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Candidate Biomarkers of Liver Fibrosis: A Concise, Pathophysiology-oriented Review

Journal of Clinical and Translational Hepatology 2018年第3期6卷 317-325页

作者： Mattia Bellan Luigi mario Castello mario Pirisi Department of Translational Medicine Universita del Piemonte Orientale UPONovaraItaly Division of Internal Medicine “Sant'Andrea Hospital”VercelliItaly IRCAD Interdisciplinary Research Center of Autoimmune DiseasesNovaraItaly Emergency Medicine Department “AOU Maggiore della Carita”NovaraItaly Division of Internal Medicine “AOU Maggiore della Carita”NovaraItaly

Repair of sustained liver injury results in fibrosis(*** accumulation of extracellular matrix proteins),and ultimately the complete distortion of parenchymal architecture of the liver,which we call *** and staging of fibrosis is thus a mainstay in the management of chronic liver diseases,since many clinically relevant decisions,such as starting treatment and/or monitoring for complications including hepatocellular carcinoma,may depend on *** gold standard for fibrosis staging is liver biopsy,the role of which,however,is questioned nowadays because of cost,hazards and poor acceptance by *** the other hand,imaging techniques and/or measurement of direct and indirect serum markers have not proved to be completely satisfactory under all circumstances as alternatives to liver *** progress in this field is nowmore crucial than ever,since treatments for established fibrosis appear on the *** dissection of the pathways involved in the pathophysiology of liver diseases has put forward several novel candidate biomarkers of liver fibrosis,such as growth arrest-specific6,Mac-2-binding protein,osteopontin,placental growth factor,growth/differentiation factor 15 and hepatocyte growth *** molecules have been suggested to have potential to complement or substitute methods currently used to stage liver ***,we review the pros and cons for their use in this setting.

关键词： Liver fibrosis Staging Biomarkers Gas6 HGF PlGF

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Modeling the arc and ring structures in the HD 143006 disk

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Science China(Physics,Mechanics & Astronomy) 2022年第6期65卷 137-149页

作者： Yao Liu mario Flock Min Fang Purple Mountain Observatory&Key Laboratory for Radio Astronomy Chinese Academy of SciencesNanjing 210023China Max-Planck-Institut für Astronomie Heidelberg D-69117Germany

Rings and asymmetries in protoplanetary disks are considered as signposts of ongoing planet *** this work,we con-duct three-dimensional radiative transfer simulations to model the intriguing disk around HD143006 that has three dust rings and a bright arc.A complex geometric configuration,with a misaligned inner disk,is assumed to account for the asymmetric *** two-dimensional surface density is constructed by iteratively fitting the ALMA *** find that the dust tem-perature displays a notable discontinuity at the boundary of the *** ring masses range from 0.6 to 16 M⊕that are systematically lower than those inferred in the younger HL Tau *** arc occupies nearly 20%of the total dust *** a high mass fraction of dust grains concentrated in a local region is consistent with the mechanism of dust trapping into *** a gas-to-dust mass ratio of 30 that is constant throughout the disk,the dense and cold arc is close to the threshold of being gravitationally unstable,with the Toomre parameter Q∼***,our estimate of Q relies on the assumption for the unknown gas-to-dust mass *** a lower gas-to-dust mass ratio would increase the inferred Q ***-up high resolution observations of dust and gas lines are needed to clarify the origin of the substructures.

关键词： protoplanetary disks radiative transfer planet formation

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Compact Greenberger-Horne-Zeilinger state generation via frequency com bs and graph theory

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Frontiers of physics 2020年第6期15卷 43-46页

作者： Xuemei Gu mario Krenn Hefei National Laboratory for Physical Sciences at Microscale and Department of Modern Physics University of Science and Technology of ChinaHefei 230026China Department of Chemistry&Computer Science Uni-versity of TorontoTorontoONM5S 3H6CanadaVector Institute for Artificial IntelligenceTorontoONM5S 1M1Canada

Quantum entanglement is one of the most mind-boggling phenomena predicted by quantum *** says that two particles can infuence each other,even though they are separated over large *** disbelieve,Einstein called this prediction spooky action at a distance[1].In the 1960s,Bell has demonstrated that quant um mechanics indeed seems to conflict with our classical worldview,which is local(information can be transmitted maximally with the speed of light)and realistic(properties exist prior to and independent of their measurement)[2].

关键词： maximal separated quantum

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Blood extracellular vesicles (EVs) of central nervous system origin: a window into the brain

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Neural Regeneration Research 2020年第1期15卷 55-56页

作者： Cristina Agliardi mario Clerici IRCCS Fondazione Don Carlo Gnocchi MilanoItaly(Agliardi CClerici M) Department of Pathophisiology and Transplantation University of MilanMilanoItaly(Clerici M)

Extracellular vesicles(EVs)are heterogeneous nano-sized vesicles of endocytic origin shed into blood and other body fluids such as urine,saliva,seminal fluid,ascites,amniotic liquid,synovial fluid,breast milk and cerebrospinal fluid(CSF)by quite all cell *** actively contribute to intercellular communication as they carry bioactive molecules that are selectively incorporated by the originating cell and are delivered to recipient cells over long and short distances(Simons and Raposo,2009).EVs can be divided into three main groups according to their size and cellular origin:1)exosomes(40–120 nm),that have an endocytic origin and are formed by inward budding of the limiting membrane of multivescicular bodies,which fuse with the plasma membrane and release exosomes into the extracellular space;2)microvesicles(50–1000 nm),budding directly off the plasma membrane;3)apoptotic bodies(>1000 nm),which are released during *** originating via distinct processes,different subtypes of EVs carry different proteins within their membrane and luminal compartments that reflect the phenotype of the tissue of origin.

关键词： Blood urine origin

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Crowd Energy Management: New Paradigm for Electricity Market

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Journal of Electronic Science and Technology 2015年第3期13卷 195-205页

作者： mario Gstrein Stephanie Teufel the International Institute of Management in Technology University of Fribourg

The traditionally centralized approach of electricity networks is progressively undergoing a shift towards a decentralized, distributed structure. The local and crowd-based principle is transforming the existing supply chain and related activities into a value network （VN）. Previous researches on crowd value network concepts focus on the activities of infrastructure and load management and neglect activities that generate collaboration. Collaboration with and within crowds particularly demands a different mindset and management of sharing values, information, benefit, and risks. Furthermore, these concepts must integrate technical, processual, and social aspects. Thus, this article proposes a holistic framework of electricity VN management for crowd energy. It redefines VN activities for infrastructure and load management while appending VN activities for social electricity handling. Additionally, the framework illustrates the interactions among these three elements and concludes with an adaption cycle for the crowd value network.

关键词： Crowd distribution systems value electricity management. energy decentralized network collaboration,

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Multifunctional nanocomposites modulating the tumor microenvironment for enhanced cancer immunotherapy

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Bioactive Materials 2024年第1期31卷 440-462页

作者： Prashant Sharma mario Otto Department of Child Health University of Arizona College of Medicine-PhoenixABC1 Building425 N 5th StreetPhoenixAZ85004USA Center for Cancer and Blood Disorders(CCBD) Phoenix Children’s1919 E Thomas RdPhoenixAZ85016USA

Cancer immunotherapy has gained momentum for treating malignant tumors over the past *** blockade and chimeric antigen receptor cell therapy(CAR-T)have shown considerable potency against liquid and solid ***,the tumor microenvironment(TME)is highly immunosuppressive and hampers the effect of currently available cancer immunotherapies on overall treatment *** in the design and engineering of nanomaterials have opened new avenues to modulate the *** in the current nanocomposite technology can overcome immunosuppression and trigger robust immunotherapeutic responses by integrating synergistic functions of different *** will review recent advancements in nanomedical applications and discuss specifically designed nanocomposites modulating the TME for cancer *** addition,we provide information on the current landscape of clinical-stage nanocomposites for cancer immunotherapy.

关键词： Tumor microenvironment Nanocomposites Immunotherapeutic Cancer Immunosuppressive

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PARALLEL HIERARCHICAL MATRIX PRECONDITIONERS FOR THE CURL-CURL OPERATOR

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Journal of Computational Mathematics 2009年第5期27卷 624-641页

作者： mario Bebendorf Joerg Ostrowski Institut fur Numerische Simulation Universitat BonnWegelerstrasse 653115 BonnGermany ABB Switzerland Ltd Corporate ResearchSegelhofstrasse 1 K/P.O.BoxCH-5405 Baden 5 Dattwil

This paper deals with the preconditioning of the curl-curl operator. We use H（curl）- conforming finite elements for the discretization of our corresponding magnetostatic model problem. Jumps in the material parameters influence the condition of the problem. We will demonstrate by theoretical estimates and numerical experiments that hierarchical matrices are well suited to construct efficient parallel preconditioners for the fast and robust iterative solution of such problems.

关键词： Computational electromagnetism Preconditioners Hierarchical matrices Parallelization.

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Mixed Phase Anatase/rutile Titanium Dioxide Nanotubes for Enhanced Photocatalytic Degradation of Methylene-blue

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Nano-Micro Letters 2011年第4期3卷 236-241页

作者： mario Boehme Wolfgang Ensinger Department of Materials Science Darmstadt University of Technology

Titanium dioxide Nanotubes(TNTs) prepared by electroless deposition have been annealed at air ambient and low temperature. As a result, the anatase/rutile phase composition of the TNTs can be tailored to the needs of later applications. Nanotubes with anatase/rutile mixed phase ratio of 4:1 have been produced in this report and further examined for their photocatalytical behavior. The photocatalytical properties of the TNTs have been observed by degradation of methylene-blue in aqueous solution under low power UV-light irradiation. The results shown in this report are based on the synergetic effect between rutile and anatase,which results in the mixed phase TiO 2 nanotubes having enhanced photocatalytical properties.

关键词： Electroless deposition Degussa P25 Nanotubes Titanium dioxide Anatase

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Secondary neurogenesis and telencephalic organization in zebrafish and mice: a brief review

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Integrative Zoology 2009年第1期4卷 123-133页

作者： mario F.WULLIMANN Department of Biology II Ludwig-Maximilians-UniversityMunich-MartinsriedGermany

Most zebrafish neurodevelopmental studies have focused on the embryo,which is characterized by primary neurogenesis of mostly transient *** neurogenesis becomes dominant in the hatching larva,when major brain parts are established and begin to *** developmental period allows for a comparative analysis of zebrafish brain organization with amniotes at equivalent stages of *** a particular time window,the early forebrains of mice(Embyronic stage[E]12.5/13.5 days[d])and zebrafish(3 d)reveal highly comparable expression patterns of genes involved in neurogenesis,for example proneural and other transcription factors(Neurogenin1,NeuroD,Mash1/Zash1a and Pax6).Further topological correspondences are seen in the expression of LIM and homeobox genes,such as Lhx6/7,Tbr2 and *** this analysis is extended to gamma-aminobutyric acid/glutamic acid decarboxylase(GABA/GAD)cell patterns during this critical time window,an astonishing degree of similarity between the two species is again seen,for example regarding the presence of GABA/GAD cells in the subpallium,with the pallium only starting to be invaded by such cells from the ***,the expression of proneural and other genes correlates with GABA cell patterns(***1/Zash1a gene expression in GABA-positive and Neurogenin1/NeuroD in GABA-negative telencephalic regions)in mice and *** from additional vertebrates,such as Xenopus,are also highly consistent with this ***,the vertebrate forebrain appears to undergo a phylotypic stage of secondary neurogenesis,characterized by regionally separated GABAergic(inhibitory)versus glutamatergic(excitatory)cell production sites,which are obscured later in development by tangential *** period is highly advantageous for molecular neuroanatomical cross-species comparisons.

关键词： basal ganglia cortex subpallium tangential migration gamma-aminobutyric acid GABA.

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A POSITIVE AND MONOTONE NUMERICAL SCHEME FOR VOLTERRA-RENEWAL EQUATIONS WITH SPACE FLUXES

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Journal of Computational Mathematics 2019年第1期37卷 33-47页

作者： mario Annunziato Eleonora Messina Dipartimento di Matematica Universita degli Studi di Salerno Via G.Paolo II 132.84084 Fisciano (SA)Italy Dipartimento di Matematica e Applicazioni "R.Caccioppoli" Universita degli Studi di Napoli "Federico II"Via CintiaMonte S.Angelo80126 NapoliItaly

We study a numerical method for solving a system of Volterra-renewal integral equations with space fluxes,that represents the Chapman-Kohnogorov equation for a class of piecewise deterministic stochastic *** solution of this equation is related to the time dependent distribution function of the stochastic process and it is a non-negative and non-decreasing function of the *** on the Bernstein polynomials,we build up and prove a non-negative and non-decreasing numerical method to solve that equation, with quadratic convergence order in space.

关键词： Volterra renewal Piecewise deterministic process Monotone positive numerical scheme Bernstein polynomials

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