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A review of pain outcomes following targeted muscle reinnervation in lower extremity limb pain

Plastic and Aesthetic Research 2022年第1期9卷 65-76页

作者： Elliot L.H.Le mark a.greyson Ryan S.Constantine Matthew L.Iorio Division of Plastic and Reconstructive Surgery University of ColoradoAnschutz Medical CenterAuroraCO 80045USA

Approximately 75%experience phantom(PLP),residual(RLP),or general(GLP)limb pain following lower extremity *** muscle reinnervation(TMR)is a peripheral nerve transfer that reroutes amputated nerves to motor endplates that can prevent or treat limb *** systematic review summarizes pain outcomes following primary and secondary treatment of lower extremity PLP,RLP,and *** literature review of three databases-PubMed,EMBASE,MEDLINE-were used for all articles related to TMR and lower extremity limb pain,querying the same keywords:“targeted muscle reinnervation”AND“pain”.Citations were then reviewed and eliminated if only upper extremities were studied or the study lacked pain *** were categorized as primary or secondary *** outcomes,including Numerical Rating Scales(NRS)and Patient-Reported Outcome Measurement Information System(PROMIS)Pain scores,were aggregated when *** studies met all inclusion and exclusion criteria after formal review for a total of 431 extremities,of which 79.1%(n=341 limbs)were lower *** primary TMR PROMIS scores for PLP and RLP were lower than amputees without primary *** NRS scores and PROMIS Pain scores in secondary TMR demonstrated improvements in PLP,RLP,and *** and Secondary TMR does prevent and improve PLP,RLP,and GLP;however,a minority of studies report quantifiable pain *** future TMR studies should include validated pain outcomes to better quantify the expected pain and quality of life improvements after lower extremity TMR.

关键词： Lower extremity amputation phantom limb pain residual limb pain targeted muscle reinnervation nerve transfer

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