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Effects of melatonin on the oxidative damage and pancreatic antioxidant defenses in ceruleininduced acute pancreatitis in rats

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Hepatobiliary & Pancreatic Diseases International 2014年第4期13卷 442-446页

作者： Cristina Carrasco Ana Beatriz rodríguez José A Pariente Department of Physiology Neuroimmunophysiology and Chrononutrition Research Group University of Extremadura

BACKGROUND： Oxidative stress is recognized as a pivotal effector of several pathogenic processes, including acute pancreatitis. Reactive oxygen species not just cause damage on the main cellular components, but also influence the expression of antioxidant system genes. Antioxidant molecules, such as melatonin, could be good candidates for the treatment of this multidimensional disease. The present study was to evaluate the chemopreventive effect of melatonin in a rat model of ceruleininduced acute ***： Four subcutaneous injections of cerulein（20 μg/kg body weight） were given to Wistar rats at two hours intervals;melatonin was injected intraperitoneally（25 mg/kg body weight）30 minutes before each injection of cerulein. Lipid peroxidation,protein oxidation（carbonyl groups）, total antioxidant status,and glutathione peroxidase activity were determined in pancreatic tissue using commercial ***： The chemopreventive administration of melatonin caused a reduction in lipid peroxidation and protein oxidation due to injections of cerulein. Additionally, melatonin treatment was also able to revert glutathione peroxidase activity and total antioxidant status near to control levels, suggesting that melatonin could prevent from oxidative phenomena in the pancreas, such as lipid peroxidation and protein oxidation,and could stimulate, directly or indirectly, the expression of antioxidant ***： Melatonin, a polyvalent antioxidant, protected the pancreatic damage via the decrease of oxidative stress andincrease of the activities of antioxidant enzymes in ceruleininduced acute pancreatitis.

关键词： acute pancreatitis antioxidants cerulein melatonin oxidative stress

Apomorphine effects on the hippocampus

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Neural Regeneration Research 2018年第12期13卷 2064-2066页

作者： Luis Enrique Arroyo-García Antonio rodríguez-Moreno Gonzalo Flores Laboratorio de Neuropsiquiatria Instituto de Fisiologia Benemerita Universidad Autenoma de Puebla Puebla Mexico Laboratorio de Neurociencia Celular y Plasticidad Universidad Pablo de Olavide Sevilla Spain

Apomorphine is a non-specific dopamine receptor agonist that has been used in the treatment of some diseases and mental disorders. Its use has particularly well documented in Parkinson＇s disease（PD）. The dopaminergic agonists like apomorphine are related to oxidative processes that could induce cell damage and the functional impairment of some structures in the brain. However, most information about apomorphine in literature is focused on the improvement of the motor problems characteristic of PD, but little is known about the effects on cognitive behaviors and brain structures indirectly related to motor function. The presence of dopaminergic receptors in the hippocampus has recently been discovered, in connection with cognitive behaviors like learning and memory, these receptors are needed in neuronal plasticity. There has been a growing interest to know if this structure could be compromised by the effect of apomorphine and elucidate if part of the cognitive impairment present in the PD is due to the effect of apomorphine. In this mini-review, we summarized how apomorphine has been used since its creation, we discuss the latest information about its effect on the hippocampus and also the future perspectives to fully understand the effects of this compound.

关键词： dopamine receptor apomorphine hippocampus learning and memory plasticity dendritic length oxidative stress Parkinson's disease

Digital Social Connectedness as a Lifeline for Older People: Use and Non-use of VinclesBCN During the Pandemic

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International Journal of Disaster Risk Science 2024年第2期15卷 251-264页

作者： Israel rodríguez‑Giralt Daniel López‑Gómez Roser Beneito‑Montagut CareNet IN3Universitat Oberta de Catalunya08018 BarcelonaSpain School of Social Sciences Cardif UniversityCardif CF103NSWalesUK

This article presents the results of a study that evaluated VinclesBCN during COVID-19. This digital-based public social service aims to prevent loneliness and isolation in +65-year-old adults living in Barcelona. Through service user(N = 12) and professional(N = 6) interviews and a questionnaire with service users(N = 255), we demonstrate the pivotal role of digital connectedness in transforming VinclesBCN into a lifeline during the pandemic. The analysis revealed the importance of sociability, social support, and, especially, entertainment in coping with pandemic fatigue and facilitating social connectivity and support among users. Users engaged in activities such as sharing images, songs, memes, and daily greetings to provide proximity, sociability, and care among users, whether they belonged to preexisting groups or were newly introduced to the platform. It also facilitated the identification of individuals who needed companionship, comfort, or more specialized support. The findings emphasize the significance of entertainment as a resilience-building strategy during times of uncertainty. Despite the positive impact, not all users equally used the platform. Non-use was strongly associated with being a woman, having a low educational level, having preexisting social relationships, less time of enrolment in the platform, as well as a high perception of loneliness, poor self-reported health, and low mood. The article underscores the need for further research into older adults' digital engagement during crises, its role in building resilience, and advocating for inclusive digital interventions that take into account diverse older adults' needs and experiences in crisis contexts.

关键词： Barcelona COVID-19 pandemic Digital social connectedness Entertainment Older adult resilience Public digital service

Determination of the ground vibration attenuation law from a singleblast: A particular case of trench blasting

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Journal of Rock Mechanics and Geotechnical Engineering 2021年第5期13卷 1182-1192页

作者： Rafael rodríguez Laura García de Marina Marc Bascompta Cristóbal Lombardía Department of Mining Exploitation and Prospecting School of MiningEnergy and Materials EngineeringUniversity of OviedoIndependencia 13Oviedo33004Spain Department of Mining Industrial and ICT EngineeringPolytechnic University of Catalonia(UPC)ManresaAv.Bases de Manresa61-73Barcelona08242Spain Perforaciones Noroeste S.A Longoria Carbajal No.3Oviedo33004Spain

The general transmissivity law of ground vibrations was studied,and a user-friendly methodology for determining the behavior of vibrations generated in any rock mass is *** study was based on a single blast in a trench excavation,analyzing the vibration components recorded from two fixed *** attenuation law and the main variables according to the legal requirements,frequency and peak particle velocity(PPV),are defined with this novel method,achieving a high confidence level in a simple *** proposed approach can also have an important impact in terms of reducing the potential consequences of vibrations for the surrounding construction and achieving the required definition of rock *** the cost and time in many projects where blasting techniques are applied is particularly useful for the design of future blasts.

关键词： Empirical analysis Blasting Ground vibration Trenching Wave propagation

New insights into Wnt signaling alterations in amyotrophic lateral sclerosis: a potential therapeutic target?

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Neural Regeneration Research 2020年第9期15卷 1580-1589页

作者： Carlos González-Fernández Pau González Francisco Javier rodríguez Laboratory of Molecular Neurology Hospital Nacional de Parapléjicos (HNP)

Amyotrophic lateral sclerosis is a fatal neurodegenerative disorder characterized by upper and lower motor neuron degeneration, which leads to progressive paralysis of skeletal muscles and, ultimately, respiratory failure between 2–5 years after symptom onset. Unfortunately, currently accepted treatments for amyotrophic lateral sclerosis are extremely scarce and only provide modest benefit. As a consequence, a great effort is being done by the scientific community in order to achieve a better understanding of the different molecular and cellular processes that influence the progression and/or outcome of this neuropathological condition and, therefore, unravel new potential targets for therapeutic intervention. Interestingly, a growing number of experimental evidences have recently shown that, besides its well-known physiological roles in the developing and adult central nervous system, the Wnt family of proteins is involved in different neuropathologica conditions, including amyotrophic lateral sclerosis. These proteins are able to modulate, at least, three different signaling pathways, usually known as canonical(β-catenin dependent) and non-canonical(β-catenin independent) signaling pathways. In the present review, we aim to provide a general overview of the current knowledge that supports the relationship between the Wnt family of proteins and its associated signaling pathways and amyotrophic lateral sclerosis pathology, as well as their possible mechanisms of action. Altogether, the currently available knowledge suggests that Wnt signaling modulation might be a promising therapeutic approach to ameliorate the histopathological and functional deficits associated to amyotrophic lateral sclerosis, and thus improve the progression and outcome of this neuropathology.

关键词： ALS astrocytes Frizzled human microglia motor neuron neurodegeneration neuroinflammation spinal cord Wnt

Large-Scale Group Decision Making:A Systematic Review and a Critical Analysis

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IEEE/CAA Journal of Automatica Sinica 2022年第6期9卷 949-966页

作者： Diego García-Zamora Alvaro Labella Weiping Ding Rosa M.rodríguez Luis Martínez Department of Computer Science University of JaénJaén 23071Spain IEEE School of Information Science and Technology Nantong UniversityNantong 226019China

The society in the digital transformation era demands new decision schemes such as e-democracy or based on social *** novel decision schemes require the participation of many experts/decision makers/stakeholders in the decision *** a result,large-scale group decision making(LSGDM)has attracted the attention of many researchers in the last decade and many studies have been conducted in order to face the challenges associated with the ***,this paper aims at reviewing the most relevant studies about LSGDM,identifying the most profitable research trends and analyzing them from a critical point of *** do so,the Web of Science database has been consulted by using different *** these results a total of 241 contributions were found and a selection process regarding language,type of contribution and actual relation with the studied topic was then carried *** 87 contributions finally selected for this review have been analyzed from four points of view that have been highly remarked in the topic,such as the preference structure in which decision-makers’opinions are modeled,the group decision rules used to define the decision making process,the techniques applied to verify the quality of these models and their applications to real world problems ***,a critical analysis of the main limitations of the existing proposals is ***,taking into account these limitations,new research lines for LSGDM are proposed and the main challenges are stressed out.

关键词： Challenges large-scale consensus models large-scale group decision making(LSGDM) systematic review

Semi-analytical finite element method applied for characterizing micropolar fibrous composites

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Applied Mathematics and Mechanics(English Edition) 2024年第12期45卷 2147-2164页

作者： J.A.OTERO Y.ESPINOSA-ALMEYDA R.rodríguez-RAMOS J.MERODIO School of Engineering and Sciences Monterrey Institute of Technology Institute of Engineering and Technology Autonomous University of Ciudad Juárez Postgraduate Program in Computational Modeling in Science and Technology Federal Fluminense University Faculty of Mathematics and Computer Science University of Havana Department of Mathematics Applied to ICT School of Informatics Systems Engineering Technical University of Madrid

A semi-analytical finite element method(SAFEM), based on the two-scale asymptotic homogenization method(AHM) and the finite element method(FEM), is implemented to obtain the effective properties of two-phase fiber-reinforced composites(FRCs). The fibers are periodically distributed and unidirectionally aligned in a homogeneous matrix. This framework addresses the static linear elastic micropolar problem through partial differential equations, subject to boundary conditions and perfect interface contact conditions. The mathematical formulation of the local problems and the effective coefficients are presented by the AHM. The local problems obtained from the AHM are solved by the FEM, which is denoted as the SAFEM. The numerical results are provided, and the accuracy of the solutions is analyzed, indicating that the formulas and results obtained with the SAFEM may serve as the reference points for validating the outcomes of experimental and numerical computations.

关键词： 74Q05 74Q15 74S05 asymptotic homogenization method (AHM) effective property fiber-reinforced composite (FRC) finite element method (FEM) micropolar elasticity O241.82 O343 semi-analytical approach

All-Orders Evolution of Parton Distributions:Principle,Practice,and Predictions

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Chinese Physics Letters 2023年第9期40卷 24-31页

作者：尹佩林徐胤禛崔钫 Craig D.Roberts José rodríguez-Quintero College of Science Nanjing University of Posts and TelecommunicationsNanjing 210023China Dpto.Ciencias Integradas Centro de Estudios Avanzados en Fis.Mat.y Comp.Fac.Ciencias ExperimentalesUniversidad de HuelvaHuelva 21071Spainl Dpto.Sistemas Físicos Químicos y NaturalesUniv.Pablo de OlavideE-41013 SevillaSpain School of Physics Nanjing UniversityNanjing 210093China Institute for Nonperturbative Physics Nanjing UniversityNanjing 210093China

Parton distribution functions(PDFs)are defining expressions of hadron *** the role of effective charges in quantum chromodynamics,an algebraic scheme is described which,given any hadron’s valence parton PDFs at the hadron scale,delivers predictions for all its PDFs(unpolarized and polarized)at any higher *** scheme delivers results that are largely independent of both the value of the hadron scale and the pointwise form of the charge;and,inter alia,enables derivation of a model-independent identity that relates the strength of the proton’s gluon helicity PDF,ΔG_(p)ζ,to that of the analogous singlet polarized quark PDF and valence quark momentum *** available data fits and theory predictions,the identity yieldsΔG_(p)(ζC=√3 GeV)=1.48(10).It furthermore entails that the measurable quark helicity contribution to the proton spin is a_(op)^(ζC)=0.32(3),thereby reconciling contemporary experiment and theory.

关键词： structure theory quark

Regulation of platelet function by natural bioactive compounds

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Food Bioscience 2022年第4期48卷 13-33页

作者： Meiby Fernandez-Rojas Lyanne rodríguez Andres Trostchansky Eduardo Fuentes Instituto de Química de Recursos Naturales Universidad de TalcaTalcaChile Thrombosis Research Center Medical Technology SchoolDepartment of Clinical Biochemistry and ImmunohematologyFaculty of Health SciencesUniversidad de TalcaTalcaChile Departamento de Bioquímica and Centro de Investigaciones Biom´edicas(CEINBIO) Facultad de MedicinaUniversidad de la RepúblicaMontevideoUruguay

Cardiovascular diseases rank first in mortality *** have been considered the main cardiovascular risk factor since they play an important role,in atherosclerosis and the development of acute thrombotic *** hyperactivation of platelets leads to platelet aggregation and the formation of clogs,blocking the passage of blood to the different organs and *** obstruction contributes to blood vessel stenosis,ischemia,and heart *** present,it is vital to find new targets for the development of safer and more effective antiplatelet agents.A diet rich in bioactive compounds can help in the prevention of cardiovascular events since it has been shown that some of these metabolites can reduce the risk of atherosclerosis and atherothrombotic disease by inhibiting platelet *** review aims to collect and discuss the largest amount of information reported updated on the cardioprotective and antiplatelet activities of the different bioactive compounds extracted from natural *** compounds were divided into different groups(phenolic acids,flavonoids,carotenoids(lycopene and B-carotenes),and sulfides.

关键词： Natural compounds Polyphenols Flavonoids Platelet activation Cardiovascular diseases