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International Journal of Sediment Research 2023年第3期38卷 303-315页

作者： mario misale Johan Augusto Bocanegra Annalisa Marchitto DIME-Department of Mechanics Energetics Management and Transportation Thermal Engineering and Environmental Conditioning Division University of Genoa

The stability of nanofluids is critical in engineering applications. The sedimentation of the nanoparticles in the base fluid limits the stability of the nanofluid. By measuring the absorbance of a visible laser through water aluminum oxide nanofluids it is possible to observe the evolution of the sedimentation process. A simple experimental setup consisting of a thin closed test cavity（0.8 mm or 1.5 mm thickness）filled with nanofluid and a set of laser diodes-photodiodes pairs was used in the experiments to determine the absorbance and the local volumetric concentration. The evolution of the local volumetric concentration of the nanofluid was measured at 13 height positions along the test cavity. Five initial volumetric concentrations of aluminum oxide（Al2O3; 0.5%, 1.0%, 1.5%, 2.0%, 3.0% and 4.0%） were considered. Data and digital photos were acquired for a total time lapse of 260 days. The results were independent of the container thickness. The same general trend was consistent for all the initial volumetric concentrations, i.e., the sedimentation rate decreases in time. The time evolution of the volumetric concentration was compared with results from a modified Mason-Weaver model. The comparison was possible by setting a variable sedimentation velocity in the model, suggesting that the sedimentation is affected by the dynamics of nanoparticle clusters with diverse sizes produced by agglomeration.

关键词： Pure nanofluid Aluminum oxide Nanoscale alumina particles Colloid sedimentation Nanoparticle settling Mason-Weaver model

Revisiting the theoretical prediction of the explosive performance found by the Trauzl test

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Defence Technology（防务技术） 2024年第6期36卷 163-174页

作者： Ivana Dobrilovic mario Dobrilovic Muhamed Suceska Faculty of Mining Geology and Petroleum EngineeringDepartment of Mining Engineering and GeotechnicsUniversity of ZagrebPierottijeva 6Zagreb10000Croatia

The Trauzl lead block test allows the determination of the approximate performance of explosives in blasting applications by measuring the volume increase(expansion)that is produced by the detonation of an explosive charge in the cavity of a lead *** this paper,we reconsider the possibility of interpreting the Trauzl test results in terms of detonation parameters or *** detonation parameters used in the analysis are calculated using the thermochemical code EXPLO5,while the hydrocode AUTODYN is used to simulate the effect of explosive charge density and reaction rate on the results of the Trauzl *** increase in the volume of the lead block cavity was found to correlate best with the product of the detonation heat and the root of the volume of detonation *** simulation showed that the density of explosive charge and the rate of explosive decomposition affect the dynamics of the interaction of the detonation product and the lead block,and consequently the lead block cavity volume increase.

关键词： Trauzl lead block test Performance of explosives EXPLO5 AUTODYN Detonation heat

Machine learning applications in stroke medicine:advancements,challenges,and future prospectives

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Neural Regeneration Research 2024年第4期19卷 769-773页

作者： mario Daidone Sergio Ferrantelli Antonino Tuttolomondo Internal Medicine and Stroke Care Ward Department of Health PromotionMother and Child CareInternal Medicine and Medical SpecialtiesUniversity of Palermo Molecular and Clinical Medicine PhD Program University of Palermo

Stroke is a leading cause of disability and mortality worldwide,necessitating the development of advanced technologies to improve its diagnosis,treatment,and patient *** recent years,machine learning techniques have emerged as promising tools in stroke medicine,enabling efficient analysis of large-scale datasets and facilitating personalized and precision medicine *** abstract provides a comprehensive overview of machine learning’s applications,challenges,and future directions in stroke *** introduced machine learning algorithms have been extensively employed in all the fields of stroke *** learning models have demonstrated remarkable accuracy in imaging analysis,diagnosing stroke subtypes,risk stratifications,guiding medical treatment,and predicting patient *** the tremendous potential of machine learning in stroke medicine,several challenges must be *** include the need for standardized and interoperable data collection,robust model validation and generalization,and the ethical considerations surrounding privacy and *** addition,integrating machine learning models into clinical workflows and establishing regulatory frameworks are critical for ensuring their widespread adoption and impact in routine stroke *** learning promises to revolutionize stroke medicine by enabling precise diagnosis,tailored treatment selection,and improved *** research and collaboration among clinicians,researchers,and technologists are essential for overcoming challenges and realizing the full potential of machine learning in stroke care,ultimately leading to enhanced patient outcomes and quality of *** review aims to summarize all the current implications of machine learning in stroke diagnosis,treatment,and prognostic *** the same time,another purpose of this paper is to explore all the future perspectives these techniques can provide in combating this disabling dis

关键词： cerebrovascular disease deep learning machine learning reinforcement learning stroke stroke therapy supervised learning unsupervised learning

Research funding and citations in papers of Nobel Laureates in Physics, Chemistry and Medicine, 2019-2020

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Journal of Data and Information Science 2024年第2期9卷 56-80页

作者： mario Coccia Saeed Roshani CNR-National Research Council of Italy IRCRES-CNRTurin Research Area of the CNRStrada delle Cacce73-10135-TurinItaly Arizona State University School of Complex Adaptive Systems1031 S.Palm WalkTempeAZ 85281-2701USA Allameh Tabataba’i University Department of Technology and Entrepreneurship ManagementDehkadeh-ye-OTehran***Iran

Purpose:The goal of this study is a comparative analysis of the relation between funding(a main driver for scientific research)and citations in papers of Nobel Laureates in physics,chemistry and medicine over 2019-2020 and the same relation in these research fields as a ***/methodology/approach:This study utilizes a power law model to explore the relationship between research funding and citations of related *** study here analyzes 3,539 recorded documents by Nobel Laureates in physics,chemistry and medicine and a broader dataset of 183,016 documents related to the fields of physics,medicine,and chemistry recorded in the Web of Science ***:Results reveal that in chemistry and medicine,funded researches published in papers of Nobel Laureates have higher citations than unfunded studies published in articles;vice versa high citations of Nobel Laureates in physics are for unfunded studies published in ***,when overall data of publications and citations in physics,chemistry and medicine are analyzed,all papers based on funded researches show higher citations than unfunded ***/value:Results clarify the driving role of research funding for science diffusion that are systematized in general properties:a)articles concerning funded researches receive more citations than(un)funded studies published in papers of physics,chemistry and medicine sciences,generating a high Matthew effect(a higher growth of citations with the increase in the number of papers);b)research funding increases the citations of articles in fields oriented to applied research(e.g.,chemistry and medicine)more than fields oriented towards basic research(e.g.,physics).Practical implications:The results here explain some characteristics of scientific development and diffusion,highlighting the critical role of research funding in fostering citations and the expansion of scientific *** finding can support decision-making of policymakers and R&D mana

关键词： Research funding Citations Science diffusion Scientific change Science of Science Power-law distribution Basic research Applied research Matthew effect Nobel Laureates Nobel Prizes

Chestnut tannin:New use,research and bioeconomy

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Journal of Bioresources and Bioproducts 2024年第3期9卷 246-252页

作者： Rosaria Ciriminna Francesco Meneguzzo Giovanna Li Petri Cosimo Meneguzzo Giuseppe Angellotti mario Pagliaro Istituto per lo Studio dei Materiali Nanostrutturati CNRvia U.La Malfa 15390146 PalermoItaly Istituto per la Bioeconomia CNRvia Madonna del Piano 1050019 Sesto Fiorentino(FI)Italy HyRes Srl via Salvator Rosa 1882100 BeneventoItaly

Chestnut tannin,extracted from the bark or wood of chestnut trees,possesses unique properties that make it valuable in various *** serves as a natural source of tannins,which are widely used in the production of leather,textiles,and wood *** research continues to explore its potential applications,chestnut tannin remains a promising resource with diverse industrial *** new use,research and bioeconomy aspects,this study provides a unified perspective on chestnut *** advanced applications will likely emerge shortly.

关键词： Tannin Chestnut Bioeconomy Tannin market Hydrolysable tannin

MIS 5e sea surface temperature estimation;a multi-proxy approach using a marine macrofossil assemblage(Mar Piccolo,Gulf of Taranto,Southern Italy)

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Journal of Palaeogeography 2024年第2期13卷 327-350页

作者： Pierluigi Santagati Edoardo Perri Maria Pia Bernasconi mario Borrelli Salvatore Guerrieri Salvatore Critelli Dipartimento di Biologia Ecologia e Scienze della TerraUniversita della Calabriavia Pietro Bucci87036 Arcavacata di RendeCosenzaItaly Dipartimento di Ingegneria Ambientale Universita della Calabriavia Pietro Bucci87036 Arcavacata di RendeCosenzaItaly

It is reported a multi-proxy palaeoclimatic study conducted on a MIS 5e calcarenite from the Mar Piccolo Basin(MP),Gulf of Taranto(GT)(Central Mediterranean).The calcarenite returned a rich malacofauna consisting of 120 extant species,including four of the tropical Senegalese Fauna,today absent in the *** biogeographic-climatic affinity of the assemblage shows,compared to today,a double percentage of warm affinity species,while the cold affinity species are nearly equally represented,indicating a warmer but not strictly tropical *** is confirmed by the most recurring preferred SST ranges of the assemblage,indicating an average of 20℃.The skeletal compositions of five well-preserved molluscan and coral specimens were analyzed for trace elements and stable isotopes for further mean SST *** the comparison of the results of several equations available in literature,it appears that only some SST estimations are realistic,converging into similar values of,on average,20.8±0.9℃.Considering all the used proxies,the MIS 5e SST difference compared to today falls in the range 1.2—2.0℃for the GT(being a more reasonable scenario)and 2.0—2.8℃for the *** is not a firmly tropical-like SST setting as suggested by the sole Senegalese fauna,indicating at least 2.7℃—3.5℃more than today’s GT and MP,*** approximations and assumptions made for obtaining SST values with any single proxy indicate the need of a multi-proxy approach to define the best SST estimation.

关键词： MiS 5e Sea surface temperature Palaeoclimate proxy Fossil fauna Gulf of Taranto

Survival effects of antibiotic exposure during the larval and adult stages in the West Nile virus vector Culex pipiens

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Insect Science 2024年第2期31卷 542-550页

作者： Marta Garrigos mario Garrido Manuel Morales-Yuste JosuéMartinez-de la Puente Jesus Veiga Faculty of Pharmacy Department of ParasitologyUniversity of GranadaGranadaSpain CIBER de Epidemiologia y Salud Publica(CIBERESP) MadridSpain

The ability of mosquitoes to transmit a pathogen is affected,among other factors,by their survival rate,which is partly modulated by their *** microbiota is acquired during the larval phase and modified during their development and adult feeding behavior,being highly dependent on environmental *** residues including antibiotics are widespread pollutants potentially being present in mosquito breeding waters likely affecting their ***,we used Culex pipiens mosquitoes to assess the impact of antibiotic exposure during the larval and adult stages on the survival rate of adult ***-collected larvae were randomly assigned to two treatments:larvae maintained in water supplemented with antibiotics and control *** adults were subsequently assigned to each of two treatments,fed with sugar solution with antibiotics and fed only with sugar solution(controls).Larval exposure to antibiotics significantly increased the survival rate of adult females that received a control *** addition,the effect of adult exposure to antibiotics on the survival rate of both male and female mosquitoes depended on the number of days that larvae fed ad libitum in the laboratory before *** particular,shorter larval ad libitum feeding periods reduced the survival rate of antibiotic-treated adult mosquitoes compared with those that emerged after a longer larval feeding *** differences were not found in control adult *** results extend the current understanding of the impact of antibiotic exposure of mosquitoes on a key component of vectorial capacity,that is the vector survival rate.

关键词： antibiotics avian malaria microbiota mosquitoes vector competence vector survival

Genomic signatures of selection,local adaptation and production type characterisation of East Adriatic sheep breeds

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Journal of Animal Science and Biotechnology 2024年第2期15卷 546-562页

作者： Boris Lukic Ino Curik Ivana Drzaic Vlatko Galić mario Shihabi LubošVostry Vlatka Cubric-Curik Faculty of Agrobiotechnical Sciences Osijek J.JStrossmayer University of OsijekVladimira Preloga 131000 OsijekCroatia Department of Animal Science Faculty of AgricultureUniversity of ZagrebSvetošimunska Cesta 2510000 ZagrebCroatia Department of Maize Breeding and Genetics Agricultural Institute OsijekJužno predgrađe 1731000 OsijekCroatia Czech University of Life Sciences Prague Kamycka 12916500 PraqueCzech Republic

Background The importance of sheep breeding in the Mediterranean part of the eastern Adriatic has a long tradition since its arrival during the Neolithic *** production system is extensive and generally carried out in traditional systems without intensive systematic breeding programmes for high uniform trait production(carcass,wool and milk yield).Therefore,eight indigenous Croatian sheep breeds from eastern Adriatic treated here as metapopulation(EAS),are generally considered as multipurpose breeds(milk,meat and wool),not specialised for a particular type of production,but known for their robustness and resistance to certain environmental *** objective was to identify genomic regions and genes that exhibit patterns of positive selection signatures,decipher their biological and productive functionality,and provide a"genomic"characterization of EAS adaptation and determine its production *** We identified positive selection signatures in EAS using several methods based on reduced local variation,linkage disequilibrium and site frequency spectrum(eROHi,iHS,nSL and CLR).Our analyses identified numerous genomic regions and genes(e.g.,desmosomal cadherin and desmoglein gene families)associated with environmental adaptation and economically important *** candidate genes were related to meat/production and health/immune response traits,while some of the candidate genes discovered were important for domestication and evolutionary processes(e.g.,HOXa gene family and FSIP2).These results were also confirmed by GO and QTL enrichment *** Our results contribute to a better understanding of the unique adaptive genetic architecture of EAS and define its productive type,ultimately providing a new opportunity for future breeding *** the same time,the numerous genes identified will improve our understanding of ruminant(sheep)robustness and resistance in the harsh and specific Mediterranean environment.

关键词： Composite-likelihood ratio East Adriatic sheep Extreme ROH islands Genomic selection signatures Integrated haplotype score Number of segregating sites by length

Multi‑omics integration identifies regulatory factors underlying bovine subclinical mastitis

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Journal of Animal Science and Biotechnology 2024年第3期15卷 987-1007页

作者： Mengqi Wang Naisu Yang mario Laterriere David Gagne Faith Omonijo Eveline M.Ibeagha‑Awemu Agriculture and Agri‑Food Canada Sherbrooke Research and Development CentreSherbrookeQCCanada Department of Animal Science Universite LavalQuebec CityQCCanada Quebec Research and Development Centre Agriculture and Agri-Food CanadaQuebec CityQCCanada

Background Mastitis caused by multiple factors remains one of the most common and costly disease of the dairy ***-omics approaches enable the comprehensive investigation of the complex interactions between mul-tiple layers of information to provide a more holistic view of disease ***,this study investigated the genomic and epigenomic signatures and the possible regulatory mechanisms underlying subclinical mastitis by integrating RNA sequencing data(mRNA and lncRNA),small RNA sequencing data(miRNA)and DNA methylation sequencing data of milk somatic cells from 10 healthy cows and 20 cows with naturally occurring subclinical mastitis caused by Staphylococcus aureus or Staphylococcus *** Functional investigation of the data sets through gene set analysis uncovered 3458 biological process GO terms and 170 KEGG pathways with altered activities during subclinical mastitis,provided further insights into subclin-ical mastitis and revealed the involvement of multi-omics signatures in the altered immune responses and impaired mammary gland productivity during subclinical *** abundant genomic and epigenomic signatures with sig-nificant alterations related to subclinical mastitis were observed,including 30,846,2552,1276 and 57 differential methylation haplotype blocks(dMHBs),differentially expressed genes(DEGs),lncRNAs(DELs)and miRNAs(DEMs),***,5 factors presenting the principal variation of differential multi-omics signatures were *** important roles of Factor 1(DEG,DEM and DEL)and Factor 2(dMHB and DEM),in the regulation of immune defense and impaired mammary gland functions during subclinical mastitis were *** of the omics within Factors 1 and 2 explained about 20%of the source of variation in subclinical ***,networks of impor-tant functional gene sets with the involvement of multi-omics signatures were demonstrated,which contributed to a comprehensive view of the possible regu

关键词： Candidate discriminant multi-omics signature Gene Long non-coding RNA Methylation haplotype block MicroRNA Multi-omics integration Natural killer cell mediated cytotoxicity pathway Staphylococcus aureus infection pathway

Stem cell technology for antitumor drug loading and delivery in oncology

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Oncology Research 2024年第3期32卷 433-437页

作者： FRANCESCO PETRELLA ENRICO mario CASSINA LIDIA LIBRETTI EMANUELE PIRONDINI FEDERICO RAVEGLIA ANTONIO TUORO Department of Thoracic Surgery Fondazione IRCCSS an Gerardo dei TintoriMonza20900Italy

The main aim of antineoplastic treatment is to maximize patient benefit by augmenting the drug accumulation within affected organs and tissues,thus incrementing drug effects and,at the same time,reducing the damage of non-involved tissues to cytotoxic *** stromal cells(MSC)represent a group of undifferentiated multipotent cells presenting wide self-renewal features and the capacity to differentiate into an assortment of mesenchymal family *** the last year,they have been proposed as natural carriers for the selective release of antitumor drugs to malignant cll,s thus optimizing cytotoxic action on cancer cll,while significantly reducing adverse side efect on healthy *** chemotherapeutic drug loading and delivery is an encouraging new area of cell therapy for several tumors,especially for those with unsatisfactory prognosis and limited treatment options *** some experim ental models have been sucesfuly developed,phase I dinical studies are needed to confirm this potential application of cell therapy,in particular in the case of primary and secondary lung cancers.

关键词： Mesenchymal stromal cell Drug loading Drug delivery Mesothelioma Melanoma Glioblastoma Pancreatic ductal adenocarcinoma Multiple myeloma