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Role of preoperative CT colonography in patients with colorectal cancer

World Journal of Gastroenterology 2014年第14期20卷 3795-3803页

作者： Lapo Sali Massimo Falchini Antonio Taddei mario mascalchi Department of Experimental and Clinical Biomedical Sciences University of Florence Department of Surgery and Translational Medicine University of Florence

In patients with colorectal cancer (CRC), accurate preoperative evaluation is essential for a correct therapeutic plan. Colonoscopy and intravenous contrast-enhanced computed tomography (CT) are currently recommended in the preoperative work-up for CRC. Preoperative colonoscopy has some limitations such as misdiagnosis of synchronous cancers in cases of incomplete exploration of the colon and inaccurate tumor localization. Intravenous contrast-enhanced CT successfully documents distant metastases although it sometimes enables unsatisfactory locoregional staging. Computed tomography colonography (CTC) is obtained after gas insufflation of the colon and offers a comprehensive preoperative evaluation in patients with CRC, including a definition of the segmental location of the tumor, presence of synchronous lesions or lack thereof, and fairly accurate locoregional staging. CTC has some limitations, including a lack of biopsy capability, suboptimal sensitivity for synchronous small polyps, and unsatisfactory nodal staging. Bearing in mind these limitations, CTC could be employed as a “one-stop-shop” examination for preoperative assessment in patients with CRC.

关键词： Colorectal cancer Colonoscopy Computed tomography colonography Synchronous cancer Cancer staging

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CT colonography after incomplete colonoscopy in subjects with positive faecal occult blood test

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World Journal of Gastroenterology 2008年第28期14卷 4499-4504页

作者： Lapo Sali Massimo Falchini Andrea Giovanni Bonanomi Guido Castiglione Stefano Ciatto Paola Mantellini Francesco Mungai Ilario Menchi Natale Villari mario mascalchi Radiodiagnostic Section Department of Clinical PhysiopathologyUniversity of FlorenceFlorence 50134Italy Centro per lo Studio e la Prevenzione Oncologica (CSPO) Florence 50100Italy Diagnostic Imaging Department Careggi HospitalFlorence 50134Italy

AIM： To report our experience with computed tomography colonography （CTC） systematically performed in subjects with positive faecal occult blood test （FOBT） and an incomplete colonoscopy in the setting of a population-based screening for colorectal cancer （CRC）. METHODS： From April 2006 to April 2007, 43 290 individuals （age range 50-70） who adhered to the regional screening program for the prevention of CRC underwent immunochemical FOBT. FOBT was positive in 1882 subjects （4.3%）. 1463 （77.7%） of these subjects underwent colonoscopy, 903 performed in a single center. Of 903 colonoscopies 65 （7.2%） were incomplete. Forty-two of these subjects underwent CTC. CTC was performed with a 16-MDCT scanner after standard bowel prep （polyethyleneglycole） in both supine and prone position. Subjects whose CTC showed polyps or masses were referred to the endoscopist for repeat colonoscopy under sedation or underwent surgery. Perlesion and per-segment positive predictive values （PPV） were calculated. RESULTS： Twenty-one （50%） of 42 CTCs showed polyps or masses. Fifty-five of these subjects underwent a repeat colonoscopy, whereas 2 subjects underwent surgery for colonic masses of indeterminate nature. Four subjects refused further examinations. CTC correctly identified 2 colonic masses and 20 polyps. PPV for masses or polyps greater than 9 mm was of 87.5%. Per-lesion and per-segment PPV were, respectively, 83.3% and 83.3% for polyps greater or equal to 10 mm, and 77.8% and 85.7% for polyps of 6-9 mm. CONCLUSION： In the context of a screening program for CRC based on FOBT, CTC shows high per-segment and per-lesion PPV for colonic masses and polyps greater than 9 mm. Therefore, CTC has the potential to become a useful technique for evaluation of the non visualized part of the colon after incomplete colonoscopy.

关键词： Computed tomography colonography Virtual colonoscopy Incomplete colonoscopy Positive faecal occult blood test Colorectal cancer screening

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ITALUNG肺癌随机筛查试验中的死亡率、生存率和发病率

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英国医学杂志中文版 2017年第6期20卷 357-357页

作者： Eugenio Paci Donella Puliti Andrea LopesPegna Laura Carrozzi Giulia Picozzi Fabio Falaschi Francesco Pistelli Ferruccio Aquilini Cristina Oeello Marco Zappa Francesca M Carozzi mario mascalchi 梁志欣陈良安不详解放军总医院呼吸内科

背景ITALUNG用来评价低剂量CT（LDCT）在欧洲人群肺癌筛查中的应用价值。

关键词：生存率死亡率试验筛查肺癌随机

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与带状回高灌注相关的癫痫发作性觉醒

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世界核心医学期刊文摘（神经病学分册） 2005年第6期1卷 47-47页

作者： Vetrugno R. mascalchi M. Vella A. 张玉龙 Dipartimento di Scienze Neurologiche Universit` adi Bologna Via Ugo Foscolo 7 40123 Bologna Italy Dr.

A patient with nocturnal frontal lobe epilepsy characterized by paroxysmal motor attacks during sleep had brief paroxysmal arousals (PAs), complex episodes of nocturnal paroxysmal dystonia, and epileptic nocturnal wandering since childhood. Ictal SPECT during an episode of PA demonstrated increased blood flow in the right anterior cingulate gyrus and cerebellar cortex with hypoperfusion in the right temporal and frontal associative cortices.

关键词：高灌注性觉醒皮质区小脑皮质血流灌注

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