检索结果-南通市图书馆

Reassessing the AMPK-MTORC1 balance in autophagy in the central nervous system

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第11期20卷 3209-3210页

作者： Marta García-Juan mario Villa Irene Benito-Cuesta Lara Ordónez-Gutiérrez Francisco Wandosell Centro de Biología Molecular“Severo Ochoa”(CSIC-UAM) Nicolas Cabrera 1Universidad Autónoma de MadridMadridSpain Fisiología Animal Departamento de BiologíaFacultad de CienciasUniversidad Autónoma de MadridMadridSpain Department of Clinical Neuroscience CMM Karolinska Universitetssjukhuset SolnaStockholmSweden Departamento de Bioquímica y Biología Molecular Universidad Complutense de MadridMadridSpain Centro de Investigación Biomédica en Red de enfermedades Neurodegenerativas(CIBeRNeD) MadridSpain

Autophagy is a cellular degradation and recycling system,indispensable for cellular and organ development,homeostasis,and *** cellular process is evolutionarily highly conserved to quality control of many proteins and dysfunctional organelles,which finally recycle components as amino *** process is effective during normal physiology as part of anabolism and plays an additional important role during starvation(Dikic and elazar,2018).Different types of autophagy have been chara cterized based on their dynamic,mechanism of action,target substrates,and protein *** of them are macroautophagy(hereafter called"autophagy"),microa utophagy,and chape rone-media ted autophagy(Fleming et al.,2022).

关键词： homeostasis system hereafter

A survey of data-centric technologies supporting decision-making before deploying military assets

在线全文

学校读者我要写书评

暂无评论

Defence Technology（防务技术） 2024年第12期42卷 226-246页

作者： Alexandra Zabala-López mario Linares-Vásquez Sonia Haiduc Yezid donoso Colombian Air Force-Air and Space Operations Command-Aerospace Technology Development Centre for the Defense-CeTAD Avenida El Dorado Cra.54 No 26-25 CANBogotaColombia Universidad de los Andes Edificio Mario Laserna Cra 1 Este No 19A-40BogotaColombia Florida State University James Jay Love Building2531017 Academic WayTallahassee 32304FLUnited States

In a time characterized by the availability of vast amounts of data,the effective utilization of information is critical for timely decision-making in military ***,processing large amounts of data requires computational resources and ***,decision makers have used data-centric technologies to take advantage of public and private data sources to support military *** survey explores the integration and application of data-centric technologies,such as data analytics,data science,and machine learning,to optimize decision-making workflows within military contexts supporting the deployment of military assets and *** address the information gap,this article presents a literature review,specifically a *** survey examines the use of the mentioned technologies to process and analyze information that contributes to the phases of situational awareness,and planning in military *** then introduce a taxonomy of the approaches associated with implementing these technologies in military ***,we discuss relevant factors for the seamless integration of data-centric technologies into military decision-making processes,and reveal the importance of specialized personnel,architectures,and cybersecurity issues in the task of developing prototypes and *** findings of this paper aim to provide valuable insights for military institutions,offering a deeper understanding of the use of data-centric technologies as innovative practices to enhance the effectiveness of military decision-making.

关键词： Data-centric technologies Military Analytics Machine learning Data science Artificial intelligence

Scientific Study Reveals that electroacupuncture Technique Can Treat PCOS Symptoms

在线全文

学校读者我要写书评

暂无评论

Chinese Medicine and Culture 2020年第4期3卷 225-231页

作者： Daniela donoso Paredes Life Flow UbudBaliIndonesia

The efficiency of traditional Chinese medicine theory and acupoints shows once more its accurate regulatory capacity by improving women biological cycles with the use of electroacupuncture(eA).Results presented in a research study that preformed ovulation induction in women with anovulation due to polycystic ovary syndrome(PCOS),successfully provided data supporting acupuncture as a natural treatment for infertile women,with no significant side *** purpose of this study is to demonstrate how eA treatment can induce ovulation related to the hormonal and neuronal system in women affected by *** study introduces proof of effectivity and improvement based on the research of the University of Gothenburg,Sweden,that presents a study on how eA can be an alternative to ovulation-inducing drugs,to be considered as a possible holistic regulator of PCOS and *** study covered 24 women with PCOS and oligo-/amenorrhea who received eA in a low frequency of 2 Hz with a total of 14 treatments applied for 3 *** were taken three times during the study to see fluctuations in hormonal,ovulatory,and symptomatic behavior of *** demonstrated effective regular ovulatory inductions in more than a third of women.

关键词： Amenorrhea irregular menstruation oligomenorrhea ovulation polycystic ovarian syndrome uterus

Broadband quantum-dot frequency-modulated comb laser

在线全文

学校读者我要写书评

暂无评论

Light(Science & Applications) 2023年第8期12卷 1696-1707页

作者： Bozhang Dong mario Dumont Osama Terra Heming Wang Andrew Netherton John e Bowers Institute for energy efficiency University of CaliforniaSanta BarbaraCAUSA Department of electrical and Computer engineering University of CaliforniaSanta BarbaraCAUSA Primary Length and Laser Technology Lab National Institute of StandardsGizaEgypt

Frequency-modulated(FM)laser combs,which offer a quasi-continuous-wave output and a flat-topped optical spectrum,are emerging as a promising solution for wavelength-division multiplexing applications,precision metrology,and ultrafast optical *** generation of FM combs relies on spatial hole burning,group velocity dispersion,Kerr nonlinearity,and four-wave mixing(FWM).While FM combs have been widely observed in quantum cascade Fabry-Perot(FP)lasers,the requirement for a low-dispersion FP cavity can be a challenge in platforms where the waveguide dispersion is mainly determined by the *** we report a 60 GHz quantum-dot(QD)mode-locked laser in which both the amplitude-modulated(AM)and the FM comb can be generated *** high FWM efficiency of-5 dB allows the QD laser to generate FM comb *** also demonstrate that the Kerr nonlinearity can be practically engineered to improve the FM comb bandwidth without the need for GVD *** maximum 3-dB bandwidth that our QD platform can deliver is as large as 2.2 *** study gives novel insights into the improvement of FM combs and paves the way for small-footprint,electrically pumped,and energy-efficient frequency combs for silicon photonic integrated circuits(PICs).

关键词： laser waveguide pumped

A digital earth platform for sustainability

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Digital earth 2017年第4期10卷 342-355页

作者： mario Hernandez engagement Committee Future EarthMexico CityMexico International Society for Digital earth Mexico CityMexico

Based on the experience of the International Society for Digital earth(ISDe),this paper describes some challenges foreseen in order to develop a Digital earth platform that can support the implementation of the Sustainable Development *** use of ready-to-use derived geospatial information is *** earth’s methodology of‘co-design’aims to bring together natural,social scientists and decision makers to plan and carry out research for *** implies transdisciplinary research,but in order for scientists of different disciplines to work together,they will need to be able to share,access and use common *** is by far not simple!While the good will to share data might exist,the associated technological,ethical and privacy issues are difficult to *** adequate e-infrastructure will be *** could consider to use the SDGs is the basis to develop the desired Digital earth *** paper,by no means,covers everything for a Digital earth platform,it aims to trigger research discussions and to have a good view about a starting point.

关键词： Digital earth platform sustainable development Sustainable Development Goals future earth

XDeM multi-physics and multi-scale simulation technology: Review of DeM-CFD coupling, methodology and engineering applications

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Particuology 2019年第3期17卷 176-193页

作者： Bernhard Peters Maryam Baniasadi Mehdi Baniasadi Xavier Besseron Alvaro estupinan donoso Mohammad Mohseni Gabriele Pozzetti Universite du Luxembourg 6. rue Coudenhove-Kalergi L-1359 Luxembourg

The extended discrete element method (XDeM) multi-physics and multi-scale simulation platform is being developed at the Institute of Computational engineering, the University of Luxembourg. The platform is an advanced multi-physics simulation technology that combines flexibility and versatility to establish the next generation of multi-physics and multi-scale simulation tools. For this purpose, the simulation framework relies on coupling various predictive tools based on an eulerian and Lagrangian approach. The euleria n approach represents the wide field of con tinuum models;the Lagra ngian approach is perfect for characterising discrete phases. Continuum models thus include classical simulation tools, such as computational fluid dynamics simulation and finite element analysis, while an extended configuration of the classical discrete element method addresses the discrete (e.g., particulate) phase. Apart from predicting the trajectories of in dividual particles, XDeM-suite extends the application of the XDeM to estimating the thermodynamic state of each particle using advanced and optimised algorithms. The thermodynamic state may include temperature and species distributions due to chemical reaction and external heat sources. Hence, coupling these extended features with either computational fluid dynamics simulation or finite element analysis opens a wide range of applications as diverse as pharmaceuticals, agriculture, food processing, mining, construction and agricultural machinery, metals manufacturing, energy production and systems biology.

关键词： Multi-phase modelling Coupled computational fluid dynamics-discrete element method

Reproductive patterns in Araucaria araucana forests in the Andean range, Chile

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

ecological Processes 2024年第1期13卷 252-261页

作者： Sergio donoso Karen Pe?a-Rojas Claudia espinoza Carolain Badaracco Rómulo Santelices-Moya Antonio Cabrera-Ariza Mediterranean Forests Laboratory Faculty of Forestry and Nature Conservation Centro Secano Faculty of Agricultural and Forestry Sciences Universidad Católica del Maule Maule Advanced Studies Research Center Vice-Rector's Office for Research and Postgraduate Studies Catholic University of Maule

Background Araucaria araucana is a mast species that presents a high variability in annual cone production. Researchers have recorded synchronization events in cone production in different populations, which allows the seed production to be concentrated, reducing the percentage of seeds consumed by different animal *** We sampled three populations located in the Andes Mountains, Araucanía Region, Chile. In 2004 we began the collection of data on cone production, for which we installed permanent plots（1200 m2each） at each location. We identified and labeled each female tree in each plot to monitor its cone production. In 2012 we selected a total of 30 trees near the plots to evaluate the number of seeds per cone. In each February from 2012 to 2014 we selected two mature cones and covered them with a porous mesh for subsequent collection and storage in March. At the beginning of June, we counted and weighed the seeds, determining the average weight, the number of seeds per cone, the germination capacity（GC）, and the germination speed（GS）.Results Cone production was synchronous across the three locations. We observed significant differences among the locations and years evaluated. The cones had fewer seeds in 2013（high production） compared to those in 2012（low production）, but their weights were similar. In 2014 the cones produced smaller seeds in fewer quantities. The difference between the years 2013 and 2014 resulted from the high-energy expenditure in 2013. Regarding GC and GS, there were significant differences among the three locations（GC: F = 45.41, p ere the highest values were observed in *** Both GC and GS are related to seed weight but not to the number of cones produced in a given year. These annual fluctuations in seed production are determining factors in the population dynamics of forest species. Our results allow a better understanding of the reproductive phenology of A. araucana and could hel

关键词： Seed weight Germination potential Masting species Sustainable use Dioecious species

Modeling antiphase boundary energies of Ni_(3)Al-based alloys using automated density functional theory and machine learning

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

npj Computational Materials 2022年第1期8卷 757-766页

作者： enze Chen Artur Tamm Tao Wang mario e.epler Mark Asta Timofey Frolov Department of Materials Science and engineering University of CaliforniaBerkeleyCA94720USA Materials Sciences Division Lawrence Berkeley National LaboratoryBerkeleyCA94720USA Materials Science Division Lawrence Livermore National LaboratoryLivermoreCA94550USA Carpenter Technology Corporation PhiladelphiaPA19103USA

Antiphase boundaries(APBs)are planar defects that play a critical role in strengthening Ni-based superalloys,and their sensitivity to alloy composition offers a flexible tuning parameter for alloy ***,we report a computational workflow to enable the development of sufficient data to train machine-learning(ML)models to automate the study of the effect of composition on the(111)APB energy in Ni_(3)Al-based *** employ ML to leverage this wealth of data and identify several physical properties that are used to build predictive models for the APB energy that achieve a cross-validation error of 0.033 J m^(−2).We demonstrate the transferability of these models by predicting APB energies in commercial ***,our use of physically motivated features such as the ordering energy and stoichiometry-based features opens the way to using existing materials properties databases to guide superalloy design strategies to maximize the APB energy.

关键词： Ni_(3)Al alloy superalloy

Phenotypic diversity in ethiopian durum wheat(Triticum turgidum ***)landraces

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The Crop Journal 2015年第3期3卷 190-199页

作者： Dejene K.Mengistu Afeworki Y.Kiros mario e.Pè Department of Dryland Crop and Horticultural Sciences Mekelle University P.O.Box 231 Mekelle Ethiopia Scuola Superiore Sant'Anna (SSSUP) Pizza Martiri Liberà 33 – 56127 Pisa Italy

The phenotypic diversity of 274 ethiopian durum wheat accessions was analyzed, taking their geographic origins into account. The aim was to assess the extent and patterns of agronomically important phenotypic variation across districts of origin and altitude classes for major qualitative traits using diversity index and multivariate methods. eight qualitative and three quantitative traits were scored for 2740 plants and analyzed for diversity. The Shannon–Weaver diversity(H′) index was used to estimate phenotypic diversity. The estimated H′ ranged from monomorphic for glume hairiness to highly polymorphic for other traits. The highest(0.86) H′ was obtained for seed degree of shriveling, possibly indicating the differential responses of the genotypes to water deficit during later growth stages. With respect to district of origin, the highest(0.72) and lowest(0.44) H′ values were obtained for the Bale and SNNP districts, respectively. With respect to altitude, the highest(0.76) and lowest(0.62) H′ values were recorded for altitudes 1600–2000and > 3000 m above sea levels, respectively. Principal components analysis explained substantial variation contributed by district of origin and altitude range. Genotypes were clustered into three groups by districts of origin and altitude class, with relatively strong bootstrap values of 57 and 62 for the former and latter, respectively. It could be concluded that ethiopian durum wheat landraces are very diverse both within and among districts of origin and altitude classes. This wealth of genetic diversity should be exploited for wheat improvement of yield and for resistance to biotic and abiotic stresses, particularly terminal drought.

关键词： Phenotypic diversity Diversity index Landraces Districts of origin Altitude ethiopia