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Diet and epigenetics in colon cancer

World Journal of Gastroenterology 2009年第3期15卷 257-263页

作者： Minna Nystrm marja mutanen Department of Biological and Environmental Sciences GeneticsUniversity of HelsinkiFI-00014 HelsinkiFinland Department of Applied Chemistry and Microbiology Division of NutritionUniversity of HelsinkiFI-00014 HelsinkiFinland

Over the past few years, evidence has accumulated indicating that apart from genetic alterations, epigenetic alterations, through e.g. aberrant promoter methylation, play a major role in the initiation and progression of colorectal cancer (CRC). Even in the hereditary colon cancer syndromes, in which the susceptibility is inherited dominantly, cancer develops only as the result of the progressive accumulation of genetic and epigenetic alterations. Diet can both prevent and induce colon carcinogenesis, for instance, through epigenetic changes, which regulate the homeostasis of the intestinal mucosa. Food-derived compounds are constantly present in the intestine and may shift cellular balance toward harmful outcomes, such as increased susceptibility to mutations. There is strong evidence that a major component of cancer risk may involve epigenetic changes in normal cells that increase the probability of cancer after genetic mutation. The recognition of epigenetic changes as a driving force in colorectal neoplasia would open new areas of research in disease epidemiology, risk assessment, and treatment, especially in mutation carriers who already have an inherited predisposition to cancer.

关键词： Colon cancer Diet DNA methylation Epigenetics Nutrition

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Climate shapes the spatiotemporal variation in color morph diversity and composition across the distribution range of Chrysomela lapponica leaf beetle

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Insect Science 2022年第3期29卷 942-955页

作者： Mikhail V.Kozlov Zowi Oudendijk Anders Forsman Vojtech Lanta Maxwell V.L.Barclay Vladimir I.Gusarov Bert Gustafsson Zheng-Zhong Huang Oksana Y.Kruglova Yuri M.Marusik Yuri E.Mikhailov Marko mutanen Alexander Schneider Lukas Sekerka Maksim E.Sergeev Vitali Zverev Elena L.Zvereva Department of Biology University of TurkuTurkuFinland Department of Animal Ecology and Physiology Radboud UniversityNijmegenThe Netherlands Department of Biology and Environmental Science Linnaeus UniversityKalmarSweden Institute of Botany The Czech Academy of SciencesDukelskaTrebohCzech Republic Department of Life Sciences Natural History MuseumLondonUnited Kingdom Natural History Museum University of OsloOsloNorway Departmant of Zoology Swedish Museum of Natural HistoryStockholmSweden elnsititute of Zoology Chinese Academy of SciencesBeijingChina Faculty of Biology Belarusian State UniversityMinskBelarus Department of Biocenology Institute for Biological Problems of the NorthFar East Branch of the Russian Academy of SciencesMagadanRussia Department of Zoology&Entomology University of the Free StateBloemfonteinSouth Africa Department of Ecology&Nature Management Ural State Forest Engineering UniversityYekaterinburgRussia Ecology and Genetics Research Unit University of OuluOuluFinland Department of Terrestrial Zoology Senckenberg Research Institute and Natural History MuseumFrankfurt am MainGermany Department of Entomology National MuseumPrague 9CirkusovaCzech Republic Federal Scientific Center of the East Asia Terrestrial Biodiversity Far East Branch of the Russian Academy of SciencesVladivostokRussia

Color polymorphism offers rich opportunities for studying the eco-evolutionary mechanisms that drive the adaptations of local populations to heterogeneous and changing *** explored the color morph diversity and composition in a Chrysomela lapponica leaf beetle across its entire distribution range to test the hypothesis that environmental and climatic variables shape spatiotemporal variation in the phenotypic structure of a polymorphic *** obtained information on 13617 specimens of this beetle from museums,private collections,and *** specimens(collected from 1830-2020)originated from 959 localities spanning 33°latitude,178°longitude,and 4200 m *** classified the beetles into five color morphs and searched for environmental factors that could explain the variation in the level of polymorphism(quantified by the Shannon diversity index)and in the relative frequencies of individual color *** highest level of polymorphism was found at high latitudes and *** color morphs differed in their climatic requirements;composition of colour morphs was independent of the geographic distance that separated populations but changed with collection year,longitude,mean July temperature and betweenyear temperature *** proportion of melanic beetles,in line with the thermal melanism hypothesis,increased with increasing latitude and altitude and decreased with increasing climate *** morph frequencies also declined during the past century,but only at high latitudes and altitudes where recent climate warming was especially *** observed patterns suggest that color polymorphism is especially advantageous for populations inhabiting unpredictable environments,presumably due to the different climatic requirements of coexisting color morphs.

关键词： adaptive polymorphism color morphs evolutionary dynamics geographic variation phenotypic diversity thermal melanism

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植物类甾醇与小儿肠衰竭引起的肝组织损伤的相关性研究

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中华普通外科学文献（电子版） 2014年第5期8卷 43-43页

作者：周蕊 mutanen A Nissinen MJ Lohi J 第三军医大学大坪医院

【据《Am J Clin Nutr》2014年8月报道】题：血清植物甾醇、胆甾烷醇、胆固醇的前体物与小儿肠衰竭引起的肝组织损伤相关（作者mutanen A等）肠功能衰竭（intestinal failure，IF）的特征是广泛的吸收障碍，需要长期的肠外营养（parente... 详细信息

【据《Am J Clin Nutr》2014年8月报道】题：血清植物甾醇、胆甾烷醇、胆固醇的前体物与小儿肠衰竭引起的肝组织损伤相关（作者mutanen A等）肠功能衰竭（intestinal failure，IF）的特征是广泛的吸收障碍，需要长期的肠外营养（parenteral nutrtion，PN）支持。对肠衰竭患者长期的PN干预往往会引起肠衰竭相关的肝疾病（intestinal failure associated liver disease，IFALD）。IFALD是患者死亡的主要原因，尤其是婴幼儿。

关键词：肝组织损伤植物甾醇肠衰竭小儿相关性类甾醇肠功能衰竭 liver

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