of a drug,analytical quantification of it in biofluid is *** chromatography mass spectrometry(LC-MS)is the conventional method of choice as it permits accurate identification and ***,it requires expensive instrumentation and is not appropriate for bedside *** soluble epoxide hydrolase(sEH)inhibitors(EC5026 and TPPU)as examples,we report development of a nanobody-based enzyme-linked immunosorbent assay(ELISA)for such small molecules and its use to accurately quantify the drug chemicals in human *** optimized conditions,two nanobody-based ELISAs were successfully established for EC5026 and TPPU with low limits of detection of 0.085 ng/mL and 0.31 ng/mL,respectively,and two order of magnitude linear ranges with high precision and *** assay was designed to detect parent and two biologically active metabolites in the investigation of a new drug candidate *** addition,the ELISAs displayed excellent correlation with LC-MS analysis and evaluation of inhibitory *** results indicate that nanobody-based ELISA methods can efficiently analyze drug like *** methods could be easily implemented by the bedside,in the field in remote areas or in veterinary *** work illustrates that nanobody based assays offer alternative and supplementary analytical tools to mass spectrometry for monitoring small molecule medicines during clinical development and *** of nanobody based pharmaceutical assays are discussed.

关键词： Nanobody Immunoassay Soluble epoxide hydrolase inhibitors Metabolites Small molecules

development of a fault-rupture environment in 3d: A numerical tool for examining the mechanical impact of a fault on underground excavations

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International Journal of Mining Science and Technology 2019年第1期29卷 105-111页

作者： Bo-Hyun Kim mark K.Larson Spokane Mining Research division CDC/NIOSH

While faults are commonly simulated as a single planar or non-planar interface for a safety or stability analysis in underground mining excavation, the real 3d structure of a fault is often very complex, with different branches that reactivate at different times. Furthermore, these branches are zones of nonzero thickness where material continuously undergoes damage even during interseismic periods. In this study, the initiation and the initial evolution of a strike-slip fault was modeled using the FLAC3d software program. The initial and boundary conditions are simplified, and mimic the Riedel shear experiment and the constitutive model in the literature. The FLAC3d model successfully replicates and creates the 3d fault zone as a strike-slip type structure in the entire thickness of the model. The strike-slip fault structure and normal displacement result in the formation of valleys in the model. Three panels of a longwall excavation are virtually placed and excavated beneath a main valley. The characteristics of stored and dissipated energy associated with the panel excavations are examined and observed at different stages of shear strain in the fault to evaluate bump potential. depending on the shear strain in the fault, the energy characteristics adjacent to the longwall panels present different degrees of bump potential, which is not possible to capture by conventional fault simulation using an interface.

关键词： 3d fault zone Strike-slip fault FLAC3d Bump potential Energy characteristics

The First Pilot Epigenetic Type Improvement of Neuropsychiatric Symptoms in a Polymorphic dopamine d2 (-dRd2/ANKK (Taq1A)), OPRM1 (A/G), dRd3 (C/T), and MAOA (4R) Compromised Preadolescence Male with Putative PANdAS/CANS: Positive Clinical Outcome with Precision-Guided dNA Testing and Pro-dopamine Regulation (KB220) and Antibacterial Therapies

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Open Journal of Immunology 2024年第3期14卷 60-86页

作者： Kenneth Blum Igor Elman david Han Colin Hanna david Baron Ashim Gupta Shan Kazmi Jag Khalsa debasis Bagchi Thomas McLaughlin Rajendra d. Badgaiyan Edward J. Modestino drew Edwards Catherine A. dennen Eric R. Braverman Abdalla Bowirrat Keerthy Sunder Kevin Murphy Nicole Jafari Foojan Zeine Paul R. Carney mark S. Gold Kai-Uwe Lewandowski Alireza Sharafshah Aryeh R. Pollack Panayotis K. Thanos division of Addiction Research & Education Center for Sports and Mental Health Western University of Health Sciences Pomona CA USA department of Psychiatry Boonshoft School of Medicine Wright State University and Dayton VA Medical Centre Dayton OH USA division of Nutrigenomics Victory Nutrition International Lederoch PA USA Institute of Psychology ELTE Etvs Lornd University Budapest Hungary department of Psychiatry School of Medicine University of Vermont Burlington VT USA The Kenneth Blum Behavioral & Neurogenetic Institute LLC. Austin TX USA department of Molecular Biology Adelson School of Medicine Ariel University Ariel Israel division of Neuromodulation Research Karma Doctors & Karma TMS Palm Springs CA USA division of Personalized Interventions Peak Logic Del Mar CA USA division of Personalized Medicine Cross-Cultural Research & Educational Institute San Clemente CA USA Awareness Integration Institute San Clemente CA USA division of Personalized Pain Therapy Center for Advanced Spine Care of Southern Arizona Tucson AZ USA department of Psychiatry Harvard School of Medicine Cambridge MA USA department of Management Science and Statistics University of Texas San Antonio TX USA Behavioral Neuropharmacology and Neuroimaging Laboratory Clinical Research Institute on Addictions Department of Pharmacology and Toxicology Jacobs School of Medicine and Biomedical Sciences University at Buffalo Buffalo NY USA Future Biologics Lawrenceville GA USA department of Microbiology Immunology & Tropic Diseases School of Medicine Georgetown University Washington DC USA department of Pharmaceutical Sciences College of Pharmacy Texas Southern University Houston TX USA department of Psychiatry School of Medicine Case Western University Cleveland OH USA Brain and Behavior Laboratory Curry College Milton MA USA The Neurogenesis Project Jacksonville FL USA department of Family Medicine Jefferson Health Northeast Philadelphia PA USA departmen

Pediatric autoimmune neuropsychiatric disorders associated with or without streptococcal and other bacterial infections (PANdAS/CANS) are emerging as a featured pediatric disorder. Although there is some controversy regarding treatment approaches, especially related to the behavioral sequelae, we have hypothesized in other published work that it is characterized by the rapid onset of Reward deficiency Syndrome (RdS) in children. We propose utilizing a multi-systems biological approach involving the coupling of genetic addiction risk testing and pro-dopamine regulation (KB220/POLYGEN®) to help induce “dopamine homeostasis” in patients with PANdAS, especially those with known dNA-induced hypodopaminergia. This case study examines a 12-year-old Caucasian male with no prior psychiatric issues who presented with a sudden onset of severe anxiety, depression, emotional liability, and suicidal ideation. The patient underwent genotyping and the genetic addiction risk score (GARS) testing, which revealed risk polymorphisms in the dopamine d2 (-dRd2/ANKK (Taq1A), OPRM1 (A/G), dRd3 (C/T), and MAOA (4R) genes. These polymorphisms have been linked to hypodopaminergia. The patient was subsequently placed on research Id-KB220ZPBMPOLY (POLYGEN®), and albeit the possibility of bias, based upon self and parental assessment, a marked rapid improvement in psychiatric symptoms was observed. In the second phase of treatment (102 days utilizing KB220), the patient received standard antibody testing, which was positive for Lyme. Antibacterial therapy started immediately, and KB220z was discontinued to provide a wash-out period. A monotonic trend analysis was performed on each outcome measure, and a consistently decreasing trend was observed utilizing antibacterial therapy. Our recommendation, albeit only one case, is to utilize and further research a combined therapeutic approach, involving precision-guided dNA testing and pro-dopamine regulation along with antibacterial therapy, as well as

关键词： PANdAS CANS Genetic Addiction Risk Testing (GARS) Pro-dopamine Regulation Hypodopaminergia Polymorphisms Antibacterial Therapy Infections

Photophobia in neurologic disorders

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Translational Neurodegeneration 2017年第1期6卷 239-244页

作者： Yiwen Wu mark Hallett Human Motor Control Section National Institute of Neurological Disorders and StrokeNational Institutes of Health10 Center Drive MSC 1428Building 10Room 7D37BethesdaMD 20892USA

Photophobia is a common symptom seen in many neurologic disorders,however,its pathophysiology remains *** the term is *** this paper,we review the epidemiology and clinical manifestations of photophobia in neurological disorders,including primary headache,blepharospasm,progressive supranuclear palsy,and traumatic brain injury,discuss the definition,etiology and pathogenesis,and summarize practical methods of diagnosis and treatment.

关键词： Photophobia Migraine Blepharospasm Progressive supranuclear palsy Traumatic brain injury Melanopsin

Importance of gastrin in the pathogenesis and treatment of gastric tumors

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World Journal of Gastroenterology 2009年第1期15卷 1-16页

作者： Michael d Burkitt Andrea Varro d mark Pritchard Gastroenterology Unit School of Clinical Sciences University of LiverpoolAshton Street Liverpool L69 3GE United Kingdom The Physiological Laboratory School of Biomedical Sciences University of LiverpoolCrown Street Liverpool L69 3BX United Kingdom

In addition to regulating acid secretion, the gastric antral hormone gastrin regulates several important cellular processes in the gastric epithelium including proliferation, apoptosis, migration, invasion, tissue remodelling and angiogenesis. Elevated serum concentrations of this hormone are caused by many conditions, particularly hypochlorhydria (as a result of autoimmune or Helicobacter pylori (H pylori)-induced chronic atrophic gastritis or acid suppressing drugs) and gastrin producing tumors (gastrinomas). There is now accumulating evidence that altered local and plasma concentrations of gastrin may play a role during the development of various gastric tumors. In the absence of H pylori infection, marked hypergastrinemia frequently results in the development of gastric enterochromaffi n cell-like neuroendocrine tumors and surgery to remove the cause of hypergastrinemia may lead to tumor resolution in this condition. In animal models such as transgenic INS-GAS mice, hypergastrinemia has also been shown to act as a cofactor with Helicobacter infection during gastric adenocarcinoma development. However, it is currently unclear as to what extent gastrin also modulates human gastric adenocarcinoma development. Therapeutic approaches targeting hypergastrinemia,such as immunization with G17dT, have been evaluated for the treatment of gastric adenocarcinoma, with some promising results. Although the mild hypergastrinemia associated with proton pump inhibitor drug use has been shown to cause ECL-cell hyperplasia and to increase H pylori-induced gastric atrophy, there is currently no convincing evidence that this class of agents contributes towards the development of gastric neuroendocrine tumors or gastric adenocarcinomas in human subjects.

关键词： Helicobacter py/ori Hypergastrinemia Neuroendocrine Gastric carcinoma Proton pumpinhibitor

dynamic Pressures on Tunnel Roofs due to Vehicle Passages

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Sound & Vibration 2018年第4期52卷 6-8页

作者： James d.Barnes Ethan R.Brush mark S.Newmark Eric E.Ungar Acentech Inc.33 Moulton StreetCambridgeMA02138USA

Pressure and proximity measurements made in a tunnel indicate that a typical vehicle passage produced on the tunnel roof an initial pressure increase of small magnitude,followed by a sharp and more substantial drop in pressure below *** magnitude of the pressure drop was found to increase with smaller clearances between the vehicle top and the tunnel roof,consistent with the Bernoulli relation and the vehicle *** dynamic pressures potentially may have significant effects on the vibration and noise environments on the lower floors of“air rights construction”buildings that span highways.

关键词： Pressure pulses vehicle passages tunnel roofs

Snow Water Equivalent Estimation for a Snow-Covered Prairie Grass Field by GPS Interferometric Reflectometry

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Positioning 2012年第3期3卷 31-41页

作者： mark d. Jacobson department of Mathematics Montana State University Billings Billings USA.

The amount of water stored in snowpack is the single most important measurement for the management of water supply and flood control systems. The available water content in snow is called the snow water equivalent (SWE). The product of snow density and depth provides an estimate of SWE. In this paper, snow depth and density are estimated by a nonlinear least squares fitting algorithm. The inputs to this algorithm are global positioning system (GPS) signals and a simple GPS interferometric reflectometry (GPS-IR) model. The elevation angles of interest at the GPS receiving antenna are between 50 and 300. A snow-covered prairie grass field experiment shows potential for inferring snow water equivalent using GPS-IR. For this case study, the average inferred snow depth (17.9 cm) is within the in situ measurement range (17.6 cm ± 1.5 cm). However, the average inferred snow density (0.13 ***-3) overestimates the in situ measurements (0.08 ***-3 ± 0.02 ***-3). Consequently, the average inferred SWE (2.33 ***-2) also overestimates the in situ calculations (1.38 ***-2 ± 0.36 ***-2).

关键词： Global Positioning System (GPS) GPS Interferometric Reflectometry (GPS-IR) Snow depth Snow density Snow Water Equivalent (SWE) Multipath Specular Reflection