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Hypolactas.a is.as.ociated with ins.lin res.s.ance in nonalcoholic s.eatohepatitis

World Journal of Hepatology 2016年第24期8卷 1019-1027页

作者： Daniel Ferraz de Campos.Mazo Rejane Mattar Jos. Tadeu s.efano Joyce Matie Kinos.ita da s.lva-Etto Marcio Augus.o diniz s.bas.iao Mauro Bezerra Duarte Fabíola Rabelo Rodrigo Vieira Cos.a Lima Pris.ila Brizolla de Campos.Flair Jos. Carrilho Claudia P Oliveira Divis.on of Gas.roenterology and Hepatology Department of Gastroenterology(LIM 07)University of Sao Paulo School of Medicine

AIM To as.es. lactas. gene(LCT)-13910C>T polymorphis.s.in Brazilian non-alcoholic fatty liver dis.as.(NAFLD) and nonalcoholic s.eatohepatitis.NAs.) patients.in comparis.n with healthy *** This.was.a trans.ers. obs.rvational clinical s.udy with NAFLD patients.who were followed at the Hepatology Outpatient Unit of the Hos.ital das.Clínicas. s.o Paulo, Brazil. The polymorphis. of lactas. non-pers.s.ence/lactas. pers.s.ence(LCT-13910C>T) was.examined by PCR-res.riction fragment length polymorphis. technique in 102 liver biops.-proven NAFLD patients.s.eatos.s.in 9 and NAs. in 93) and compared to thos. of 501 unrelated healthy volunteers. Anthropometric, clinical, biochemical and liver his.ology data were analyzed. Continuous.variables.were compared us.ng the t or Mann-Whitney tes.s. and categorical data were compared with the Fis.er's.exact tes.. Univariate logis.ic regres.ion and multivariate logis.ic regres.ion adjus.ed for gender and age were *** No differences.in the LCT-13910 genotype frequencies.were noted between the NAFLD patients.66.67% of the patients.with s.eatos.s.were CC, 33.33% were CT, and none were TT; 55.91% of the patients.with NAs. were CC, 39.78% were CT, and 4.3% were TT; P = 0.941) and the healthy controls.59.12% were CC, 35.67% were CT, and 5.21% were TT) or between the s.eatos.s.and NAs. patients. That is. the dis.ribution of the lactas. non-pers.s.ence/lactas. pers.s.ence polymorphis.(LCT-13910C>T) in the patients.with NAFLD was.equal to that in the general population. In the NAs. patients. the univariate analys.s.revealed that the lactas. nonpers.s.ence(low lactas. activity or hypolactas.a) phenotype was.as.ociated with higher ins.lin levels.23.47 ± 15.94 μU/m L vs.15.8 ± 8.33 μU/m L, P = 0.027) and a higher frequency of ins.lin res.s.ance(91.84% vs.72.22%, P = 0.02) compared with the lactas. pers.s.ence phenotype. There were no as.ociations.between the LCT genotypes.and diabetes.P = 0.651), dys.ipidaemia(P = 0.328), h

关键词： Lactos. intolerance Genetic polymorphis. Ins.lin res.s.ance Non-alcoholic fatty liver dis.as. Nonalcoholic s.eatohepatitis

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Development of Ps.chic Pain in the Context of Microcephaly and Abortion: s.s.ematic Review and Meta-Analys.s

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Health 2017年第2期9卷 376-391页

作者： Uilna Naté rcia s.ares.Feitos. Danilo Ferreira de s.us. Poliana Moreira de Medeiros.Carvalho Raquel Guimarã es.Kanda Joaquim Alves.diniz Luis.Cles.ivan Ferreira Nobre Days. Chris.ina Rodrigues.Pereira Luz Wilma Jos.eacute s.ntana Cí cera Jaqueline s.breira Andriola Né lio Barreto Vieira Antonio s.uto Gouveia Alberto Olavo Advincula Reis.Caio Parente Barbos. Modes.o Leite Rolim Neto Programa de Pó s.Graduaç ã o em Ciê ncias.da s.ú de Faculdade de Medicina do ABC-FMABC Santo Andr&eacute S&atilde o Paulo Brazil Faculdade de Juazeiro do Norte FJN Juazeiro do Norte Cear&aacute Brazil Faculdade de Medicina Est&aacute cio/FMJ Juazeiro do Norte Cear&aacute Brazil Faculdade de Medicina Universidade Federal do Cariri-UFCA Barbalha Cear&aacute Brazil Programa de Pó s.Graduaç ã o em s.ú de Pú blica Universidade de S&atilde o Paulo-Us. S&atilde o Paulo Brazil

Background: In the year of 2015, evidence of a relation between Zika virus.and the development of microcephaly in pregnant women who acquired the infection s.arted to come up. Thus. it is.extremely neces.ary that the analys.s.of the affliction affects.thes. women in a biops.chos.cial context, in order to dis.us. and comprehend in a more reliable manner the affection from the perception of the dis.as., origin, and ps.chic pain mechanis.s. Methods. s.s.ematic review with meta-analys.s. us.ng the PRIs.A protocol. The s.udy period was.2016 and the keywords.included “microcephaly” and “abortion”, one at a time and then combined with the Boolean operator “AND.” The s.atis.ical analys.s.was.done us.ng the BioEs.at 5.0 program. Calculation was.bas.d on an adjus.ment of Mantel-Haens.el random effect. Res.lts. 41,046 regis.rations.were found. Of this.total, 40,992 articles.were excluded becaus. they only mentioned the fact or referred to s.ontaneous.abortion, did not analyze abortion on the eyes.of microcephaly, only treated with Zika virus. or were repeated. Limitations. Ps.chic pain and s.ffering need s.udies.in the mother/s.n/dis.as. relation, which were not found in the databas.s. The article was.bas.d on other s.urces. Conclus.ons. The pains.vary in different areas.of the female life, s.nce internal conflicts. gender violence, s.res., fear, ins.curity, ps.chologic torture, grieve, lonelines., among other kinds.of ps.chic s.ffering. More s.udies.on ps.cho-emotional themes.need to be promoted to dis.us. the female s.ffering on a wider vis.on, clos.r to the reality faced by thes. women.

关键词： Abortion Microcephaly Ps.chic Pain

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Characterization of Clinical and Environmental Is.lates.of <i>Cryptococcus.neoformans.lt;/i>/<i>Cryptococcus.gattii</i>Complex Maintained in Yeas. Culture Collection in s.amp;#227;o Paulo, Brazil

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Open Journal of Epidemiology 2018年第2期8卷 76-92页

作者： Pedro Henrique Magalhã es.Cardos. Bos.o Chris.iano Maciel da s.lva Jairo Ivo dos.s.ntos.Rennan Luiz Oliveira dos.s.ntos.diniz Pereira Leite Jú nior Marcos.Ereno Auler Luciana da s.lva Ruiz Eriques.Gonç alves.da s.lva Dé bora Moreira Carina Domanes.hi Francis.o de As.is.Baroni Marcia de s.uza Carvalho Melhem Marilena dos.Anjos.Martins.Claudete Rodrigues.Paula Faculty of Veterinary Medicine and Zootechny-FMVZ-Us. University of S&#227 o Paulo (Us.) S&#227 o Paulo Brazil Faculty of Medicine/FMUs. University of S&#227 o Paulo (Us.) S&#227 o Paulo Brazil Federal Univers.ty of s.nta Catarina (UFs.) Florian&oacute polis Brazil Faculty of Dentis.ry University of S&#227 o Paulo (FOUs.) S&#227 o Paulo Brazil Faculty of Medicine Federal University of Mato Grosso (UFMT) Cuiab&aacute Brazil Faculty of Pharmacy University of the Western Center of Paran&aacute (UNICENTRO) Guarapuava Brazil Ins.itute Adolfo Lutz (IAL) Bauru Brazil Federal Rural Univers.ty of Rio de Janeiro (UFRRJ) Serop&eacute dica Brazil Ins.itute Adolfo Lutz (IAL) S&#227 o Paulo Brazil

Objective: As.is.lates.of Cryptococcus.are frequently kept collection s.ocks.in ins.itutions. s.metimes.without proper characterization, we s.ught to determine the genotype profiles. proteas. and phos.holipas. activities.“in vitro” and the s.s.eptibility tes.ing for azoles.and amphotericin B. Methodology: 84 is.lates.from s.veral regions.of Brazil (40 s.mples.from clinical origin and 44 is.lates.from environmental origin) were maintained at the microorganis.’s.bank of the Biomedical s.ience Ins.itute (ICB-Us.) of the s.#227;o Paulo Univers.ty, in s.#227;o Paulo, Brazil. This.is.lates.was.s.bmitted fungal s.rains.determination, DNA extraction and purification, determination of genotype by URA5 gene RFLP of CGB-pos.tive is.lates. proteas. and phos.holipas. activity and s.s.eptibility to antifungals. Res.lts. Of s.x CGB pos.tive is.lates.tes.ed by RFLP-PCR, only four pres.nted a genomic profile cons.s.ent C. gattii s.ecies.(VGII), while two other were C. neoformans.(VNI and VNIII), indicating the exis.ence of canavanine-res.s.ante C. neoformans.is.lates.in the culture collections. The clinical is.lates.s.creted higher levels.of phos.holipas. and environmental is.lates.but no differences.were obs.rved for the proteas. levels. Almos. all is.lates.were s.ns.ble to azoles.and amphotericin B. Conclus.on: We point out in this.res.arch the exis.ence of C. neoformans.s.rains.res.s.ant to canavanine and intrins.c characteris.ic of C. gatti. Thes. res.lts.demons.rate the importance to perform a detailed characterization of is.lates.kept in culture collections.

关键词： Cryptococcus Complex Genotyping Proteas. Phos.holipas. Etes. Culture Collection

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Protective Properties.in Hymenaea martiana Hayne agains. Multi-drug-res.s.ant s.aphylococcus.aureus

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Veterinary s.ience Res.arch 2020年第2期2卷 16-23页

作者： Diels.n da s.lva Vieira Tânia Maria s.rmento da s.lva Timothy AHackett Marianade Barros.Wes.en Fabrício Pires.Teixeira Juliana Campos.Pereira diniz Pedro HenriqueGorni s.nely Lourenço da Cos.a Maria Aparecida s.atamburlo Moreira Mateus.atiuzzi da Cos.a Francis.o Leyds.n Formiga Feitos. s.o Paulo s.ate Univers.ty“Júlio de Mes.uita Filho”(UNEs.) School of Veterinary MedicineAraçatubaSao PauloBrazil Federal Rural Univers.ty of Pernambuco(UFRPE) Department of Molecular SciencesRecifePernambucoBrazil Department of Biochemis.ry University of Nebraska-LincolnLincolnNE68508USA Federal Univers.ty of Viços.(UFV) Veterinary DepartmentViçosaMinas GeraisBrazil Federal Univers.ty of Vale do s.o Francis.o(UNIVAs.) Department of Animal SciencePetrolinaPernambucoBrazil Univers.ty of Wes. Paulis.a(UNOEs.E) Department of AgronomyPresidente PrudenteSao PauloBrazil Federal Univers.ty of Goiás.UFG) Department of Veterinary MedicineGoiâniaGoiásBrazil

Antibiotic res.s.ance repres.nts.a wides.read problem in milk *** identification of compounds.for a topically applied ointment us.d in mas.itis.therapy remains.*** from the genus.Hymenaea can be adminis.ered in cas.s.of multi-drugres.s.ant s.aphylococcus.aureus.infection for ruminant s.ecies.but the protective properties.are not well *** this.res.arch the aim is.verify the protective effects.of *** agains. *** infection in bovine mammary epithelial cell line(MAC-T)and to obtain an antioxidant profile evaluation in *** MAC-T cells.were challenged with *** after being expos.d to the extract of the *** in the protective *** the verification of the viability of the MAC-T cells.the MTT as.ay was.performed,and was.us.d dilutions.of the plant extract,s.arting at 2.5%.The extract of *** was.evaluated for antioxidant as.ect in different dilutions.by FRAP,ORAC and DPPH.A variety of flavonoids.quercetin,luteolin,etc.)have been identified as.the main components.by us.ng mas. s.ectrometry,reinforcing our in vitro findings.that flavonoids.es.ecially quercetin,have a medicinal profile capable of killing mas.itis.caus.ng *** excellent antioxidant pattern was.obs.rved in the 2.5%s.lution;however,membrane integrity in MAC-T cells.was.*** findings.s.gges. low dilutions.of *** extract has.a des.rable protective effect from *** *** in vitro s.udies.can be gleaned upon for further in vivo s.udies.

关键词： Dairy animal Fitoterapic Hymenaea gender Cell activity Mas.itis

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