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Helicobacter pylori,gastric microbiota and gastric cancer relationship:Unrolling the tangle

World Journal of Gastrointestinal Oncology 2022年第5期14卷 959-972页

作者： Christos Liatsos Apostolis Papaefthymiou Nikolaos Kyriakos Michail Galanopoulos Michael Doulberis marios giakoumis Evangelia Petridou Christos Mavrogiannis Theodore Rokkas Jannis Kountouras Department of Gastroenterology 401 General Military Hospital of AthensAthens 11525Greece Gastroenterology University Hospital of LarissaLarissa 41336Greece Division of Gastroenterology and Hepatology Medical University DepartmentKantonsspital AarauAarau 1234Switzerland Department of Microbiology “Agia Sofia”Paediatric HospitalGoudiAthens 11527Greece Gastrointestinal and Liver Unit Faculty of NursingKifissia General and Oncology HospitalKaliftakiN.Kifisia 14564Greece Gastroenterological Clinic Henry Dunant HospitalAthens 11525Greece Department of Internal Medicine Second Medical ClinicIppokration HospitalAristotle University of ThessalonikiThessaloniki 41336MacedoniaGreece

Helicobacter pylori infection(Hp-I)represents a typical microbial agent intervening in the complex mechanisms of gastric homeostasis by disturbing the balance between the host gastric microbiota and mucosa-related factors,leading to inflammatory changes,dysbiosis and eventually gastric *** normal gastric microbiota shows diversity,with Proteobacteria[Helicobacter pylori(***)belongs to this family],Firmicutes,Actinobacteria,Bacteroides and Fusobacteria being the most abundant *** studies indicate that *** has inhibitory effects on the colonization of other bacteria,harboring a lower diversity of them in the *** comparing the healthy with the diseased stomach,there is a change in the composition of the gastric microbiome with increasing abundance of ***(where present)in the gastritis stage,while as the gastric carcinogenesis cascade progresses to gastric cancer,the oral and intestinal-type pathogenic microbial strains ***-I creates a premalignant environment of atrophy and intestinal metaplasia and the subsequent alteration in gastric microbiota seems to play a crucial role in gastric tumorigenesis *** *** eradication is suggested to restore gastric microbiota,at least in primary *** is more than clear that Hp-I,gastric microbiota and gastric cancer constitute a challenging tangle and the strong interaction between them makes it difficult to *** studies are considered of crucial importance to test the complex interaction on the modulation of the gastric microbiota by *** as well as on the relationships between the gastric microbiota and gastric carcinogenesis.

关键词： Helicobacter pylori infection Gastric microbiota Gastric cancer Oncogenesis Dysbiosis Helicobacter pylori eradication

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