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Evaluation of imatinib mesylate(Gleevec) on KAI1/CD82 gene expression in breast cancer MCF-7 cells using quantitative real-time PCR

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Asian Pacific Journal of Tropical Biomedicine 2016年第2期6卷 159-163页

作者： Seyed Ataollah Sadat Shandiz marjan Khosravani Sepideh Mohammadi Hassan Noorbazargan Amir Mirzaie Davoud Nouri Inanlou Mojgan Dalirsaber Jalali Hamidreza Jouzaghkar Fahimeh Baghbani-Arani Behta Keshavarz-Pakseresht Young Researchers and Elite Club East Tehran Branch Islamic Azad University Department of Microbiology Shiraz Azad University Department of Microbiology Islamic Azad University Pharmaceutical Sciences Branch Department of Biotechnology Shahid Beheshti University of Medical Sciences R&D Department Research and Production Complex Pasteur Institute of Iran Department of Microbiology Faculty of Basic Science Young Researcher Club Lahijan Branch Islamic Azad University Department of Genetics & Biotechnology School of Biological Science Varamin-Pishva Branch Islamic Azad University

Objective: To evaluate the effect of imatinib mesylate on cell viability, anti cancer effect through modulation of KAI1/CD82 gene expression in breast cancer MCF-7 cell ***: The effects of imatinib mesylate on cell viability in MCF-7 cell line were assessed using MTT assay and IC_(50) value was determined. GAPDH and KAI1/CD82 were selected as reference and target genes, respectively. Quantitative real time PCR technique was applied for investigation of KAI1/CD82 gene expression in human breast cancer MCF-7 cells. Subsequently, the quantity of KAI1 compared to GAPDH gene expressions were analyzed using the formula; 2^(-DDCt).Results: Imatinib was showed to have a dose-dependent inhibitory effect on the viability of MCF-7 cells. CD82/GAPDH gene expression ratios were 1.322 ± 0.030(P > 0.05),2.052 ± 0.200(P < 0.05), 2.151 ± 0.270(P < 0.05) for 10, 20 and 40 mmol/L of imatinib ***: Based on the present data, imatinib mesylate might modulate metastasis by up-regulating KAI1/CD82 gene expression in human breast MCF-7 cancer cell line.

关键词： Imatinib mesylate KAI1/CD82 Metastasis Breast cancer Real-time PCR

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What the Internist Should Know about Thrombotic Microangiopathies

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International Journal of Clinical Medicine 2019年第12期10卷 651-661页

作者： marjan Alidoost Attiya Haroon Varsha Gupta Arif Asif Mohammad A. Hossain Department of Medicine JSUMC Neptune NJ USA

Thrombotic microangiopathy (TMA) is a group of diseases that are life-threatening and can lead to end organ damage (EOD) due to ischemia caused by microthrombi in capillaries and arterioles. TMAs can affect any organ system but usually affect the kidney, intestines, and nervous system. The triad of TMA is Coombs-negative hemolytic anemia with schistocytes seen on peripheral smear, thrombocytopenia (platelets under 150,000 or a decrease of 25% or more from baseline), and evidence of ischemic EOD. Primary TMAs include Thrombotic Thrombocytopenic Purpura (TTP), Hemolytic Uremic Syndrome (HUS) and atypical HUS (aHUS). Pathophysiologically, all of these diseases are caused by aggregation of von Willebrand Factor (vWF) multimers, via different mechanisms, which eventually leads to thrombus formation. TTP and aHUS benefit from plasma exchange (PEX), whereas HUS is treated symptomatically. Urgent recognition with timely treatment is crucial to managing these potentially life-threatening conditions.

关键词： TMA aHUS HUS TTP

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基于DSL优化脑瘫康复智能训练系统

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高技术通讯 2021年第7期31卷 773-780页

作者：卢振利王红马志鹏沈玄霖 Marko Pencic 刘燕单长考赵宇 Roumiana Ilieva Tomaz Kosar marjan Horvat marjan Mernik 常熟理工学院电气与自动化工程学院常熟215500 中国矿业大学信息与控制工程学院徐州221116 常熟市第二人民医院康复医学科常熟215500 诺维萨德大学技术科学学院诺维萨德21000塞尔维亚常熟理工学院商学院常熟215500 索非亚技术大学管理学院索非亚1000保加利亚马里博尔大学电气工程和计算机科学学院马里博尔462000斯洛文尼亚

本文针对脑瘫患儿差异化康复训练方案难于定制的问题,基于领域特定语言(DSL)优化了脑瘫康复系统架构。根据专家给出的脑瘫患儿训练计划,在Eclipse平台的Xtext构建了控制机械手完成手势动作所需要的领域模型,并且完成了对该领域模型的实... 详细信息

本文针对脑瘫患儿差异化康复训练方案难于定制的问题,基于领域特定语言(DSL)优化了脑瘫康复系统架构。根据专家给出的脑瘫患儿训练计划,在Eclipse平台的Xtext构建了控制机械手完成手势动作所需要的领域模型,并且完成了对该领域模型的实现,将其成功用于机械手辅助脑瘫康复动作训练系统中,使得理疗师等非编程技术人员能够为脑瘫患儿康复定制训练方案。

关键词：脑瘫康复训练领域特定语言(DSL) 智能系统

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A Comparison between Dietary Habits for Pregnant Women with Preterm and Term Delivery in Khorasan, Iran

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Open Journal of Nursing 2015年第9期5卷 790-796页

作者： Zohreh Teimouri Mahrokh Dolatian Sara Shishehgar marjan Ajami Hamid Alavi Majd Department of Midwifery International branch of ShahidBeheshti University of Medical Sciences Tehran Iran Department of Midwifery School of nursing and midwifery Shahid Beheshti University of Medical Sciences Tehran Iran Faculty of Health University of Technology Sydney Australia Department of Nutrition Iran University of Medical Sciences Tehran Iran Department of Biostatistics School of Paramedical Sciences Shahid Beheshti University of Medical Sciences Tehran Iran

Background: Despite the advances in prenatal care and improving health indicators, preterm delivery and resultant infant mortality rate are still considerable. Emerged financial, social, mental and emotional damages could result in mental and behavioral disabilities for mothers as well as children. Although spontaneous preterm labor is well known as a multifactorial issue, yet poor nutrition is assumed as a strong related factor. Objective: To identify the role of dietary habits on preterm delivery prevalence in Iran, this study was conducted on pregnant women with preterm and term delivery. Methods: In this retrospective case-control study, 70 women with preterm labor and 70 women with term labor were compared in terms of their dietary habits. Women who met the inclusion criteria and referred to two hospitals in North-East of Iran were selected using purposive convenience sampling method and completed 163-item food frequency and dietary habits questionnaire. Results: This study showed that dietary habits of women with preterm labor are more unfavorable compared to women with term labor (P = 0.023). Generally, dietary habit of more than half of the women with preterm labor, in this study, was assessed unfavorable. In terms of different food groups, daily intake of vegetables was significantly lower in women with preterm labor (P = 0.02). Consumption of dairy products was also lower in women with preterm labor than women with term labor which was significant (P = 0.05). Conclusion: To prevent adverse outcomes of preterm delivery more attention regarding nutritional planning for pregnant women seems to be essential.

关键词： Dietary Habit Preterm Delivery Pregnancy

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Generalized seizure, the only manifestation of a small ischemic atherothrombotic infarction

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World Journal of Emergency Medicine 2016年第1期7卷 71-73页

作者： Assadollahi marjan Ramezani Mahtab Karimialavijeh Ehsan Mirfazaelian Hadi Neurology Department Shahid Beheshti University of Medical Sciences Emergency Medicine Department Tehran University of Medical Sciences

BACKGROUND:According to the literature,generalized seizure as a presenting sign of stroke is rare,and in the reported cases it was accompanied by a focal neurological *** of a small ischemic atherothrombotic brain infarction with convulsive generalized seizure is very ***:We reported a patient with acute small ischemic atherothrombotic infarction associated with an episode of generalized tonic-clonic seizure,a rare clinical manifestation in this type of *** patient was treated with anti-epileptic therapy after ***:The patient was discharged with oral administration of phenytoin 100 mg TDS,aspirin 80 mg daily,and atorvastatin 40 mg ***:Small ischemic atherothrombotic infarction can present only with a seizure without any focal neurological deficit.

关键词： Small ischemic atherothrombotic infarction Seizure Neurological deficit

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Dew Computing and Transition of Internet Computing Paradigms

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ZTE Communications 2017年第4期15卷 30-37页

作者： WANG Yingwei Karolj Skala Andy Rindos marjan Gusev YANG Shuhui PAN Yi University of Prince Edward Island CharlottetownC1A 4P3Canada Ruđer Boškovic'Institute Zagreb 10000Croatia IBM Emerging Technology Institute Durham 27709USA Ss.Cyril and Methodius University in Skopje Skopje 1000Macedonia Purdue University Northwest Hammond 46323USA Georgia State University Atlanta 30302USA

The goal of this paper focuses on the development of dew computing, including its origins, research status, development status,and its impact on the transition history of Internet computing paradigms. By gathering and studying all the research papers related to dew computing that we are aware of, we found that these papers can be classified into three groups: dew computing early explorations, dew computing feature research, and dew computing application research. Commercial development in the dew computing area also has progressed fast recently; many dew computing products were developed and put into the market. To distinguish dew computing from other Internet computing paradigms and to reveal its essential features, we analyze the transition history of the Internet computing paradigms from information location and distribution aspects. Online impact and redundancy rate are two indices introduced to perform the analysis. The analysis reveals that dew computing is significantly different from other Internet computing paradigms.

关键词： dew computing cloud computing online impact redundancy rate Internet computing paradigm

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Response of Contrasting Rice Genotypes to Zinc Sources under Saline Condition

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Phyton-International Journal of Experimental Botany 2023年第5期92卷 1361-1375页

作者： Muhammad Jan Muhammad Anwar-Ul-Haq Talha Javed Sadam Hussain Ilyas Ahmad Muhammad Ashraf Sumrah Javed Iqbal Babar Hussain Babar Aqsa Hafeez Muhammad Aslam Muhammad Tahir Akbar marjan Aziz Khadiga Alharbi Izhar Ullah Department of Soil and Environmental Sciences Ghazi UniversityDera Ghazi Khan32200Pakistan Institute of Soil and Environmental Sciences University of AgricultureFaisalabad38040Pakistan Department of Agronomy University of AgricultureFaisalabad38040Pakistan College of Agronomy Northwest A&F UniversityYangling712100China Pesticide Quality Control Lab MultanPunjab59300Pakistan Barani Agricultural Research Institute Chakwal48800Pakistan Soil and Water Testing Laboratory for Research Dera Ghazi Khan32200Pakistan Agronomic Research Institute Ayub Agricultural Research InstituteFaisalabad38000Pakistan Department of Plant Sciences Quaid-i-Azam UniversityIslamabad45320Pakistan Soil Fertility(Field) Multan59300Pakistan Department of Biology College of SciencePrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh11671Saudi Arabia Queensland University of Technology QueenslandAustralia

Abiotic stresses are among the major limiting factors for plant growth and crop *** these,salinity is one of the major risk factors for plant growth and development in arid to semi-arid *** of salt tolerant crop genotypes is one of the imperative approaches to meet the food demand for increasing *** current experiment was carried out to access the performance of different rice genotypes under salinity stress and Zinc(Zn)*** rice genotypes were grown in a pot experiment and were exposed to salinity stress(7 dS m^(−1)),and Zn(15 mg kg^(-1)soil)was applied from two sources,ZnSO4 and Zn-EDTA.A control of both salinity and Zn was kept for *** showed that based on the biomass accumulation and K^(+)/Na^(+)ratio,KSK-133 and BAS-198 emerged as salt tolerant and salt sensitive,***,based on the Zn concentration,BAS-2000 was reported as Zn-in-efficient while IR-6 was a Zn-efficient *** results also revealed that plant growth,relative water content(RWC),physiological attributes including chlorophyll contents,ionic concentrations in straw and grains of all rice genotypes were decreased under salinity ***,salt tolerant and Zn-in-efficient rice genotypes showed significantly higher shoot K^(+)and Zn concentrations under saline *** application significantly alleviates the harmful effects of salinity by improving morpho-physiological attributes and enhancing antioxidant enzyme activities,and the uptake of K and *** beneficial effect of Zn was more pronounced in salt-tolerant and Zn in-efficient rice genotypes as compared with salt-sensitive and Zn-efficient *** sum,our results confirmed that Zn application increased overall plant’s performance under saline conditions,particularly in Zn in-efficient and tolerant genotypes as compared with salt-sensitive and Zn efficient rice genotypes.

关键词： Agronomic efficiency antioxidant enzymes:physiology Oryza sativa salinity Zn efficient

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柔性高灵敏单壁碳纳米管气体传感器研究

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传感器与微系统 2011年第7期30卷 38-40,44页

作者：李兴辉 Selvarasah Selvapraba LIU Yu Mohebbi marjan Dokmeci Mehmet R 中国电子科技集团公司第十二研究所大功率微波电真空器件技术国防科技重点实验室北京100015 Department of Electrical and Computer Engineering Northeastern University

在柔性聚对二甲苯C基底上制作了基于单壁碳纳米管的小型化、高灵敏、反应快速的气体传感器。使用介质电泳集成碳管束,并利用单链脱氧核糖核酸修饰增强器件灵敏度。当传感器暴露在甲醇蒸气中时,会出现明显可重复的反应,它可以检测含量低... 详细信息

在柔性聚对二甲苯C基底上制作了基于单壁碳纳米管的小型化、高灵敏、反应快速的气体传感器。使用介质电泳集成碳管束,并利用单链脱氧核糖核酸修饰增强器件灵敏度。当传感器暴露在甲醇蒸气中时,会出现明显可重复的反应,它可以检测含量低至4.3×10-6的甲醇,并且在相当宽的体积分数范围有清晰的分辨能力。对于4.3×10-6的含量,未修饰的传感器对应电阻变化率是4.8%;经过脱氧核糖核酸修饰,电阻变化率增加到了12.3%。此外,该传感器还显示了很快的响应速度和很好的测试复验性。研究表明:这种柔性气体传感器在未来环境监测应用中有很好的前景。

关键词：碳纳米管纳米传感器气体传感器柔性的脱氧核糖核酸修饰

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让企业文化像多乐士那样丰富

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商学院 2012年第3期 I0002-I0003页

作者： marjan Oudeman

从律帅刮钢铁公司带钢产品区域总监，冉到荷兰银行fABNAiilf（）hallk）和】同家铁路（NationalRailwaysl的非执行董事以及全球领先的涂料和特殊化学品公司阿克苏诺叭尔管理委员会成员，欧玛妍（MarianOudeman）作为女性管理者，在以男... 详细信息

从律帅刮钢铁公司带钢产品区域总监，冉到荷兰银行fABNAiilf（）hallk）和】同家铁路（NationalRailwaysl的非执行董事以及全球领先的涂料和特殊化学品公司阿克苏诺叭尔管理委员会成员，欧玛妍（MarianOudeman）作为女性管理者，在以男性为主的行业取得了非比寻常的成就，就存被《华尔街日报》誉为“欧洲最值得关注的女性”（TheWomantoWatchinEurope）后不久，2010年她又成为荷兰最有影响力的人物之一。

关键词：企业文化《华尔街日报》女性管理者荷兰银行管理委员会化学品公司非执行董事 2010年

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A New Diterpene Extracted from Daphne Mucronata, Effects on Human K562 and CCRF-CEM Cell Lines

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Journal of Cancer Therapy 2011年第1期2卷 71-75页

作者： Mehdi Hedayati Razieh Yazdanparast marjan Zarif Yeganeh Laleh Hoghooghi Rad Fereidoun Azizi 不详

Background: Daphne Mucronata extract has a decreasing effect on the size of breast adenocarcinoma in rats. So in this study, the effect of Daphne Mucronata purified diterpene were investigated on co culture of human monocytes and two human leukemia cell lines (K562, CCRF-CEM). Materials and Methods: Each cell line mono-layer culture, in log phase growth, was treated with 10 to 160 μL of the extract (1 g/ml leave powder) and purified compound (0.94 nM). For a comparative study, Taxol (5 to 40 μM) was used in the presence and absence of LPS. Human monocytes were isolated by adhesion method. TNF-α in cultured media were measured by sensitive biotin-streptoavidin ELISA method. Results: Fifty percent of growth inhibition was shown by 160 μL (1:100 dilution, 0.5 g of the powdered leaves/ml) of the extract and 0.94 nM of the purified component, and there was more inhibition in K562 cells (P < 0.05). Four fold increases in growth inhibition was shown in co culture of isolated human monocytes and leukemia cell lines. There was a direct relationship between monocytes TNF-α secretion and growth inhibition degree. Conclusion: Daphne Mucronata extract and its purified diterpene through increasing monocytes TNF-α releasing, potentially inhibit Leukemia cell line.

关键词： TNF-α Leukemia Daphne Mucronata K562 CCRF-CEM

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